{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:22:45Z","timestamp":1789521765448,"version":"build-2803163510"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JQ-864"],"award-info":[{"award-number":["2022JQ-864"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017614","name":"Xi'an Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.biopha.2022.113166","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T23:23:02Z","timestamp":1653348182000},"page":"113166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Roles of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in non-neoplastic liver diseases"],"prefix":"10.1016","volume":"151","author":[{"given":"Di","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2019.03.004","article-title":"Global liver disease burdens and research trends: analysis from a Chinese perspective","volume":"71","author":"Xiao","year":"2019","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.biopha.2022.113166_bib3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41575-020-0304-x","article-title":"Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis","volume":"17","author":"Ramachandran","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.biopha.2022.113166_bib4","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41568-019-0168-y","article-title":"YAP and TAZ: a signalling hub of the tumour microenvironment","volume":"19","author":"Zanconato","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biopha.2022.113166_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-pathol-030420-105050","article-title":"The Hippo pathway in liver homeostasis and pathophysiology","volume":"16","author":"Driskill","year":"2021","journal-title":"Annu Rev. Pathol."},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib6","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.gastro.2014.05.004","article-title":"Activation of beta-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice","volume":"147","author":"Tao","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113166_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ceb.2019.07.006","article-title":"Role of the transcriptional coactivators YAP\/TAZ in liver cancer","volume":"61","author":"Zhang","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"issue":"9","key":"10.1016\/j.biopha.2022.113166_bib8","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1136\/gutjnl-2017-314061","article-title":"Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma","volume":"67","author":"Kim","year":"2018","journal-title":"Gut"},{"issue":"547","key":"10.1016\/j.biopha.2022.113166_bib9","doi-asserted-by":"crossref","first-page":"eaaj1757","DOI":"10.1126\/scisignal.aaj1757","article-title":"The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors","volume":"11","author":"Hagenbeek","year":"2018","journal-title":"Sci. Signal"},{"key":"10.1016\/j.biopha.2022.113166_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.coph.2016.05.002","article-title":"YAP\/TAZ as therapeutic targets in cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Curr. Opin. Pharm."},{"key":"10.1016\/j.biopha.2022.113166_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105009","article-title":"Yes-associated protein and transcriptional coactivator with PDZ-binding motif as new targets in cardiovascular diseases","volume":"159","author":"Yu","year":"2020","journal-title":"Pharm. Res."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1101\/gad.9.5.534","article-title":"The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation","volume":"9","author":"Justice","year":"1995","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.devcel.2020.06.025","article-title":"Integration of Hippo-YAP signaling with metabolism","volume":"54","author":"Ibar","year":"2020","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ncb3111","article-title":"Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway","volume":"17","author":"Mo","year":"2015","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.celrep.2014.09.036","article-title":"Energy stress regulates Hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein","volume":"9","author":"DeRan","year":"2014","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.molcel.2017.10.010","article-title":"Regulation of the Hippo-YAP pathway by glucose sensor O-GlcNAcylation","volume":"68","author":"Peng","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biopha.2022.113166_bib17","doi-asserted-by":"crossref","first-page":"15280","DOI":"10.1038\/ncomms15280","article-title":"The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat. Commun."},{"issue":"26","key":"10.1016\/j.biopha.2022.113166_bib18","doi-asserted-by":"crossref","first-page":"22089","DOI":"10.1074\/jbc.M111.334714","article-title":"A novel acetylation cycle of transcription co-activator yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents","volume":"287","author":"Hata","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.devcel.2013.05.025","article-title":"Control of the Hippo pathway by Set7-dependent methylation of Yap","volume":"26","author":"Oudhoff","year":"2013","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ccell.2018.06.002","article-title":"SET1A-mediated mono-methylation at K342 regulates YAP activation by blocking its nuclear export and promotes tumorigenesis","volume":"34","author":"Fang","year":"2018","journal-title":"Cancer Cell"},{"issue":"46","key":"10.1016\/j.biopha.2022.113166_bib21","doi-asserted-by":"crossref","first-page":"17693","DOI":"10.1074\/jbc.REV119.007963","article-title":"Control of cellular responses to mechanical cues through YAP\/TAZ regulation","volume":"294","author":"Dasgupta","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"7730","key":"10.1016\/j.biopha.2022.113166_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-018-0658-1","article-title":"The SWI\/SNF complex is a mechanoregulated inhibitor of YAP and TAZ","volume":"563","author":"Chang","year":"2018","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/ncb3336","article-title":"Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity","volume":"18","author":"Elosegui-Artola","year":"2016","journal-title":"Nat. Cell Biol."},{"issue":"7634","key":"10.1016\/j.biopha.2022.113166_bib24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nature20602","article-title":"Integrin-YAP\/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow","volume":"540","author":"Wang","year":"2016","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib25","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI122440","article-title":"c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow","volume":"129","author":"Li","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.biopha.2022.113166_bib27","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1091\/mbc.e11-04-0300","article-title":"Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor","volume":"22","author":"Paramasivam","year":"2011","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib28","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.celrep.2017.07.032","article-title":"The epithelial circumferential actin belt regulates YAP\/TAZ through nucleocytoplasmic shuttling of Merlin","volume":"20","author":"Furukawa","year":"2017","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.biopha.2022.113166_bib29","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.1074\/jbc.C110.212621","article-title":"Hippo pathway-independent restriction of TAZ and YAP by angiomotin","volume":"286","author":"Chan","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.devcel.2009.12.011","article-title":"Kibra is a regulator of the Salvador\/Warts\/Hippo signaling network","volume":"18","author":"Genevet","year":"2010","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib31","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.cell.2011.02.031","article-title":"Yap1 acts downstream of alpha-catenin to control epidermal proliferation","volume":"144","author":"Schlegelmilch","year":"2011","journal-title":"Cell"},{"issue":"174","key":"10.1016\/j.biopha.2022.113166_bib32","doi-asserted-by":"crossref","first-page":"ra33","DOI":"10.1126\/scisignal.2001823","article-title":"alpha-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1","volume":"4","author":"Silvis","year":"2011","journal-title":"Sci. Signal"},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib33","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.biopha.2022.113166_bib34","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib35","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jhep.2015.07.008","article-title":"Emerging evidence on the role of the Hippo\/YAP pathway in liver physiology and cancer","volume":"63","author":"Yimlamai","year":"2015","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.205","article-title":"Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration","volume":"50","author":"Lu","year":"2018","journal-title":"Exp. Mol. Med"},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib37","first-page":"410","article-title":"Differences in yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinoma","volume":"5","author":"Wang","year":"2012","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib38","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1096\/fj.201801256RR","article-title":"TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury","volume":"33","author":"Kim","year":"2019","journal-title":"FASEB J."},{"issue":"13","key":"10.1016\/j.biopha.2022.113166_bib39","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.7150\/thno.33370","article-title":"Suppression of YAP\/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2022.113166_bib40","doi-asserted-by":"crossref","first-page":"16017","DOI":"10.1038\/ncomms16017","article-title":"YAP determines the cell fate of injured mouse hepatocytes in vivo","volume":"8","author":"Miyamura","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib41","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1053\/j.gastro.2020.10.035","article-title":"Regeneration defects in Yap and Taz mutant mouse livers are caused by bile duct disruption and cholestasis","volume":"160","author":"Verboven","year":"2021","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1096\/fba.1023","article-title":"Yes-associated protein promotes early hepatocyte cell cycle progression in regenerating liver after tissue loss","volume":"1","author":"Tschuor","year":"2018","journal-title":"FASEB Bioadv."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jhep.2018.05.008","article-title":"Liver regeneration requires Yap1-TGFbeta-dependent epithelial-mesenchymal transition in hepatocytes","volume":"69","author":"Oh","year":"2018","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.biopha.2022.113166_bib44","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/dvg.20568","article-title":"Cre activity in fetal albCre mouse hepatocytes: utility for developmental studies","volume":"47","author":"Weisend","year":"2009","journal-title":"Genesis"},{"issue":"352","key":"10.1016\/j.biopha.2022.113166_bib45","doi-asserted-by":"crossref","first-page":"352ra108","DOI":"10.1126\/scitranslmed.aaf2304","article-title":"Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration","volume":"8","author":"Fan","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib46","doi-asserted-by":"crossref","first-page":"46","DOI":"10.15252\/emmm.201506089","article-title":"Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2","volume":"9","author":"Loforese","year":"2017","journal-title":"EMBO Mol. Med."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib47","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2009.09.026","article-title":"Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene","volume":"16","author":"Zhou","year":"2009","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","article-title":"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/hep.30131","article-title":"Pregnane X receptor regulates liver size and liver cell fate by yes-associated protein activation in mice","volume":"69","author":"Jiang","year":"2019","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib50","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.30150","article-title":"Ductular reaction in liver diseases: pathological mechanisms and translational significances","volume":"69","author":"Sato","year":"2019","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib51","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/hep.30270","article-title":"Hepatocyte-specific \u03b2-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes","volume":"69","author":"Russell","year":"2019","journal-title":"Hepatology"},{"issue":"7663","key":"10.1016\/j.biopha.2022.113166_bib52","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature23015","article-title":"Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"547","author":"Raven","year":"2017","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib53","doi-asserted-by":"crossref","first-page":"G471","DOI":"10.1152\/ajpgi.00153.2017","article-title":"Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury","volume":"314","author":"Konishi","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/hep.28542","article-title":"Hedgehog regulates yes-associated protein 1 in regenerating mouse liver","volume":"64","author":"Swiderska-Syn","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib56","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2009.03.008","article-title":"Kupffer cells in non-alcoholic fatty liver disease: the emerging view","volume":"51","author":"Baffy","year":"2009","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/hep.30990","article-title":"Yes-associated protein in Kupffer cells enhances the production of proinflammatory cytokines and promotes the development of nonalcoholic steatohepatitis","volume":"72","author":"Song","year":"2020","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102427","article-title":"Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling","volume":"24","author":"Wang","year":"2021","journal-title":"iScience"},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib59","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cmet.2016.09.016","article-title":"Hepatocyte TAZ\/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis","volume":"24","author":"Wang","year":"2016","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib60","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jhep.2008.12.016","article-title":"Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH","volume":"50","author":"Caballero","year":"2009","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib61","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/hep.30401","article-title":"Dietary lipids differentially shape nonalcoholic steatohepatitis progression and the transcriptome of Kupffer cells and infiltrating macrophages","volume":"70","author":"McGettigan","year":"2019","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib62","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cmet.2020.03.010","article-title":"Cholesterol stabilizes TAZ in hepatocytes to promote experimental non-alcoholic steatohepatitis","volume":"31","author":"Wang","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2022.113166_bib63","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2020.12.038","article-title":"Hepatocyte-specific TAZ deletion downregulates p62\/ Sqstm1 expression in nonalcoholic steatohepatitis","volume":"535","author":"Yang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib64","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12072-017-9841-y","article-title":"Pathogenesis of non-alcoholic fatty liver disease mediated by YAP","volume":"12","author":"Chen","year":"2018","journal-title":"Hepatol. Int."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib65","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/hep.30928","article-title":"Hepatocyte stress increases expression of yes-associated protein and transcriptional coactivator with PDZ-binding motif in hepatocytes to promote parenchymal inflammation and fibrosis","volume":"71","author":"Mooring","year":"2020","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib66","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1111\/jcmm.14262","article-title":"A functional interaction between Hippo-YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice","volume":"23","author":"Shu","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"7","key":"10.1016\/j.biopha.2022.113166_bib67","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1101\/gad.274167.115","article-title":"The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation","volume":"30","author":"Aylon","year":"2016","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib68","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.bbrc.2016.02.059","article-title":"Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice","volume":"471","author":"Geng","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"44","key":"10.1016\/j.biopha.2022.113166_bib69","doi-asserted-by":"crossref","first-page":"E10417","DOI":"10.1073\/pnas.1808968115","article-title":"Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis","volume":"115","author":"Kodama","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib70","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI95802","article-title":"Hippo-mediated suppression of IRS2\/AKT signaling prevents hepatic steatosis and liver cancer","volume":"128","author":"Jeong","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib71","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.gastro.2007.05.012","article-title":"Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction","volume":"133","author":"Richardson","year":"2007","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib72","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib73","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jhep.2015.05.031","article-title":"Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease","volume":"63","author":"Machado","year":"2015","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib74","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.biopha.2022.113166_bib75","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.cgh.2014.04.020","article-title":"Short-term and long-term causes of death in patients with alcoholic hepatitis in Denmark","volume":"12","author":"Orntoft","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib76","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/hep.25614","article-title":"Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis","volume":"55","author":"Sancho-Bru","year":"2012","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib77","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3727\/105221618X15361728786767","article-title":"Single-cell gene expression analysis identifies chronic alcohol-mediated shift in hepatocyte molecular states after partial hepatectomy","volume":"19","author":"Achanta","year":"2019","journal-title":"Gene Expr."},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib78","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI132691","article-title":"Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis","volume":"130","author":"Hyun","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib79","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2021.05.041","article-title":"Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis","volume":"75","author":"Bou Saleh","year":"2021","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib80","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12431","article-title":"Oroxylin A inhibits ethanol-induced hepatocyte senescence via YAP pathway","volume":"51","author":"Jin","year":"2018","journal-title":"Cell Prolif."},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib81","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/hep.31800","article-title":"Stress-responsive gene FK506-binding protein 51 mediates alcohol-induced liver injury through the Hippo pathway and chemokine (C-X-C motif) ligand 1 signaling","volume":"74","author":"Kusumanchi","year":"2021","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib82","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/lt.24072","article-title":"Analysis of ischemia\/reperfusion injury in time-zero biopsies predicts liver allograft outcomes","volume":"21","author":"Ali","year":"2015","journal-title":"Liver Transpl."},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib83","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/hep.27334","article-title":"T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury","volume":"60","author":"Ji","year":"2014","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib84","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jhep.2019.05.029","article-title":"Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury","volume":"71","author":"Liu","year":"2019","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib85","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/hep.32015","article-title":"TNFAIP3 interacting protein 3 is an activator of Hippo-YAP signaling protecting against hepatic ischemia\/reperfusion injury","volume":"74","author":"Zhou","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2022.113166_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101745","article-title":"Nogo-B is a key mediator of hepatic ischemia and reperfusion injury","volume":"37","author":"Rao","year":"2020","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib87","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/hep.30700","article-title":"Hippo signaling controls NLR family pyrin domain containing 3 activation and governs immunoregulation of mesenchymal stem cells in mouse liver injury","volume":"70","author":"Li","year":"2019","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib88","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jhep.2018.12.003","article-title":"Fibrosis and alcohol-related liver disease","volume":"70","author":"Lackner","year":"2019","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib89","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.jhep.2017.06.001","article-title":"Hepatic stellate cell activation and pro-fibrogenic signals","volume":"67","author":"Gandhi","year":"2017","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2022.113166_bib90","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","article-title":"The Hippo pathway effector YAP controls mouse hepatic stellate cell activation","volume":"63","author":"Mannaerts","year":"2015","journal-title":"J. Hepatol."},{"issue":"557","key":"10.1016\/j.biopha.2022.113166_bib91","doi-asserted-by":"crossref","first-page":"eaay8798","DOI":"10.1126\/scitranslmed.aay8798","article-title":"Targeting acid ceramidase inhibits YAP\/TAZ signaling to reduce fibrosis in mice","volume":"12","author":"Alsamman","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib92","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1055\/s-0035-1550065","article-title":"Fibrosis in nonalcoholic fatty liver disease: mechanisms and clinical implications","volume":"35","author":"Angulo","year":"2015","journal-title":"Semin Liver Dis."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib93","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2017.12.022","article-title":"Hedgehog-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells","volume":"154","author":"Du","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113166_bib94","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1038\/ncomms12502","article-title":"PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis","volume":"7","author":"Martin","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2022.113166_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106139","article-title":"Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway","volume":"178","author":"Tong","year":"2022","journal-title":"Pharm. Res."},{"issue":"25","key":"10.1016\/j.biopha.2022.113166_bib96","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.7150\/thno.36942","article-title":"The hepatocyte-specifically expressed lnc-HSER alleviates hepatic fibrosis by inhibiting hepatocyte apoptosis and epithelial-mesenchymal transition","volume":"9","author":"Zhang","year":"2019","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib97","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jcmgh.2021.06.003","article-title":"Fatty acids activate the transcriptional coactivator YAP1 to promote liver fibrosis via p38 mitogen-activated protein kinase","volume":"12","author":"Salloum","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.biopha.2022.113166_bib98","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib99","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2021.09.032","article-title":"Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis","volume":"76","author":"Qing","year":"2022","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.biopha.2022.113166_bib100","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/s41591-018-0158-8","article-title":"Transcriptional addiction in cancer cells is mediated by YAP\/TAZ through BRD4","volume":"24","author":"Zanconato","year":"2018","journal-title":"Nat. Med."},{"issue":"51","key":"10.1016\/j.biopha.2022.113166_bib101","doi-asserted-by":"crossref","first-page":"15713","DOI":"10.1073\/pnas.1522163112","article-title":"BRD4 is a novel therapeutic target for liver fibrosis","volume":"112","author":"Ding","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.biopha.2022.113166_bib102","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/hep4.1405","article-title":"A therapeutic silencing RNA targeting hepatocyte TAZ prevents and reverses fibrosis in nonalcoholic steatohepatitis in mice","volume":"3","author":"Wang","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.biopha.2022.113166_bib103","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biopha.2018.06.102","article-title":"The inhibition of Hippo\/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation","volume":"106","author":"Li","year":"2018","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2022.113166_bib104","doi-asserted-by":"crossref","first-page":"30029","DOI":"10.1038\/srep30029","article-title":"omega-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP\/TAZ degradation","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.113166_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153294","article-title":"Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-beta\/Smad and YAP signaling","volume":"78","author":"Xiang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2022.113166_bib106","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biochi.2017.05.017","article-title":"Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo\/Yap and TGF-\u03b21\/Smad signaling","volume":"140","author":"Perumal","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.biopha.2022.113166_bib107","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3399357","article-title":"Resveratrol inhibits hepatic stellate cell activation via the Hippo pathway","volume":"2021","author":"Li","year":"2021","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib108","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/08923973.2019.1566926","article-title":"Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-\u03b2 signaling pathways in carbon tetrachloride (CCl4)-induced liver fibrosis in rats","volume":"41","author":"Mohseni","year":"2019","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.biopha.2022.113166_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.12.003","article-title":"Liquiritigenin inhibits hepatic fibrogenesis and TGF-\u03b21\/Smad with Hippo\/YAP signal","volume":"62","author":"Lee","year":"2019","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib110","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11033-020-05978-3","article-title":"Therapeutic effects of Chlorella vulgaris on carbon tetrachloride induced liver fibrosis by targeting Hippo signaling pathway and AMPK\/FOXO1 axis","volume":"48","author":"Mohseni","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"8","key":"10.1016\/j.biopha.2022.113166_bib111","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1097\/TP.0000000000002742","article-title":"Pituitary adenylate cyclase-activating polypeptides prevent hepatocyte damage by promoting yes-associated protein in liver ischemia-reperfusion injury","volume":"103","author":"Liu","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.biopha.2022.113166_bib112","article-title":"Ginsenoside Rg1 alleviates hepatic ischemia-reperfusion injury in mice via activating ER\u03b1-regulating YAP expression","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.biopha.2022.113166_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115975","article-title":"Octreotide ameliorates hepatic ischemia-reperfusion injury through SNHG12\/TAF15-mediated Sirt1 stabilization and YAP1 transcription","volume":"442","author":"Zou","year":"2022","journal-title":"Toxicol. Appl. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib114","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/mmr.2021.12126","article-title":"Parthenolide plays a protective role in the liver of mice with metabolic dysfunction\u2011associated fatty liver disease through the activation of the HIPPO pathway.","volume":"24","author":"Wang","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2022.113166_bib115","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2020.04.001","article-title":"Lytic cell death in metabolic liver disease","volume":"73","author":"Gautheron","year":"2020","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113166_bib116","article-title":"Hippo pathway effectors YAP\/TAZ as novel determinants of ferroptosis","volume":"7","author":"Yang","year":"2019","journal-title":"Mol. Cell Oncol."},{"issue":"7769","key":"10.1016\/j.biopha.2022.113166_bib117","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib118","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41575-021-00571-w","article-title":"Hippo signalling in the liver: role in development, regeneration and disease","volume":"19","author":"Russell","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2022.113166_bib119","article-title":"Targeting non-apoptotic cell death in cancer treatment by nanomaterials: recent advances and future outlook","volume":"29","author":"Sepand","year":"2020","journal-title":"Nanomedicine"},{"issue":"4","key":"10.1016\/j.biopha.2022.113166_bib120","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.jhep.2015.11.028","article-title":"RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver","volume":"64","author":"Yin","year":"2016","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113166_bib121","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222005558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222005558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:48:08Z","timestamp":1787597288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222005558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":121,"alternative-id":["S0753332222005558"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113166","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in non-neoplastic liver diseases","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113166"}}