{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:58:01Z","timestamp":1793674681505,"version":"4.5.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673426"],"award-info":[{"award-number":["81673426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730012"],"award-info":[{"award-number":["81730012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170240"],"award-info":[{"award-number":["82170240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["81861128022"],"award-info":[{"award-number":["81861128022"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2019H003"],"award-info":[{"award-number":["LH2019H003"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.biopha.2022.113162","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T16:36:57Z","timestamp":1653669417000},"page":"113162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Daming capsule protects against myocardial infarction by promoting mitophagy via the SIRT1\/AMPK signaling pathway"],"prefix":"10.1016","volume":"151","author":[{"given":"Xi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaorun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.113162_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109303","article-title":"Downregulation of miR-200a protects cardiomyocyte against apoptosis","volume":"123","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2022.113162_bib2","first-page":"18","article-title":"A molecular approach to mitophagy and mitochondrial dynamics","volume":"41","author":"Yoo","year":"2018","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biopha.2022.113162_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature06501","article-title":"NLRX1 is a regulator of mitochondrial antiviral immunity","volume":"451","author":"Moore","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113162_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.intimp.2019.03.001","article-title":"NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-kappaB signaling","volume":"71","author":"Ma","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2022.113162_bib5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.molimm.2016.06.013","article-title":"NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation","volume":"76","author":"Li","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.biopha.2022.113162_bib6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41590-019-0324-2","article-title":"Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biopha.2022.113162_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","article-title":"The Sir2 family of protein deacetylases","volume":"73","author":"Blander","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.biopha.2022.113162_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20070140","article-title":"Sirtuins in mammals: insights into their biological function","volume":"404","author":"Michan","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2022.113162_bib9","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.15252\/embj.201695737","article-title":"SIRT1 regulates macrophage self-renewal","volume":"36","author":"Imperatore","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.biopha.2022.113162_bib10","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1681\/ASN.2017111218","article-title":"Sirtuins in renal health and disease","volume":"29","author":"Morigi","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2022.113162_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cca.2014.07.019","article-title":"SIRT1 in cardiovascular aging","volume":"437","author":"Luo","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2022.113162_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070680","article-title":"Mitochondria in health and disease","volume":"8","author":"Annesley","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2022.113162_bib13","article-title":"AMPK, mitochondrial function, and cardiovascular disease","volume":"21","author":"Wu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.113162_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.645041","article-title":"Function and mechanism of trimetazidine in myocardial infarction-induced myocardial energy metabolism disorder through the SIRT1-AMPK pathway","volume":"12","author":"Luo","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2022.113162_bib15","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1080\/21655979.2021.1938500","article-title":"Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK\/FUNDC1 axis","volume":"12","author":"Mao","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.biopha.2022.113162_bib16","article-title":"17Beta-estradiol induces mitophagy upregulation to protect chondrocytes via the SIRT1-mediated AMPK\/mTOR signaling pathway","volume":"11","author":"Mei","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113162_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110618","article-title":"Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-beta1\/Smad2\/3 pathways","volume":"130","author":"Shen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2022.113162_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1472-6882-10-80","article-title":"Protective effect of the damming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia","volume":"10","author":"Ai","year":"2010","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2022.113162_bib19","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1248\/bpb.32.1354","article-title":"The protective effect of Daming capsule on heart function in streptozocin-induced diabetic rats with hyperlipidemia","volume":"32","author":"Ai","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2022.113162_bib20","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/CIRCULATIONAHA.120.050812","article-title":"LARP7 protects against heart failure by enhancing mitochondrial biogenesis","volume":"143","author":"Yu","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2022.113162_bib21","article-title":"Astragaloside IV ameliorates myocardial infarction induced apoptosis and restores cardiac function","volume":"9","author":"Sun","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2022.113162_bib22","doi-asserted-by":"crossref","first-page":"34284","DOI":"10.1038\/srep34284","article-title":"The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.113162_bib23","article-title":"Mitochondrial ROS in myocardial ischemia reperfusion and remodeling","volume":"2020","author":"Bugger","year":"1866","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2022.113162_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41419-020-2374-7","article-title":"Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2022.113162_bib25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1074\/jbc.M112.411363","article-title":"Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction","volume":"288","author":"Kubli","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.113162_bib26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2011.10.008","article-title":"p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia","volume":"52","author":"Hoshino","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biopha.2022.113162_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.632383","article-title":"The role of Sirtuin-1 in immune response and systemic lupus erythematosus","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2022.113162_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.arr.2016.04.003","article-title":"Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways","volume":"28","author":"Salminen","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.biopha.2022.113162_bib29","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/jcmm.16329","article-title":"Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1\/FoxO3a pathway","volume":"25","author":"Chen","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2022.113162_bib30","first-page":"1267","article-title":"Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro","volume":"10","author":"Xiao","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.biopha.2022.113162_bib31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2022.113162_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phrs.2018.03.017","article-title":"Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1\/AMPK signaling pathway","volume":"131","author":"Yao","year":"2018","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biopha.2022.113162_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00395-020-0781-7","article-title":"M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment","volume":"115","author":"Liu","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.biopha.2022.113162_bib34","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1111\/bph.15007","article-title":"P2\u2009\u00d7\u20097 receptor-targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: a new strategy towards macrophage-hepatocyte crosstalk","volume":"177","author":"Zhang","year":"2020","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.biopha.2022.113162_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ceb.2017.01.005","article-title":"AMPK signalling in health and disease","volume":"45","author":"Carling","year":"2017","journal-title":"Curr. Opin. Cell Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222005510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222005510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:01:53Z","timestamp":1787598113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222005510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":35,"alternative-id":["S0753332222005510"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113162","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daming capsule protects against myocardial infarction by promoting mitophagy via the SIRT1\/AMPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113162"}}