{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:38:50Z","timestamp":1793878730395,"version":"4.7.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2108085MH317"],"award-info":[{"award-number":["2108085MH317"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.biopha.2023.114684","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T11:34:02Z","timestamp":1681299242000},"page":"114684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["5-aminolevulinic acid-loaded dissolving microneedle array for photodynamic therapy of rheumatoid arthritis on rats"],"prefix":"10.1016","volume":"162","author":[{"given":"Yingying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10055","key":"10.1016\/j.biopha.2023.114684_bib1","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2023.114684_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/cells10113017","article-title":", Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies","volume":"10","author":"Mueller","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.biopha.2023.114684_bib3","doi-asserted-by":"crossref","DOI":"10.7326\/AITC201901010","article-title":"Rheumatoid arthritis","volume":"170","author":"Sparks","year":"2019","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.biopha.2023.114684_bib4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.berh.2018.10.005","article-title":"Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis","volume":"32","author":"van der Woude","year":"2018","journal-title":"Best. Pr. Res Clin. Rheuma"},{"key":"10.1016\/j.biopha.2023.114684_bib5","first-page":"4","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2023.114684_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/ijms23020905","article-title":"Rheumatoid arthritis: pathogenic roles of diverse immune cells","volume":"23","author":"Jang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.biopha.2023.114684_bib7","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s12272-011-1109-9","article-title":"Designing micro- and nano-particles for treating rheumatoid arthritis","volume":"34","author":"Mitragotri","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2023.114684_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biopha.2016.02.001","article-title":"Advancement in contemporary diagnostic and therapeutic approaches for rheumatoid arthritis","volume":"79","author":"Kumar","year":"2016","journal-title":"Biomed. Pharm."},{"issue":"2","key":"10.1016\/j.biopha.2023.114684_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/RHU.0000000000001807","article-title":"Arthroscopic synovectomy of the wrist in patients with rheumatoid arthritis: a systematic review of the current literature","volume":"28","author":"d'Ailly","year":"2022","journal-title":"J. Clin. Rheuma"},{"issue":"13","key":"10.1016\/j.biopha.2023.114684_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133339","article-title":"Photosensitizers used in the photodynamic therapy of rheumatoid arthritis","volume":"20","author":"Gallardo-Villagran","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2023.114684_bib11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1517\/14656566.2.6.917","article-title":"Photodynamic therapy in oncology","volume":"2","author":"Sibata","year":"2001","journal-title":"Expert Opin. Pharm."},{"issue":"9","key":"10.1016\/j.biopha.2023.114684_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091332","article-title":"Photodynamic therapy review: principles, photosensitizers, applications, and future directions","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.biopha.2023.114684_bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s12276-021-00599-7","article-title":"Tailoring photosensitive ROS for advanced photodynamic therapy","volume":"53","author":"Sai","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"45","key":"10.1016\/j.biopha.2023.114684_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801350","article-title":"Photosensitizers with aggregation-induced emission: materials and biomedical applications","volume":"30","author":"Hu","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biopha.2023.114684_bib15","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biopha.2018.07.049","article-title":"Photodynamic therapy - mechanisms, photosensitizers and combinations","volume":"106","author":"Kwiatkowski","year":"2018","journal-title":"Biomed. Pharm."},{"issue":"6","key":"10.1016\/j.biopha.2023.114684_bib16","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1211\/jpp.62.06.0004","article-title":"Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches","volume":"62","author":"Morrow","year":"2010","journal-title":"J. Pharm. Pharm."},{"key":"10.1016\/j.biopha.2023.114684_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.841443","article-title":"Natural 5-Aminolevulinic acid: sources, biosynthesis, detection and applications","volume":"10","author":"Jiang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"5","key":"10.1016\/j.biopha.2023.114684_bib18","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/jdv.12031","article-title":"European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications - actinic keratoses, Bowen's disease, basal cell carcinoma","volume":"27","author":"Morton","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.biopha.2023.114684_bib19","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/jdv.12026","article-title":"European guidelines for topical photodynamic therapy part 2: emerging indications--field cancerization, photorejuvenation and inflammatory\/infective dermatoses","volume":"27","author":"Morton","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"27","key":"10.1016\/j.biopha.2023.114684_bib20","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.2217\/fon-2017-0247","article-title":"A review of BF-200 ALA for the photodynamic treatment of mild-to-moderate actinic keratosis","volume":"13","author":"Reinhold","year":"2017","journal-title":"Future Oncol."},{"key":"10.1016\/j.biopha.2023.114684_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102599","article-title":"Quantitative intracellular oxygen availability before and after 5-aminolevulinic acid skin photodynamic therapy","volume":"36","author":"Ubbink","year":"2021","journal-title":"Photod Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.biopha.2023.114684_bib22","doi-asserted-by":"crossref","first-page":"1802057","DOI":"10.1002\/advs.201802057","article-title":"Robust photodynamic therapy using 5-ALA-Incorporated nanocomplexes cures metastatic melanoma through priming of CD4(+)CD8(+) double positive T cells","volume":"6","author":"Li","year":"2019","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2023.114684_bib23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13018-020-01606-9","article-title":"5-Aminolevulinic acid tumor paint and photodynamic therapy for myxofibrosarcoma: an in vitro study","volume":"15","author":"Kenan","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.biopha.2023.114684_bib24","article-title":"Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for the treatment of ulcerative squamous cell carcinoma","volume":"30","author":"Dong","year":"2020","journal-title":"Photo Photodyn Ther."},{"issue":"6","key":"10.1016\/j.biopha.2023.114684_bib25","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/neuros\/nyab361","article-title":"5-Aminolevulinic acid-induced porphyrin contents in various brain tumors: implications regarding imaging device design and their validation","volume":"89","author":"Suero Molina","year":"2021","journal-title":"Neurosurgery"},{"key":"10.1016\/j.biopha.2023.114684_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105361","article-title":"Dissolving microneedle arrays with optimized needle geometry for transcutaneous immunization","volume":"151","author":"Li","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2023.114684_bib27","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.2147\/IJN.S365523","article-title":"High efficacy combined microneedles array with methotrexate nanocrystals for effective anti-rheumatoid arthritis","volume":"17","author":"Wei","year":"2022","journal-title":"Int J. Nanomed."},{"issue":"1","key":"10.1016\/j.biopha.2023.114684_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-020-01865-z","article-title":"Transdermal delivery of salmon calcitonin using a dissolving microneedle array: characterization, stability, and in vivo pharmacodynamics","volume":"22","author":"Zhang","year":"2020","journal-title":"AAPS PharmSciTech"},{"issue":"6","key":"10.1016\/j.biopha.2023.114684_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12060569","article-title":"Microneedle-Based delivery: an overview of current applications and trends","volume":"12","author":"Guillot","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biopha.2023.114684_bib30","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.biopha.2018.10.078","article-title":"Microneedles: a smart approach and increasing potential for transdermal drug delivery system","volume":"109","author":"Waghule","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"12","key":"10.1016\/j.biopha.2023.114684_bib31","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1166\/jbn.2017.2474","article-title":"Microneedles-Based transdermal drug delivery systems: a review","volume":"13","author":"Hao","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.biopha.2023.114684_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejps.2014.09.011","article-title":"Investigation on fabrication process of dissolving microneedle arrays to improve effective needle drug distribution","volume":"66","author":"Wang","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2023.114684_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2015.12.007","article-title":"BAFF and its receptors involved in the inflammation progress in adjuvant induced arthritis rats","volume":"31","author":"Wei","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2023.114684_bib34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2018.08.011","article-title":"Therapeutic effects of Caesalpinia minax Hance on complete Freund's adjuvant (CFA)-induced arthritis and the anti-inflammatory activity of cassane diterpenes as main active components","volume":"226","author":"Tong","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2023.114684_bib35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08923973.2018.1434793","article-title":"Experimental animal models for rheumatoid arthritis","volume":"40","author":"Choudhary","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.biopha.2023.114684_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114917","article-title":"Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis","volume":"391","author":"Samarpita","year":"2020","journal-title":"Toxicol. Appl. Pharm."},{"issue":"6","key":"10.1016\/j.biopha.2023.114684_bib37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10067-007-0794-8","article-title":"Photodynamic therapy using talaporfin sodium for synovial membrane from rheumatoid arthritis patients and collagen-induced arthritis rats","volume":"27","author":"Torikai","year":"2008","journal-title":"Clin. Rheuma"},{"issue":"4","key":"10.1016\/j.biopha.2023.114684_bib38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.joca.2008.08.005","article-title":"Differential response of porcine osteoblasts and chondrocytes in cell or tissue culture after 5-aminolevulinic acid-based photodynamic therapy","volume":"17","author":"Bastian","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.114684_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.147025","article-title":", Single nucleotide polymorphisms (rs3736228 and rs4988321) in low-density lipoprotein receptor-related protein-5 gene with predisposition to rheumatoid arthritis","volume":"851","author":"Zehra","year":"2023","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.biopha.2023.114684_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8020177","article-title":"Association between negatively charged low-density lipoprotein L5 and subclinical atherosclerosis in rheumatoid arthritis patients","volume":"8","author":"Chang","year":"2019","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.biopha.2023.114684_bib41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4067\/S0034-98872019000500612","article-title":"Evaluation of the Health Assessment Questionnaire Disability Index in Chilean patients with rheumatoid arthritis","volume":"147","author":"Duran","year":"2019","journal-title":"Rev. Med Chil."},{"issue":"11","key":"10.1016\/j.biopha.2023.114684_bib42","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1172\/JCI36389","article-title":"Evidence that cytokines play a role in rheumatoid arthritis","volume":"118","author":"Brennan","year":"2008","journal-title":"J. Clin. Invest"},{"issue":"1","key":"10.1016\/j.biopha.2023.114684_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","article-title":"TNF biology, pathogenic mechanisms and emerging therapeutic strategies","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat. Rev. Rheuma"},{"issue":"4","key":"10.1016\/j.biopha.2023.114684_bib44","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s40265-013-0018-2","article-title":"Targeting interleukin-6 in rheumatoid arthritis","volume":"73","author":"Md Yusof","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.biopha.2023.114684_bib45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fimmu.2014.00048","article-title":"Classical and paradoxical effects of TNF-alpha on bone homeostasis","volume":"5","author":"Osta","year":"2014","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2023.114684_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/rheumatology\/kep329","article-title":"Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor","volume":"49","author":"Dayer","year":"2010","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.biopha.2023.114684_bib47","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20192048","article-title":"Interleukin-17 in rheumatoid arthritis: trials and tribulations","volume":"217","author":"Taams","year":"2020","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.biopha.2023.114684_bib48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/eji.201344184","article-title":"Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis","volume":"44","author":"Benedetti","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2023.114684_bib49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/07853899709007474","article-title":"Pro- and anti-inflammatory cytokines in rheumatoid arthritis","volume":"29","author":"Isomaki","year":"1997","journal-title":"Ann. Med."},{"issue":"11","key":"10.1016\/j.biopha.2023.114684_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113000","article-title":"Significance of interleukin (IL)-4 and IL-13 in inflammatory arthritis","volume":"10","author":"Iwaszko","year":"2021","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.biopha.2023.114684_bib51","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/rheumatology\/37.11.1207","article-title":"Interleukin-10 inhibits the capacity of synovial macrophages to function as antigen-presenting cells","volume":"37","author":"Mottonen","year":"1998","journal-title":"Br. J. Rheuma"},{"issue":"1","key":"10.1016\/j.biopha.2023.114684_bib52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10408398.2017.1358139","article-title":"Immune modulation by curcumin: the role of interleukin-10","volume":"59","author":"Mollazadeh","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223004729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223004729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:18:10Z","timestamp":1778246290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223004729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":52,"alternative-id":["S0753332223004729"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.114684","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-aminolevulinic acid-loaded dissolving microneedle array for photodynamic therapy of rheumatoid arthritis on rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.114684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"114684"}}