{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:46:34Z","timestamp":1790599594248,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.biopha.2023.115083","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T11:56:53Z","timestamp":1688471813000},"page":"115083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Phloretin ameliorates heart function after myocardial infarction via NLRP3\/Caspase-1\/IL-1\u03b2 signaling"],"prefix":"10.1016","volume":"165","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.biopha.2023.115083_bib1","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.biopha.2023.115083_bib2","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1161\/ATVBAHA.111.224915","article-title":"Mechanisms of cell death in heart disease","volume":"32","author":"Konstantinidis","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biopha.2023.115083_bib3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fimmu.2019.00300","article-title":"Selectins and immune cells in acute myocardial infarction and post-infarction ventricular remodeling: pathophysiology and novel treatments","volume":"10","author":"Weil","year":"2019","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115083_bib4","first-page":"109","article-title":"An efficient algorithm based on electrograms characteristics to identify ventricular tachycardia isthmus entrance in post-infarct patients","volume":"22","author":"Battaglia","year":"2020","journal-title":"Europace"},{"issue":"1","key":"10.1016\/j.biopha.2023.115083_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: incidence and predictors","volume":"8","author":"Jen\u010da","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"24","key":"10.1016\/j.biopha.2023.115083_bib6","doi-asserted-by":"crossref","first-page":"12580","DOI":"10.1039\/D1FO02040D","article-title":"The short-chain fatty acid propionate improved ventricular electrical remodeling in a rat model with myocardial infarction","volume":"12","author":"Zhou","year":"2021","journal-title":"Food Funct."},{"issue":"Pt A","key":"10.1016\/j.biopha.2023.115083_bib7","article-title":"Maresin1 ameliorates ventricular remodelling and arrhythmia in mice models of myocardial infarction via NRF2\/HO-1 and TLR4\/NF-kB signalling","volume":"113","author":"Wang","year":"2022","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.biopha.2023.115083_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175357","article-title":"Effect of sotagliflozin on ventricular arrhythmias in mice with myocardial infraction","volume":"936","author":"Gong","year":"2022","journal-title":"Eur. J. Pharm."},{"issue":"9","key":"10.1016\/j.biopha.2023.115083_bib9","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","article-title":"Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease","volume":"126","author":"Abbate","year":"2020","journal-title":"Circ. Res"},{"issue":"4","key":"10.1016\/j.biopha.2023.115083_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biopha.2023.115083_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113364","article-title":"The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies","volume":"153","author":"Butnariu","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"3","key":"10.1016\/j.biopha.2023.115083_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.31083\/j.fbs1403024","article-title":"Naturally-occurring bioactives in oral cancer: preclinical and clinical studies","volume":"14","author":"Butnariu","year":"2022","journal-title":"Bottle Future Dir. Front Biosci. (Sch. Ed. )"},{"issue":"6","key":"10.1016\/j.biopha.2023.115083_bib13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2014.05.014","article-title":"Diet, metabolites, and \"western-lifestyle\" inflammatory diseases","volume":"40","author":"Thorburn","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2023.115083_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/nu14173638","article-title":"Therapeutic potential and pharmaceutical development of a multitargeted flavonoid phloretin","volume":"14","author":"Nakhate","year":"2022","journal-title":"Nutrients"},{"issue":"46","key":"10.1016\/j.biopha.2023.115083_bib15","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2120393119","article-title":"Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation","volume":"119","author":"Dierckx","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.biopha.2023.115083_bib16","doi-asserted-by":"crossref","first-page":"16447","DOI":"10.3390\/molecules191016447","article-title":"Synthesis, crystal structure, and biological evaluation of a series of phloretin derivatives","volume":"19","author":"Wang","year":"2014","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.biopha.2023.115083_bib17","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.foodchem.2012.03.002","article-title":"Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages","volume":"134","author":"Chang","year":"2012","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.biopha.2023.115083_bib18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1039\/C8FO01699B","article-title":"The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.biopha.2023.115083_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104489","article-title":"Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota","volume":"150","author":"Wu","year":"2019","journal-title":"Pharm. Res"},{"key":"10.1016\/j.biopha.2023.115083_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153111","article-title":"Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption","volume":"66","author":"Cui","year":"2020","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.biopha.2023.115083_bib21","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/jbm.a.35014","article-title":"Enhanced cardioprotective effects mediated by plasmid containing the short-hairpin RNA of angiotensin converting enzyme with a biodegradable hydrogel after myocardial infarction","volume":"102","author":"Wan","year":"2014","journal-title":"J. Biomed. Mater. Res A"},{"issue":"154)","key":"10.1016\/j.biopha.2023.115083_bib22","article-title":"Echocardiographic assessment of cardiac anatomy and function in adult rats","author":"Ribeiro","year":"2019","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.biopha.2023.115083_bib23","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12265-019-09941-x","article-title":"Intra-myocardial delivery of a novel thermosensitive hydrogel inhibits post-infarct heart failure after degradation in rat","volume":"13","author":"Wen","year":"2020","journal-title":"J. Cardiovasc Transl. Res"},{"issue":"4","key":"10.1016\/j.biopha.2023.115083_bib24","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cardiores.2006.12.001","article-title":"Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart","volume":"73","author":"Ng","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.biopha.2023.115083_bib25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/1074248416628676","article-title":"Chronic administration of catestatin improves autonomic function and exerts cardioprotective effects in myocardial infarction rats","volume":"21","author":"Wang","year":"2016","journal-title":"J. Cardiovasc Pharm. Ther."},{"key":"10.1016\/j.biopha.2023.115083_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107863","article-title":"The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications","volume":"227","author":"Kuwahara","year":"2021","journal-title":"Pharm. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2023.115083_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/glia.20438","article-title":"Modulation of connexin expression and gap junction communication in astrocytes by the gram-positive bacterium S. aureus","volume":"55","author":"Esen","year":"2007","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.biopha.2023.115083_bib28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/cvr\/cvz336","article-title":"Cardiac monocytes and macrophages after myocardial infarction","volume":"116","author":"Peet","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.biopha.2023.115083_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/ijms21207711","article-title":"Adipokines and inflammation: focus on cardiovascular diseases","volume":"21","author":"Feij\u00f3o-Band\u00edn","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.115083_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtbi.2022.111122","article-title":"A mathematical model of immunomodulatory treatment in myocardial infarction","volume":"544","author":"Moise","year":"2022","journal-title":"J. Theor. Biol."},{"issue":"17","key":"10.1016\/j.biopha.2023.115083_bib31","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.jacc.2016.01.073","article-title":"Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction","volume":"67","author":"Westman","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"16","key":"10.1016\/j.biopha.2023.115083_bib32","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.jacc.2014.01.014","article-title":"Anti-inflammatory strategies for ventricular remodeling following ST-segment elevation acute myocardial infarction","volume":"63","author":"Seropian","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115083_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ctm2.13","article-title":"NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases","volume":"10","author":"Wang","year":"2020","journal-title":"Clin. Transl. Med"},{"issue":"13","key":"10.1016\/j.biopha.2023.115083_bib34","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1089\/ars.2014.5989","article-title":"The inflammasome in myocardial injury and cardiac remodeling","volume":"22","author":"Toldo","year":"2015","journal-title":"Antioxid. Redox Signal"},{"issue":"6","key":"10.1016\/j.biopha.2023.115083_bib35","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.biopha.2023.115083_bib36","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/sj.cdd.4402194","article-title":"The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation","volume":"14","author":"Fernandes-Alnemri","year":"2007","journal-title":"Cell Death Differ."},{"issue":"7","key":"10.1016\/j.biopha.2023.115083_bib37","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00018-016-2396-6","article-title":"Assembly and regulation of ASC specks","volume":"74","author":"Hoss","year":"2017","journal-title":"Cell Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.biopha.2023.115083_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1517\/14728222.2016.1088005","article-title":"Targeting danger-associated molecular patterns after myocardial infarction","volume":"20","author":"van Hout","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"issue":"50","key":"10.1016\/j.biopha.2023.115083_bib39","doi-asserted-by":"crossref","first-page":"36321","DOI":"10.1074\/jbc.M708182200","article-title":"The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock","volume":"282","author":"Shao","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.biopha.2023.115083_bib40","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1073\/pnas.041611398","article-title":"Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta","volume":"98","author":"Pomerantz","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.biopha.2023.115083_bib41","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1038\/s41401-021-00845-8","article-title":"The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1\u03b2\/p38 MAPK pathway","volume":"43","author":"Su","year":"2022","journal-title":"Acta Pharm. Sin."},{"issue":"5","key":"10.1016\/j.biopha.2023.115083_bib42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00395-014-0415-z","article-title":"TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia\/reperfusion injury","volume":"109","author":"Liu","year":"2014","journal-title":"Basic Res Cardiol."},{"key":"10.1016\/j.biopha.2023.115083_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22010260","article-title":"Cardiac Connexin-43 hemichannels and Pannexin1 channels: provocative antiarrhythmic targets","volume":"22","author":"Andelova","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2023.115083_bib44","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-019-0748-8","article-title":"Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia\/reperfusion hearts","volume":"114","author":"Xue","year":"2019","journal-title":"Basic Res Cardiol."},{"issue":"9","key":"10.1016\/j.biopha.2023.115083_bib45","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1172\/JCI134682","article-title":"Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias","volume":"130","author":"Xiao","year":"2020","journal-title":"J. Clin. Invest"},{"issue":"2","key":"10.1016\/j.biopha.2023.115083_bib46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.104.525493","article-title":"Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein","volume":"112","author":"Ando","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.biopha.2023.115083_bib47","doi-asserted-by":"crossref","first-page":"H1762","DOI":"10.1152\/ajpheart.00346.2004","article-title":"Altered connexin43 expression produces arrhythmia substrate in heart failure","volume":"287","author":"Poelzing","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2023.115083_bib48","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.intimp.2016.08.035","article-title":"Phloretin attenuates LPS-induced acute lung injury in mice via modulation of the NF-\u03baB and MAPK pathways","volume":"40","author":"Huang","year":"2016","journal-title":"Int Immunopharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2023.115083_bib49","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.18632\/aging.101954","article-title":"Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model","volume":"11","author":"Ying","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.biopha.2023.115083_bib50","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223008740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223008740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:38:50Z","timestamp":1777880330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223008740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":50,"alternative-id":["S0753332223008740"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115083","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phloretin ameliorates heart function after myocardial infarction via NLRP3\/Caspase-1\/IL-1\u03b2 signaling","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115083"}}