{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:04:05Z","timestamp":1793333045904,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.biopha.2022.113526","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T18:25:57Z","timestamp":1660328757000},"page":"113526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden"],"prefix":"10.1016","volume":"153","author":[{"given":"Mohamed Ibrahim Mohamed","family":"Fahmy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab Hamed","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Farag","family":"El-Yamany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham","family":"El-Naggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"A. Eliwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.113526_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s13098-019-0503-1","article-title":"The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies","volume":"12","author":"Sigit","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.biopha.2022.113526_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.NAJ.0000508662.88220.7a","article-title":"Examining the links between lifestyle factors and metabolic syndrome","volume":"116","author":"Shu-Hung","year":"2016","journal-title":"AJN Am. J. Nurs."},{"key":"10.1016\/j.biopha.2022.113526_bib3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome--a new world-wide definition. a Consensus Statement from the International Diabetes Federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabet. Med."},{"key":"10.1016\/j.biopha.2022.113526_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13098-019-0423-0","article-title":"Prevalence of metabolic syndrome and the comparison of fasting plasma glucose and HbA1c as the glycemic criterion for MetS definition in non-diabetic population in Ghana","volume":"11","author":"Annani-Akollor","year":"2019","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.biopha.2022.113526_bib5","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: An American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2022.113526_bib6","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1161\/CIRCULATIONAHA.105.539528","article-title":"Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus","volume":"112","author":"Wilson","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2022.113526_bib7","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2022.113526_bib8","article-title":"Rodent models for metabolic syndrome research","volume":"2011","author":"Brown","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.biopha.2022.113526_bib9","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1113\/expphysiol.2014.079632","article-title":"Fructose supplementation worsens the deleterious effects of short-term high-fat feeding on hepatic steatosis and lipid metabolism in adult rats","volume":"99","author":"Crescenzo","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.biopha.2022.113526_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pharmthera.2010.03.007","article-title":"Pharmacology & therapeutics perspectives of the non-statin hypolipidemic agents","volume":"127","author":"Rozman","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2022.113526_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0021-9150(99)00352-4","article-title":"Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients","volume":"150","author":"Paolisso","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2022.113526_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/01.CIR.103.3.357","article-title":"Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study","volume":"103","author":"Freeman","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2022.113526_bib13","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1345\/aph.1D391","article-title":"Approximate equivalent rosuvastatin doses for temporary statin interchange programs","volume":"38","author":"Kendrach","year":"2004","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.biopha.2022.113526_bib14","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.atherosclerosis.2007.11.003","article-title":"Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance: Evidence for statin-induced hepatic insulin sensitization","volume":"198","author":"Naples","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2022.113526_bib15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.etap.2011.12.011","article-title":"Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity","volume":"33","author":"Fouad","year":"2011","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113526_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.pharmthera.2009.07.003","article-title":"Pharmacology & Therapeutics Role of coenzyme Q10 ( CoQ10) in cardiac disease, hypertension and Meniere-like syndrome","volume":"124","author":"Kumar","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2022.113526_bib17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/10715760600617843","article-title":"Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics","volume":"40","author":"Bhagavan","year":"2006","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biopha.2022.113526_bib18","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.nut.2011.11.008","article-title":"Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease","volume":"28","author":"Lee","year":"2012","journal-title":"Nutrition"},{"key":"10.1016\/j.biopha.2022.113526_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1550-2783-5-8","article-title":"Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals","volume":"5","author":"Cooke","year":"2008","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"10.1016\/j.biopha.2022.113526_bib20","article-title":"Cardiology & cardiovascular therapy coenzyme Q10: the cardiac bio-energizer in cardiovascular diseases","volume":"1","author":"Maladkar","year":"2016","journal-title":"Cardiovasc Ther."},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2022.113526_bib21","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1017\/S0007114500001008","article-title":"Diet composition and insulin action in animal models","volume":"83","author":"Storlien","year":"2000","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.biopha.2022.113526_bib22","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1590\/S0100-879X2001000900008","article-title":"A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats","volume":"34","author":"Bezerra","year":"2001","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.biopha.2022.113526_bib23","first-page":"1","article-title":"Red yeast rice and coenzyme Q 10 as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats","volume":"9","author":"Abdelbaset","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113526_bib24","author":"Trinder","year":"1969","journal-title":"Ann. Clin. Biochem. Int. J. Biochem. Med."},{"key":"10.1016\/j.biopha.2022.113526_bib25","doi-asserted-by":"crossref","unstructured":"P.F. & L. Prencipe, zerum Triglycerides Determined Produces Hydrogen Peroxide Colorimetrically with an Enzyme That, Clin. Chem. 28 (1982) 2077\u20132080.","DOI":"10.1093\/clinchem\/28.10.2077"},{"key":"10.1016\/j.biopha.2022.113526_bib26","doi-asserted-by":"crossref","unstructured":"W. Richmond, Preparation and Properties of a Cholesterol Oxidase from Nocardia sp. and Its Application to the Enzymatic Assay of Total Cholesterol in Serum, 19 (1973) 1350\u20131356.","DOI":"10.1093\/clinchem\/19.12.1350"},{"key":"10.1016\/j.biopha.2022.113526_bib27","first-page":"109","article-title":"Precipitation of serum lipoproteins by anionic detergents in the presence of bivalent cations","volume":"15","author":"Burstein","year":"1970","journal-title":"Rev. Eur. Etud. Clin. Biol."},{"key":"10.1016\/j.biopha.2022.113526_bib28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2022.113526_bib29","unstructured":"M. Uchiyama, M. Mihara, Determination of Malonaldehyde Thiobarbituric Precursor Acid Test in Tissues by, 278 (1978)."},{"key":"10.1016\/j.biopha.2022.113526_bib30","first-page":"882","article-title":"Improved method for the determination of blood glutathione.","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med"},{"key":"10.1016\/j.biopha.2022.113526_bib31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.biopha.2022.113526_bib32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/clinchem\/22.5.650","article-title":"Creatine kinase in serum: of optimum reaction conditions","volume":"22","author":"Gabor Szasz","year":"1976","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2022.113526_bib33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ypmed.2017.01.012","article-title":"Is waist circumference \u2265 102\/88cm better than body mass index \u2265 30 to predict hypertension and diabetes development regardless of gender, age group, and race\/ethnicity? Meta-analysis","volume":"97","author":"Seo","year":"2017","journal-title":"Prev. Med."},{"key":"10.1016\/j.biopha.2022.113526_bib34","article-title":"Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders","volume":"121","author":"Tappy","year":"2018","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.biopha.2022.113526_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/15376516.2011.603391","article-title":"Enhancement of antioxidant defense mechanism by pitavastatin and rosuvastatin on obesity-induced oxidative stress in Wistar rats","volume":"22","author":"Ansari","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.biopha.2022.113526_bib36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejphar.2008.06.007","article-title":"Baseline triglyceride levels and insulin sensitivity are major determinants of the increase of LDL particle size and buoyancy induced by rosuvastatin treatment in patients with primary hyperlipidemia","volume":"590","author":"Kostapanos","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113526_bib37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2147\/VHRM.S3662","article-title":"Ef fi cacy and safety of rosuvastatin in the management of dyslipidemia","volume":"5","author":"Rubba","year":"2009","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.biopha.2022.113526_bib38","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1053\/j.gastro.2006.05.054","article-title":"Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance","volume":"131","author":"Tilg","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.113526_bib39","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijcard.2006.06.058","article-title":"Elevated circulating oxidized LDL levels in Japanese subjects with the metabolic syndrome","volume":"118","author":"Yamagishi","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2022.113526_bib40","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1001\/jama.299.19.2287","article-title":"Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome","volume":"299","author":"Holvoet","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2022.113526_bib41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0002-9149(03)00530-7","article-title":"Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* trial)","volume":"92","author":"Jones","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.biopha.2022.113526_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4137\/CMED.S7591","article-title":"Clinical medicine insights: endocrinology and diabetes rosuvastatin and atorvastatin: comparative effects on glucose metabolism in non-diabetic patients with dyslipidaemia","volume":"5","author":"Abbas","year":"2012","journal-title":"Clin. Med. Insights Endocrinol. Diabetes"},{"key":"10.1016\/j.biopha.2022.113526_bib43","first-page":"1","article-title":"The effects of rosuvastatin on lipid-lowering, inflammatory, antioxidant and fibrinolytics blood biomarkers are influenced by Val16Ala superoxide dismutase manganese-dependent gene polymorphism","author":"Duarte","year":"2016","journal-title":"Pharm. J."},{"key":"10.1016\/j.biopha.2022.113526_bib44","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.peptides.2010.03.023","article-title":"Peptides effect of statin therapy on leptin levels in patients with coronary heart disease","volume":"31","author":"Sun","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2022.113526_bib45","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2337\/diaclin.21.4.168","article-title":"Statin treatment in diabetes mellitus","volume":"21","author":"Buse","year":"2003","journal-title":"Clin. Diabetes"},{"key":"10.1016\/j.biopha.2022.113526_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.45.120403.095748","article-title":"Pleiotropic effects of statins","volume":"45","author":"Liao","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2022.113526_bib47","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0021-9150(02)00037-0","article-title":"Dose-dependent action of atorvastatin in type IIB hyperlipidemia: Preferential and progressive reduction of atherogenic apoB-containing lipoprotein subclasses (VLDL-2, IDL, small dense LDL) and stimulation of cellular cholesterol efflux","volume":"163","author":"Guerin","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2022.113526_bib48","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.jacc.2011.12.035","volume":"59","author":"Mora","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2022.113526_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-13-22","article-title":"Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet","volume":"13","author":"Jim\u00e9nez-Santos","year":"2014","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.biopha.2022.113526_bib50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0021-9150(99)00273-7","article-title":"Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits","volume":"148","author":"Singh","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2022.113526_bib51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1385\/BTER:109:1:025","article-title":"Effect of coenzyme Q10 on catalase activity and other antioxidant parameters in streptozotocin-induced diabetic rats","volume":"109","author":"Modi","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2022.113526_bib52","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1681\/ASN.2009111111","article-title":"Increased fructose associates with elevated blood pressure","volume":"21","author":"Jalal","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2022.113526_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/230868","article-title":"Hypertension in metabolic syndrome: vascular pathophysiology","volume":"2013","author":"Mendiz\u00e1bal","year":"2013","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.biopha.2022.113526_bib54","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/eurheartj\/ehm540","article-title":"Rosuvastatin increases vascular endothelial PPAR g expression and corrects blood pressure variability in obese dyslipidaemic mice","volume":"29","author":"Verreth","year":"2008","journal-title":"Eur. Hear. J."},{"key":"10.1016\/j.biopha.2022.113526_bib55","first-page":"1","article-title":"Endocrinology & metabolic syndrome beneficial effects of rosuvastatin in heart of C57Bl \/ 6 mice with diet- induced metabolic syndrome - a preliminary study","volume":"3","author":"Rocha","year":"2014","journal-title":"Endocrinol. Metab. Syndr."},{"key":"10.1016\/j.biopha.2022.113526_bib56","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.ejcn.1601464","article-title":"Coenzyme Q 10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes","volume":"56","author":"Hodgson","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.113526_bib57","doi-asserted-by":"crossref","unstructured":"F.L. Rosenfeldt, S.J. Haas, H. Krum, A. Hadj, K. Ng, J. Leong, G.F. Watts, Coenzyme Q 10 in the treatment of hypertension: a meta-analysis of the clinical trials, (2007) 297\u2013306. https:\/\/doi.org\/10.1038\/sj.jhh.1002138.","DOI":"10.1038\/sj.jhh.1002138"},{"key":"10.1016\/j.biopha.2022.113526_bib58","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0885-4505(91)90024-F","article-title":"Effect of coenzyme Q10 on structural alterations in the renal membrane of stroke-prone spontaneously hypertensive rats","volume":"45","author":"Okamoto","year":"1991","journal-title":"Biochem. Med. Metab. Biol."},{"key":"10.1016\/j.biopha.2022.113526_bib59","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.21327","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes","volume":"44","author":"Ekstedt","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2022.113526_bib60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.diabres.2018.08.011","article-title":"Non-alcoholic fatty liver disease: Relationship with cardiovascular risk markers and clinical endpoints","volume":"144","author":"Buckley","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2022.113526_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0060430","article-title":"BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE-\/- mice","volume":"8","author":"Kyaw","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2022.113526_bib62","first-page":"E11","article-title":"Association between statin-associated myopathy and skeletal muscle damage.","volume":"181","author":"Mohaupt","year":"2009","journal-title":"CMA J."},{"key":"10.1016\/j.biopha.2022.113526_bib63","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1152\/japplphysiol.01270.2001","article-title":"Break point of serum creatine kinase release after endurance exercise","volume":"93","author":"Totsuka","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.biopha.2022.113526_bib64","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.2522\/ptj.20090251","article-title":"Effects of statins on skeletal muscle: a perspective for physical therapists","volume":"90","author":"Di Stasi","year":"2010","journal-title":"Phys. Ther."},{"key":"10.1016\/j.biopha.2022.113526_bib65","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2165\/00002018-200528080-00002","article-title":"The Effect of HMG-CoA Reductase Inhibitors on Coenzyme Q 10 Possible Biochemical \/ Clinical Implications","volume":"28","author":"Hargreaves","year":"2005","journal-title":"Drug Saf."},{"key":"10.1016\/j.biopha.2022.113526_bib66","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s10545-011-9434-1","article-title":"Update on clinical aspects and treatment of selected vitamin-responsive disorders II (riboflavin and CoQ10)","volume":"35","author":"Horvath","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.biopha.2022.113526_bib67","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/nure.12011","article-title":"Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation","volume":"71","author":"Potgieter","year":"2013","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.biopha.2022.113526_bib68","first-page":"165","article-title":"Coenzyme Q 10 and selenium in statin-associated myopathy treatment","volume":"170","author":"Fedacko","year":"2013","journal-title":"NRC Res. Press."},{"key":"10.1016\/j.biopha.2022.113526_bib69","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1590\/S0100-879X2008005000030","article-title":"Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats","volume":"41","author":"Brito","year":"2008","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.biopha.2022.113526_bib70","first-page":"1263","author":"Bantle","year":"2009","journal-title":"Diet. Fruct. Metab. Syndr."},{"key":"10.1016\/j.biopha.2022.113526_bib71","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.bjp.0704070","article-title":"A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid","volume":"133","author":"Stalker","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113526_bib72","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.amjcard.2006.01.055","article-title":"Effect of atorvastatin ( 10mg \/ day) on glucose metabolism in patients with the metabolic syndrome","volume":"98","author":"Huptas","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.biopha.2022.113526_bib73","first-page":"57","article-title":"Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet","volume":"57","author":"Lalli","year":"2008","journal-title":"Sci. Direct"},{"key":"10.1016\/j.biopha.2022.113526_bib74","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1046\/j.1464-5491.1999.00064.x","article-title":"Impact of ubiqinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with Type 1 diabetes mellitus","volume":"16","author":"Henriksen","year":"1999","journal-title":"Diabet. Med."},{"key":"10.1016\/j.biopha.2022.113526_bib75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biomag.2013.12.003","article-title":"Protective effect of umbelliferone on high-fructose diet-induced insulin resistance and oxidative stress in rats","volume":"4","author":"Chandramohan","year":"2014","journal-title":"Biomed. Aging Pathol."},{"key":"10.1016\/j.biopha.2022.113526_bib76","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.freeradbiomed.2006.10.045","article-title":"Antioxidant and antiplatelet effects of rosuvastatin in a hamster model of prediabetes","volume":"42","author":"Miersch","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2022.113526_bib77","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2004.10.123","article-title":"Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1","volume":"325","author":"Grosser","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2022.113526_bib78","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2013.04.025","article-title":"Pleiotropic antioxidant potential of rosuvastatin in preventing cardiovascular disorders","volume":"711","author":"Mahalwar","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113526_bib79","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/2251-6581-13-60","article-title":"Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome","volume":"13","author":"Alam","year":"2014","journal-title":"J. Diabetes Metab. Disord."},{"key":"10.1016\/j.biopha.2022.113526_bib80","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.2174\/092986709789878265","article-title":"Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy","volume":"16","author":"Victor","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2022.113526_bib81","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/bja\/aer093","article-title":"Oxidative stress and mitochondrial dysfunction in sepsis","volume":"107","author":"Galley","year":"2011","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.biopha.2022.113526_bib82","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1073\/pnas.88.5.1646","article-title":"Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol","volume":"88","author":"Stocker","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2022.113526_bib83","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/01.CIR.0000158483.13093.9D","article-title":"Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation","volume":"111","author":"Dandona","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2022.113526_bib84","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2022.113526_bib85","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/hep.22402","article-title":"Statins in liver disease: a molehill, an iceberg, or","volume":"48","author":"Argo","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2022.113526_bib86","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jbspin.2012.07.007","article-title":"Rosuvastatin inhibits spontaneous and IL-1??-induced interleukin-6 production from human cultured osteoblastic cells","volume":"80","author":"Lazzerini","year":"2013","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.biopha.2022.113526_bib87","first-page":"2368","article-title":"Improvement of the survival and therapeutic effects of implanted mesenchymal stem cells in a rat model of coronary microembolization by rosuvastatin treatment","volume":"20","author":"Fu","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2022.113526_bib88","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1081\/IPH-51755","article-title":"Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1\u03b2-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets","volume":"27","author":"Schroeder","year":"2005","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.biopha.2022.113526_bib89","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3177\/jnsv.56.77","article-title":"Coenzyme Q10 decreases TNF-alpha and IL-2 secretion by human peripheral blood mononuclear cells.","volume":"56","author":"Bessler","year":"2010","journal-title":"J. Nutr. Sci. Vitaminol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113526_bib90","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/clinchem\/24.1.58","article-title":"Optimization of methods for aspartate aminotransferase and alanine aminotransferase","volume":"24","author":"Bergmeyer","year":"1978","journal-title":"Clinical Chemistry"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222009155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222009155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:38:00Z","timestamp":1779968280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222009155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":90,"alternative-id":["S0753332222009155"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113526","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113526"}}