{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:15Z","timestamp":1791216495691,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81603106"],"award-info":[{"award-number":["81603106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["82061160374"],"award-info":[{"award-number":["82061160374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["U1801287"],"award-info":[{"award-number":["U1801287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.biopha.2022.113804","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T20:17:14Z","timestamp":1666210634000},"page":"113804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice"],"prefix":"10.1016","volume":"156","author":[{"given":"Huihui","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houde","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biopha.2022.113804_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2022.113804_bib2","doi-asserted-by":"crossref","first-page":"i1585","DOI":"10.1136\/bmj.i1585","article-title":"Sepsis: pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.biopha.2022.113804_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","article-title":"Sepsis and septic shock - basics of diagnosis, pathophysiology and clinical decision making","volume":"104","author":"Font","year":"2020","journal-title":"Med Clin. N. Am."},{"issue":"3","key":"10.1016\/j.biopha.2022.113804_bib4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s100169900052","article-title":"The role of nitric oxide in vascular biology and pathobiology","volume":"11","author":"Dattilo","year":"1997","journal-title":"Ann. Vasc. Surg."},{"issue":"6","key":"10.1016\/j.biopha.2022.113804_bib5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S1357-2725(96)00167-7","article-title":"Nitric oxide","volume":"29","author":"Robbins","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.biopha.2022.113804_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/cr.2013.6","article-title":"Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock","volume":"23","author":"Mao","year":"2013","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.biopha.2022.113804_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/bph.14512","article-title":"Inhaled nitric oxide","volume":"176","author":"Yu","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2022.113804_bib8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.freeradbiomed.2019.11.029","article-title":"Clinical use of inhaled nitric oxide: local and systemic applications","volume":"152","author":"Barnes","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.biopha.2022.113804_bib9","first-page":"CD002787","article-title":"Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults","volume":"2016","author":"Gebistorf","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2022.113804_bib10","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1016\/j.bja.2020.10.011","article-title":"Inhaled nitric oxide minimally improves oxygenation in COVID-19 related acute respiratory distress syndrome","volume":"126","author":"Longobardo","year":"2021","journal-title":"Br. J. Anaesth."},{"issue":"6","key":"10.1016\/j.biopha.2022.113804_bib11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.biopha.2022.113804_bib12","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1073\/pnas.93.10.4688","article-title":"Excitoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly (ADP-ribose) polymerase","volume":"93","author":"Said","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.biopha.2022.113804_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1165\/rcmb.2003-0177OC","article-title":"Ionotropic glutamate receptors in lungs and airways: molecular basis for glutamate toxicity","volume":"30","author":"Dickman","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"22","key":"10.1016\/j.biopha.2022.113804_bib14","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1161\/CIRCULATIONAHA.117.029930","article-title":"NMDA-type glutamate receptor activation promotes vascular remodeling and pulmonary arterial hypertension","volume":"137","author":"Dumas","year":"2018","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.biopha.2022.113804_bib15","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.intimp.2011.01.016","article-title":"Treatment with N-methyl-D-aspartate receptor antagonist (MK-801) protects against oxidative stress in lipopolysaccharide-induced acute lung injury in the rat","volume":"11","author":"da Cunha","year":"2011","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2022.113804_bib16","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/SHK.0000000000001790","article-title":"Memantine alleviates acute lung injury via inhibiting macrophage pyroptosis","volume":"56","author":"Ding","year":"2021","journal-title":"Shock"},{"issue":"17","key":"10.1016\/j.biopha.2022.113804_bib17","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1111\/bph.14763","article-title":"The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models","volume":"176","author":"Luo","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2022.113804_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13371","article-title":"Therapeutic efficacy of novel memantine nitrate MN-08 in animal models of Alzheimer's disease","volume":"20","author":"Wu","year":"2021","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.biopha.2022.113804_bib19","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1161\/HYPERTENSIONAHA.120.15994","article-title":"Dual-functional MN-08 attenuated pulmonary arterial hypertension through vasodilation and inhibition of pulmonary arterial remodeling","volume":"77","author":"Luo","year":"2021","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.biopha.2022.113804_bib20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113804_bib21","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1007\/s10753-021-01478-z","article-title":"Benzoylaconine modulates LPS-induced responses through inhibition of toll-like receptor-mediated NF-\u03baB and MAPK signaling in RAW264.7 cells","volume":"44","author":"Zhou","year":"2021","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.biopha.2022.113804_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10753-019-01124-9","article-title":"The NLRP3 inflammasome and its role in sepsis development","volume":"43","author":"Danielski","year":"2020","journal-title":"Inflammation"},{"issue":"12","key":"10.1016\/j.biopha.2022.113804_bib23","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"18","key":"10.1016\/j.biopha.2022.113804_bib24","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.3390\/ijms20184341","article-title":"Inflammatory response to different toxins in experimental sepsis models","volume":"20","author":"Dickson","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.biopha.2022.113804_bib25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd1854","article-title":"Animal models for sepsis: setting the stage","volume":"4","author":"Buras","year":"2005","journal-title":"Nat. Rev. Drug Disco"},{"issue":"3","key":"10.1016\/j.biopha.2022.113804_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ajem.2019.10.023","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis","volume":"38","author":"Huang","year":"2020","journal-title":"Am. J. Emerg. Med."},{"issue":"Suppl. 5","key":"10.1016\/j.biopha.2022.113804_bib27","doi-asserted-by":"crossref","first-page":"S313","DOI":"10.1097\/00003246-200205001-00022","article-title":"Platelet function in sepsis","volume":"30","author":"Vincent","year":"2002","journal-title":"Crit. Care Med."},{"issue":"24","key":"10.1016\/j.biopha.2022.113804_bib28","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1182\/blood-2015-11-680744","article-title":"Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients","volume":"127","author":"Claushuis","year":"2016","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.biopha.2022.113804_bib29","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.3390\/ijms18102200","article-title":"Platelets and multi-organ failure in sepsis","volume":"18","author":"Greco","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2022.113804_bib30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00024382-200212000-00001","article-title":"Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome","volume":"18","author":"Le Tulzo","year":"2002","journal-title":"Shock"},{"issue":"8","key":"10.1016\/j.biopha.2022.113804_bib31","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.4049\/jimmunol.174.8.5110","article-title":"Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways","volume":"174","author":"Hotchkiss","year":"2005","journal-title":"J. Immunol."},{"issue":"19","key":"10.1016\/j.biopha.2022.113804_bib32","article-title":"CD3+ CD4- CD8- double-negative \u03b1\u03b2 T cells attenuate lung ischemia-reperfusion injury","volume":"S0022\u20135223","author":"Hsu","year":"2019","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"5","key":"10.1016\/j.biopha.2022.113804_bib33","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200830","article-title":"From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches","volume":"40","author":"Hu","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.biopha.2022.113804_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jpeds.2020.05.006","article-title":"Clinical characteristics and outcomes of hospitalized and critically Ill children and adolescents with coronavirus disease 2019 at a Tertiary Care Medical Center in New York City","volume":"223","author":"Chao","year":"2020","journal-title":"J. Pediatr."},{"key":"10.1016\/j.biopha.2022.113804_bib35","doi-asserted-by":"crossref","first-page":"m1091","DOI":"10.1136\/bmj.m1091","article-title":"Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study","volume":"368","author":"Chen","year":"2020","journal-title":"BMJ"},{"issue":"10229","key":"10.1016\/j.biopha.2022.113804_bib36","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.biopha.2022.113804_bib37","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1097\/CCM.0000000000005195","article-title":"Coronavirus disease 2019 as cause of viral sepsis: a systematic review and meta-analysis","volume":"49","author":"Karakike","year":"2021","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.biopha.2022.113804_bib38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1039\/C6MD00509H","article-title":"Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases","volume":"8","author":"Liu","year":"2016","journal-title":"MedChemComm"},{"issue":"4","key":"10.1016\/j.biopha.2022.113804_bib39","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s10753-019-00990-7","article-title":"Dihydromyricetin alleviates sepsis-induced acute lung injury through inhibiting NLRP3 inflammasome-dependent pyroptosis in mice model","volume":"42","author":"Wang","year":"2019","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.biopha.2022.113804_bib40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cardfail.2015.01.002","article-title":"Cortistatin inhibits NLRP3 inflammasome activation of cardiac fibroblasts during sepsis","volume":"21","author":"Zhang","year":"2015","journal-title":"J. Card. Fail."},{"issue":"12","key":"10.1016\/j.biopha.2022.113804_bib41","first-page":"5685","article-title":"Inhibition of hepatic cells pyroptosis attenuates CLP-induced acute liver injury","volume":"8","author":"Chen","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"50","key":"10.1016\/j.biopha.2022.113804_bib42","doi-asserted-by":"crossref","first-page":"82602","DOI":"10.18632\/oncotarget.13010","article-title":"Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways","volume":"7","author":"Chunzhi","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.biopha.2022.113804_bib43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s10753-018-0894-4","article-title":"NLRP3\/Caspase-1 pathway-induced pyroptosis mediated cognitive deficits in a mouse model of sepsis-associated encephalopathy","volume":"42","author":"Fu","year":"2019","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.biopha.2022.113804_bib44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1378\/chest.09-1570","article-title":"N-methyl-D-aspartate glutamate receptor blockade attenuates lung injury associated with experimental sepsis","volume":"137","author":"da Cunha","year":"2010","journal-title":"Chest"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222011933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222011933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:14:46Z","timestamp":1778242486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222011933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":44,"alternative-id":["S0753332222011933"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113804","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113804"}}