{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:07:22Z","timestamp":1792494442540,"version":"4.5.0"},"reference-count":191,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.biopha.2022.113285","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T12:02:50Z","timestamp":1655553770000},"page":"113285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["A comprehensive look into the association of vitamin D levels and vitamin D receptor gene polymorphism with obesity in children"],"prefix":"10.1016","volume":"153","author":[{"given":"Raushanara","family":"Akter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrina","family":"Afrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahana","family":"Sharmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifat","family":"Rezwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Rashidur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmind","family":"Neelotpol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.113285_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-14-70","article-title":"Obesity and overweight in Bangladeshi children and adolescents: a scoping review","volume":"14","author":"Rahman","year":"2014","journal-title":"BMC Public Health"},{"key":"10.1016\/j.biopha.2022.113285_bib2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.pcd.2020.06.006","article-title":"Serum 25-hydroxyvitamin D is associated with insulin resistance independently of obesity in children ages 5-17","volume":"14","author":"G\u00fcn","year":"2020","journal-title":"Prim. Care Diabetes"},{"key":"10.1016\/j.biopha.2022.113285_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cca.2016.01.023","article-title":"Association of 25-hydroxyvitamin D status with obesity as well as blood glucose and lipid concentrations in children and adolescents in China","volume":"455","author":"Liu","year":"2016","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"10.1016\/j.biopha.2022.113285_bib4","first-page":"4","article-title":"Determinants of vitamin D deficiency among Bangladeshi children: a hospital based case-control study, Epidemiol. Biostat","volume":"16","author":"Hawlader","year":"2019","journal-title":"Public Health"},{"key":"10.1016\/j.biopha.2022.113285_bib5","first-page":"222","article-title":"Calcium intake, serum vitamin D and obesity in children: is there an association?","volume":"33","author":"da Cunha","year":"2015","journal-title":"Rev. Paul. Pediatr. Orgao . Soc. Pediatr. Sao Paulo"},{"key":"10.1016\/j.biopha.2022.113285_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1515\/jpem-2017-0391","article-title":"Vitamin D deficiency in childhood: old lessons and current challenges","volume":"31","author":"Antonucci","year":"2018","journal-title":"J. Pediatr. Endocrinol. Metab. JPEM"},{"key":"10.1016\/j.biopha.2022.113285_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-019-1027-2","article-title":"Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese","volume":"18","author":"Shen","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.biopha.2022.113285_bib8","first-page":"22","article-title":"Study of serum vitamin D level in different socio-demographic population - a pilot study","volume":"19","author":"Hossain","year":"2018","journal-title":"J. Med."},{"key":"10.1016\/j.biopha.2022.113285_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.6065\/apem.2013.18.2.45","article-title":"The pleiomorphic actions of vitamin D and its importance for children","volume":"18","author":"Kim","year":"2013","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-77574-6_1","article-title":"Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need?","volume":"624","author":"Holick","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib11","doi-asserted-by":"crossref","first-page":"1080S","DOI":"10.1093\/ajcn\/87.4.1080S","article-title":"Vitamin D deficiency: a worldwide problem with health consequences","volume":"87","author":"Holick","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102141","article-title":"Vitamin D Receptor Gene Polymorphisms Are Associated with Obesity and Inflammosome Activity","volume":"9","author":"Al-Daghri","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.biopha.2022.113285_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089907","article-title":"Common variants in CYP2R1 and GC genes predict vitamin D concentrations in healthy Danish children and adults","volume":"9","author":"Nissen","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.biopha.2022.113285_bib14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1017\/S0007114517000538","article-title":"Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes","volume":"117","author":"Petersen","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2431-12-62","article-title":"Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants","volume":"12","author":"Santos","year":"2012","journal-title":"BMC Pedia"},{"key":"10.1016\/j.biopha.2022.113285_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/IJGM.S287205","article-title":"Association of vitamin D receptor gene polymorphisms with metabolic syndrome in Chinese children","volume":"14","author":"Wang","year":"2021","journal-title":"Int. J. Gen. Med"},{"key":"10.1016\/j.biopha.2022.113285_bib17","unstructured":"Global Atlas on Childhood Obesity, World Obes. Fed. (n.d.). https:\/\/www.worldobesity.org\/membersarea\/global-atlas-on-childhood-obesity (Accessed 15 May 2022)."},{"key":"10.1016\/j.biopha.2022.113285_bib18","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3945\/ajcn.2010.29786","article-title":"Global prevalence and trends of overweight and obesity among preschool children","volume":"92","author":"de Onis","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib19","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1111\/ijpo.12070","article-title":"Increasing prevalence of childhood overweight and obesity in a coastal province in China","volume":"11","author":"Zhang","year":"2016","journal-title":"Pediatr. Obes."},{"key":"10.1016\/j.biopha.2022.113285_bib20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3109\/09540261.2012.688195","article-title":"The global childhood obesity epidemic and the association between socio-economic status and childhood obesity","volume":"24","author":"Wang","year":"2012","journal-title":"Int. Rev. Psychiatry Abingdon Engl."},{"key":"10.1016\/j.biopha.2022.113285_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fendo.2019.00103","article-title":"Vitamin D insufficiency in overweight and obese children and adolescents","volume":"10","author":"Zakharova","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib22","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1542\/peds.2012-1711","article-title":"Prevalence of vitamin D deficiency among overweight and obese US children","volume":"131","author":"Turer","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopha.2022.113285_bib23","unstructured":"S. Shuhana, Prevalence and risk factor of childhood overweight and obesity in primary school primary school: children of Dhaka city, (2010). https:\/\/www.duo.uio.no\/handle\/10852\/30024 (Accessed 25 April 2022)."},{"key":"10.1016\/j.biopha.2022.113285_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2891-9-65","article-title":"Vitamin D in health and disease: Current perspectives","volume":"9","author":"Zhang","year":"2010","journal-title":"Nutr. J."},{"key":"10.1016\/j.biopha.2022.113285_bib25","unstructured":"Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Dietary Reference Intakes for Calcium and Vitamin D, National Academies Press (US), Washington (DC), 2011. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK56070\/ (Accessed 25 April 2022)."},{"key":"10.1016\/j.biopha.2022.113285_bib26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00223-012-9693-3","article-title":"Vitamin D assays: past and present debates, difficulties, and developments","volume":"92","author":"Fraser","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.biopha.2022.113285_bib27","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF03391602","article-title":"The vitamin D deficiency pandemic: a forgotten hormone important for health","volume":"32","author":"Holick","year":"2010","journal-title":"Public Health Rev."},{"key":"10.1016\/j.biopha.2022.113285_bib29","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1126\/science.277.5333.1827","article-title":"25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis","volume":"277","author":"Takeyama","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.biopha.2022.113285_bib30","unstructured":"V. Kamale, P. Sharma, Y. Yewale, R. Thamke, Role of Vitamin D in Health and Diseases in Children, New Indian J. Pediatr. (2022). https:\/\/nijp.org\/role-of-vitamin-d-in-health-and-diseases-in-children\/ (Accessed 25 April 2022)."},{"key":"10.1016\/j.biopha.2022.113285_bib31","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1210\/jcem-63-3-656","article-title":"Serum vitamin D2 and vitamin D3 metabolite concentrations and absorption of vitamin D2 in elderly subjects","volume":"63","author":"Clemens","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib32","doi-asserted-by":"crossref","first-page":"582S","DOI":"10.1093\/ajcn\/88.2.582S","article-title":"Pharmacokinetics of vitamin D toxicity","volume":"88","author":"Jones","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib33","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1210\/jcem-46-5-756","article-title":"Metabolism and excretion of 3H-1,25-(OH)2-vitamin D3 in healthy adults","volume":"46","author":"Gray","year":"1978","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib34","first-page":"65","article-title":"Vitamin D and bone health, Scand","volume":"243","author":"Turner","year":"2012","journal-title":"J. Clin. Lab. Investig. Suppl."},{"key":"10.1016\/j.biopha.2022.113285_bib35","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/ijms19061618","article-title":"Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies","volume":"19","author":"Umar","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.113285_bib36","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1210\/endo.134.4.8137734","article-title":"Effects of 1,25-dihydroxyvitamin D3 on proliferation and differentiation of Caco-2cells","volume":"134","author":"Halline","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2022.113285_bib37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ghir.2017.09.002","article-title":"Vitamin D increases IGF-I and insulin levels in experimental diabetic rats","volume":"36","author":"Derakhshanian","year":"2017","journal-title":"Growth Horm. IGF Res. . J. Growth Horm. Res. Soc. Int. IGF Res. Soc."},{"key":"10.1016\/j.biopha.2022.113285_bib38","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.3892\/mmr.2016.5531","article-title":"Vitamin D induces autophagy of pancreatic \u03b2-cells and enhances insulin secretion","volume":"14","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2022.113285_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000097812","article-title":"Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells","volume":"44","author":"Wu-Wong","year":"2007","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.biopha.2022.113285_bib40","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1038\/nutd.2016.50","article-title":"Prevalence of hypovitaminosis D and associated factors in obese Spanish children","volume":"7","author":"Dur\u00e1-Trav\u00e9","year":"2017","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.biopha.2022.113285_bib41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.15537\/smj.2017.4.18753","article-title":"Prevalence of vitamin D deficiency and its associated factors in three regions of Saudi Arabia","volume":"38","author":"Kaddam","year":"2017","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.biopha.2022.113285_bib42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/jpem-2017-0246","article-title":"Obesity is associated with vitamin D deficiency in Danish children and adolescents","volume":"31","author":"Plesner","year":"2018","journal-title":"J. Pediatr. Endocrinol. Metab. JPEM"},{"key":"10.1016\/j.biopha.2022.113285_bib43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1155\/2011\/495101","article-title":"Vitamin D deficiency in obese children and its relationship to insulin resistance and adipokines","volume":"2011","author":"Roth","year":"2011","journal-title":"J. Obes."},{"key":"10.1016\/j.biopha.2022.113285_bib44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/tropej\/fmv091","article-title":"Assessment of vitamin D status and response to vitamin d3 in obese and non-obese Iranian children","volume":"62","author":"Motlaghzadeh","year":"2016","journal-title":"J. Trop. Pediatr."},{"key":"10.1016\/j.biopha.2022.113285_bib45","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3945\/jn.109.112250","article-title":"Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents","volume":"140","author":"Delvin","year":"2010","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/2574254X.2020.1812964","article-title":"Serum 25-hydroxyvitamin D levels and its relationship with sex hormones, puberty and obesity degree in children and adolescents","volume":"3","author":"Viana Pires","year":"2020","journal-title":"Child Adolesc. Obes."},{"key":"10.1016\/j.biopha.2022.113285_bib47","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3390\/nu13051597","article-title":"25-hydroxyvitamin D and Cardiorespiratory fitness in prepubertal overweight and obese children","volume":"13","author":"Villalba-Heredia","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113285_bib48","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s41043-022-00287-w","article-title":"High burden of hypovitaminosis D among the children and adolescents in South Asia: a systematic review and meta-analysis","volume":"41","author":"Siddiqee","year":"2022","journal-title":"J. Health Popul. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jped.2020.08.006","article-title":"Vitamin D deficiency in children and adolescents with obesity: a meta-analysis","volume":"97","author":"Fiamenghi","year":"2021","journal-title":"J. Pediatr. (Rio J. )"},{"key":"10.1016\/j.biopha.2022.113285_bib50","first-page":"111","article-title":"Vitamin D Status in Children in Greece and Its Relationship with Sunscreen Application","volume":"8","author":"Feketea","year":"2021","journal-title":"Child. Basel Switz."},{"key":"10.1016\/j.biopha.2022.113285_bib51","first-page":"60","volume":"14","author":"Demiral","year":"2016","journal-title":"Endokrin Polik-.-. ba\u015fvuran \u00e7ocuklarda D. Vitam. d\u00fczeyleri"},{"key":"10.1016\/j.biopha.2022.113285_bib52","first-page":"4228","article-title":"Vitamin D deficiency among preschool children and its correlation with nutritional habits and sun exposure","author":"Aboulghar","year":"2021","journal-title":"Ann. Rom. Soc. Cell Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib53","article-title":"Current evidence on vitamin D deficiency and metabolic syndrome in obese children: what does the evidence from Saudi Arabia tell us?","volume":"5","author":"Alaklabi","year":"2018","journal-title":"Child. Basel Switz."},{"key":"10.1016\/j.biopha.2022.113285_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/nu12030842","article-title":"Neonatal vitamin D status and risk of asthma in childhood: results from the D-tect study","volume":"12","author":"Thorsteinsdottir","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113285_bib55","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/ppul.23485","article-title":"Vitamin D and pulmonary function in obese asthmatic children","volume":"51","author":"Lautenbacher","year":"2016","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.biopha.2022.113285_bib56","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.arcped.2019.12.005","article-title":"Metabolic disturbances and cardiovascular risk factors in obese children with vitamin D deficiency","volume":"27","author":"Colak","year":"2020","journal-title":"Arch. Pediatr. Organe . Soc. Fr. Pediatr."},{"key":"10.1016\/j.biopha.2022.113285_bib57","first-page":"1353","article-title":"Vitamin D deficiency is associated with metabolic syndrome in Tunisian children with obesity","volume":"97","author":"Yahyaoui","year":"2019","journal-title":"Tunis. Med."},{"key":"10.1016\/j.biopha.2022.113285_bib58","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1530\/EJE-19-0369","article-title":"Vitamin D affects insulin sensitivity and \u03b2-cell function in obese non-diabetic youths","volume":"181","author":"Corica","year":"2019","journal-title":"Eur. J. Endocrinol."},{"issue":"105","key":"10.1016\/j.biopha.2022.113285_bib59","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/apa.13363","article-title":"Vitamin D deficiency is associated with prediabetes in obese Swedish children","volume":"1992","author":"Ekbom","year":"2016","journal-title":"Acta Paediatr. Oslo Nor."},{"key":"10.1016\/j.biopha.2022.113285_bib60","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.metabol.2007.08.023","article-title":"Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season","volume":"57","author":"Alemzadeh","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2022.113285_bib61","first-page":"S8","article-title":"Association of vitamin D deficiency with cardiovascular disease risk in children: implications for the Asia Pacific Region, Asia Pac","volume":"25","author":"Murni","year":"2016","journal-title":"J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib62","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/gerona\/60.11.1414","article-title":"25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults","volume":"60","author":"Maggio","year":"2005","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.biopha.2022.113285_bib63","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1210\/jc.2010-2202","article-title":"Vitamin D and hyperparathyroidism in obesity","volume":"96","author":"Grethen","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib64","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/EJE-13-0435","article-title":"Management of endocrine disease: value and limitations of assessing vitamin D nutritional status and advised levels of vitamin D supplementation","volume":"169","author":"Romagnoli","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib65","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jsbmb.2012.12.003","article-title":"The effect of vitamin D supplementation on serum 25(OH)D in thin and obese women","volume":"136","author":"Gallagher","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib66","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00223-013-9714-x","article-title":"Intermittent high doses of vitamin D: a need for further studies","volume":"92","author":"Minisola","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.biopha.2022.113285_bib67","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2796.2009.02181.x","article-title":"No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year","volume":"267","author":"Jorde","year":"2010","journal-title":"J. Intern. Med"},{"key":"10.1016\/j.biopha.2022.113285_bib68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00223-012-9663-9","article-title":"Prevention and treatment of vitamin D deficiency","volume":"92","author":"Sinha","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.biopha.2022.113285_bib69","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5694\/j.1326-5377.2006.tb00558.x","article-title":"Paediatric Bone Australasia, Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement","volume":"185","author":"Munns","year":"2006","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.biopha.2022.113285_bib70","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0140-6736(96)12098-5","article-title":"Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children","volume":"349","author":"Muhe","year":"1997","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.biopha.2022.113285_bib71","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/eurpub\/ckw270","article-title":"Preventing vitamin D deficiency (VDD): a systematic review of economic evaluations","volume":"27","author":"Aguiar","year":"2017","journal-title":"Eur. J. Public Health"},{"key":"10.1016\/j.biopha.2022.113285_bib72","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1542\/peds.111.4.908","article-title":"Section on breastfeeding and committee on nutrition. American Academy of Pediatrics, Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake","volume":"111","author":"Gartner","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopha.2022.113285_bib73","first-page":"1116","article-title":"Vitamin D deficiency: pragmatic suggestions for prevention and treatment","volume":"67","author":"Kalra","year":"2017","journal-title":"JPMA J. Pak. Med. Assoc."},{"key":"10.1016\/j.biopha.2022.113285_bib74","first-page":"1195","article-title":"Vitamin D deficiency and prevention: Turkish experience","volume":"100","author":"Hatun","year":"2011","journal-title":"Acta Paediatr. Oslo Nor. 1992"},{"key":"10.1016\/j.biopha.2022.113285_bib75","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1136\/adc.2006.098467","article-title":"Vitamin D deficiency: prevention or treatment","volume":"91","author":"Zipitis","year":"2006","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.biopha.2022.113285_bib76","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1542\/peds.2008-1862","article-title":"American academy of pediatrics section on breastfeeding, american academy of pediatrics committee on nutrition, prevention of rickets and vitamin D deficiency in infants, children, and adolescents","volume":"122","author":"Wagner","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopha.2022.113285_bib77","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/MPG.0b013e31828f3c05","article-title":"ESPGHAN committee on nutrition, vitamin D in the healthy European paediatric population","volume":"56","author":"Braegger","year":"2013","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib78","doi-asserted-by":"crossref","first-page":"P23","DOI":"10.1530\/EJE-18-0736","article-title":"Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society","volume":"180","author":"Lips","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib79","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00223-019-00560-x","article-title":"Vitamin D, and maternal and child health","volume":"106","author":"Moon","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.biopha.2022.113285_bib80","first-page":"S673","article-title":"Vitamin D intoxication in 7-month-old infant with recommended daily intake of vitamin D","volume":"Suppl 1","author":"Waheed","year":"2018","journal-title":"J. Ayub Med. Coll. Abbottabad Jamc. 30"},{"issue":"Suppl 2","key":"10.1016\/j.biopha.2022.113285_bib81","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000505635","article-title":"Vitamin D in toddlers, preschool children, and adolescents","volume":"76","author":"Taylor","year":"2020","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib82","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/ejcn.2013.48","article-title":"Hypovitaminosis D and incidence of obesity: a prospective study","volume":"67","author":"Gonz\u00e1lez-Molero","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib83","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3390\/nu5030949","article-title":"Vitamin D and obesity","volume":"5","author":"Vanlint","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113285_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001383","article-title":"Causal relationship between obesity and vitamin D status: bi-directional mendelian randomization analysis of multiple cohorts","volume":"10","author":"Vimaleswaran","year":"2013","journal-title":"PLoS Med"},{"key":"10.1016\/j.biopha.2022.113285_bib85","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","article-title":"Decreased bioavailability of vitamin D in obesity","volume":"72","author":"Wortsman","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib86","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/cs0430413","article-title":"The distribution and storage of vitamin D and its metabolites in human tissues","volume":"43","author":"Mawer","year":"1972","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2022.113285_bib87","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jsbmb.2006.12.032","article-title":"Outdoor exercise reduces the risk of hypovitaminosis D in the obese","author":"Florez","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib88","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.numecd.2006.04.002","article-title":"Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease","volume":"17","author":"Targher","year":"2007","journal-title":"Nutr. Metab. Cardiovasc. Dis. NMCD"},{"key":"10.1016\/j.biopha.2022.113285_bib89","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2796.2010.02267.x","article-title":"Not a simple fat-soluble vitamin: Changes in serum 25-(OH)D levels are predicted by adiposity and adipocytokines in older adults","volume":"268","author":"Ding","year":"2010","journal-title":"J. Intern. Med"},{"key":"10.1016\/j.biopha.2022.113285_bib90","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/apha.12246","article-title":"Adipose tissue and its role in organ crosstalk","volume":"210","author":"Romacho","year":"2014","journal-title":"Acta Physiol. Oxf. Engl."},{"key":"10.1016\/j.biopha.2022.113285_bib91","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.2337\/db13-0473","article-title":"Restricted Adipogenesis in Hypertrophic Obesity","volume":"62","author":"Gustafson","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2022.113285_bib92","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bbadis.2013.05.031","article-title":"Understanding the variegation of fat: Novel regulators of adipocyte differentiation and fat tissue biology","volume":"1842","author":"Mueller","year":"2014","journal-title":"Biochim. Biophys. Acta BBA - Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2022.113285_bib93","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ijo.2011.119","article-title":"The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications","volume":"36","author":"Earthman","year":"2012","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biopha.2022.113285_bib94","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/jpc.12935","article-title":"Low vitamin D is associated with hypertension in paediatric obesity","volume":"51","author":"Kao","year":"2015","journal-title":"J. Paediatr. Child Health"},{"key":"10.1016\/j.biopha.2022.113285_bib95","first-page":"432","article-title":"Obesity and diabetes as determinants of vitamin D deficiency","volume":"31","author":"Hussain Gilani","year":"2019","journal-title":"J. Ayub Med. Coll. Abbottabad Jamc."},{"key":"10.1016\/j.biopha.2022.113285_bib96","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.numecd.2012.04.013","article-title":"Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children","volume":"23","author":"Lee","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis. NMCD"},{"key":"10.1016\/j.biopha.2022.113285_bib97","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1530\/EJE-07-0188","article-title":"Vitamin D status and parathyroid hormone in obese children before and after weight loss","volume":"157","author":"Reinehr","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib98","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/MPG.0000000000001598","article-title":"Vitamin D status, cardiometabolic, liver, and mental health status in obese youth attending a pediatric weight management center","volume":"65","author":"MacDonald","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib99","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00394-008-0700-4","article-title":"Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index","volume":"47","author":"Konradsen","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jsbmb.2008.09.006","article-title":"1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes, J","volume":"112","author":"Li","year":"2008","journal-title":"Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib101","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0306-9877(03)00227-5","article-title":"PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight","volume":"61","author":"McCarty","year":"2003","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.biopha.2022.113285_bib102","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ejim.2013.03.005","article-title":"Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - results from a randomized trial","volume":"24","author":"Wamberg","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.biopha.2022.113285_bib103","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/1753465813503029","article-title":"Beneficial role of vitamin D3 in the prevention of certain respiratory diseases","volume":"7","author":"Luong","year":"2013","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.biopha.2022.113285_bib104","doi-asserted-by":"crossref","first-page":"E886","DOI":"10.1210\/jc.2012-3369","article-title":"The effect of obesity on the relationship between serum parathyroid hormone and 25-hydroxyvitamin D in women","volume":"98","author":"Shapses","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib105","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1210\/jc.2009-2822","article-title":"Left-shifted relation between calcium and parathyroid hormone in obesity","volume":"95","author":"Hultin","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib106","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1530\/EJE-08-0339","article-title":"Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects","volume":"159","author":"Sneve","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib107","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/ejcn.2011.106","article-title":"Calcium and vitamin D for obesity: a review of randomized controlled trials","volume":"65","author":"Soares","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib108","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/07315724.2009.10719779","article-title":"Vitamin D3 distribution and status in the body","volume":"28","author":"Heaney","year":"2009","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib109","first-page":"888","article-title":"Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase","volume":"86","author":"Zehnder","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib110","first-page":"28","article-title":"Vitamin D, vitamin D receptor and the importance of its activation in patients with chronic kidney disease","volume":"35","author":"Bover","year":"2015","journal-title":"Nefrol. Publ. . Soc. Esp. Nefrol."},{"key":"10.1016\/j.biopha.2022.113285_bib111","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/oxfordjournals.jbchem.a022662","article-title":"The function of vitamin D receptor in vitamin D action","volume":"127","author":"Kato","year":"2000","journal-title":"J. Biochem. (Tokyo)."},{"key":"10.1016\/j.biopha.2022.113285_bib112","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1210\/er.2004-0002","article-title":"Noncalcemic actions of vitamin D receptor ligands","volume":"26","author":"Nagpal","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biopha.2022.113285_bib113","first-page":"89","article-title":"Vitamin D-regulated gene expression","volume":"3","author":"Darwish","year":"1993","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.biopha.2022.113285_bib114","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1359\/jbmr.1998.13.3.325","article-title":"The nuclear vitamin D receptor: biological and molecular regulatory properties revealed","volume":"13","author":"Haussler","year":"1998","journal-title":"J. Bone Miner. Res. . J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2022.113285_bib115","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1128\/MCB.16.7.3393","article-title":"Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway","volume":"16","author":"Ebihara","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib116","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(00)80708-4","article-title":"Increasing the complexity of coactivation in nuclear receptor signaling","volume":"97","author":"Freedman","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2022.113285_bib117","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0092-8674(00)80516-4","article-title":"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P\/CAF and CBP\/p300","volume":"90","author":"Chen","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2022.113285_bib118","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0092-8674(00)81118-6","article-title":"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors","volume":"85","author":"Kamei","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2022.113285_bib119","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.1073\/pnas.95.14.7939","article-title":"The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion","volume":"95","author":"Yuan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2022.113285_bib120","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/19783","article-title":"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex","volume":"398","author":"Rachez","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113285_bib121","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/377397a0","article-title":"Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor","volume":"377","author":"H\u00f6rlein","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113285_bib122","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1440-1819.2008.01748.x","article-title":"Reevaluating the incidence of pervasive developmental disorders: impact of elevated rates of detection through implementation of an integrated system of screening in Toyota, Japan","volume":"62","author":"Kawamura","year":"2008","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.biopha.2022.113285_bib123","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1210\/endo-128-4-1792","article-title":"Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells","volume":"128","author":"Takahashi","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2022.113285_bib124","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s40200-020-00561-w","article-title":"Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: a literature review","volume":"19","author":"Alathari","year":"2020","journal-title":"J. Diabetes Metab. Disord."},{"key":"10.1016\/j.biopha.2022.113285_bib125","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jsbmb.2016.08.004","article-title":"Physiological functions of Vitamin D in adipose tissue","volume":"165","author":"Abbas","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib126","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib127","doi-asserted-by":"crossref","first-page":"38084","DOI":"10.1074\/jbc.M307028200","article-title":"De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase","volume":"278","author":"Cheng","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.113285_bib128","first-page":"119","article-title":"Metabolism of vitamin D3 by cytochromes P450","volume":"10","author":"Sakaki","year":"2005","journal-title":"Front. Biosci. J. Virtual Libr"},{"key":"10.1016\/j.biopha.2022.113285_bib129","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jsbmb.2012.09.012","article-title":"Interplay between vitamin D and the drug metabolizing enzyme CYP3A4","volume":"136","author":"Wang","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib130","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1172\/JCI113156","article-title":"Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man","volume":"80","author":"Watkins","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2022.113285_bib131","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.abb.2012.01.013","article-title":"Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?","volume":"523","author":"Zhu","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2022.113285_bib132","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/bbrc.1997.7551","article-title":"Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase","volume":"241","author":"Postlind","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2022.113285_bib133","doi-asserted-by":"crossref","first-page":"34650","DOI":"10.1074\/jbc.M004185200","article-title":"Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6","volume":"275","author":"Hosseinpour","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.113285_bib134","doi-asserted-by":"crossref","first-page":"E753","DOI":"10.1152\/ajpendo.00201.2004","article-title":"Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase","volume":"288","author":"Rahmaniyan","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1387-2656(01)07037-5","article-title":"Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24)","volume":"7","author":"Inouye","year":"2001","journal-title":"Biotechnol. Annu. Rev."},{"key":"10.1016\/j.biopha.2022.113285_bib136","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12018-009-9033-y","article-title":"Extra renal synthesis of 1,25-dihydroxyvitamin D and its health implications","volume":"7","author":"Bikle","year":"2009","journal-title":"Clin. Rev. Bone Miner. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib137","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1210\/endo-124-2-655","article-title":"Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma","volume":"124","author":"Bikle","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2022.113285_bib138","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/endo-129-1-33","article-title":"Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes","volume":"129","author":"Bikle","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2022.113285_bib139","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.161.4.755","article-title":"Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis","volume":"161","author":"Adams","year":"1985","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.biopha.2022.113285_bib140","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/jcp.1041420327","article-title":"Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages","volume":"142","author":"Pryke","year":"1990","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2022.113285_bib141","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1359\/JBMR.050908","article-title":"Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes,","volume":"21","author":"Stoffels","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2022.113285_bib142","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.abb.2011.11.003","article-title":"25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D","volume":"523","author":"Jones","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2022.113285_bib143","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1998.78.4.1193","article-title":"Current understanding of the molecular actions of vitamin D","volume":"78","author":"Jones","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2022.113285_bib144","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tibs.2004.10.005","article-title":"Enzymes involved in the activation and inactivation of vitamin D","volume":"29","author":"Prosser","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.biopha.2022.113285_bib145","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1046\/j.1432-1327.2000.01680.x","article-title":"Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24","volume":"267","author":"Sakaki","year":"2000","journal-title":"Eur. J. Biochem"},{"key":"10.1016\/j.biopha.2022.113285_bib146","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1073\/pnas.0702093104","article-title":"Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone","volume":"104","author":"Prosser","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2022.113285_bib147","doi-asserted-by":"crossref","first-page":"15599","DOI":"10.1074\/jbc.M110.119958","article-title":"A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3","volume":"285","author":"Meyer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.113285_bib148","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/abbi.2000.1964","article-title":"Regulation of the procine 1,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) by 1,25-dihydroxyvitamin D3 and parathyroid hormone in AOK-B50 cells","volume":"381","author":"Zierold","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2022.113285_bib149","doi-asserted-by":"crossref","first-page":"13572","DOI":"10.1073\/pnas.241516798","article-title":"Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability","volume":"98","author":"Zierold","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2022.113285_bib150","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1210\/en.2005-0777","article-title":"Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice","volume":"146","author":"Perwad","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2022.113285_bib151","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00280-005-0059-7","article-title":"Expression of VDR and CYP24A1 mRNA in human tumors","volume":"57","author":"Anderson","year":"2006","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113285_bib152","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009907","article-title":"Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity","volume":"5","author":"Slominski","year":"2010","journal-title":"PloS One"},{"issue":"Pt A","key":"10.1016\/j.biopha.2022.113285_bib153","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jsbmb.2013.10.012","article-title":"The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions","volume":"144","author":"Slominski","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113285_bib154","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.abb.2019.03.010","article-title":"Catalytic properties of 25-hydroxyvitamin D3 3-epimerase in rat and human liver microsomes","volume":"666","author":"Tuckey","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2022.113285_bib155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00223-009-9251-9","article-title":"Vitamin D binding protein genotype and osteoporosis","volume":"85","author":"Fang","year":"2009","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.biopha.2022.113285_bib156","doi-asserted-by":"crossref","first-page":"345","DOI":"10.14310\/horm.2002.1484","article-title":"Association of genetic variants of vit D binding protein (DBP\/GC) and of the enzyme catalyzing its 25-hydroxylation (DCYP2R1) and serum vit D in postmenopausal women","volume":"13","author":"Xu","year":"2014","journal-title":"Horm. Athens Greece"},{"key":"10.1016\/j.biopha.2022.113285_bib157","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.beem.2015.06.006","article-title":"Behind the scenes of vitamin D binding protein: more than vitamin D binding","volume":"29","author":"Delanghe","year":"2015","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2006.02.016","article-title":"Vitamin D receptor polymorphisms and diseases","volume":"371","author":"Valdivielso","year":"2006","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"10.1016\/j.biopha.2022.113285_bib159","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2147\/IJNRD.S111538","article-title":"Vitamin D receptor gene TaqI and Apal polymorphisms and steroid responsiveness in childhood idiopathic nephrotic syndrome","volume":"9","author":"Al-Eisa","year":"2016","journal-title":"Int. J. Nephrol. Renov. Dis."},{"key":"10.1016\/j.biopha.2022.113285_bib160","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000490669","article-title":"Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship","volume":"73","author":"Ruiz-Ojeda","year":"2018","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib161","first-page":"1","article-title":"A comprehensive insight into the potential roles of VDR gene polymorphism in obesity: a systematic review","author":"Faghfouri","year":"2020","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2022.113285_bib162","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fendo.2018.00448","article-title":"Relationship Between Vitamin D Status and Vitamin D Receptor Gene Polymorphisms With Markers of Metabolic Syndrome Among Adults","volume":"9","author":"Karonova","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib163","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41390-018-0092-y","article-title":"Vitamin D receptor gene (FokI, TaqI, BsmI, and ApaI) polymorphisms in children with urinary tract infection","volume":"84","author":"Mahyar","year":"2018","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.biopha.2022.113285_bib164","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1359\/jbmr.2000.15.11.2206","article-title":"Vitamin D Receptor Polymorphisms and Nutritional Rickets in Nigerian Children","volume":"15","author":"Fischer","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2022.113285_bib165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jocd.2020.10.009","article-title":"Vitamin D, vitamin D receptor (VDR) gene polymorphisms (ApaI and FokI), and Bone Mineral Density in Patients With Inflammatory Bowel Disease","volume":"24","author":"Szymczak-Tomczak","year":"2021","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.biopha.2022.113285_bib166","first-page":"24","article-title":"Vitamin D receptor gene polymorphism among egyptian obese children","volume":"9","author":"Saad","year":"2017","journal-title":"Asian J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib167","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/eje.0.1450181","article-title":"Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset","volume":"145","author":"Ye","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib168","first-page":"25","article-title":"Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients","volume":"15","author":"Gendy","year":"2019","journal-title":"J. Clin. Transl. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib169","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/ijpo.12293","article-title":"Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease","volume":"13","author":"Gibson","year":"2018","journal-title":"Pediatr. Obes."},{"key":"10.1016\/j.biopha.2022.113285_bib170","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jneuroim.2017.01.009","article-title":"Vitamin D receptor gene polymorphisms are associated with multiple sclerosis in Mexican adults","volume":"306","author":"Berm\u00fadez-Morales","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.biopha.2022.113285_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.mgene.2020.100766","article-title":"Vitamin D receptor (VDR) gene polymorphism BsmI in Syrian breast cancer patients","volume":"26","author":"Haddad","year":"2020","journal-title":"Meta Gene"},{"key":"10.1016\/j.biopha.2022.113285_bib172","doi-asserted-by":"crossref","DOI":"10.7754\/Clin.Lab.2020.200931","article-title":"Haplotype analysis of vitamin D receptor (VDR) gene in breast cancer patients","volume":"67","author":"Ergul","year":"2021","journal-title":"Clin. Lab."},{"key":"10.1016\/j.biopha.2022.113285_bib173","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/bs.vh.2015.10.003","article-title":"Structural studies of vitamin D nuclear receptor ligand-binding properties","volume":"100","author":"Belorusova","year":"2016","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.biopha.2022.113285_bib174","doi-asserted-by":"crossref","first-page":"E591","DOI":"10.1210\/jc.2014-3016","article-title":"Serum 25-hydroxyvitamin D and adipose tissue vitamin D receptor gene expression: relationship with obesity and type 2 diabetes","volume":"100","author":"Clemente-Postigo","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib175","doi-asserted-by":"crossref","first-page":"E916","DOI":"10.1152\/ajpendo.00410.2005","article-title":"Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells","volume":"290","author":"Kong","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib176","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1074\/jbc.M510343200","article-title":"Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells","volume":"281","author":"Blumberg","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.113285_bib177","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/jcp.24371","article-title":"Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue","volume":"228","author":"Narvaez","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2022.113285_bib178","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.metabol.2012.03.018","article-title":"Allelic variations in the vitamin D receptor gene, insulin secretion and parents\u2019 heights are independently associated with height in obese children and adolescents","volume":"61","author":"Ferrarezi","year":"2012","journal-title":"Metab. - Clin. Exp."},{"key":"10.1016\/j.biopha.2022.113285_bib179","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000504872","article-title":"Vitamin D levels, frequency of vitamin D receptor gene polymorphisms, and associations with overweight and asthma in Brazilian Schoolchildren","volume":"75","author":"Rodrigues Sim\u00f5es","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/chi.2015.0055","article-title":"Childhood obesity incidence in the united states: a systematic review","volume":"12","author":"Cheung","year":"2016","journal-title":"Child. Obes. Print."},{"key":"10.1016\/j.biopha.2022.113285_bib181","first-page":"25","article-title":"Pediatric metabolic syndrome: pathophysiology and laboratory assessment","volume":"28","author":"Higgins","year":"2017","journal-title":"EJIFCC"},{"key":"10.1016\/j.biopha.2022.113285_bib182","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.beem.2018.09.014","article-title":"Vitamin D insufficiency: definition, diagnosis and management","volume":"32","author":"Bouillon","year":"2018","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113285_bib183","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178695","article-title":"The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country","volume":"12","author":"Rahmadhani","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.biopha.2022.113285_bib184","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/10408391003785458","article-title":"Vitamin d and metabolic syndrome risk factors: evidence and mechanisms","volume":"52","author":"Awad","year":"2012","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib185","doi-asserted-by":"crossref","first-page":"33804","DOI":"10.1074\/jbc.M111.257568","article-title":"Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice *","volume":"286","author":"Wong","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.113285_bib186","first-page":"39","article-title":"European Society for Paediatric Endocrinology (ESPE) Bone Club, Consensus development for the supplementation of vitamin D in childhood and adolescence","volume":"58","author":"Hochberg","year":"2002","journal-title":"Horm. Res."},{"key":"10.1016\/j.biopha.2022.113285_bib187","doi-asserted-by":"crossref","first-page":"1159S","DOI":"10.1093\/jn\/126.suppl_4.1159S","article-title":"Vitamin D and bone health","volume":"126","author":"Holick","year":"1996","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2022.113285_bib188","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4065\/81.3.353","article-title":"High prevalence of vitamin D inadequacy and implications for health","volume":"81","author":"Holick","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.biopha.2022.113285_bib189","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/nu12061617","article-title":"Cholecalciferol or calcifediol in the management of vitamin D deficiency","volume":"12","author":"Sosa Henr\u00edquez","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113285_bib190","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nrendo.2016.29","article-title":"Therapy: New findings on vitamin D3 supplementation and falls - when more is perhaps not better","volume":"12","author":"Sanders","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113285_bib191","unstructured":"C. for D.E. and Research, FDA approves weight management drug for patients aged 12 and older, FDA. (2021). https:\/\/www.fda.gov\/drugs\/news-events-human-drugs\/fda-approves-weight-management-drug-patients-aged-12-and-older (Accessed 15 May 2022)."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222006746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222006746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:27:32Z","timestamp":1779967652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222006746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":191,"alternative-id":["S0753332222006746"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113285","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive look into the association of vitamin D levels and vitamin D receptor gene polymorphism with obesity in children","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113285","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113285"}}