{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:52:14Z","timestamp":1793789534455,"version":"4.6.1"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.biopha.2022.114017","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T05:26:08Z","timestamp":1668403568000},"page":"114017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Targeting apoptosis in MCF-7 and Ehrlich ascites carcinoma cells by saponifiable fractions from green and black Vitis vinifera seed oil"],"prefix":"10.1016","volume":"157","author":[{"given":"Nadia Z.","family":"Shaban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf A.","family":"El-Faham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Abu-Serie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha H.","family":"Habashy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.114017_bib1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jmwh.2007.05.004","article-title":"Inside the lactating breast: the latest anatomy research","volume":"52","author":"Geddes","year":"2007","journal-title":"J. Midwifery Women Heal"},{"key":"10.1016\/j.biopha.2022.114017_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.maturitas.2004.04.011","article-title":"Development of the human breast","volume":"49","author":"Russo","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.biopha.2022.114017_bib3","unstructured":"M. Pawlina, Histology: A text and atlas: with cell and molecular biology., 4th ed, Philadelphia, PA: Lippincott Williams Wilkins, 2003."},{"issue":"9","key":"10.1016\/j.biopha.2022.114017_bib4","first-page":"11","article-title":"Potential effect of Olea europea leaves, Sonchus oleraceus leaves and Mangifera indica peel extracts on aromatase activity in human placental microsomes and CYP19A1 expression in MCF-7 cell line: Comparative study","volume":"62","author":"Shaban","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.114017_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/437971","article-title":"Cancer incidence in Egypt: results of the national population-based cancer registry program","volume":"2014","author":"Ibrahim","year":"2014","journal-title":"J. Cancer Epidemiol."},{"key":"10.1016\/j.biopha.2022.114017_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gendis.2018.05.001","article-title":"Breast cancer development and progression: risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis","volume":"5","author":"Feng","year":"2018","journal-title":"Genes Dis."},{"issue":"3","key":"10.1016\/j.biopha.2022.114017_bib8","first-page":"285","article-title":"miR-34a and miR-21 as biomarkers in evaluating the response of chemo-radiotherapy in Egyptian breast cancer patients","volume":"15","author":"Shaban","year":"2022","journal-title":"J. Radiat. Res. Appl. Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/jpm8010006","article-title":"Polymer therapeutics: Biomarkers and new approaches for personalized cancer treatment","volume":"8","author":"Atkinson","year":"2018","journal-title":"J. Pers. Med"},{"key":"10.1016\/j.biopha.2022.114017_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jnci\/djv073","article-title":"M.C.F.\u20137 cells - changing the course of breast cancer research and care for 45 years","volume":"107","author":"Lee","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.biopha.2022.114017_bib11","first-page":"727","article-title":"The effects of epirubicin on proliferation and DNA synthesis of Ehrlich ascites carcinoma cells in vitro and in vivo","volume":"59","author":"Ulakoglu","year":"2004","journal-title":"Biol. - Sect. Cell. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.114017_bib12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jep.2010.03.010","article-title":"Evaluation of anticancer activity of Cleome gynandra on Ehrlich\u2019s Ascites Carcinoma treated mice","volume":"129","author":"Bala","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2022.114017_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0165801","article-title":"Use of Complementary and Alternative Medicine (CAM) as part of the oncological treatment: survey about patients\u2019 attitude towards CAM in a university-based oncology center in Germany","volume":"11","author":"Kessel","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2022.114017_bib14","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s10620-013-2704-z","article-title":"Inhibitory effect of a standardized pomegranate fruit extract on wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis","volume":"58","author":"Sadik","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib15","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1021\/jf800898p","article-title":"Grapes and human health: a perspective","volume":"56","author":"Pezzuto","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2022.114017_bib16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.0031-9317.2004.0281.x","article-title":"Wheat seedlings as a model to understand desiccation tolerance and sensitivity","volume":"120","author":"Farrant","year":"2004","journal-title":"Physiol. Plant."},{"key":"10.1016\/j.biopha.2022.114017_bib17","first-page":"306","article-title":"Contents of resveratrol in different parts of grapes","volume":"35","author":"Cho","year":"2003","journal-title":"Korean J. Food Sci. Technol."},{"key":"10.1016\/j.biopha.2022.114017_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/foods9101360","article-title":"Grape (Vitis vinifera l.) seed oil: a functional food from the winemaking industry","volume":"9","author":"Martin","year":"2020","journal-title":"Foods"},{"key":"10.1016\/j.biopha.2022.114017_bib19","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1093\/jn\/134.12.3445S","article-title":"Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent","volume":"134","author":"Kim","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2022.114017_bib20","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/BF02653670","article-title":"Antioxidant activity of some spice essential oils on linoleic acid oxidation in aqueous media","volume":"66","author":"Farag","year":"1989","journal-title":"J. Am. Oil Chem. Soc."},{"key":"10.1016\/j.biopha.2022.114017_bib21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/chromsci\/16.11.538","article-title":"Coupling of two-dimensional thin-layer chromatography with gas chromatography for the quantitative analysis of lipid classes and their constituent fatty acids","volume":"16","author":"Radwan","year":"1978","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib22","first-page":"90","article-title":"GC-MS analysis of Cassia italica leaf methanol extract","volume":"5","author":"Sermakkani","year":"2012","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.biopha.2022.114017_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.biopha.2022.114017_bib24","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/s41598-020-59489-z","article-title":"Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators","volume":"10","author":"Abu-Serie","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.114017_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.biopha.2022.114017_bib26","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1177\/00220345660450060901","article-title":"Some principles of psychological stress and their relation to dentistry","volume":"45","author":"Lazarus","year":"1966","journal-title":"J. Dent. Res"},{"key":"10.1016\/j.biopha.2022.114017_bib27","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/00071668.2010.520302","article-title":"Effect of dietary protein regime on meat quality traits and carcase nutrient content of broilers from two commercial genotypes","volume":"51","author":"Yal\u00e7in","year":"2010","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.21608\/amj.2020.82575","article-title":"Grape seed extract versus captopril in ameliorating 5-fluorouracil-induced nephrotoxicity in adult male albino rats: biochemical, histological and immunohistochemical study","volume":"49","author":"Abd El-Salam Abd El-Wahab","year":"2020","journal-title":"Al-Azhar Med. J."},{"key":"10.1016\/j.biopha.2022.114017_bib29","first-page":"87","article-title":"Blood sample collection in small laboratory animals","volume":"1","author":"Parasuraman","year":"2010","journal-title":"J. Pharmacol. Pharm."},{"key":"10.1016\/j.biopha.2022.114017_bib30","first-page":"7","article-title":"Cell viability assays: introduction","author":"Stoddart","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2022.114017_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0003-2697(80)90139-6","article-title":"Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine","volume":"106","author":"Griffith","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2022.114017_bib32","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S0891-5849(99)00145-8","article-title":"Glutathione redox potential in response to differentiation and enzyme inducers","volume":"27","author":"Kirlin","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2022.114017_bib33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0031-3025(16)34462-2","article-title":"Theory and practice of histological techniques: fifth edition","volume":"34","author":"Cordatos","year":"2002","journal-title":"Pathology"},{"key":"10.1016\/j.biopha.2022.114017_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/onc.2012.611","article-title":"Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling","volume":"33","author":"Zeilstra","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2022.114017_bib35","first-page":"825","article-title":"Anaplasma phagocytophilum infection (granulocytic anaplasmosis) in a dog from Vancouver Island","volume":"46","author":"Lester","year":"2005","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.biopha.2022.114017_bib36","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gki481","article-title":"PatchDock and SymmDock: Servers for rigid and symmetric docking","volume":"33","author":"Schneidman-Duhovny","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biopha.2022.114017_bib37","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.114017_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/pro.3289","article-title":"PDBsum: structural summaries of PDB entries","author":"Laskowski","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib39","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biopha.2022.114017_bib40","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.18632\/oncotarget.3629","article-title":"Targeting AMPK for cancer prevention and treatment","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2022.114017_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/EJMP\/2018\/45751","article-title":"GC-MS analysis, antioxidant and cytotoxic activities of mentha spicata","volume":"26","author":"Abdel-Hady","year":"2018","journal-title":"Eur. J. Med. Plants"},{"key":"10.1016\/j.biopha.2022.114017_bib42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jff.2017.11.022","article-title":"Chemical characterization, antioxidant and anti-inflammatory properties of Greek Thymus vulgaris extracts and their possible synergism with Egyptian Chlorella vulgaris","volume":"40","author":"Habashy","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.biopha.2022.114017_bib43","doi-asserted-by":"crossref","unstructured":"M.M. Abu-Serie, N.H. Habashy, W.E. Attia, In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris, (n.d.). https:\/\/doi.org\/10.1186\/s12906\u2013018-2218\u20135.","DOI":"10.1186\/s12906-018-2218-5"},{"key":"10.1016\/j.biopha.2022.114017_bib44","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.ijbiomac.2019.01.210","article-title":"Two purified proteins from royal jelly with in vitro dual anti-hepatic damage potency: Major royal jelly protein 2 and its novel isoform X1","volume":"128","author":"Abu-Serie","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2022.114017_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-020-03056-6","article-title":"The synergistic hepatoprotective potential of Beta vulgaris juice and 2,3- dimercaptosuccinic acid in lead-intoxicated rats via improving the hepatic oxidative and inflammatory stress","volume":"20","author":"Shaban","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.biopha.2022.114017_bib46","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.foodchem.2013.04.134","article-title":"Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats","volume":"141","author":"Shaban","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2022.114017_bib47","article-title":"Targeting of crucial oncogenes and apoptotic genes for collapsing human myeloid and lymphoid leukemia cells by major royal jelly proteins","author":"Marwa","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.biopha.2022.114017_bib48","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ijbiomac.2019.09.080","article-title":"Major royal-jelly protein 2 and its isoform X1 are two novel safe inhibitors for hepatitis C and B viral entry and replication","volume":"141","author":"Habashy","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2022.114017_bib49","doi-asserted-by":"crossref","first-page":"28341","DOI":"10.1039\/C8RA04370A","article-title":"The ameliorating effect of the combined extract from Greek Thymus vulgaris and bee\u2019s honey on the hydrocortisone-induced osteoporosis in rat bone cells via modulating the bone turnover, oxidative stress, and inflammation","volume":"8","author":"Abu-Serie","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2022.114017_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113667","article-title":"Inhibition of oxidative stress, IL-13, and WNT\/\u03b2-catenin in ovalbumin-sensitized rats by a novel organogel of Punica granatum seed oil saponifiable fraction","volume":"154","author":"Shaban","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2022.114017_bib51","unstructured":"S. Akan, The Products Obtained from Grape Seed (a by-product of the Grape Processing Industry) and Their Usage in the Food Products, in: 1969: pp. 259\u2013265."},{"key":"10.1016\/j.biopha.2022.114017_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16962-6","article-title":"Efficiency of novel nanocombinations of bovine milk proteins (lactoperoxidase and lactoferrin) for combating different human cancer cell lines","volume":"7","author":"Abu-Serie","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.114017_bib53","first-page":"1","article-title":"Apoptosis: a target for anticancer therapy","author":"Pfeffer","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib54","first-page":"2993","article-title":"Selective cytotoxic activities of two novel synthetic drugs on human breast carcinoma MCF-7 cells","volume":"29","author":"Badisa","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biopha.2022.114017_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-99953-y","article-title":"Acacia senegal gum attenuates systemic toxicity in CCl4-intoxicated rats via regulation of the ROS\/NF-\u03baB signaling pathway","volume":"11","author":"Abu-Serie","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.114017_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-96008-0","article-title":"Targeting ROS\/NF-\u03baB sigaling pathway by the seedless black Vitis vinifera polyphenols in CCl4-intoxicated kidney, lung, brain, and spleen in rats","volume":"11","author":"Habashy","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.114017_bib57","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2147\/OTT.S161109","article-title":"Role of the NF\u03baB-signaling pathway in cancer","volume":"11","author":"Xia","year":"2018","journal-title":"Oncol. Targets Ther."},{"key":"10.1016\/j.biopha.2022.114017_bib58","doi-asserted-by":"crossref","first-page":"51427","DOI":"10.1007\/s11356-022-19383-9","article-title":"Protective and therapeutic role of mango pulp and eprosartan drug and their anti-synergistic effects against thioacetamide-induced hepatotoxicity in male rats","volume":"29","author":"Shaban","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.biopha.2022.114017_bib59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0002-9440(10)61708-7","article-title":"New insights into the role of nuclear factor-\u03baB in cell growth regulation","volume":"159","author":"Chen","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2022.114017_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113721","article-title":"Regulation of the NF-\u03baB signaling pathway and IL-13 in asthmatic rats by aerosol inhalation of the combined active constituents of Punica granatum juice and peel","volume":"155","author":"Shaban","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2022.114017_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-021-03479-9","article-title":"The antioxidant and anti-inflammatory effects of Carica papaya Linn. seeds extract on CCl4-induced liver injury in male rats","volume":"21","author":"Shaban","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.biopha.2022.114017_bib62","doi-asserted-by":"crossref","first-page":"8411","DOI":"10.7314\/APJCP.2015.16.18.8411","article-title":"Inhibition of NF-\u03baB, Bcl-2 and COX-2 gene expression by an extract of Eruca sativa seeds during rat mammary gland carcinogenesis","volume":"16","author":"Abdel-Rahman","year":"2016","journal-title":"Asian Pacific J. Cancer Prev."},{"key":"10.1016\/j.biopha.2022.114017_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093070","article-title":"Can nf-\u03bab be considered a valid drug target in neoplastic diseases? Our point of view","volume":"21","author":"Labbozzetta","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib64","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3892\/ol.2013.1524","article-title":"Triptolide avoids cisplatin resistance and induces apoptosis via the reactive oxygen species\/nuclear factor-\u03baB pathway in SKOV3PT platinum-resistant human ovarian cancer cells","volume":"6","author":"Zhong","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2022.114017_bib65","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1158\/0008-5472.CAN-09-3950","article-title":"Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: Inactivation of the NF-\u03baB pathway and generation of reactive oxygen species","volume":"70","author":"Jin","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.biopha.2022.114017_bib66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4137\/NMI.S32910","article-title":"Grape seed oil compounds: biological and chemical actions for health","volume":"9","author":"Garavaglia","year":"2016","journal-title":"Nutr. Metab. Insights"},{"key":"10.1016\/j.biopha.2022.114017_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2021.100149","article-title":"Grape bioactive molecules, and the potential health benefits in reducing the risk of heart diseases","volume":"12","author":"Sabra","year":"2021","journal-title":"Food Chem. X"},{"key":"10.1016\/j.biopha.2022.114017_bib68","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ardp.200800223","article-title":"Synthesis and biological evaluation of some novel polysubstituted pyrimidine derivatives as potential antimicrobial and anticancer agents","volume":"342","author":"Rostom","year":"2009","journal-title":"Arch. Pharm. (Weinh. )."},{"key":"10.1016\/j.biopha.2022.114017_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0240156","article-title":"Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites","volume":"15","author":"Soliman","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2022.114017_bib70","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1039\/C1NR11188D","article-title":"Gold nanoparticles- preparation, properties, and applications in bionanotechnology","volume":"4","author":"Yeh","year":"2012","journal-title":"Nanoscale"},{"key":"10.1016\/j.biopha.2022.114017_bib71","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jab.2015.04.001","article-title":"Anticancer potential of bioactive 16-methylheptadecanoic acid methyl ester derived from marine Trichoderma","volume":"13","author":"Saravanakumar","year":"2015","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.biopha.2022.114017_bib72","doi-asserted-by":"crossref","first-page":"195","DOI":"10.21608\/ejabf.2019.30550","article-title":"Snailicidal, antimicrobial, antioxidant and anticancer activities of beauveria bassiana, metarhizium anisopliae and paecilomyces lilacinus fungal extracts, Egypt","volume":"23","author":"Abdel-Wareth","year":"2019","journal-title":"J. Aquat. Biol. Fish."},{"key":"10.1016\/j.biopha.2022.114017_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10010175","article-title":"Exogenous fatty acids modulate er lipid composition and metabolism in breast cancer cells","volume":"10","author":"Rizzo","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2022.114017_bib74","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2022.114017_bib75","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1194\/jlr.M900119-JLR200","article-title":"AMPK inhibitor compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells","volume":"50","author":"Jin","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.biopha.2022.114017_bib76","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1074\/jbc.M704432200","article-title":"Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53","volume":"283","author":"Kim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.114017_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2021.800481","article-title":"CD44-targeted nanocarrier for cancer therapy","volume":"12","author":"Kesharwani","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2022.114017_bib78","first-page":"1","article-title":"Innovative approaches to inactivation of cancer stem cells in experimental ehrlich carcinoma model","volume":"2017","author":"Goltsev","year":"2017","journal-title":"Stem Cell Adv. Res. Ther."},{"key":"10.1016\/j.biopha.2022.114017_bib79","doi-asserted-by":"crossref","first-page":"10151","DOI":"10.18632\/oncotarget.2467","article-title":"Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells","volume":"5","author":"Kumar","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2022.114017_bib80","first-page":"1","article-title":"Chemical constituents, nutritional, pharmcological and therapeutic importance of Juglans regia- a review","volume":"8","author":"Al-Snafi","year":"2018","journal-title":"IOSR J. Pharm."},{"key":"10.1016\/j.biopha.2022.114017_bib81","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.3168\/jds.2019-17415","article-title":"New function of the CD44 gene: lipid metabolism regulation in bovine mammary epithelial cells","volume":"103","author":"Jiang","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.biopha.2022.114017_bib82","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1042\/BCJ20200628","article-title":"Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy","volume":"478","author":"Yosef","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2022.114017_bib83","doi-asserted-by":"crossref","first-page":"26991","DOI":"10.1074\/jbc.M311838200","article-title":"CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion","volume":"279","author":"Bourguignon","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.114017_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-016-0503-9","article-title":"Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients","volume":"15","author":"Ruan","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.biopha.2022.114017_bib85","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1111\/febs.15776","article-title":"A guide to the composition and functions of the extracellular matrix","volume":"288","author":"Karamanos","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.biopha.2022.114017_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/bcr3058","article-title":"Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion","volume":"13","author":"Victor","year":"2011","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.biopha.2022.114017_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.adcanc.2022.100029","article-title":"Ehrlich Ascites carcinoma mice model for studying liver inflammation and fibrosis","volume":"4","author":"Sannappa Gowda","year":"2022","journal-title":"Adv. Cancer Biol. Metastas."},{"key":"10.1016\/j.biopha.2022.114017_bib88","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1017\/S1751731116002056","article-title":"Effects of dietary grape proanthocyanidins on the growth performance, jejunum morphology & plasma biochemical indices of broiler chicks","volume":"11","author":"Yang","year":"2017","journal-title":"Animal"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222014068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222014068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:08:29Z","timestamp":1778242109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222014068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":87,"alternative-id":["S0753332222014068"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.114017","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting apoptosis in MCF-7 and Ehrlich ascites carcinoma cells by saponifiable fractions from green and black Vitis vinifera seed oil","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.114017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"114017"}}