{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:32:00Z","timestamp":1790224320490,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.biopha.2023.115396","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:47:39Z","timestamp":1693198059000},"page":"115396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases"],"prefix":"10.1016","volume":"166","author":[{"given":"George J.","family":"Dugbartey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2023.115396_bib1","series-title":"The Latin text of 1713, rev. with translation and notes by W.C. Wright","first-page":"151","author":"Ramazzini","year":"1940"},{"key":"10.1016\/j.biopha.2023.115396_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/4577000","article-title":"Hydrogen sulphide literature","volume":"39","author":"Mitchell","year":"1924","journal-title":"Public Health Rep."},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0736-4679(00)00301-2","article-title":"Twenty-foot fall averts fatality from massive hydrogen sulfide exposure","volume":"20","author":"Gabbay","year":"2001","journal-title":"J. Emerg. Med"},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib4","first-page":"25","article-title":"A critical review of the literature on hydrogen sulfide toxicity","volume":"13","author":"Beauchamp","year":"1984","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.biopha.2023.115396_bib5","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2023.115396_bib6","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.biopha.2023.115396_bib7","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1124\/mol.105.017467","article-title":"Direct stimulation of KATP channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells","volume":"68","author":"Tang","year":"2005","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biopha.2023.115396_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112435","article-title":"Sodium thiosulfate-supplemented UW solution protects renal grafts against prolonged cold ischemia-reperfusion injury in a murine model of syngeneic kidney transplantation","volume":"145","author":"Zhang","year":"2022","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2023.115396_bib9","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2023.115396_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2004.02617.x","article-title":"The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite \u2018scavenger\u2019?","volume":"90","author":"Whiteman","year":"2004","journal-title":"J. Neurochem"},{"key":"10.1016\/j.biopha.2023.115396_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.biopha.2023.115396_bib12","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2023.115396_bib13","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2023.115396_bib14","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1096\/fj.06-7407com","article-title":"Sulfide, the first inorganic substrate for human cells","volume":"21","author":"Goubern","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2023.115396_bib15","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-\u03b2-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2023.115396_bib16","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1096\/fj.12-216507","article-title":"Intramitochondrial H2S production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics","volume":"27","author":"M\u00f3dis","year":"2013","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jss.2011.03.073","article-title":"A biphasic response to nitric oxide donation in an ex vivo model of donation after cardiac death renal transplantation","volume":"175","author":"Yates","year":"2012","journal-title":"J. Surg. Res"},{"key":"10.1016\/j.biopha.2023.115396_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105883","article-title":"Application of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for a broader use of suboptimal renal and cardiac grafts","volume":"173","author":"Dugbartey","year":"2021","journal-title":"Pharm. Res"},{"key":"10.1016\/j.biopha.2023.115396_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114752","article-title":"Carbon monoxide as an emerging pharmacological tool to improve lung and liver transplantation protocols","volume":"193","author":"Dugbartey","year":"2021","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.biopha.2023.115396_bib20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.biopha.2023.115396_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferease produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.biopha.2023.115396_bib22","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2023.115396_bib23","series-title":"Vanders Renal Physiology","author":"Eaton","year":"2018"},{"key":"10.1016\/j.biopha.2023.115396_bib24","series-title":"Medical Physiology: A Cellular and Molecular Approach","first-page":"767","article-title":"Glomerular filtration and renal blood flow","author":"Giebisch","year":"2009"},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1152\/advan.00195.2017","article-title":"A simple model for demonstrating the factors affecting glomerular filtration rate","volume":"42","author":"Bhaskar","year":"2018","journal-title":"Adv. Physiol. Educ."},{"issue":"Pt 1","key":"10.1016\/j.biopha.2023.115396_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj3280287","article-title":"Characterization of homocysteine metabolism in the rat kidney","volume":"328","author":"House","year":"1997","journal-title":"Biochem J."},{"issue":"Pt 1","key":"10.1016\/j.biopha.2023.115396_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/BJ20040243","article-title":"Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression","volume":"381","author":"Ishii","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2023.115396_bib28","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/01.HYP.0000219634.83928.6e","article-title":"Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats","volume":"47","author":"Li","year":"2006","journal-title":"Hypertension"},{"issue":"1\u20133","key":"10.1016\/j.biopha.2023.115396_bib29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejphar.2009.01.041","article-title":"Characterisation of cystathionine gamma-lyase\/hydrogen sulphide pathway in ischaemia\/reperfusion injury of the mouse kidney: an in vivo study","volume":"606","author":"Tripatara","year":"2009","journal-title":"Eur. J. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s10157-012-0670-y","article-title":"Distribution of hydrogen sulfide (H\u2082S)-producing enzymes and the roles of the H\u2082S donor sodium hydrosulfide in diabetic nephropathy","volume":"17","author":"Yamamoto","year":"2013","journal-title":"Clin. Exp. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115396_bib31","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1124\/jpet.108.149963","article-title":"Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys","volume":"329","author":"Xia","year":"2009","journal-title":"J. Pharm. Exp. Ther."},{"issue":"7","key":"10.1016\/j.biopha.2023.115396_bib32","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1074\/jbc.M111.278325","article-title":"Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells","volume":"387","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.biopha.2023.115396_bib33","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1681\/ASN.2008121269","article-title":"Hydrogen sulfide-induced hypometabolism prevents renal ischemia\/reperfusion injury","volume":"20","author":"Bos","year":"2009","journal-title":"Am. J. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib34","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2012030268","article-title":"Cystathionine \u03b3-lyase protects against renal ischemia\/reperfusion by modulating oxidative stress","volume":"24","author":"Bos","year":"2013","journal-title":"Am. J. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2023.115396_bib35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2015.11.022","article-title":"Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming - The role of renal H2S-producing enzymes","volume":"769","author":"Dugbartey","year":"2015","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.biopha.2023.115396_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113386","article-title":"Activation of renal CSE\/H2S pathway by alpha-lipoic acid protects against histological and functional changes in the diabetic kidney","volume":"153","author":"Dugbartey","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib37","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/ndt\/gfr560","article-title":"Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease","volume":"27","author":"Aminzadeh","year":"2012","journal-title":"Nephrol. Dial. Transpl."},{"issue":"3","key":"10.1016\/j.biopha.2023.115396_bib38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s004180050286","article-title":"Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis","volume":"110","author":"Nagahara","year":"1998","journal-title":"Histochem Cell Biol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/bjp.2008.296","article-title":"Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice","volume":"155","author":"Brancaleone","year":"2008","journal-title":"Br. J. Pharm."},{"issue":"11","key":"10.1016\/j.biopha.2023.115396_bib40","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1089\/ars.2009.2956","article-title":"Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?","volume":"12","author":"Jain","year":"2010","journal-title":"Antioxid. Redox Signal"},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib41","doi-asserted-by":"crossref","first-page":"S483","DOI":"10.12980\/APJTB.4.201414B58","article-title":"Evaluation of plasma H2S levels and H2S synthesis in streptozotocin induced Type-2 diabetes-an experimental study based on Swietenia macrophylla seeds","volume":"4","author":"Dutta","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"issue":"3","key":"10.1016\/j.biopha.2023.115396_bib42","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1159\/000479295","article-title":"Loss of the Protein Cystathionine \u03b2-Synthase During Kidney Injury Promotes Renal Tubulointerstitial Fibrosis","volume":"42","author":"Yuan","year":"2017","journal-title":"Kidney Blood Press Res"},{"issue":"8","key":"10.1016\/j.biopha.2023.115396_bib43","first-page":"452","article-title":"Garlic (Allium sativum L.) and cardiovascular diseases","volume":"111","author":"Ginter","year":"2010","journal-title":"Bratisl. Lek. Listy"},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib44","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pharep.2014.08.001","article-title":"H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway","volume":"67","author":"Safar","year":"2015","journal-title":"Pharm. Rep."},{"issue":"Pt A","key":"10.1016\/j.biopha.2023.115396_bib46","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.phrs.2016.08.019","article-title":"The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro","volume":"113","author":"Ger\u0151","year":"2016","journal-title":"Pharm. Res."},{"issue":"4","key":"10.1016\/j.biopha.2023.115396_bib47","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1755-5922.12128","article-title":"A novel hydrogen sulfide prodrug, SG1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patients","volume":"33","author":"Polhemus","year":"2015","journal-title":"Cardiovasc Ther."},{"issue":"96","key":"10.1016\/j.biopha.2023.115396_bib48","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal"},{"issue":"29","key":"10.1016\/j.biopha.2023.115396_bib49","doi-asserted-by":"crossref","first-page":"21903","DOI":"10.1074\/jbc.R110.128363","article-title":"Redox biochemistry of hydrogen sulfide","volume":"285","author":"Kabil","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2023.115396_bib50","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/FJC.0b013e31820eb7a1","article-title":"Hydrogen sulfide: a novel signaling molecule in the vascular system","volume":"58","author":"Liu","year":"2011","journal-title":"J. Cardiovasc Pharm."},{"issue":"8","key":"10.1016\/j.biopha.2023.115396_bib51","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2023.115396_bib52","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jss.2015.02.061","article-title":"Hydrogen sulphide as a novel therapy to ameliorate cyclosporine nephrotoxicity","volume":"197","author":"Lee","year":"2015","journal-title":"J. Surg. Res"},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib53","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/s41598-018-38467-6","article-title":"Hydrogen Sulfide Protects Hyperhomocysteinemia-Induced Renal Damage by Modulation of Caveolin and eNOS Interaction","volume":"9","author":"Pushpakumar","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2023.115396_bib54","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1124\/jpet.108.149963","article-title":"Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys","volume":"329","author":"Xia","year":"2009","journal-title":"J. Pharm. Exp. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib55","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ajh.2011.149","article-title":"Interdependency of cystathione \u03b3-lyase and cystathione \u03b2-synthase in hydrogen sulfide-induced blood pressure regulation in rats","volume":"25","author":"Roy","year":"2012","journal-title":"Am. J. Hypertens."},{"issue":"15","key":"10.1016\/j.biopha.2023.115396_bib56","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1089\/ars.2013.5304","article-title":"Hydrogen sulfide targets EGFR Cys797\/Cys798 residues to induce Na(+)\/K(+)-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats","volume":"21","author":"Ge","year":"2014","journal-title":"Antioxid. Redox Signal"},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib57","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000489606","article-title":"Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction","volume":"47","author":"Kuang","year":"2018","journal-title":"Am. J. Nephrol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115396_bib58","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1081\/JDI-120026024","article-title":"ATP-dependent K+ channels in renal ischemia reperfusion injury","volume":"25","author":"Rahgozar","year":"2003","journal-title":"Ren. Fail"},{"key":"10.1016\/j.biopha.2023.115396_bib59","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MNH.0b013e3283430651","article-title":"Signaling pathways for the vascular effects of hydrogen sulfide","volume":"20","author":"Wang","year":"2011","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.biopha.2023.115396_bib60","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.tips.2015.05.007","article-title":"The role of H2S bioavailability in endothelial dysfunction","volume":"36","author":"Wang","year":"2015","journal-title":"Trends Pharm. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064304","article-title":"Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN\/PI(3,4,5)P3 dependent pathway","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biopha.2023.115396_bib62","doi-asserted-by":"crossref","first-page":"C866","DOI":"10.1152\/ajpcell.00105.2010","article-title":"Bicarbonate-dependent effect of hydrogen sulfide on vascular contractility in rat aortic rings","volume":"299","author":"Liu","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2023.115396_bib63","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.bbrc.2007.05.063","article-title":"Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells","volume":"358","author":"Lee","year":"2007","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.biopha.2023.115396_bib64","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-94-024-1057-0_9","article-title":"Aquaporins in urinary system","volume":"969","author":"Li","year":"2017","journal-title":"Adv. Exp. Med Biol."},{"issue":"4","key":"10.1016\/j.biopha.2023.115396_bib65","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI5704","article-title":"Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice","volume":"103","author":"Chou","year":"1999","journal-title":"J. Clin. Invest"},{"issue":"10","key":"10.1016\/j.biopha.2023.115396_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141714","article-title":"NSAIDs alter phosphorylated forms of AQP2 in the Inner Medullary Tip","volume":"10","author":"Ren","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.biopha.2023.115396_bib67","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1073\/pnas.080499597","article-title":"Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels","volume":"97","author":"Ma","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.biopha.2023.115396_bib68","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1681\/ASN.V1291795","article-title":"Aquaporin-4 expression in adult and developing mouse and rat kidney","volume":"12","author":"Kim","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.biopha.2023.115396_bib69","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1159\/000335762","article-title":"AQP5 is expressed in type-B intercalated cells in the collecting duct system of the rat, mouse and human kidney","volume":"28","author":"Procino","year":"2011","journal-title":"Cell Physiol. Biochem"},{"issue":"6","key":"10.1016\/j.biopha.2023.115396_bib70","doi-asserted-by":"crossref","first-page":"F1014","DOI":"10.1152\/ajprenal.2000.279.6.F1014","article-title":"Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance","volume":"279","author":"Promeneur","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4\u20135","key":"10.1016\/j.biopha.2023.115396_bib71","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000020676","article-title":"Cellular localization of aquaporin 7 in the rat kidney","volume":"8","author":"Ishibashi","year":"2000","journal-title":"Exp. Nephrol."},{"issue":"10","key":"10.1016\/j.biopha.2023.115396_bib72","doi-asserted-by":"crossref","first-page":"F1295","DOI":"10.1152\/ajprenal.00344.2012","article-title":"Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress","volume":"304","author":"Atochina-Vasserman","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115396_bib73","doi-asserted-by":"crossref","first-page":"F1189","DOI":"10.1152\/ajprenal.00150.2016","article-title":"Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane","volume":"311","author":"Ren","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib74","doi-asserted-by":"crossref","first-page":"F306","DOI":"10.1152\/ajprenal.00391.2017","article-title":"Manganese promotes intracellular accumulation of AQP2 via modulating F-actin polymerization and reduces urinary concentration in mice","volume":"314","author":"Lei","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115396_bib75","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1681\/ASN.V86861","article-title":"Transcriptional regulation of aquaporin-2 water channel gene by cAMP","volume":"8","author":"Matsumura","year":"1997","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib76","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1681\/ASN.2017050545","article-title":"Genome-Wide Mapping of DNA Accessibility and Binding Sites for CREB and C\/EBP\u03b2 in Vasopressin-Sensitive Collecting Duct Cells","volume":"29","author":"Jung","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2023.115396_bib77","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.16654.1","article-title":"Vasopressin-aquaporin-2 pathway: recent advances in understanding water balance disorders","volume":"8","author":"Ranieri","year":"2019","journal-title":"F1000Res."},{"key":"10.1016\/j.biopha.2023.115396_bib78","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/B978-0-12-820683-6.00018-X","article-title":"The vasopressin-aquaporin-2 pathway syndromes","volume":"181","author":"Valenti","year":"2021","journal-title":"Handb. Clin. Neurol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib79","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1096\/fj.201800436R","article-title":"Hydrogen sulfide upregulates renal AQP-2 protein expression and promotes urine concentration","volume":"33","author":"Luo","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2023.115396_bib80","doi-asserted-by":"crossref","first-page":"H474","DOI":"10.1152\/ajpheart.00013.2002","article-title":"H2S-induced vasorelaxation and underlying cellular and molecular mechanisms","volume":"283","author":"Zhao","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib81","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1148\/rg.2016150124","article-title":"Renal arteriovenous shunts: Clinical features, imaging appearance, and transcatheter embolization based on angioarchitecture","volume":"36","author":"Maruno","year":"2016","journal-title":"Radiographics"},{"issue":"Pt 20","key":"10.1016\/j.biopha.2023.115396_bib82","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1242\/jeb.02480","article-title":"Hydrogen sulfide as an oxygen sensor\/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation","volume":"209","author":"Olson","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.biopha.2023.115396_bib83","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.niox.2015.01.005","article-title":"Hydrogen sulfide in renal physiology, disease and transplantation--the smell of renal protection","volume":"46","author":"Koning","year":"2015","journal-title":"Nitric Oxide"},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib84","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/jpet.110.166637","article-title":"Hypoxia in the renal medulla: implications for hydrogen sulfide signaling","volume":"334","author":"Be\u0142towski","year":"2010","journal-title":"J. Pharm. Exp. Ther."},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib85","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/ars.2014.5930","article-title":"Hydrogen sulfide as an oxygen sensor","volume":"22","author":"Olson","year":"2015","journal-title":"Antioxid. Redox Signal"},{"issue":"3","key":"10.1016\/j.biopha.2023.115396_bib86","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1515\/cclm-2012-0551","article-title":"Hydrogen sulfide as an oxygen sensor","volume":"51","author":"Olson","year":"2013","journal-title":"Clin. Chem. Lab Med"},{"key":"10.1016\/j.biopha.2023.115396_bib87","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-3-319-63245-2_15","article-title":"Hydrogen Sulfide as an O2 Sensor: A Critical Analysis","volume":"967","author":"Prieto-Lloret","year":"2017","journal-title":"Adv. Exp. Med Biol."},{"issue":"31","key":"10.1016\/j.biopha.2023.115396_bib88","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1073\/pnas.1308487110","article-title":"Oxygen-sensitive mitochondrial accumulation of cystathionine \u03b2-synthase mediated by Lon protease","volume":"110","author":"Teng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.biopha.2023.115396_bib89","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1089\/ars.2009.2921","article-title":"Hydrogen sulfide and oxygen sensing in the cardiovascular system","volume":"12","author":"Olson","year":"2010","journal-title":"Antioxid. Redox Signal"},{"issue":"4","key":"10.1016\/j.biopha.2023.115396_bib90","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.neuroscience.2008.08.025","article-title":"Endogenous hydrogen sulfide is involved in regulation of respiration in medullary slice of neonatal rats","volume":"156","author":"Hu","year":"2008","journal-title":"Neuroscience"},{"issue":"Pt 23","key":"10.1016\/j.biopha.2023.115396_bib91","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1242\/jeb.061473","article-title":"Hydrogen sulfide (H\u2082S) and hypoxia inhibit salmonid gastrointestinal motility: evidence for H\u2082S as an oxygen sensor","volume":"214","author":"Dombkowski","year":"2011","journal-title":"J. Exp. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2023.115396_bib92","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1681\/ASN.2016070734","article-title":"Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update","volume":"28","author":"Yang","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2023.115396_bib93","series-title":"Physiology, Renin Angiotensin System","author":"Fountain","year":"2023"},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib94","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1681\/ASN.2008070740","article-title":"Activation of the succinate receptor GPR91 in macula densa cells causes renin release","volume":"20","author":"Vargas","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.biopha.2023.115396_bib95","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1681\/ASN.2009070759","article-title":"Macula densa sensing and signaling mechanisms of renin release","volume":"21","author":"Peti-Peterdi","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2023.115396_bib96","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1111\/j.1523-1755.2005.09911.x","article-title":"The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease","volume":"99","author":"Remuzzi","year":"2005","journal-title":"Kidney Int Suppl."},{"issue":"2","key":"10.1016\/j.biopha.2023.115396_bib97","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/jvim.15454","article-title":"The renin\u2010angiotensin\u2010aldosterone system and its suppression","volume":"33","author":"Ames","year":"2019","journal-title":"J. Vet. Intern Med"},{"issue":"3","key":"10.1016\/j.biopha.2023.115396_bib98","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1172\/JCI116292","article-title":"Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium","volume":"91","author":"Peters","year":"1993","journal-title":"J. Clin. Invest"},{"issue":"15","key":"10.1016\/j.biopha.2023.115396_bib99","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1073\/pnas.95.15.9003","article-title":"Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells","volume":"95","author":"Gambaryan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2023.115396_bib100","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.RES.0000017622.25365.71","article-title":"Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases","volume":"90","author":"Friis","year":"2002","journal-title":"Circ. Res"},{"key":"10.1016\/j.biopha.2023.115396_bib101","doi-asserted-by":"crossref","first-page":"F989","DOI":"10.1152\/ajprenal.00201.2005","article-title":"Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells","volume":"289","author":"Friis","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115396_bib102","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1681\/ASN.2009090949","article-title":"Hydrogen sulfide inhibits plasma renin activity","volume":"21","author":"Lu","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib103","doi-asserted-by":"crossref","first-page":"C59","DOI":"10.1152\/ajpcell.00341.2010","article-title":"Hydrogen sulfide regulates cAMP homeostasis and renin degranulation in As4.1 and rat renin-rich kidney cells","volume":"302","author":"Lu","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115396_bib104","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ars.2012.4888","article-title":"Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats","volume":"20","author":"Liu","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.biopha.2023.115396_bib105","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.niox.2015.01.004","article-title":"Down-regulated CBS\/H2S pathway is involved in high-salt-induced hypertension in Dahl rats","volume":"46","author":"Huang","year":"2015","journal-title":"Nitric Oxide"},{"issue":"10","key":"10.1016\/j.biopha.2023.115396_bib106","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1097\/HJH.0b013e32829b8fd0","article-title":"The novel gaseous vasorelaxant hydrogen sulfide inhibits angiotensin-converting enzyme activity of endothelial cells","volume":"25","author":"Laggner","year":"2007","journal-title":"J. Hypertens."},{"issue":"9","key":"10.1016\/j.biopha.2023.115396_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074366","article-title":"H(2)S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generation","volume":"8","author":"Xue","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib108","doi-asserted-by":"crossref","first-page":"F193","DOI":"10.1152\/ajprenal.00304.2019","article-title":"Aquaporins in the kidney: physiology and pathophysiology","volume":"318","author":"Su","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.biopha.2023.115396_bib109","article-title":"Many kinases for controlling the water channel aquaporin-2","author":"Kharin","year":"2023","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115396_bib110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/ajh\/hpw104","article-title":"Hydrogen Sulfide Improves Myocardial Remodeling via Downregulated Angiotensin \u2161\/AT1R Pathway in Renovascular Hypertensive Rats","volume":"30","author":"Liu","year":"2017","journal-title":"Am. J. Hypertens."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223011940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223011940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:39:38Z","timestamp":1782369578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223011940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":110,"alternative-id":["S0753332223011940"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115396","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115396"}}