{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:36:09Z","timestamp":1790174169288,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2022R91"],"award-info":[{"award-number":["PNURSP2022R91"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.biopha.2022.113752","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T01:14:50Z","timestamp":1664414090000},"page":"113752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Dihydromyricetin alleviates methotrexate-induced hepatotoxicity via suppressing the \u200eTLR4\/NF-\u03baB pathway and NLRP3 inflammasome\/caspase 1 axis"],"prefix":"10.1016","volume":"155","author":[{"given":"Asmaa I.","family":"Matouk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman M.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa F.G.","family":"El-Tahawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza A.K.","family":"El-Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Waz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2022.113752_bib1","first-page":"256","article-title":"Chemotherapy-induced liver injury in children","volume":"91","author":"Urrutia-Maldonado","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopha.2022.113752_bib2","doi-asserted-by":"crossref","unstructured":"Qin F.L., Sang G.Y., Zou X.Q., Cheng D.H. Drug-induced liver injury during consolidation therapy in childhood acute lymphoblastic leukemia as assessed for causality using the updated RUCAM. Marasco G, editor. Can J Gastroenterol Hepatol [Internet]. 2022 Mar 24;2022:1\u20139. Available from: \u3008https:\/\/www.hindawi.com\/journals\/cjgh\/2022\/5914593\/\u3009.","DOI":"10.1155\/2022\/5914593"},{"issue":"8","key":"10.1016\/j.biopha.2022.113752_bib3","first-page":"363","article-title":"Methotrexate hepatotoxicity monitoring guidelines in psoriasis and rheumatoid arthritis: is there a consensus?","volume":"74","author":"Clary","year":"2021","journal-title":"S D. Med."},{"issue":"2","key":"10.1016\/j.biopha.2022.113752_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/ajd.13546","article-title":"Is methotrexate hepatotoxicity associated with cumulative dose? A systematic review and meta-analysis","volume":"62","author":"Azzam","year":"2021","journal-title":"Austral J. Dermatol. [Internet]"},{"issue":"6","key":"10.1016\/j.biopha.2022.113752_bib5","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1007\/s11033-020-05481-9","article-title":"Molecular mechanism of action and pharmacokinetic properties of methotrexate","volume":"47","author":"Maksimovic","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.biopha.2022.113752_bib6","first-page":"458","article-title":"Hepatotoxic potentials of methotrexate: understanding the possible toxicological molecular mechanisms","author":"Ezhilarasan","year":"2021","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.biopha.2022.113752_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/ijp.IJP_824_19","article-title":"Modulation of liver P-Glycoprotien Expression May Contribute to Gossypin Protection against Methotrexate-Induced Hepatotoxicity","volume":"53","author":"Mohamed","year":"2021","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113752_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.774387","article-title":"Paeonol protects against methotrexate-induced nephrotoxicity via upregulation of P-gp expression and inhibition of TLR4\/NF-\u03baB pathway","volume":"13","author":"Morsy","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113752_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.634607","article-title":"Inflammasome: a promising therapeutic target for drug-induced toxicity","volume":"9","author":"Wei","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2022.113752_bib10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00011-019-01241-z","article-title":"Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-\u03baB\/NLRP3 inflammasome activation and up-regulating Nrf2\/ARE\/HO-1 signaling","volume":"68","author":"Abd El-Twab","year":"2019","journal-title":"Inflamm. Res."},{"issue":"8","key":"10.1016\/j.biopha.2022.113752_bib11","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1039\/C9FO00114J","article-title":"Ferulic acid protects against methotrexate nephrotoxicity: via activation of Nrf2\/ARE\/HO-1 signaling and PPAR\u03b3, and suppression of NF-\u03baB\/NLRP3 inflammasome axis","volume":"10","author":"Mahmoud","year":"2019","journal-title":"Food Funct."},{"issue":"12","key":"10.1016\/j.biopha.2022.113752_bib12","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1292\/jvms.19-0347","article-title":"In vitro efficacy of ampelopsin against echinococcus granulosus and echinococcus multilocularis","volume":"81","author":"Xin","year":"2019","journal-title":"J. Vet. Med Sci."},{"issue":"1","key":"10.1016\/j.biopha.2022.113752_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1523\/JNEUROSCI.4639-11.2012","article-title":"Dihydromyricetin as a novel anti-alcohol intoxication medication","volume":"32","author":"Shen","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2022.113752_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6692579","article-title":"Dihydromyricetin acts as a potential redox balance mediator in cancer chemoprevention","volume":"2021","author":"Chen","year":"2021","journal-title":"Mediat. Inflamm."},{"issue":"OCT","key":"10.1016\/j.biopha.2022.113752_bib15","article-title":"Recent update on the pharmacological effects and mechanisms of dihydromyricetin","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.biopha.2022.113752_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.794563","article-title":"Mechanism of dihydromyricetin on inflammatory diseases","volume":"12","author":"Sun","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113752_bib17","first-page":"142","article-title":"Molecular mechanisms and therapeutic implications of dihydromyricetin in liver disease","author":"Chen","year":"2021","journal-title":"Biomed. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113752_bib18","first-page":"1","article-title":"Preventive effect of dihydromyricetin against cisplatin-induced nephrotoxicity in vitro and in vivo","volume":"2016","author":"Wu","year":"2016","journal-title":"Evid. -Based Complement Alter. Med."},{"issue":"8","key":"10.1016\/j.biopha.2022.113752_bib19","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1021\/acs.jproteome.0c00230","article-title":"A two-way interaction between methotrexate and the gut microbiota of male sprague\u2013dawley rats","volume":"19","author":"Letertre","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.biopha.2022.113752_bib20","first-page":"278","article-title":"Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis","author":"Dogra","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2022.113752_bib21","first-page":"511","article-title":"Effect of histone deacetylase inhibitor on epithelial-mesenchymal transition of liver fibrosis","volume":"70","author":"Ramzy","year":"2018"},{"issue":"6","key":"10.1016\/j.biopha.2022.113752_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113752_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/hep.510310136","article-title":"Grading and staging the histopathological lesions of chronic hepatitis: the Knodell histology activity index and beyond","volume":"31","author":"Brunt","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2022.113752_bib24","doi-asserted-by":"crossref","unstructured":"Buege J.A., Aust S.D. Microsomal Lipid Peroxidation. In: Methods in Enzymology [Internet]. 1978. p. 302\u2013310. Available from: \u3008https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0076687978520326\u3009.","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"10.1016\/j.biopha.2022.113752_bib25","first-page":"817","article-title":"The past and present of serum aminotransferases and the future of liver injury biomarkers","volume":"15","author":"McGill","year":"2016","journal-title":"EXCLI J."},{"issue":"2","key":"10.1016\/j.biopha.2022.113752_bib26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.biopha.2022.113752_bib27","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.3390\/ijms21103483","article-title":"Overview of dual-acting drug methotrexate in different neurological diseases, autoimmune pathologies and cancers","volume":"21","author":"Ko\u017ami\u0144ski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2022.113752_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12986-021-00589-6","article-title":"Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect","volume":"18","author":"Zhou","year":"2021","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.biopha.2022.113752_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.783886","article-title":"Dihydromyricetin reverses thioacetamide-induced liver fibrosis through inhibiting NF-\u03baB-mediated inflammation and TGF-\u03b21-regulated of PI3K\/Akt signaling pathway","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2022.113752_bib30","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1021\/acsomega.0c05488","article-title":"UPLC-Q-TOF\/MS-based metabolomics approach to reveal the hepatotoxicity of emodin and detoxification of dihydromyricetin","volume":"6","author":"Gao","year":"2021","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.biopha.2022.113752_bib31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13567-022-01024-1","article-title":"Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome","volume":"53","author":"Shi","year":"2022","journal-title":"Vet. Res."},{"issue":"5","key":"10.1016\/j.biopha.2022.113752_bib32","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1039\/D1FO03971G","article-title":"Dihydromyricetin prevents obesity via regulating bile acid metabolism associated with the farnesoid X receptor in ob\/ob mice","volume":"13","author":"Song","year":"2022","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/j.biopha.2022.113752_bib33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0889-857X(05)70365-3","article-title":"Methotrexate hepatotoxicity","volume":"23","author":"West","year":"1997","journal-title":"Rheum. Dis. Clin. North Am."},{"issue":"2","key":"10.1016\/j.biopha.2022.113752_bib34","first-page":"721","article-title":"Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the I\u0138B\u03b1\/NF\u0138B in rats. DARU","volume":"27","author":"Ebrahimi","year":"2019","journal-title":"J. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2022.113752_bib35","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/antiox11040704","article-title":"Dihydromyricetin enhances intestinal antioxidant capacity of growing-finishing pigs by activating ERK\/Nrf2\/HO-1 signaling pathway","volume":"11","author":"Wei","year":"2022","journal-title":"Antioxidants"},{"issue":"3","key":"10.1016\/j.biopha.2022.113752_bib36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/10495398.2021.2006204","article-title":"Effect of dietary dihydromyricetin supplementation on lipid metabolism, antioxidant capacity and skeletal muscle fiber type transformation in mice","volume":"33","author":"Guo","year":"2022","journal-title":"Anim. Biotechnol."},{"issue":"4","key":"10.1016\/j.biopha.2022.113752_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202101002","article-title":"Dihydromyricetin improves cognitive impairments in d-galactose-induced aging mice through regulating oxidative stress and inhibition of acetylcholinesterase","volume":"66","author":"Sun","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"issue":"7","key":"10.1016\/j.biopha.2022.113752_bib38","first-page":"842","article-title":"The role of miR-199b-3p in regulating Nrf2 pathway by dihydromyricetin to alleviate septic acute kidney injury","volume":"55","author":"Tian","year":"2021","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biopha.2022.113752_bib39","first-page":"1","article-title":"Dihydromyricetin protects against diabetic cardiomyopathy in streptozotocin-induced diabetic mice","volume":"2017","author":"Wu","year":"2017","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.biopha.2022.113752_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/859383","article-title":"Mechanisms of thymoquinone hepatorenal protection in methotrexate-induced toxicity in rats","volume":"2015","author":"El-Sheikh","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"32","key":"10.1016\/j.biopha.2022.113752_bib41","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.4254\/wjh.v8.i32.1354","article-title":"Toll-like receptors in pathophysiology of liver diseases","volume":"8","author":"Kiziltas","year":"2016","journal-title":"World J. Hepatol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113752_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00005-020-00595-1","article-title":"Pattern recognition receptors: significance of expression in the liver","volume":"68","author":"\u017beromski","year":"2020","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"6","key":"10.1016\/j.biopha.2022.113752_bib43","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.4049\/jimmunol.173.6.3589","article-title":"Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-\u03baB","volume":"173","author":"Park","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2022.113752_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6978936","article-title":"The role of toll-like receptor 4 in infectious and noninfectious inflammation","volume":"2016","author":"Molteni","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.biopha.2022.113752_bib45","first-page":"148","article-title":"The contribution of sterile inflammation to the fatty liver disease and the potential therapies","author":"Shaker","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.biopha.2022.113752_bib46","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2022.113752_bib47","first-page":"430","article-title":"Role of NLRP3 inflammasome in liver disease","volume":"21","author":"Al Mamun","year":"2020"},{"issue":"5","key":"10.1016\/j.biopha.2022.113752_bib48","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3390\/ph15050549","article-title":"Mechanistic insights on the in vitro antibacterial activity and in vivo hepatoprotective effects of salvinia auriculata aubl against methotrexate-induced liver injury","volume":"15","author":"Attallah","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"6","key":"10.1016\/j.biopha.2022.113752_bib49","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.3892\/mmr.2017.7742","article-title":"Dihydromyricetin protects against lipopolysaccharide-induced cardiomyocyte injury through the toll-like receptor-4\/nuclear factor-\u03baB pathway","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2022.113752_bib50","first-page":"423","article-title":"Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4\/Akt\/HIF1a\/NLRP3 pathway","author":"Wei","year":"2022","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.biopha.2022.113752_bib51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13567-020-00796-8","article-title":"Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4\/NF-\u03baB signalling pathway","volume":"51","author":"Chang","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.biopha.2022.113752_bib52","first-page":"188","article-title":"Dihydromyricetin attenuates streptozotocin\u2010induced liver injury and inflammation in rats via regulation of NF\u2010 \u03ba B and AMPK signaling pathway","volume":"1","author":"Chen","year":"2020"},{"issue":"1","key":"10.1016\/j.biopha.2022.113752_bib53","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/13880209.2021.1917625","article-title":"Effect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice","volume":"59","author":"Cheng","year":"2021","journal-title":"Pharm. Biol."},{"issue":"39","key":"10.1016\/j.biopha.2022.113752_bib54","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.2174\/1381612826666200730221035","article-title":"Plant compounds for the treatment of diabetes, a metabolic disorder: NF-\u03baB as a therapeutic target","volume":"26","author":"Sahukari","year":"2020","journal-title":"Curr. Pharm. Des."},{"issue":"13","key":"10.1016\/j.biopha.2022.113752_bib55","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.3390\/molecules26133877","article-title":"Ige-induced mast cell activation is suppressed by dihydromyricetin through the inhibition of nf-\u03bab signaling pathway","volume":"26","author":"Chang","year":"2021","journal-title":"Molecules"},{"issue":"30","key":"10.1016\/j.biopha.2022.113752_bib56","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.1021\/acs.jafc.8b02433","article-title":"Dihydromyricetin inhibits lead-induced cognitive impairments and inflammation by the adenosine 5\u2032-monophosphate-activated protein kinase pathway in mice","volume":"66","author":"Liu","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.biopha.2022.113752_bib57","first-page":"641","article-title":"Dihydromyricetin improves cardiac insufficiency by inhibiting HMGB1 in diabetic rats","volume":"42","author":"Liu","year":"2022","journal-title":"Nan Fang. Yi Ke Da Xue Xue Bao"},{"issue":"7","key":"10.1016\/j.biopha.2022.113752_bib58","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1039\/D0FO00396D","article-title":"DMY protects the knee joints of rats with collagen-induced arthritis by inhibition of NF-?B signaling and osteoclastic bone resorption","volume":"11","author":"Wu","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.biopha.2022.113752_bib59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.toxlet.2017.04.009","article-title":"Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1\/Nrf2 pathway to alleviate ethanol-induced hepatic injury","volume":"274","author":"Qiu","year":"2017","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.biopha.2022.113752_bib60","first-page":"1638","article-title":"Protective effect of dihydromyricetin revents fatty liver through nuclear factor-\u03baB\/p53\/B-cell lymphoma 2-associated X protein signaling pathways in a rat model","volume":"19","author":"Guo","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2022.113752_bib61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/biof.1395","article-title":"Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells","volume":"44","author":"Hu","year":"2018","journal-title":"BioFactors"},{"issue":"4","key":"10.1016\/j.biopha.2022.113752_bib62","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s10753-019-00990-7","article-title":"Dihydromyricetin alleviates sepsis-induced acute lung injury through inhibiting NLRP3 inflammasome-dependent pyroptosis in mice model","volume":"42","author":"Wang","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.biopha.2022.113752_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113888","article-title":"Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1","volume":"175","author":"Sun","year":"2020","journal-title":"Biochem Pharmacol."},{"issue":"41","key":"10.1016\/j.biopha.2022.113752_bib64","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.3748\/wjg.v26.i41.6346","article-title":"Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis","volume":"26","author":"Cheng","year":"2020","journal-title":"World J. Gastroenterol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222011416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222011416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:24:38Z","timestamp":1781781878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222011416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":64,"alternative-id":["S0753332222011416"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113752","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydromyricetin alleviates methotrexate-induced hepatotoxicity via suppressing the \u200eTLR4\/NF-\u03baB pathway and NLRP3 inflammasome\/caspase 1 axis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113752"}}