{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:28:33Z","timestamp":1782743313395,"version":"3.54.5"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21060"],"award-info":[{"award-number":["ZYJC21060"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2022SCUH0033"],"award-info":[{"award-number":["2022SCUH0033"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273556"],"award-info":[{"award-number":["82273556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.biopha.2023.115397","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T17:04:33Z","timestamp":1693847073000},"page":"115397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Toxic effects of sirolimus and everolimus on the development and behavior of zebrafish embryos"],"prefix":"10.1016","volume":"166","author":[{"given":"Zixin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-3566","authenticated-orcid":false,"given":"Xue","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuepeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuru","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-9660","authenticated-orcid":false,"given":"Yi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2023.115397_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.transproceed.2020.09.021","article-title":"Long-term outcomes of everolimus therapy in De Novo liver transplantation: a systematic review and meta-analysis of randomized controlled trials","volume":"53","author":"Bzeizi","year":"2021","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.biopha.2023.115397_bib2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(12)61767-X","article-title":"Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"381","author":"Bissler","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2023.115397_bib3","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S1470-2045(14)70489-9","article-title":"Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study","volume":"15","author":"Franz","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.biopha.2023.115397_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101376","article-title":"The role of rapamycin in healthspan extension via the delay of organ aging","volume":"70","author":"Zhang","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.biopha.2023.115397_bib5","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.devcel.2022.02.024","article-title":"The central moTOR of metabolism","volume":"57","author":"Simcox","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biopha.2023.115397_bib6","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood.2021014027","article-title":"Sirolimus plus prednisolone vs sirolimus monotherapy for kaposiform hemangioendothelioma: a randomized clinical trial","volume":"139","author":"Ji","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2023.115397_bib7","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.2147\/IJN.S373777","article-title":"Rapamycin Liposomes Combined with 5-Fluorouracil inhibits angiogenesis and tumor growth of APC ((Min\/+)) mice and AOM\/DSS-induced colorectal cancer mice","volume":"17","author":"Liu","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2023.115397_bib8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn3068","article-title":"Fighting neurodegeneration with rapamycin: mechanistic insights","volume":"12","author":"Bov\u00e9","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.biopha.2023.115397_bib9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: one drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2023.115397_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1523-1755.2001.00460.x","article-title":"Rapamycin in transplantation: a review of the evidence","volume":"59","author":"Saunders","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2023.115397_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1074\/mcp.M900415-MCP200","article-title":"Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin","volume":"9","author":"Fournier","year":"2010","journal-title":"Mol. Cell. Proteom.: MCP"},{"key":"10.1016\/j.biopha.2023.115397_bib12","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.cell.2017.10.037","article-title":"Post-transcriptional regulation of De Novo lipogenesis by mTORC1-S6K1-SRPK2 signaling","volume":"171","author":"Lee","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2023.115397_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021945118","article-title":"mTORC1-chaperonin CCT signaling regulates m(6)A RNA methylation to suppress autophagy","volume":"118","author":"Tang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2023.115397_bib14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/jamadermatol.2021.3459","article-title":"Sirolimus (Rapamycin) for Slow-Flow Malformations in Children: The Observational-Phase Randomized Clinical PERFORMUS Trial","volume":"157","author":"Maruani","year":"2021","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.biopha.2023.115397_bib15","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3257","article-title":"Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies","volume":"137","author":"Adams","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.biopha.2023.115397_bib16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/pbc.25241","article-title":"Successful treatment of Kaposiform hemangioendothelioma with everolimus","volume":"62","author":"Uno","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.biopha.2023.115397_bib17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12519-018-0171-5","article-title":"Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options","volume":"14","author":"Schmid","year":"2018","journal-title":"World J. Pediatr.: WJP"},{"key":"10.1016\/j.biopha.2023.115397_bib18","article-title":"Long-term outcomes of sirolimus treatment for kaposiform hemangioendothelioma: continuing successes and ongoing challenges","author":"Zhou","year":"2023","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2023.115397_bib19","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13023-021-01893-3","article-title":"Sirolimus in the treatment of kaposiform lymphangiomatosis","volume":"16","author":"Zhou","year":"2021","journal-title":"Orphanet J. rare Dis."},{"key":"10.1016\/j.biopha.2023.115397_bib20","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/pbc.25422","article-title":"Successful treatment of kaposiform lymphangiomatosis with sirolimus","volume":"62","author":"Wang","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.biopha.2023.115397_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s40272-019-00337-7","article-title":"Off-label use of sirolimus and everolimus in a pediatric center: a case series and review of the literature","volume":"21","author":"Bevacqua","year":"2019","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.biopha.2023.115397_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054952","article-title":"Effects of single and combined ciprofloxacin and lead treatments on zebrafish behavior, oxidative stress, and elements content","volume":"24","author":"Jijie","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.115397_bib23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.17221\/40\/2023-VETMED","article-title":"Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish (Danio rerio)?","volume":"68","author":"Cahova","year":"2023","journal-title":"Vet. Med."},{"key":"10.1016\/j.biopha.2023.115397_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109597","article-title":"Evaluation of single and combined effects of mancozeb and metalaxyl on the transcriptional and biochemical response of zebrafish (Danio rerio)","volume":"268","author":"Banaee","year":"2023","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol.: CBP"},{"key":"10.1016\/j.biopha.2023.115397_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109439","article-title":"Impact of pharmaceutical products on zebrafish: an effective tool to assess aquatic pollution","volume":"261","author":"Porretti","year":"2022","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol.: CBP"},{"key":"10.1016\/j.biopha.2023.115397_bib26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd4627","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2023.115397_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2014.09.005","article-title":"Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing","volume":"55","author":"Ducharme","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.biopha.2023.115397_bib28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.toxlet.2014.11.020","article-title":"A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen","volume":"232","author":"Driessen","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2023.115397_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103923","article-title":"Evaluation of toxicity of Personal Care Products (PCPs) in freshwaters: zebrafish as a model","volume":"94","author":"Zicarelli","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.biopha.2023.115397_bib30","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.0000061912.88753.87","article-title":"Drugs that induce repolarization abnormalities cause bradycardia in zebrafish","volume":"107","author":"Milan","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2023.115397_bib31","doi-asserted-by":"crossref","first-page":"21468","DOI":"10.1007\/s11356-020-08634-2","article-title":"Exposure to ractopamine hydrochloride induces changes in heart rate and behavior in zebrafish embryos and larvae","volume":"27","author":"Garbinato","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.biopha.2023.115397_bib32","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3389\/fnins.2018.00976","article-title":"The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity","volume":"12","author":"d'Amora","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.biopha.2023.115397_bib33","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1007\/s11356-019-04488-5","article-title":"2,4-Dichlorophenoxyacetic acid herbicide effects on zebrafish larvae: development, neurotransmission and behavior as sensitive endpoints","volume":"27","author":"Gaaied","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.biopha.2023.115397_bib34","article-title":"Microplastics alone or co-exposed with copper induce neurotoxicity and behavioral alterations on zebrafish larvae after a subchronic exposure","volume":"235","author":"Santos","year":"2021","journal-title":"Aquat. Toxicol. (Amst., Neth. )"},{"key":"10.1016\/j.biopha.2023.115397_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12070898","article-title":"Assessing anti-social and aggressive behavior in a Zebrafish (Danio rerio) model of Parkinson's disease chronically exposed to rotenone","volume":"12","author":"Ilie","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.biopha.2023.115397_bib36","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/02757540.2017.1420176","article-title":"The effects of subchronic exposure to NeemAzal T\/S on zebrafish (Danio rerio","volume":"34","author":"Plhalova","year":"2018","journal-title":"Chem. Ecol."},{"key":"10.1016\/j.biopha.2023.115397_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ntt.2014.01.006","article-title":"Zebrafish models for assessing developmental and reproductive toxicity","volume":"42","author":"He","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.biopha.2023.115397_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312714","article-title":"Vitamin C mitigates oxidative stress and behavioral impairments induced by deltamethrin and lead toxicity in zebrafish","volume":"22","author":"Paduraru","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.115397_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/app112110015","article-title":"Embryotoxicity of selective serotonin reuptake inhibitors-comparative sensitivity of Zebrafish (Danio rerio) and African Clawed Frog (Xenopus laevis) embryos","volume":"11","author":"Blahova","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.biopha.2023.115397_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/w13162203","article-title":"Do single-component and mixtures selected organic UV filters induce embryotoxic effects in Zebrafish (Danio rerio)","volume":"13","author":"Cahova","year":"2021","journal-title":"Water"},{"key":"10.1016\/j.biopha.2023.115397_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ph14060578","article-title":"Zebrafish as a screening model to study the single and joint effects of antibiotics","volume":"14","author":"Jijie","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.biopha.2023.115397_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145671","article-title":"Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion","volume":"775","author":"Faria","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biopha.2023.115397_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/jmse8020073","article-title":"Toxicity of deltamethrin to zebrafish gonads revealed by cellular biomarkers","volume":"8","author":"Petrovici","year":"2020","journal-title":"J. Mar. Sci. Eng."},{"key":"10.1016\/j.biopha.2023.115397_bib44","doi-asserted-by":"crossref","first-page":"41269","DOI":"10.1039\/C9RA07655G","article-title":"Comprehensive evaluation of the composition of Mingshan Laochuancha green tea and demonstration of hypolipidemic activity in a zebrafish obesity model","volume":"9","author":"Xiao","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2023.115397_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-022-01225-2","article-title":"SCGN deficiency is a risk factor for autism spectrum disorder","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.biopha.2023.115397_bib46","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10565-018-09453-5","article-title":"The effects of five types of tea solutions on epiboly process, neural and cardiovascular development, and locomotor capacity of zebrafish","volume":"35","author":"Li","year":"2019","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.biopha.2023.115397_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.vascn.2008.05.130","article-title":"Zebrafish based assays for the assessment of cardiac, visual and gut function--potential safety screens for early drug discovery","volume":"58","author":"Berghmans","year":"2008","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.biopha.2023.115397_bib48","article-title":"Fluorescent transgenic zebrafish Tg(nkx2.2a:mEGFP) provides a highly sensitive monitoring tool for neurotoxins","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2023.115397_bib49","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.jvs.2021.04.071","article-title":"A prospective multicenter study of sirolimus for complicated vascular anomalies","volume":"74","author":"Ji","year":"2021","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.biopha.2023.115397_bib50","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/neuonc\/nou235","article-title":"Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis clinical trials consortium phase II study","volume":"17","author":"Weiss","year":"2015","journal-title":"Neuro-Oncol."},{"key":"10.1016\/j.biopha.2023.115397_bib51","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/ijc.30775","article-title":"Sirolimus for the treatment of progressive kaposiform hemangioendothelioma: a multicenter retrospective study","volume":"141","author":"Ji","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2023.115397_bib52","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1111\/bjd.15640","article-title":"Sirolimus therapy for children with problematic kaposiform haemangioendothelioma and tufted angioma","volume":"177","author":"Tasani","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biopha.2023.115397_bib53","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.jacc.2021.04.013","article-title":"Systemic sirolimus therapy for infants and children with pulmonary vein stenosis","volume":"77","author":"Patel","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2023.115397_bib54","first-page":"321","article-title":"Use of sirolimus in patients with primary steroid-resistant nephrotic syndrome. Nefrologia: publicacion oficial de la Sociedad Espanola","volume":"32","author":"Liern","year":"2012","journal-title":"Nefrologia"},{"key":"10.1016\/j.biopha.2023.115397_bib55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13023-019-1118-1","article-title":"The impact of sirolimus therapy on lesion size, clinical symptoms, and quality of life of patients with lymphatic anomalies","volume":"14","author":"Ozeki","year":"2019","journal-title":"Orphanet J. rare Dis."},{"key":"10.1016\/j.biopha.2023.115397_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.27614","article-title":"Efficacy of systemic sirolimus in the treatment of generalized lymphatic anomaly and Gorham-Stout disease","volume":"66","author":"Ricci","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.biopha.2023.115397_bib57","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/jamadermatol.2019.4141","article-title":"Targeted inhibition of the epidermal growth factor receptor and mammalian target of rapamycin signaling pathways in olmsted syndrome","volume":"156","author":"Zhang","year":"2020","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.biopha.2023.115397_bib58","doi-asserted-by":"crossref","first-page":"241","DOI":"10.11622\/smedj.2018132","article-title":"Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish","volume":"60","author":"Feng","year":"2019","journal-title":"Singap. Med. J."},{"key":"10.1016\/j.biopha.2023.115397_bib59","doi-asserted-by":"crossref","first-page":"503","DOI":"10.14348\/molcells.2014.0108","article-title":"A tale of two models: mouse and zebrafish as complementary models for lymphatic studies","volume":"37","author":"Kim","year":"2014","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biopha.2023.115397_bib60","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1111\/bcp.14752","article-title":"Drug-induced peripheral oedema: An aetiology-based review","volume":"87","author":"Largeau","year":"2021","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2023.115397_bib61","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1365-2133.2009.09098.x","article-title":"Sirolimus-associated lymphoedema: eight new cases and a proposed mechanism","volume":"160","author":"Desai","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biopha.2023.115397_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161272","article-title":"Lipidomic, metabolomic, and behavior responses of zebrafish (Danio rerio) exposed to environmental levels of the beta blocker atenolol","volume":"866","author":"Ivantsova","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biopha.2023.115397_bib63","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2165\/00003088-200645110-00007","article-title":"Sirolimus population pharmacokinetic\/pharmacogenetic analysis and bayesian modelling in kidney transplant recipients","volume":"45","author":"Djebli","year":"2006","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.biopha.2023.115397_bib64","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1200\/JCO.2007.11.4017","article-title":"Phase I study of everolimus in pediatric patients with refractory solid tumors","volume":"25","author":"Fouladi","year":"2007","journal-title":"J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.biopha.2023.115397_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12030677","article-title":"A model of a zebrafish avatar for co-clinical trials","volume":"12","author":"Usai","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.biopha.2023.115397_bib66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.lfs.2016.02.076","article-title":"Expression of zTOR-associated microRNAs in zebrafish embryo treated with rapamycin","volume":"150","author":"Khor","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2023.115397_bib67","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1172\/JCI67084","article-title":"RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity","volume":"124","author":"Kawasaki","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2023.115397_bib68","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00709-021-01695-1","article-title":"MiR-107 inhibits the sprouting of intersegmental vessels of zebrafish embryos","volume":"259","author":"Khor","year":"2022","journal-title":"Protoplasma"},{"key":"10.1016\/j.biopha.2023.115397_bib69","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/cts.13488","article-title":"and D. Te Loo, Clinical differences in sirolimus treatment with low target levels between children and adults with vascular malformations - A nationwide trial","volume":"16","author":"Harbers","year":"2023","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.biopha.2023.115397_bib70","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-4614-0106-3_15","article-title":"Zebrafish: model for the study of inflammation and the innate immune response to infectious diseases","volume":"946","author":"Novoa","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biopha.2023.115397_bib71","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fcell.2019.00012","article-title":"Resident immunity in tissue repair and maintenance: the zebrafish model coming of age","volume":"7","author":"Martins","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2023.115397_bib72","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S1470-2045(16)30107-3","article-title":"Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial","volume":"17","author":"Choueiri","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.biopha.2023.115397_bib73","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/cmi.2014.24","article-title":"Effect of everolimus on the immunomodulation of the human neutrophil inflammatory response and activation","volume":"12","author":"Vitiello","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.biopha.2023.115397_bib74","first-page":"1483","article-title":"Effects of ciclosporin A, tacrolimus and sirolimus on cytokine production in neonatal immune cells","author":"Puzik","year":"2007"},{"key":"10.1016\/j.biopha.2023.115397_bib75","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/sj.bjp.0704142","article-title":"Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain","volume":"133","author":"Serkova","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2023.115397_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048063","article-title":"Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat","volume":"7","author":"Bohra","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.biopha.2023.115397_bib77","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.1024","article-title":"Effects of a ritonavir-containing regimen on the pharmacokinetics of sirolimus or everolimus in healthy adult subjects","volume":"10","author":"Zha","year":"2022","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.biopha.2023.115397_bib78","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2165\/00003088-200443020-00002","article-title":"Clinical pharmacokinetics of everolimus","volume":"43","author":"Kirchner","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.biopha.2023.115397_bib79","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1016\/j.transproceed.2010.07.083","article-title":"Comparative analysis of adverse events requiring suspension of mTOR inhibitors: everolimus versus sirolimus","volume":"42","author":"S\u00e1nchez-Fructuoso","year":"2010","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.biopha.2023.115397_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/children9091295","article-title":"Safety evaluation of oral sirolimus in the treatment of childhood diseases: a systematic review","volume":"9","author":"Zhang","year":"2022","journal-title":"Children"},{"key":"10.1016\/j.biopha.2023.115397_bib81","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpeds.2021.02.040","article-title":"Sirolimus can increase the disappearance rate of cardiac rhabdomyomas associated with tuberous sclerosis: a prospective cohort and self-controlled case series study","volume":"233","author":"Chen","year":"2021","journal-title":"J. Pediatr."},{"key":"10.1016\/j.biopha.2023.115397_bib82","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1200\/JCO.2007.14.5482","article-title":"Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors","volume":"26","author":"Tabernero","year":"2008","journal-title":"J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223011952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223011952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:30:08Z","timestamp":1782372608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223011952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":82,"alternative-id":["S0753332223011952"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115397","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxic effects of sirolimus and everolimus on the development and behavior of zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115397"}}