{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:50:47Z","timestamp":1794351047020,"version":"4.9.0"},"reference-count":229,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202805"],"award-info":[{"award-number":["81202805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074254"],"award-info":[{"award-number":["82074254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172185"],"award-info":[{"award-number":["7172185"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.biopha.2022.113290","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:42:46Z","timestamp":1655444566000},"page":"113290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"special_numbering":"C","title":["Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics"],"prefix":"10.1016","volume":"153","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.113290_bib1","unstructured":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet,\u00a02016, 388, 1659\u20131724."},{"key":"10.1016\/j.biopha.2022.113290_bib2","unstructured":"Health effects of dietary risks in 195 countries, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2019, 393, 1958\u20131972."},{"key":"10.1016\/j.biopha.2022.113290_bib3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1053\/j.gastro.2014.01.052","article-title":"Compositional and functional features of the gastrointestinal microbiome and their effects on human health","volume":"146","author":"Hollister","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113290_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nature13178","article-title":"Dynamics and associations of microbial community types across the human body","volume":"509","author":"Ding","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib5","first-page":"10","article-title":"The western diet-microbiome-host interaction and its role in metabolic disease","author":"Zin\u00f6cker","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib6","first-page":"81","article-title":"The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota","author":"Milani","year":"2017","journal-title":"Microbiol Mol. Biol. Rev."},{"key":"10.1016\/j.biopha.2022.113290_bib7","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2022.113290_bib8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-019-0965-1","article-title":"A new genomic blueprint of the human gut microbiota","volume":"568","author":"Almeida","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.biopha.2022.113290_bib11","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1038\/ismej.2017.72","article-title":"Genomics and metagenomics of trimethylamine-utilizing Archaea in the human gut microbiome","volume":"11","author":"Borrel","year":"2017","journal-title":"ISME J."},{"key":"10.1016\/j.biopha.2022.113290_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41586-020-2729-3","article-title":"Host-microbiota maladaptation in colorectal cancer","volume":"585","author":"Janney","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/j.gastro.2020.09.057","article-title":"The healthy microbiome-what is the definition of a healthy gut microbiome?","volume":"160","author":"Shanahan","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113290_bib14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nature25979","article-title":"Extensive impact of non-antibiotic drugs on human gut bacteria","volume":"555","author":"Maier","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib15","doi-asserted-by":"crossref","DOI":"10.1007\/s40122-022-00386-w","article-title":"Clinical observation of the effects of oral opioid on inflammatory cytokines and gut microbiota in patients with moderate to severe cancer pain: a retrospective cohort study","author":"Wang","year":"2022","journal-title":"Pain. Ther."},{"key":"10.1016\/j.biopha.2022.113290_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41398-022-01947-5","article-title":"Effects of pharmacological treatment on metabolomic alterations in animal models of depression","volume":"12","author":"Pu","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.biopha.2022.113290_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.tem.2022.04.004","article-title":"Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease","author":"Haikonen","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113290_bib18","doi-asserted-by":"crossref","first-page":"goac010","DOI":"10.1093\/gastro\/goac010","article-title":"Intestinal microbiota research from a global perspective","volume":"10","author":"Wallenborn","year":"2022","journal-title":"Gastroenterol. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.biopha.2022.113290_bib20","doi-asserted-by":"crossref","first-page":"28926","DOI":"10.1007\/s11356-021-13862-1","article-title":"The link among microbiota, epigenetics, and disease development","volume":"28","author":"El-Sayed","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.biopha.2022.113290_bib21","first-page":"19","article-title":"The impact of nutrition and environmental epigenetics on human health and disease","author":"Tiffon","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.682696","article-title":"Regulation of carbohydrate-responsive metabolic genes by histone acetylation and the acetylated histone reader BRD4 in the gene body region","volume":"8","author":"Mochizuki","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.biopha.2022.113290_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.2022407","article-title":"Epigenetic regulation by gut microbiota","volume":"14","author":"Woo","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biopha.2022.113290_bib24","article-title":"Epigenetics and BEyond: targeting histone methylation to treat type 2 diabetes mellitus","volume":"12","author":"Yang","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.biopha.2022.113290_bib25","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1194\/jlr.M048504","article-title":"Methylation at CPT1A locus is associated with lipoprotein subfraction profiles","volume":"55","author":"Frazier-Wood","year":"2014","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.biopha.2022.113290_bib26","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.25584","article-title":"Effect of the histone deacetylase inhibitor FRM-0334 on progranulin levels in patients with progranulin gene haploinsufficiency: a randomized clinical trial","volume":"4","author":"Ljubenkov","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.biopha.2022.113290_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.18632\/aging.100597","article-title":"Multiple dietary supplements do not affect metabolic and cardio-vascular health","volume":"6","author":"Soare","year":"2014","journal-title":"Aging"},{"key":"10.1016\/j.biopha.2022.113290_bib28","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1038\/s41467-020-18414-8","article-title":"Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2022.113290_bib29","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1210\/jc.2019-00481","article-title":"Effect of prebiotic on microbiota, intestinal permeability, and glycemic control in children with type 1 diabetes","volume":"104","author":"Ho","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2022.113290_bib30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/gutjnl-2020-322630","article-title":"Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial","volume":"70","author":"de Groot","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2022.113290_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.aad3369","article-title":"Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity","volume":"352","author":"Zhernakova","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.biopha.2022.113290_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature18846","article-title":"Diet-microbiota interactions as moderators of human metabolism","volume":"535","author":"Sonnenburg","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nature25973","article-title":"Environment dominates over host genetics in shaping human gut microbiota","volume":"555","author":"Rothschild","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib34","doi-asserted-by":"crossref","first-page":"343ra82","DOI":"10.1126\/scitranslmed.aad7121","article-title":"Antibiotics, birth mode, and diet shape microbiome maturation during early life","volume":"8","author":"Bokulich","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib35","article-title":"Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life","volume":"172","author":"Forbes","year":"2018","journal-title":"JAMA Pedia"},{"key":"10.1016\/j.biopha.2022.113290_bib36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S095442241700004X","article-title":"Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health","volume":"30","author":"Stephen","year":"2017","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.biopha.2022.113290_bib37","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2022.113290_bib38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.biopha.2022.113290_bib39","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.biopha.2022.113290_bib40","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3389\/fmicb.2019.01046","article-title":"Fermented dairy foods: impact on intestinal microbiota and health-linked biomarkers","volume":"10","author":"Gonz\u00e1lez","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.biopha.2022.113290_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12967-017-1175-y","article-title":"Influence of diet on the gut microbiome and implications for human health","volume":"15","author":"Singh","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1053\/j.gastro.2016.10.007","article-title":"Isocaloric diets high in animal or plant protein reduce liver fat and inflammation in individuals with type 2 diabetes","volume":"152","author":"Markova","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113290_bib43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cmet.2018.01.005","article-title":"An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans","volume":"27","author":"Mardinoglu","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2022.113290_bib44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/09637486.2017.1343286","article-title":"Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity","volume":"69","author":"C\u00e2ndido","year":"2018","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.biopha.2022.113290_bib45","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1097\/MIB.0000000000000465","article-title":"Maternal high-fat diet accelerates development of Crohn\u2019s disease-like ileitis in TNF\u0394ARE\/WT offspring","volume":"21","author":"Gruber","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.biopha.2022.113290_bib46","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41575-021-00452-2","article-title":"Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism","volume":"18","author":"Choi","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2022.113290_bib47","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.aba3683","article-title":"High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide","volume":"373","author":"Yoo","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.biopha.2022.113290_bib48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3390\/nu8030173","article-title":"Probiotics and prebiotics: present status and future perspectives on metabolic disorders","volume":"8","author":"Yoo","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib49","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s40200-021-00855-7","article-title":"A randomized double-blind placebo controlled pilot study of probiotics in adolescents with severe obesity","volume":"20","author":"Verma","year":"2021","journal-title":"J. Diabetes Metab. Disord."},{"key":"10.1016\/j.biopha.2022.113290_bib50","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00592-018-1175-2","article-title":"The effects of probiotics and synbiotic supplementation on glucose and insulin metabolism in adults with prediabetes: a double-blind randomized clinical trial","volume":"55","author":"Kassaian","year":"2018","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.biopha.2022.113290_bib51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s40168-018-0494-4","article-title":"Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics","volume":"6","author":"Krumbeck","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.biopha.2022.113290_bib52","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12916-022-02299-z","article-title":"Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals","volume":"20","author":"Rodriguez","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.biopha.2022.113290_bib53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fimmu.2018.00197","article-title":"Abnormal epigenetic regulation of immune system during aging","volume":"9","author":"Jasiulionis","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.biopha.2022.113290_bib54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.copsyc.2018.11.010","article-title":"Epigenetics and meditation","volume":"28","author":"Kaliman","year":"2019","journal-title":"Curr. Opin. Psychol."},{"key":"10.1016\/j.biopha.2022.113290_bib55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-4939-8751-1_8","article-title":"Diet, microbiome, and epigenetics in the era of precision medicine","volume":"1856","author":"Riscuta","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113290_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.658551","article-title":"The heritability of behaviors associated with the host gut microbiota","volume":"12","author":"Manterola","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2022.113290_bib57","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease","volume":"20","author":"Greenberg","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2022.113290_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41586-020-2747-1","article-title":"Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B","volume":"586","author":"Xu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.651258","article-title":"DNA methylation patterning and the regulation of beta cell homeostasis","volume":"12","author":"Parveen","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113290_bib60","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.gendis.2020.01.013","article-title":"Insulin-resistance and depression cohort data mining to identify nutraceutical related DNA methylation biomarker for type 2 diabetes","volume":"8","author":"Liang","year":"2021","journal-title":"Genes Dis."},{"key":"10.1016\/j.biopha.2022.113290_bib61","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1038\/s41467-019-10487-4","article-title":"An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2022.113290_bib62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12263-020-00671-3","article-title":"Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice","volume":"15","author":"Yao","year":"2020","journal-title":"Genes Nutr."},{"key":"10.1016\/j.biopha.2022.113290_bib63","first-page":"5","article-title":"Gut microbiota as an epigenetic regulator: pilot study based on whole-genome methylation analysis","author":"Kumar","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.biopha.2022.113290_bib64","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3389\/fgene.2019.00613","article-title":"Gut microbiota composition is associated with the global DNA methylation pattern in Obesity","volume":"10","author":"Ramos-Molina","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2022.113290_bib65","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/dnares\/dsy001","article-title":"Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs","volume":"25","author":"Pan","year":"2018","journal-title":"DNA Res."},{"key":"10.1016\/j.biopha.2022.113290_bib66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13073-018-0534-5","article-title":"Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development","volume":"10","author":"Pan","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/j.biopha.2022.113290_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-15-8104-5_1","article-title":"Overview of histone modification","volume":"1283","author":"Zhang","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biopha.2022.113290_bib68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15252\/embr.201541809","article-title":"Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man","volume":"17","author":"Harr","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib69","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral thinking: how histone modifications regulate gene expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet."},{"key":"10.1016\/j.biopha.2022.113290_bib70","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijbiomac.2020.12.173","article-title":"Histone acetyl transferases and their epigenetic impact on bone remodeling","volume":"170","author":"Gomathi","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2022.113290_bib71","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10620-017-4538-6","article-title":"Influences of the gut microbiota on DNA methylation and histone modification","volume":"62","author":"Ye","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib72","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1101\/lm.036012.114","article-title":"A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory","volume":"21","author":"Mahgoub","year":"2014","journal-title":"Learn Mem."},{"key":"10.1016\/j.biopha.2022.113290_bib73","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13059-018-1389-1","article-title":"An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression","volume":"19","author":"Qin","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.biopha.2022.113290_bib74","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.molcel.2016.10.025","article-title":"Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues","volume":"64","author":"Krautkramer","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biopha.2022.113290_bib75","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nature07777","article-title":"Role of Jhdm2a in regulating metabolic gene expression and obesity resistance","volume":"458","author":"Tateishi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib76","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1993513","article-title":"Effects of fecal microbiota transplant on DNA methylation in subjects with metabolic syndrome","volume":"13","author":"van der Vossen","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biopha.2022.113290_bib77","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/mnfr.201300829","article-title":"Resistant starch type 4-enriched diet lowered blood cholesterols and improved body composition in a double blind controlled cross-over intervention","volume":"58","author":"Nichenametla","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biopha.2022.113290_bib78","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1039\/C6FO00856A","article-title":"Dietary resistant starch type 4-derived butyrate attenuates nuclear factor-kappa-B1 through modulation of histone H3 trimethylation at lysine 27","volume":"7","author":"Liu","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.biopha.2022.113290_bib79","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s13258-018-0725-x","article-title":"Homeostatic balance of histone acetylation and deconstruction of repressive chromatin marker H3K9me3 during adipocyte differentiation of 3T3-L1 cells","volume":"40","author":"Na","year":"2018","journal-title":"Genes Genom."},{"key":"10.1016\/j.biopha.2022.113290_bib80","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature12687","article-title":"Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis","volume":"504","author":"Alenghat","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib81","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1053\/j.gastro.2018.04.017","article-title":"Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice","volume":"155","author":"Whitt","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113290_bib82","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1172\/JCI85963","article-title":"HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage","volume":"127","author":"Qian","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2022.113290_bib83","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1096\/fj.201701586R","article-title":"Loss of HDAC6 alters gut microbiota and worsens obesity","volume":"33","author":"Lieber","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2022.113290_bib84","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2022.113290_bib85","first-page":"281","article-title":"Diagnostic microRNA markers for screening sporadic human colon cancer and active ulcerative colitis in stool and tissue","volume":"6","author":"Ahmed","year":"2009","journal-title":"Cancer Genom. Proteom."},{"key":"10.1016\/j.biopha.2022.113290_bib86","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1128\/MMBR.00014-10","article-title":"From structure to function: the ecology of host-associated microbial communities","volume":"74","author":"Robinson","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.biopha.2022.113290_bib87","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2105-15-S7-S4","article-title":"Identifying microRNA targets in different gene regions","volume":"15 Suppl 7","author":"Xu","year":"2014","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.biopha.2022.113290_bib88","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3389\/fgene.2019.00638","article-title":"Epigenetic regulation at the interplay between gut microbiota and host metabolism","volume":"10","author":"Miro-Blanch","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2022.113290_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1862612","article-title":"Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family","volume":"13","author":"Du","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biopha.2022.113290_bib90","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chom.2015.12.005","article-title":"The host shapes the gut microbiota via fecal MicroRNA","volume":"19","author":"Liu","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biopha.2022.113290_bib91","first-page":"11","article-title":"The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs","author":"Virtue","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib92","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.21037\/atm-20-6717","article-title":"Correlation between alterations of gut microbiota and miR-122-5p expression in patients with type 2 diabetes mellitus","volume":"8","author":"Li","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib93","article-title":"Gut microbiota regulates the sympathetic nerve activity and peripheral serotonin through hypothalamic MicroRNA-204 in order to increase the browning of white adipose tissue in obesity","volume":"14","author":"Kassan","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.biopha.2022.113290_bib94","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0029665120006916","article-title":"SCFA: mechanisms and functional importance in the gut","volume":"80","author":"Martin-Gallausiaux","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.biopha.2022.113290_bib95","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.09.014","article-title":"Metabolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity","volume":"51","author":"Chun","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2022.113290_bib96","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"The impact of dietary fiber on gut microbiota in host health and disease","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biopha.2022.113290_bib97","doi-asserted-by":"crossref","first-page":"16767","DOI":"10.1073\/pnas.0808567105","article-title":"Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41","volume":"105","author":"Samuel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2022.113290_bib98","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2022.113290_bib99","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/10408398.2020.1828813","article-title":"Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications","volume":"62","author":"Wu","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.biopha.2022.113290_bib100","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib101","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3389\/fphar.2018.00533","article-title":"The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor \u03b1-stimulated endothelial cells via activation of GPR41\/43 and inhibition of HDACs","volume":"9","author":"Li","year":"2018","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.biopha.2022.113290_bib102","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2022.113290_bib103","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2022.113290_bib104","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/nutrit\/nux001","article-title":"Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals","volume":"75","author":"Bhat","year":"2017","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.biopha.2022.113290_bib105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0029665114001463","article-title":"Links between diet, gut microbiota composition and gut metabolism","volume":"74","author":"Flint","year":"2015","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.biopha.2022.113290_bib106","first-page":"362","article-title":"Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis","author":"Rios-Covian","year":"2015","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.biopha.2022.113290_bib107","doi-asserted-by":"crossref","first-page":"G900","DOI":"10.1152\/ajpgi.00265.2013","article-title":"Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids","volume":"305","author":"den Besten","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2022.113290_bib108","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1741-7007-11-61","article-title":"Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent","volume":"11","author":"Wrzosek","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.biopha.2022.113290_bib109","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/nu7042839","article-title":"Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation","volume":"7","author":"Kasubuchi","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib110","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.3748\/wjg.15.5549","article-title":"Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines","volume":"15","author":"Cox","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2022.113290_bib111","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10753-019-01133-8","article-title":"The anti-inflammatory immune regulation induced by butyrate is impaired in inflamed intestinal mucosa from patients with ulcerative colitis","volume":"43","author":"Magnusson","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.biopha.2022.113290_bib112","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/ibd\/izz119","article-title":"Intestinal inflammation modulates the epithelial response to butyrate in patients with inflammatory bowel disease","volume":"26","author":"Ferrer-Pic\u00f3n","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.biopha.2022.113290_bib113","first-page":"13","article-title":"Does folic acid protect patients with inflammatory bowel disease from complications?","author":"Ratajczak","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib114","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fgene.2015.00148","article-title":"Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes","volume":"6","author":"Magn\u00fasd\u00f3ttir","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2022.113290_bib115","first-page":"11","article-title":"Probiotic potential of a folate-producing strain Latilactobacillus sakei LZ217 and its modulation effects on human gut microbiota","author":"Liu","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.biopha.2022.113290_bib116","first-page":"11","article-title":"Dietary nutrients involved in one-carbon metabolism and colonic mucosa-associated gut microbiome in individuals with an endoscopically normal colon","author":"Gurwara","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib117","first-page":"434","article-title":"Infant growth, neurodevelopment and gut microbiota during infancy: which nutrients are crucial?","volume":"22","author":"Cerd\u00f3","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.biopha.2022.113290_bib118","doi-asserted-by":"crossref","first-page":"R1065","DOI":"10.1152\/ajpregu.00551.2012","article-title":"More than just a gut instinct-the potential interplay between a baby\u2019s nutrition, its gut microbiome, and the epigenome","volume":"304","author":"Mischke","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.biopha.2022.113290_bib119","first-page":"13","article-title":"Excess vitamins or imbalance of folic acid and choline in the gestational diet alter the gut microbiota and obesogenic effects in wistar rat offspring","author":"Mjaaseth","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib120","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000426","article-title":"Functional roles of B-vitamins in the gut and gut microbiome","volume":"64","author":"Uebanso","year":"2020","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1016\/j.biopha.2022.113290_bib121","first-page":"10","article-title":"SunGold kiwifruit supplementation of individuals with prediabetes alters gut microbiota and improves vitamin C status, anthropometric and clinical markers","author":"Wilson","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib122","doi-asserted-by":"crossref","first-page":"G241","DOI":"10.1152\/ajpgi.00071.2018","article-title":"Tumor necrosis factor alpha reduces intestinal vitamin C uptake: a role for NF-\u03baB-mediated signaling","volume":"315","author":"Subramanian","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2022.113290_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108838","article-title":"Histone deacetylase inhibitors regulate vitamin C transporter functional expression in intestinal epithelial cells","volume":"98","author":"Subramanian","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2022.113290_bib124","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jnutbio.2018.12.001","article-title":"MicroRNA-103a regulates sodium-dependent vitamin C transporter-1 expression in intestinal epithelial cells","volume":"65","author":"Subramanian","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2022.113290_bib125","first-page":"24","article-title":"Role of intestinal microbiota in the bioavailability and physiological functions of dietary polyphenols","author":"Kawabata","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2022.113290_bib126","first-page":"9","article-title":"Insight into polyphenol and gut microbiota crosstalk: are their metabolites the key to understand protective effects against metabolic disorders?","author":"Koudoufio","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.biopha.2022.113290_bib127","first-page":"25","article-title":"Epigallocatechin-3-gallate (EGCG) alters histone acetylation and methylation and impacts chromatin architecture profile in human endothelial cells","author":"Ciesielski","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2022.113290_bib128","article-title":"Inhibition of class I HDACs imprints adipogenesis toward oxidative and brown-like phenotype","volume":"1865","author":"Ferrari","year":"2020","journal-title":"Biochim Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.biopha.2022.113290_bib129","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jnutbio.2014.04.008","article-title":"Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification","volume":"25","author":"Kang","year":"2014","journal-title":"J. Nutr. Biochem"},{"key":"10.1016\/j.biopha.2022.113290_bib130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/2045-3701-3-47","article-title":"Resveratrol induces insulin gene expression in mouse pancreatic \u03b1-cells","volume":"3","author":"Xie","year":"2013","journal-title":"Cell Biosci."},{"key":"10.1016\/j.biopha.2022.113290_bib131","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/639469","article-title":"Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms","volume":"2012","author":"Kim","year":"2012","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib132","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1089\/jmf.2017.3968","article-title":"Combination treatments with luteolin and fisetin enhance anti-inflammatory effects in high glucose-treated THP-1 cells through histone acetyltransferase\/histone deacetylase regulation","volume":"20","author":"Kim","year":"2017","journal-title":"J. Med. Food"},{"key":"10.1016\/j.biopha.2022.113290_bib133","article-title":"Lycium ruthenicum anthocyanins attenuate high-fat diet-induced colonic barrier dysfunction and inflammation in mice by modulating the gut microbiota","volume":"65","author":"Tian","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biopha.2022.113290_bib134","doi-asserted-by":"crossref","first-page":"goac009","DOI":"10.1093\/gastro\/goac009","article-title":"Interplays between drugs and the gut microbiome","volume":"10","author":"Wan","year":"2022","journal-title":"Gastroenterol. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib135","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-022-00871-9","article-title":"An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis","author":"Cubillos-Ruiz","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.biopha.2022.113290_bib136","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1542\/peds.2011-2879","article-title":"Trends of outpatient prescription drug utilization in US children, 2002-2010","volume":"130","author":"Chai","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopha.2022.113290_bib137","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s40168-017-0313-3","article-title":"Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates","volume":"5","author":"Nogacka","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.biopha.2022.113290_bib138","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cmet.2016.06.016","article-title":"Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial","volume":"24","author":"Reijnders","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2022.113290_bib139","doi-asserted-by":"crossref","DOI":"10.1007\/s12020-022-03042-7","article-title":"Association of antibiotics exposure within the first 2 years after birth with subsequent childhood type 1 diabetes","author":"Lee","year":"2022","journal-title":"Endocrine"},{"key":"10.1016\/j.biopha.2022.113290_bib140","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1136\/gutjnl-2016-312297","article-title":"Antibiotics as deep modulators of gut microbiota: between good and evil","volume":"65","author":"Ianiro","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2022.113290_bib141","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1038\/s41598-020-65595-9","article-title":"The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice","volume":"10","author":"Zemanov\u00e1","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib142","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.83","article-title":"Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat","volume":"3","author":"Davey","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.biopha.2022.113290_bib143","first-page":"356","article-title":"Chemical transformation of xenobiotics by the human gut microbiota","author":"Koppel","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.biopha.2022.113290_bib144","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-019-1291-3","article-title":"Mapping human microbiome drug metabolism by gut bacteria and their genes","volume":"570","author":"Zimmermann","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib145","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.trsl.2016.08.002","article-title":"Gut microbiome interactions with drug metabolism, efficacy, and toxicity","volume":"179","author":"Wilson","year":"2017","journal-title":"Transl. Res."},{"key":"10.1016\/j.biopha.2022.113290_bib146","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.maturitas.2018.03.012","article-title":"Microbiota-drug interactions: Impact on metabolism and efficacy of therapeutics","volume":"112","author":"Wilkinson","year":"2018","journal-title":"Maturitas"},{"key":"10.1016\/j.biopha.2022.113290_bib147","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/cpdd.310","article-title":"Omics for understanding the gut-liver-microbiome axis and precision medicine","volume":"6","author":"Khalsa","year":"2017","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"10.1016\/j.biopha.2022.113290_bib148","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/03602532.2020.1718691","article-title":"The metabolic effect of gut microbiota on drugs","volume":"52","author":"Xie","year":"2020","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.biopha.2022.113290_bib149","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3109\/00498258409151481","article-title":"Role of the intestinal microflora in clonazepam metabolism in the rat","volume":"14","author":"Elmer","year":"1984","journal-title":"Xenobiotica"},{"key":"10.1016\/j.biopha.2022.113290_bib150","article-title":"Maternal high-fat diet disturbs the DNA methylation profile in the brown adipose tissue of offspring mice","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113290_bib151","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1038\/s41467-021-27171-1","article-title":"Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2022.113290_bib152","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1038\/s41467-021-27141-7","article-title":"Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2022.113290_bib153","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13059","article-title":"Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice","volume":"19","author":"Tian","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.biopha.2022.113290_bib154","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jnutbio.2018.05.010","article-title":"Folic acid supplementation alters the DNA methylation profile and improves insulin resistance in high-fat-diet-fed mice","volume":"59","author":"Li","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2022.113290_bib155","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S0007114518001526","article-title":"Effects of SCFA on the DNA methylation pattern of adiponectin and resistin in high-fat-diet-induced obese male mice","volume":"120","author":"Lu","year":"2018","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.biopha.2022.113290_bib156","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1530\/JME-14-0066","article-title":"Inhibition of HDAC3 promotes ligand-independent PPAR\u03b3 activation by protein acetylation","volume":"53","author":"Jiang","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113290_bib157","article-title":"Medium-chain fatty acids enhance expression and histone acetylation of genes related to lipid metabolism in insulin-resistant adipocytes","volume":"29","author":"Kawamura","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib158","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1159\/000447858","article-title":"HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor","volume":"39","author":"Jia","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.biopha.2022.113290_bib159","first-page":"3","article-title":"HDAC11 suppresses the thermogenic program of adipose tissue via BRD2","author":"Bagchi","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.biopha.2022.113290_bib160","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1017\/S0007114521001197","article-title":"Impact of maternal obesity and prebiotic supplementation on select maternal milk microRNA levels and correlation with offspring outcomes","volume":"127","author":"Lowry","year":"2022","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.biopha.2022.113290_bib161","first-page":"21","article-title":"Comprehensive analysis reveals novel interactions between circulating MicroRNAs and gut microbiota composition in human obesity","author":"Assmann","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib162","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1186\/1471-2164-9-507","article-title":"Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism","volume":"9","author":"Chittur","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.biopha.2022.113290_bib163","first-page":"5","article-title":"Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids","author":"Lukovac","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.biopha.2022.113290_bib164","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/1535370220913847","article-title":"Suppression of HDAC by sodium acetate rectifies cardiac metabolic disturbance in streptozotocin-nicotinamide-induced diabetic rats","volume":"245","author":"Olaniyi","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib165","doi-asserted-by":"crossref","first-page":"416","DOI":"10.26444\/aaem\/75456","article-title":"Gut microbiome as a biomarker of cardiometabolic disorders","volume":"24","author":"G\u00f3zd-Barszczewska","year":"2017","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib166","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(10)61449-3","article-title":"Triglyceride-mediated pathways and coronary heart disease","volume":"376","author":"Zeng","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2022.113290_bib167","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1042\/CS20160433","article-title":"APOA5 genetic and epigenetic variability jointly regulate circulating triacylglycerol levels","volume":"130","author":"Oliva","year":"2016","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib168","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1136\/gutjnl-2015-311326","article-title":"The effect of heritability and host genetics on the gut microbiota and metabolic syndrome","volume":"66","author":"Lim","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2022.113290_bib169","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4161\/rna.18827","article-title":"Liver-specific microRNA-122: biogenesis and function","volume":"9","author":"Jopling","year":"2012","journal-title":"RNA Biol."},{"key":"10.1016\/j.biopha.2022.113290_bib170","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.740528","article-title":"Crosstalk between polygonatum kingianum, the miRNA, and gut microbiota in the regulation of lipid metabolism","volume":"12","author":"Dong","year":"2021","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.biopha.2022.113290_bib171","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1136\/gutjnl-2014-308430","article-title":"MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway","volume":"65","author":"Wu","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2022.113290_bib172","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s00125-017-4209-3","article-title":"Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice","volume":"60","author":"Blasco-Baque","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopha.2022.113290_bib173","first-page":"21","article-title":"Pathophysiology of type 2 diabetes mellitus","author":"Galicia-Garcia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib174","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/JME-19-0132","article-title":"Butyrate modulates diabetes-linked gut dysbiosis: epigenetic and mechanistic modifications","volume":"64","author":"Noureldein","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113290_bib175","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.761834","article-title":"Therapeutic potential of butyrate for treatment of type 2 diabetes","volume":"12","author":"Arora","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2022.113290_bib176","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41598-017-18259-0","article-title":"SCFAs strongly stimulate PYY production in human enteroendocrine cells","volume":"8","author":"Larraufie","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib177","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.gene.2013.11.081","article-title":"Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity","volume":"537","author":"Remely","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.biopha.2022.113290_bib178","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3920\/BM2013.006","article-title":"Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity","volume":"5","author":"Remely","year":"2014","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.biopha.2022.113290_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119928","article-title":"Berberine combined with stachyose improves glycometabolism and gut microbiota through regulating colonic microRNA and gene expression in diabetic rats","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib180","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1007\/s00018-019-03114-4","article-title":"Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease","volume":"76","author":"Kim","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.biopha.2022.113290_bib181","first-page":"323","article-title":"Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates","volume":"119","author":"McCurdy","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2022.113290_bib182","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.2337\/db14-0276","article-title":"Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates","volume":"63","author":"Thorn","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2022.113290_bib183","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175675","article-title":"Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations","volume":"12","author":"Wankhade","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2022.113290_bib184","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1159\/000495830","article-title":"Microbial intervention as a novel target in treatment of non-alcoholic fatty liver disease progression","volume":"51","author":"Zhou","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.biopha.2022.113290_bib185","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678360","article-title":"Prebiotic inulin and sodium butyrate attenuate obesity-induced intestinal barrier dysfunction by induction of antimicrobial peptides","volume":"12","author":"Beisner","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.biopha.2022.113290_bib186","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12986-018-0323-6","article-title":"Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in Gynostemma pentaphylla (Thunb.) Makino treated mice","volume":"15","author":"Jia","year":"2018","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.biopha.2022.113290_bib187","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/1099800418816175","article-title":"Associations between unhealthy lifestyle behaviors and metabolic syndrome by gender in young adults","volume":"21","author":"Lin","year":"2019","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.biopha.2022.113290_bib188","doi-asserted-by":"crossref","first-page":"269","DOI":"10.23938\/ASSN.0267","article-title":"Alimentary and lifestyle changes as a strategy in the prevention of metabolic syndrome and diabetes mellitus type 2: milestones and perspectives","volume":"39","author":"MHRdE","year":"2016","journal-title":"Sist. Sanit. Navar."},{"key":"10.1016\/j.biopha.2022.113290_bib189","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/jama.2017.0947","article-title":"Association between dietary factors and mortality from heart disease, stroke, and type 2 diabetes in the United States","volume":"317","author":"Micha","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2022.113290_bib190","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2337\/dc20-0256","article-title":"Individual and combined associations of modifiable lifestyle and metabolic health status with new-onset diabetes and major cardiovascular events: the China Cardiometabolic Disease and Cancer Cohort (4C) Study","volume":"43","author":"Li","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2022.113290_bib191","first-page":"12","article-title":"Dietary fiber, gut microbiota, and metabolic regulation-current status in human randomized trials","author":"Myhrstad","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib192","first-page":"14","article-title":"Colonic microbiota profile characterization of the responsiveness to dietary fibre treatment in hypercholesterolemia","author":"Granado-Serrano","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib193","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/gutjnl-2019-320438","article-title":"Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake","volume":"69","author":"Meslier","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2022.113290_bib194","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.662159","article-title":"Effect of fecal microbiota transplantation combined with mediterranean diet on insulin sensitivity in subjects with metabolic syndrome","volume":"12","author":"Koopen","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.biopha.2022.113290_bib195","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13174","article-title":"The role of dietary diversity in preventing metabolic-related outcomes: Findings from a systematic review","volume":"22","author":"Mozaffari","year":"2021","journal-title":"Obes. Rev."},{"key":"10.1016\/j.biopha.2022.113290_bib196","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/jn\/nxaa435","article-title":"Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial","volume":"151","author":"Basu","year":"2021","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2022.113290_bib197","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1002\/oby.21552","article-title":"Dietary supplementation with omega-3 fatty acids and oleate enhances exercise training effects in patients with metabolic syndrome","volume":"24","author":"Ortega","year":"2016","journal-title":"Obesity"},{"key":"10.1016\/j.biopha.2022.113290_bib198","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ijcard.2016.10.008","article-title":"Mediterranean diet and physical activity impact on metabolic syndrome among children and adolescents from Southern Italy: Contribution from the Calabrian Sierras Community Study (CSCS)","volume":"225","author":"Martino","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2022.113290_bib199","doi-asserted-by":"crossref","first-page":"goab046","DOI":"10.1093\/gastro\/goab046","article-title":"Microbiome therapeutics: exploring the present scenario and challenges","volume":"10","author":"Yadav","year":"2022","journal-title":"Gastroenterol. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib200","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3389\/fmicb.2015.00685","article-title":"Probiotic-based strategies for therapeutic and prophylactic use against multiple gastrointestinal diseases","volume":"6","author":"Varankovich","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.biopha.2022.113290_bib201","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12328-014-0456-8","article-title":"Erratum to: probiotic treatments for induction and maintenance of remission in inflammatory bowel diseases: a meta-analysis of randomized controlled trials","volume":"7","author":"Fujiya","year":"2014","journal-title":"Clin. J. Gastroenterol."},{"key":"10.1016\/j.biopha.2022.113290_bib202","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.113290_bib203","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1038\/s41467-019-13336-6","article-title":"Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut","volume":"10","author":"Praveschotinunt","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2022.113290_bib204","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nbt.4222","article-title":"Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria","volume":"36","author":"Isabella","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biopha.2022.113290_bib205","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41401-019-0330-9","article-title":"Fecal microbiota transplantation improves metabolism and gut microbiome composition in db\/db mice","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2022.113290_bib206","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s41591-021-01399-2","article-title":"Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial","volume":"27","author":"Mocanu","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib207","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.14309\/ajg.0000000000000661","article-title":"Allogenic fecal microbiota transplantation in patients with nonalcoholic fatty liver disease improves abnormal small intestinal permeability: a randomized control trial","volume":"115","author":"Craven","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.biopha.2022.113290_bib208","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.cmet.2017.09.008","article-title":"Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition","volume":"26","author":"Kootte","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2022.113290_bib209","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41598-022-05127-9","article-title":"Health improvements of type 2 diabetic patients through diet and diet plus fecal microbiota transplantation","volume":"12","author":"Su","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib210","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.gastro.2020.08.041","article-title":"Effects of diet-modulated autologous fecal microbiota transplantation on weight regain","volume":"160","author":"Rinott","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113290_bib211","first-page":"1239","article-title":"The effects of probiotic supplementation on markers of blood lipids, and blood pressure in patients with prediabetes: a randomized clinical trial","volume":"5","author":"Mahboobi","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib212","doi-asserted-by":"crossref","unstructured":"Briot T., Kolenda C., Ferry T., Medina M., Laurent F., Leboucher G. et al.; Paving the way for phage therapy using novel drug delivery approaches. J Control Release, 2022.","DOI":"10.1016\/j.jconrel.2022.05.021"},{"key":"10.1016\/j.biopha.2022.113290_bib213","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3389\/fmicb.2015.01050","article-title":"Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches","volume":"6","author":"Beliz\u00e1rio","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.biopha.2022.113290_bib214","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/femsre\/fuaa020","article-title":"Bacteriophage-mediated manipulation of the gut microbiome - promises and presents limitations","volume":"44","author":"Rasmussen","year":"2020","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.biopha.2022.113290_bib215","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1136\/gutjnl-2019-320005","article-title":"Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model","volume":"69","author":"Rasmussen","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2022.113290_bib216","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s13238-018-0547-2","article-title":"Pharmacomicrobiomics: a novel route towards personalized medicine?","volume":"9","author":"Doestzada","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.biopha.2022.113290_bib217","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-59745-205-2_1","article-title":"The integration of personalized and systems medicine: bioinformatics support for pharmacogenomics and drug discovery","volume":"448","author":"Yan","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2022.113290_bib218","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nm.4345","article-title":"Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug","volume":"23","author":"Wu","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2022.113290_bib219","doi-asserted-by":"crossref","unstructured":"Wardman JF, Bains RK, Rahfeld P., Withers SG. Carbohydrate-active enzymes (CAZymes) in the gut microbiome. Nat Rev Microbiol. (2022).","DOI":"10.1038\/s41579-022-00712-1"},{"key":"10.1016\/j.biopha.2022.113290_bib220","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-017-02651-5","article-title":"Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases","volume":"9","author":"Fellows","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2022.113290_bib221","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1017\/S2040174417000733","article-title":"Epigenetics and DOHaD: from basics to birth and beyond","volume":"8","author":"Bianco-Miotto","year":"2017","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.biopha.2022.113290_bib222","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/jdi.12598","article-title":"Associations between changes in the maternal gut microbiome and differentially methylated regions of diabetes-associated genes in fetuses: a pilot study from a birth cohort study","volume":"8","author":"Tachibana","year":"2017","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.biopha.2022.113290_bib223","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1757-4749-2-24","article-title":"Epigenome targeting by probiotic metabolites","volume":"2","author":"Licciardi","year":"2010","journal-title":"Gut Pathog."},{"key":"10.1016\/j.biopha.2022.113290_bib224","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-020-00321-5","article-title":"Microbiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.biopha.2022.113290_bib225","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1515\/hsz-2021-0216","article-title":"High cellulose diet promotes intestinal motility through regulating intestinal immune homeostasis and serotonin biosynthesis","volume":"403","author":"Xie","year":"2022","journal-title":"Biol. Chem."},{"key":"10.1016\/j.biopha.2022.113290_bib226","first-page":"9","article-title":"Precision nutrition: a review of personalized nutritional approaches for the prevention and management of metabolic syndrome","author":"de Toro-Mart\u00edn","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.113290_bib227","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105174","article-title":"Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome","volume":"160","author":"Bridgeman","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biopha.2022.113290_bib228","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13679-020-00379-w","article-title":"Probiotics, prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives","volume":"9","author":"Vallianou","year":"2020","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.biopha.2022.113290_bib229","first-page":"12","article-title":"Effects of a low-fat vegan diet on gut microbiota in overweight individuals and relationships with body weight, body composition, and insulin sensitivity. a randomized clinical trial","author":"Kahleova","year":"2020","journal-title":"Nutrients"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222006795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222006795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:41:11Z","timestamp":1779968471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222006795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":229,"alternative-id":["S0753332222006795"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113290","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113290","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113290"}}