{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:21:08Z","timestamp":1794561668492,"version":"4.9.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006761","name":"Universidad de Vigo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.biopha.2023.114686","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T16:49:33Z","timestamp":1681145373000},"page":"114686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats"],"prefix":"10.1016","volume":"162","author":[{"given":"Muhammad Umar","family":"Ijaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Najam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hamza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Azmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah Oshiomame","family":"Unuofin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sogolo Lucky","family":"Lebelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-9737","authenticated-orcid":false,"given":"Jesus","family":"Simal-Gandara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2023.114686_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126777","article-title":"Lipidomic analysis of single and combined effects of polyethylene microplastics and polychlorinated biphenyls on human hepatoma cells","volume":"421","author":"Men\u00e9ndez-Pedriza","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biopha.2023.114686_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pecs.2020.100899","article-title":"Co-pyrolysis of waste plastic and solid biomass for synergistic production of biofuels and chemicals-A review","volume":"84","author":"Wang","year":"2021","journal-title":"Prog. Energy Combust. Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/acs.est.8b05297","article-title":"Are we speaking the same language? Recommendations for a definition and categorization framework for plastic debris","volume":"53","author":"Hartmann","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biopha.2023.114686_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biopha.2023.114686_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2193-1801-2-398","article-title":"Photodegradation and photostabilization of polymers, especially polystyrene","volume":"2","author":"Yousif","year":"2013","journal-title":"SpringerPlus"},{"key":"10.1016\/j.biopha.2023.114686_bib6","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1038\/s41598-020-61146-4","article-title":"Microplastics generated when opening plastic packaging","volume":"10","author":"Sobhani","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2023.114686_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.envpol.2017.03.062","article-title":"Microplastic ingestion in fish larvae in the western English Channel","volume":"226","author":"Steer","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.biopha.2023.114686_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111310","article-title":"Protective effect of naringenin against cadmium-induced testicular toxicity in male SD rats","volume":"214","author":"Wang","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2023.114686_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142518","article-title":"Micro-and nanoplastic induced cellular toxicity in mammals: A review","volume":"755","author":"Banerjee","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biopha.2023.114686_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112904","article-title":"Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine","volume":"162","author":"Wang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2023.114686_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114031","article-title":"A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: Differential lipid metabolism and inflammation reaction","volume":"244","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.biopha.2023.114686_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.aquatox.2018.04.015","article-title":"Accumulation of polystyrene microplastics in juvenile Eriocheir sinensis and oxidative stress effects in the liver","volume":"200","author":"Yu","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.biopha.2023.114686_bib13","first-page":"489","article-title":"Methanolic extract of Fraxinus xanthoxyloides attenuates cisplatin-induced reproductive toxicity in male albino rats, Pak","volume":"40","author":"Ijaz","year":"2020","journal-title":"Vet. J."},{"key":"10.1016\/j.biopha.2023.114686_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.marpolbul.2019.01.069","article-title":"Ingestion and effects of micro-and nanoplastics in blue mussel (Mytilus edulis) larvae","volume":"140","author":"Rist","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.biopha.2023.114686_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153059","article-title":"Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice","volume":"465","author":"Wei","year":"2022","journal-title":"Toxicol"},{"key":"10.1016\/j.biopha.2023.114686_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biopha.2023.114686_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.biopha.2023.114686_bib18","doi-asserted-by":"crossref","DOI":"10.1177\/15593258211019882","article-title":"Dose-dependent effect of polystyrene microplastics on the testicular tissues of the male Sprague Dawley rats","volume":"19","author":"Ijaz","year":"2021","journal-title":"Dose-Response"},{"key":"10.1016\/j.biopha.2023.114686_bib19","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/14786419.2018.1493588","article-title":"Flavonoids: biological activities and therapeutic potential","volume":"34","author":"Juc\u00e1","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib20","first-page":"253","article-title":"Flavonoids (antioxidants systems) in higher plants and their response to stresses, Antioxidants and Antioxidant Enzymes in Higher","volume":"12","author":"Baskar","year":"2018","journal-title":"Plants"},{"key":"10.1016\/j.biopha.2023.114686_bib21","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1080\/14786419.2015.1107556","article-title":"A review on biological sources, chemistry and pharmacological activities of Pinostrobin","volume":"30","author":"Patel","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib22","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.phymed.2014.02.011","article-title":"Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-\u03b1 and IL-1\u03b2 production: In vitro and in vivo experimentation","volume":"21","author":"Patel","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2023.114686_bib23","first-page":"183","article-title":"Antioxidant activity of palmitic acid and pinostrobin from methanol extract of Syzygium litoralle (Myrtaceae","author":"Hidajati","year":"2018","journal-title":"Int. Conf. Sci. Tech."},{"key":"10.1016\/j.biopha.2023.114686_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113193","article-title":"Boesenbergia rotunda extract inhibits Candida albicans biofilm formation by pinostrobin and pinocembrin","volume":"261","author":"Kanchanapiboon","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2023.114686_bib25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jphs.2022.02.003","article-title":"Pinostrobin inhibits renal CFTR-mediated Cl\u2212 secretion and retards cyst growth in cell-derived cyst and polycystic kidney disease rats","volume":"148","author":"Tonum","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112904","article-title":"Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine","volume":"162","author":"Wang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2023.114686_bib27","first-page":"764","article-title":"Assay of catalases and peroxidases","volume":"136","author":"Chance","year":"1995","journal-title":"Meth. Enzym."},{"key":"10.1016\/j.biopha.2023.114686_bib28","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0891-5849(97)00291-8","article-title":"Role of antioxidant enzymes on ionizing radiation resistance","volume":"24","author":"Sun","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2023.114686_bib29","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","article-title":"Glutathione peroxidase activity in selenium-deficient rat liver","volume":"71","author":"Lawrence","year":"1976","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2023.114686_bib30","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","article-title":"Purification and characterization of the flavoenzyme glutathione reductase from rat liver","volume":"250","author":"Carlberg","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2023.114686_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrgentox.2007.04.006","article-title":"High-throughput spectrophotometric assay of reactive oxygen species in serum","volume":"631","author":"Hayashi","year":"2007","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.biopha.2023.114686_bib32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0003-2697(66)90167-9","article-title":"Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems","volume":"16","author":"Placer","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2023.114686_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1385\/BTER:93:1-3:141","article-title":"Nickel deficiency diminishes sperm quantity and movement in rats","volume":"93","author":"Yokoi","year":"2003","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib34","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/ptr.2369","article-title":"Effects of Chlorophytum borivilianum on sexual behaviour and sperm count in male rats","volume":"22","author":"Kenjale","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib35","first-page":"33","article-title":"Acute effects of Ruta graveolens L. on sperm parameters and DNA integrity in rats","volume":"13","author":"Halvaei","year":"2012","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.biopha.2023.114686_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12011-017-0997-z","article-title":"Protective effect of selenium on aflatoxin B1-induced testicular toxicity in mice","volume":"180","author":"Cao","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0093-691X(94)90280-1","article-title":"The hypoosmotic swelling test: its employment as an assay to evaluate the functional integrity of the frozen-thawed bovine sperm membrane","volume":"42","author":"Correa","year":"1994","journal-title":"Theriogenology"},{"key":"10.1016\/j.biopha.2023.114686_bib38","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.biopha.2023.114686_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.biopha.2023.114686_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125423","article-title":"Toxic effects on bioaccumulation, hematological parameters, oxidative stress, immune responses and neurotoxicity in fish exposed to microplastics: A review","volume":"413","author":"Kim","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.biopha.2023.114686_bib41","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1139\/facets-2017-0008","article-title":"Microplastics in the gastrointestinal tracts of fish and the water from an urban prairie creek","volume":"2","author":"Campbell","year":"2017","journal-title":"Facets"},{"key":"10.1016\/j.biopha.2023.114686_bib42","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.scitotenv.2019.05.071","article-title":"An assessment of the toxicity of polypropylene microplastics in human derived cells","volume":"684","author":"Hwang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biopha.2023.114686_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e10413","article-title":"Study of the dermal anti-inflammatory, antioxidant, and analgesic activity of pinostrobi","volume":"8","author":"Gonz\u00e1lez","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.biopha.2023.114686_bib44","first-page":"612","article-title":"Antioxidant properties of polyphenols and their potential use in improvement of male fertility: a review","volume":"1","author":"Seddiki","year":"2017","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib45","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","article-title":"Plastic and human health: a micro issue?","volume":"51","author":"Wright","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biopha.2023.114686_bib46","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1089\/ars.2019.7985","article-title":"Antioxidant enzymes and male fertility: Lessons from knockout models","volume":"32","author":"Scarlata","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2023.114686_bib47","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1089\/ars.2018.7601","article-title":"Analyzing the function of catalase and the ascorbate\u2013glutathione pathway in H2O2 processing: Insights from an experimentally constrained kinetic model","volume":"30","author":"Tuzet","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2023.114686_bib48","first-page":"6","article-title":"Factors associated with oxidative stress in the testes and the mitigating role of antioxidants: a review","volume":"1","author":"Siva Kumar","year":"2019","journal-title":"Int. J. Recent. Innov. Med. Clin. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib49","article-title":"The impact of oxidative stress on testicular function and the role of antioxidants in improving it: a review","volume":"11","author":"Asadi","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fendo.2014.00056","article-title":"Roles of reactive oxygen species in the spermatogenesis regulation","volume":"5","author":"Guerriero","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2023.114686_bib51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3390\/antiox11020306","article-title":"Male infertility and oxidative stress: a focus on the underlying mechanisms","volume":"11","author":"Aitken","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.biopha.2023.114686_bib52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-030-32300-4_6","article-title":"Oxidative stress and its association with male infertility","author":"Agarwal","year":"2020","journal-title":"Male Infertil."},{"key":"10.1016\/j.biopha.2023.114686_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/and.12593","article-title":"Rutin ameliorates cisplatin\u2010induced reproductive damage via suppression of oxidative stress and apoptosis in adult male rats","volume":"49","author":"Aksu","year":"2017","journal-title":"Andrologia"},{"key":"10.1016\/j.biopha.2023.114686_bib54","first-page":"1822","article-title":"Antioxidant and antimicrobial potentials of Artemisia Indica collected from the Nepal region","volume":"9","author":"Nahid","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib55","article-title":"The sperm specific protein proAKAP4 as an innovative marker to evaluate sperm quality and fertility","volume":"11","author":"Sergeant","year":"2019","journal-title":"J. Dairy Vet. Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/19396368.2012.729174","article-title":"Sperm with large nuclear vacuoles and semen quality in the evaluation of male infertility","volume":"59","author":"Komiya","year":"2013","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.biopha.2023.114686_bib57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib58","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.fct.2010.07.003","article-title":"Influence of combined treatment with zinc and selenium on cadmium induced testicular pathophysiology in rat","volume":"48","author":"Sa\u00efd","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2023.114686_bib59","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/antiox9020134","article-title":"Molecular changes induced by oxidative stress that impair human sperm motility","volume":"9","author":"Nowicka-Bauer","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.biopha.2023.114686_bib60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative stress and sperm function: A systematic review on evaluation and management","volume":"17","author":"Dutta","year":"2019","journal-title":"Arab J. Urol."},{"key":"10.1016\/j.biopha.2023.114686_bib61","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fendo.2020.00373","article-title":"Effects of bisphenols on testicular steroidogenesis","volume":"11","author":"Barbagallo","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2023.114686_bib62","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1007\/s00726-011-0904-4","article-title":"Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis","volume":"42","author":"Das","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.biopha.2023.114686_bib63","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mce.2014.12.011","article-title":"The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis","volume":"408","author":"Castillo","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biopha.2023.114686_bib64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10565-019-09481-9","article-title":"Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells","volume":"36","author":"Couture","year":"2020","journal-title":"Cell Bio. Toxicol."},{"key":"10.1016\/j.biopha.2023.114686_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156820","article-title":"Polystyrene microplastics induced male reproductive toxicity and transgenerational effects in freshwater prawn","volume":"842","author":"Sun","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biopha.2023.114686_bib66","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/antiox9030237","article-title":"Improvement of testicular steroidogenesis using flavonoids and isoflavonoids for prevention of late-onset male hypogonadism","volume":"9","author":"Martin","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.biopha.2023.114686_bib67","article-title":"Endocrine control of spermatogenesis: Role of FSH and LH\/testosterone, Spermatogenesis","volume":"4","author":"Ramaswamy","year":"2014"},{"key":"10.1016\/j.biopha.2023.114686_bib68","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/andr.12459","article-title":"Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin\u2013inhibin signaling","volume":"6","author":"Winters","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.biopha.2023.114686_bib69","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.etp.2011.03.002","article-title":"Dichlorvos-induced testicular toxicity in male rats and the protective role of vitamins C and E","volume":"64","author":"Dirican","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2023.114686_bib70","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/jcm9041014","article-title":"Follicle-stimulating hormone (FSH) action on spermatogenesis: a focus on physiological and therapeutic roles","volume":"9","author":"Santi","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.biopha.2023.114686_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102064","article-title":"Toxic effect of polyethylene microplastic on testicles and ameliorative effect of luteolin in adult rats: Environmental challenge","volume":"34","author":"Ijaz","year":"2022","journal-title":"J. King Saud. Univ. Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib72","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cell.2018.07.041","article-title":"TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging","volume":"174","author":"Xu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2023.114686_bib73","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/febs.14186","article-title":"Bax, Bak and beyond\u2014mitochondrial performance in apoptosis","volume":"285","author":"Pe\u00f1a\u2010Blanco","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.biopha.2023.114686_bib74","first-page":"5275","article-title":"Assessment of doxorubicin-induced mouse testicular damage by the novel second-harmonic generation microscopy","volume":"9","author":"Yang","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.biopha.2023.114686_bib75","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1073\/pnas.1406425111","article-title":"Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak","volume":"111","author":"Lindqvist","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib76","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.3390\/ijms221810043","article-title":"Oxidative stress, testicular inflammatory pathways, and male reproduction","volume":"22","author":"Dutta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.114686_bib77","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3389\/fphar.2018.01047","article-title":"Chelerythrine attenuates the inflammation of lipopolysaccharide-induced acute lung inflammation through NF-\u03baB signaling pathway mediated by Nrf2","volume":"9","author":"Fan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2023.114686_bib78","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.biopha.2018.06.048","article-title":"Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney","volume":"105","author":"Kandemir","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2023.114686_bib79","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biomaterials.2019.03.034","article-title":"Anti-inflammatory actions of folate-functionalized bioactive ion-releasing nanoparticles imply drug-free nanotherapy of inflamed tissues","volume":"207","author":"Kim","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2023.114686_bib80","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/and.12302","article-title":"Cisplatin\u2010induced testicular dysfunction and its amelioration by L aunaea taraxacifolia leaf extract","volume":"47","author":"Adejuwon","year":"2015","journal-title":"Andrologia"},{"key":"10.1016\/j.biopha.2023.114686_bib81","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.etap.2014.09.014","article-title":"Increase in the expression of inducible nitric oxide synthase on exposure to bisphenol A: a possible cause for decline in steroidogenesis in male mice","volume":"39","author":"Chouhan","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2024.117565","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000}}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223004742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223004742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:43:57Z","timestamp":1778247837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223004742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":81,"alternative-id":["S0753332223004742"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.114686","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.114686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"114686"}}