{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:44:03Z","timestamp":1792712643859,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["PDCPN2013\u201301-2157230"],"award-info":[{"award-number":["PDCPN2013\u201301-2157230"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.biopha.2022.113708","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T07:35:16Z","timestamp":1663918516000},"page":"113708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Evaluation of the therapeutic efficacy of dressings with ZnO nanoparticles in the treatment of diabetic foot ulcers"],"prefix":"10.1016","volume":"155","author":[{"given":"Ra\u00fal","family":"Loera-Valencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Espinosa","family":"Neira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha Puente","family":"Urbina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Betancourt","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.113708_bib1","unstructured":"WHO, Prevalence of diabetes in the WHO Region of the Americas: Mexico. 2006."},{"issue":"5","key":"10.1016\/j.biopha.2022.113708_bib2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2022.113708_bib3","unstructured":"A.C, F.Md.D., Los n\u00fameros de la diabetes: Informaci\u00f3n para medios de comunicaci\u00f3n. 2006."},{"issue":"1","key":"10.1016\/j.biopha.2022.113708_bib4","first-page":"19","article-title":"The cost of diabetes in Latin America and the Caribbean","volume":"81","author":"Barcelo","year":"2003","journal-title":"Bull. World Health Organ"},{"issue":"5","key":"10.1016\/j.biopha.2022.113708_bib5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1067-2516(07)60001-5","article-title":"Diabetic foot disorders: a clinical practice guideline (2006 Revision)","volume":"45","author":"Frykberg","year":"2006","journal-title":"J. Foot Ankle Surg."},{"issue":"134)","key":"10.1016\/j.biopha.2022.113708_bib6","article-title":"Punto de acuerdo Senado de la Rep\u00fablica sobre la prevenci\u00f3n de amputaciones en el diab\u00e9tico","author":"Cruz-Mu\u00f1oz","year":"2005","journal-title":"Senado De. la Rep\u00fab. Mex."},{"key":"10.1016\/j.biopha.2022.113708_bib7","unstructured":"Organization, W.H., Prevention of Diabetes Mellitus, in Series 844, W.T. Report, Editor. 1994."},{"issue":"5 Suppl","key":"10.1016\/j.biopha.2022.113708_bib8","first-page":"S1","article-title":"Diabetic foot disorders: a clinical practice guideline. American College of Foot and Ankle Surgeons","volume":"39","author":"Frykberg","year":"2000","journal-title":"J. Foot Ankle Surg."},{"issue":"2","key":"10.1016\/j.biopha.2022.113708_bib9","first-page":"130","article-title":"[Necessary multidisciplinary management of diabetic foot]","volume":"26","author":"Got","year":"2001","journal-title":"J. Mal. Vasc."},{"issue":"8","key":"10.1016\/j.biopha.2022.113708_bib10","first-page":"230","article-title":"[Care of patients with the diabetic foot syndrome based on an international consensus]","volume":"140","author":"Jirkovska","year":"2001","journal-title":"Cas. Lek. Cesk"},{"issue":"2","key":"10.1016\/j.biopha.2022.113708_bib11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2337\/diacare.18.2.216","article-title":"The independent contributions of diabetic neuropathy and vasculopathy in foot ulceration. How great are the risks?","volume":"18","author":"McNeely","year":"1995","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biopha.2022.113708_bib12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diacare.22.1.157","article-title":"Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings","volume":"22","author":"Reiber","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2022.113708_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/biomedicines9091235","article-title":"Modern wound dressings: hydrogel dressings","volume":"9","author":"Brumberg","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.biopha.2022.113708_bib14","doi-asserted-by":"crossref","unstructured":"Zhang, K., et al., Bioactive Injectable Hydrogel Dressings for Bacteria-Infected Diabetic Wound Healing: A \"Pull-Push\" Approach. ACS Appl Mater Interfaces, 2022.","DOI":"10.1021\/acsami.2c04300"},{"key":"10.1016\/j.biopha.2022.113708_bib15","first-page":"6","article-title":"Fisiolog\u00eda de la cicatrizaci\u00f3n de la herida: de la lesi\u00f3n a la maduraci\u00f3n.","volume":"89","author":"Teller","year":"2009","journal-title":"Surg. Clin. N. Am."},{"issue":"6","key":"10.1016\/j.biopha.2022.113708_bib16","first-page":"481","article-title":"Gu\u00eda cl\u00ednica basada en evidencia para el manejo del pie diab\u00e9tico","volume":"25","author":"Castro G","year":"2009","journal-title":"Med Int Mex."},{"issue":"1","key":"10.1016\/j.biopha.2022.113708_bib17","article-title":"Cicatrizaci\u00f3n: conceptos actuales","volume":"17","author":"Porras-Reyes","year":"1992","journal-title":"Acta M\u00e9dica Colomb."},{"issue":"1","key":"10.1016\/j.biopha.2022.113708_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2006.00179.x","article-title":"Zinc in wound healing: theoretical, experimental, and clinical aspects","volume":"15","author":"Lansdown","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"1\/2","key":"10.1016\/j.biopha.2022.113708_bib19","first-page":"2","article-title":"Efecto de los niveles plasm\u00e1ticos de zinc: en la cicatrizaci\u00f3n de piel e intestino de ratas \/ Effect of the zinc plasmatic level: in the wound healing process of skin and intestine in rats","volume":"51","author":"Sanint Ocampo","year":"1998","journal-title":"Rev. Venez. Cir."},{"issue":"3","key":"10.1016\/j.biopha.2022.113708_bib20","first-page":"161","article-title":"Treatment of veno-lymphatic ulcer with compression system of coumarin-zinc-oxide.","volume":"10","author":"Vega Rasgado","year":"2007","journal-title":"Rev. Esp. Investig. Quir."},{"issue":"3","key":"10.1016\/j.biopha.2022.113708_bib21","first-page":"93","volume":"30","author":"Tankova","year":"2001","journal-title":"Zinc hyaluronate Treat. Diabet. foot ulcers: a Control. Random Open-Label. Study"},{"issue":"2","key":"10.1016\/j.biopha.2022.113708_bib22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4321\/S1134-928X2007000200006","article-title":"Casta\u00f1eda Andrade, I., Efecto del hialuronato de zinc sobre las \u00faceras en pacientes con diabetes.","volume":"18","author":"Ramos Cuevas","year":"2007","journal-title":"Gerokomos"},{"key":"10.1016\/j.biopha.2022.113708_bib23","doi-asserted-by":"crossref","first-page":"39463","DOI":"10.1039\/C8RA06922K","article-title":"High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings","volume":"8","author":"Cai","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2022.113708_bib24","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/10601325.2017.1320752","article-title":"Extended release of Gliclazide from highly stabilized calcium alginate\/poly(acrylamide) beads for diabetes management","volume":"54","author":"Bajpai","year":"2017","journal-title":"J. Macromol. Sci., Part A"},{"key":"10.1016\/j.biopha.2022.113708_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtla.2020.100839","article-title":"Calcium ion mediated rapid wound healing by nano-ZnO doped calcium phosphate-chitosan-alginate biocomposites","volume":"13","author":"Rahman","year":"2020","journal-title":"Materialia"},{"key":"10.1016\/j.biopha.2022.113708_bib26","article-title":"Alginate-pluronic topical gels loaded with thymol, norfloxacin and ZnO nanoparticles as potential wound dressings","volume":"60","author":"Buyana","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2022.113708_bib27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ijpharm.2017.07.083","article-title":"Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus","volume":"530","author":"Maestrelli","year":"2017","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.biopha.2022.113708_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.carbpol.2018.10.015","article-title":"Poly(methacrylic acid)-modified medical cotton gauzes with antimicrobial and drug delivery properties for their use as wound dressings","volume":"205","author":"Lumbreras-Aguayo","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.biopha.2022.113708_bib29","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot087379","article-title":"Crystal violet assay for determining viability of cultured cells","volume":"2016","author":"Feoktistova","year":"2016","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.biopha.2022.113708_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1062562","article-title":"The advancing of zinc oxide nanoparticles for biomedical applications","volume":"2018","author":"Jiang","year":"2018","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.biopha.2022.113708_bib31","series-title":"Effects of Simultaneous Delivery of Silver and Zinc Oxide on the Efficacy of Healing Acute Wounds, in Bioengineering.","author":"Halldorson","year":"2013"},{"issue":"2","key":"10.1016\/j.biopha.2022.113708_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.colsurfb.2005.12.007","article-title":"Zn2+ release from zinc and zinc oxide particles in simulated uterine solution","volume":"47","author":"Yang","year":"2006","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"8","key":"10.1016\/j.biopha.2022.113708_bib33","article-title":"Clinical, pathological and microbiological evaluation of diabetic foot syndrome","volume":"56","author":"Uivaraseanu","year":"2020","journal-title":"Med. (Kaunas. )"},{"issue":"3","key":"10.1016\/j.biopha.2022.113708_bib34","first-page":"138","article-title":"Amputaci\u00f3n del miembro inferior por pie diab\u00e9tico en hospitales de la costa norte peruana 1990 - 2000: caracter\u00edsticas cl\u00ednico-epidemiol\u00f3gicas","volume":"20","author":"Escalante Guti\u00e9rrez D","year":"2003","journal-title":"Rev. per\u00fa. Med. Exp. Salud Publica"},{"issue":"7\u20138","key":"10.1016\/j.biopha.2022.113708_bib35","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0899-9007(00)00295-1","article-title":"Nutrition transition and global dietary trends","volume":"16","author":"Drewnowski","year":"2000","journal-title":"Nutrition"},{"issue":"6","key":"10.1016\/j.biopha.2022.113708_bib36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1370\/afm.754","article-title":"Obesity and diabetes in vulnerable populations: reflection on proximal and distal causes","volume":"5","author":"Candib","year":"2007","journal-title":"Ann. Fam. Med."},{"issue":"6","key":"10.1016\/j.biopha.2022.113708_bib37","article-title":"Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis","volume":"12","author":"Das","year":"2020","journal-title":"Polym. (Basel)"},{"issue":"21","key":"10.1016\/j.biopha.2022.113708_bib38","doi-asserted-by":"crossref","first-page":"18511","DOI":"10.1021\/am5058713","article-title":"Polylactic acid with improved heat deflection temperatures and self-healing properties for durable goods applications","volume":"6","author":"Wertz","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.biopha.2022.113708_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/2231-4040.107498","article-title":"Formulation and in vitro evaluation of Eudragit S-100 coated naproxen matrix tablets for colon-targeted drug delivery system","volume":"4","author":"Mehta","year":"2013","journal-title":"J. Adv. Pharm. Technol. Res"},{"issue":"1","key":"10.1016\/j.biopha.2022.113708_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/1574892816666211013113841","article-title":"Eudragit, a nifty polymer for anticancer preparations: a patent review","volume":"17","author":"Kriplani","year":"2022","journal-title":"Recent Pat. Anticancer Drug Disco"},{"key":"10.1016\/j.biopha.2022.113708_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/pharmaceutics13091424","article-title":"Eudragit((R)): a versatile family of polymers for hot melt extrusion and 3d printing processes in pharmaceutics","volume":"13","author":"Dos Santos","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biopha.2022.113708_bib42","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.ijbiomac.2020.03.221","article-title":"Accelerated healing of full thickness excised skin wound in rabbits using single application of alginate\/acacia based nanocomposites of ZnO nanoparticles","volume":"155","author":"Manuja","year":"2020","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2022.113708_bib43","first-page":"1","article-title":"Studies on zinc in wound healing","volume":"154","author":"Agren","year":"1990","journal-title":"Acta Derm. Venereol. Suppl. (Stock. )"},{"key":"10.1016\/j.biopha.2022.113708_bib44","article-title":"Potential for enhanced wound healing with ZnO nanoparticles, in","author":"Aloe C","year":"2016","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.biopha.2022.113708_bib45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijbiomac.2016.12.009","article-title":"Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells","volume":"96","author":"Raguvaran","year":"2017","journal-title":"Int J. Biol. Macromol."},{"issue":"23","key":"10.1016\/j.biopha.2022.113708_bib46","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1039\/C7TB00664K","article-title":"ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure","volume":"5","author":"Gao","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.biopha.2022.113708_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00449-013-0982-7","article-title":"Biosynthesis and safety evaluation of ZnO nanoparticles","volume":"37","author":"Sarkar","year":"2014","journal-title":"Bioprocess Biosyst. Eng."},{"key":"10.1016\/j.biopha.2022.113708_bib48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/NSA.S19419","article-title":"Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness","volume":"4","author":"Smijs","year":"2011","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.biopha.2022.113708_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2020.100282","article-title":"In vitro skin toxicity of CuO and ZnO nanoparticles: application in the safety assessment of antimicrobial coated textiles","volume":"21","author":"Bengalli","year":"2021","journal-title":"NanoImpact"},{"issue":"3","key":"10.1016\/j.biopha.2022.113708_bib50","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1021\/acsami.9b17597","article-title":"Alginate-based electrospun membranes containing ZnO nanoparticles as potential wound healing patches: biological, mechanical, and physicochemical characterization","volume":"12","author":"Dodero","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222010976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222010976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:27:53Z","timestamp":1781782073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222010976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":50,"alternative-id":["S0753332222010976"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113708","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the therapeutic efficacy of dressings with ZnO nanoparticles in the treatment of diabetic foot ulcers","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113708"}}