{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:42:44Z","timestamp":1787928164386,"version":"build-2784847793"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20171ACB21075"],"award-info":[{"award-number":["20171ACB21075"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224BAB206116"],"award-info":[{"award-number":["20224BAB206116"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074211"],"award-info":[{"award-number":["82074211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160828"],"award-info":[{"award-number":["82160828"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.biopha.2023.115153","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T13:31:45Z","timestamp":1688995905000},"page":"115153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Sodium Danshensu stabilizes atherosclerotic vulnerable plaques by targeting IKK\u03b2 mediated inflammation in macrophages"],"prefix":"10.1016","volume":"165","author":[{"given":"Miao","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-3376","authenticated-orcid":false,"given":"Xijuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biopha.2023.115153_bib1","first-page":"927","article-title":"Atherosclerosis: process, indicators, risk factors and new hopes","volume":"5","author":"Rafieian-Kopaei","year":"2014","journal-title":"Int. J. Prev. Med."},{"issue":"6","key":"10.1016\/j.biopha.2023.115153_bib2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/CIRCRESAHA.111.257535","article-title":"Multiple roles for neutrophils in atherosclerosis","volume":"110","author":"Soehnlein","year":"2012","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.biopha.2023.115153_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/pin.12921","article-title":"Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques","volume":"70","author":"Asada","year":"2020","journal-title":"Pathol. Int"},{"issue":"1","key":"10.1016\/j.biopha.2023.115153_bib4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.biopha.2023.115153_bib5","first-page":"9830627","article-title":"Bionic microbubble neutrophil composite for inflammation-responsive atherosclerotic vulnerable plaque pluripotent intervention","author":"Liu","year":"2022","journal-title":"Res. (Wash. D.C.)"},{"key":"10.1016\/j.biopha.2023.115153_bib6","first-page":"13","article-title":"Folate receptor-targeted single-photon emission computed tomography\/computed tomography to detect activated macrophages in atherosclerosis: can it distinguish vulnerable from stable atherosclerotic plaques?","author":"Winkel","year":"2014","journal-title":"Mol. Imaging"},{"key":"10.1016\/j.biopha.2023.115153_bib7","article-title":"Platelet membrane biomimetic nanoparticles combined with UTMD to improve the stability of atherosclerotic plaques","volume":"10","author":"Zhou","year":"2022","journal-title":"Front Chem."},{"issue":"2","key":"10.1016\/j.biopha.2023.115153_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/cvr\/cvt097","article-title":"Biomechanical factors and macrophages in plaque stability","volume":"99","author":"Seneviratne","year":"2013","journal-title":"Cardiovasc Res."},{"issue":"3","key":"10.1016\/j.biopha.2023.115153_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1400223","article-title":"Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation","volume":"1","author":"Tang","year":"2015","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.biopha.2023.115153_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/nu12123657","article-title":"Phenethyl isothiocyanate protects against high fat\/cholesterol diet-induced obesity and atherosclerosis in C57BL\/6 mice","volume":"12","author":"Gwon","year":"2020","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.biopha.2023.115153_bib11","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/01.ATV.0000160340.72641.87","article-title":"Nuclear factor kappaB signaling in atherogenesis","volume":"25","author":"de Winther","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"19","key":"10.1016\/j.biopha.2023.115153_bib12","first-page":"8665","article-title":"LncRNA SNHG16 promoted proliferation and inflammatory response of macrophages through miR-17-5p\/NF-kappaB signaling pathway in patients with atherosclerosis","volume":"23","author":"An","year":"2019","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2023.115153_bib13","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.18632\/aging.202273","article-title":"Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148\u20133\u2009P via inhibiting the IKKbeta\/NF-kappaB pathway in macrophages","volume":"13","author":"Yin","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.biopha.2023.115153_bib14","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1161\/ATVBAHA.112.254573","article-title":"Myeloid-specific IkappaB kinase beta deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"32","author":"Park","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biopha.2023.115153_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172710","article-title":"Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu","volume":"864","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.biopha.2023.115153_bib16","article-title":"Anti-osteogenic effect of danshensu in ankylosing spondylitis: an in vitro study based on integrated network pharmacology","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.biopha.2023.115153_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104306","article-title":"Ethanol extracts of Danlou tablet attenuate atherosclerosis via inhibiting inflammation and promoting lipid effluent","volume":"146","author":"Hao","year":"2019","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biopha.2023.115153_bib18","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.biopha.2018.10.147","article-title":"Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro","volume":"109","author":"Song","year":"2019","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2023.115153_bib19","first-page":"370","article-title":"The influence of emodin and danshensu on monocyte secretion of inflammatory cytokines","volume":"11","author":"Wenjun Wang","year":"1995","journal-title":"Chin. J. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115153_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22050667","article-title":"High-throughput determination of sodium danshensu in beagle dogs by the LCMS\/MS method, employing liquid-liquid extraction based on 96-well format plates","volume":"22","author":"Jiang","year":"2017","journal-title":"Molecules"},{"issue":"21","key":"10.1016\/j.biopha.2023.115153_bib21","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.7150\/thno.35572","article-title":"DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma","volume":"9","author":"Zhao","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.biopha.2023.115153_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-kappaB and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115153_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2023.115153_bib24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fimmu.2016.00378","article-title":"Crosstalk between Wnt\/beta-Catenin and NF-kappaB signaling pathway during inflammation","volume":"7","author":"Ma","year":"2016","journal-title":"Front Immunol."},{"key":"10.1016\/j.biopha.2023.115153_bib25","first-page":"64","article-title":"The structure of NF-kappaB family proteins and their role in apoptosis","volume":"62","author":"Piotrowska","year":"2008","journal-title":"Post. Hig. Med. Dosw (Online)"},{"issue":"2","key":"10.1016\/j.biopha.2023.115153_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.atherosclerosis.2006.07.018","article-title":"Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation","volume":"192","author":"Ferreira","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2023.115153_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111995","article-title":"Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-kappaB","volume":"142","author":"Yu","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2023.115153_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106419","article-title":"Inhibition of nuclear factor kappa B as a mechanism of Danshensu during Toll-like receptor 2-triggered inflammation in macrophages","volume":"83","author":"Ye","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115153_bib29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s10020-021-00329-9","article-title":"Danshensu inhibits the IL-1beta-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-kappaB signaling pathway","volume":"27","author":"Xu","year":"2021","journal-title":"Mol. Med."},{"issue":"9","key":"10.1016\/j.biopha.2023.115153_bib30","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41419-019-1914-5","article-title":"The emerging role of IMD 0354 on bone homeostasis by suppressing osteoclastogenesis and bone resorption, but without affecting bone formation","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.biopha.2023.115153_bib31","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1039\/C7MD00278E","article-title":"4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-kappaB cascade","volume":"8","author":"Pippione","year":"2017","journal-title":"Medchemcomm"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223009447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223009447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:05:22Z","timestamp":1777878322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223009447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":31,"alternative-id":["S0753332223009447"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115153","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium Danshensu stabilizes atherosclerotic vulnerable plaques by targeting IKK\u03b2 mediated inflammation in macrophages","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115153"}}