{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:47:08Z","timestamp":1793278028874,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.biopha.2023.115437","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T01:23:53Z","timestamp":1693963433000},"page":"115437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Tea polyphenols (TPP) as a promising wound healing agent: TPP exerts multiple and distinct mechanisms at different phases of wound healing in a mouse model"],"prefix":"10.1016","volume":"166","author":[{"given":"Hangye","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyou","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8239-2786","authenticated-orcid":false,"given":"Jingli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youying","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"03","key":"10.1016\/j.biopha.2023.115437_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0041-1731460","article-title":"Updates in diabetic wound healing, inflammation, and scarring","volume":"35","author":"Dasari","year":"2021","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.biopha.2023.115437_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.eurpolymj.2018.12.019","article-title":"The production and application of hydrogels for wound management: a review","volume":"111","author":"Gupta","year":"2019","journal-title":"Eur. Polym. J."},{"issue":"2","key":"10.1016\/j.biopha.2023.115437_bib3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/gels8020127","article-title":"Functional hydrogels for treatment of chronic wounds","volume":"8","author":"Firlar","year":"2022","journal-title":"Gels"},{"issue":"16","key":"10.1016\/j.biopha.2023.115437_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100477","article-title":"Wound healing: from passive to smart dressings","volume":"10","author":"Farahani","year":"2021","journal-title":"Adv. Healthc. Mater."},{"issue":"4","key":"10.1016\/j.biopha.2023.115437_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaad.2015.08.070","article-title":"Wound healing and treating wounds: Chronic wound care and management","volume":"74","author":"Powers","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"issue":"8","key":"10.1016\/j.biopha.2023.115437_bib6","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s12325-014-0140-x","article-title":"Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights","volume":"31","author":"Baltzis","year":"2014","journal-title":"Adv. Ther."},{"key":"10.1016\/j.biopha.2023.115437_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ijsu.2017.06.073","article-title":"Povidone iodine in wound healing: a review of current concepts and practices","volume":"44","author":"Bigliardi","year":"2017","journal-title":"Int. J. Surg."},{"issue":"9\u201310","key":"10.1016\/j.biopha.2023.115437_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s10354-017-0610-2","article-title":"Hydrogen peroxide (H(2)O(2)): a review of its use in surgery","volume":"169","author":"Urban","year":"2019","journal-title":"Wien. Med. Woche"},{"issue":"8","key":"10.1016\/j.biopha.2023.115437_bib9","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/ced.15235","article-title":"Effect of the most common wound antiseptics on human skin fibroblasts","volume":"47","author":"Rueda-Fernandez","year":"2022","journal-title":"Clin. Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115437_bib10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fshw.2021.12.010","article-title":"Multi-omics approach in tea polyphenol research regarding tea plant growth, development and tea processing: current technologies and perspectives","volume":"11","author":"Li","year":"2022","journal-title":"Food Sci. Hum. Well"},{"issue":"1","key":"10.1016\/j.biopha.2023.115437_bib11","first-page":"118","article-title":"Effects of tea polyphenols on anti-inflammation and promotion of wound healing and its mechanisms","volume":"47","author":"Zhao","year":"2021","journal-title":"J. Zhejiang Univ. Agric. Life Sci."},{"issue":"4","key":"10.1016\/j.biopha.2023.115437_bib12","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.foodchem.2011.05.120","article-title":"Characterization of the constituents and antioxidative activity of cocoa tea (Camellia ptilophylla)","volume":"129","author":"Peng","year":"2011","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.biopha.2023.115437_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/wound.2020.1165","article-title":"MicroRNA-146a deficiency delays wound healing in normal and diabetic mice","volume":"11","author":"Bi","year":"2022","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.biopha.2023.115437_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.peptides.2012.10.011","article-title":"Involvement of neurotransmitters in the action of apelin-13 on passive avoidance learning in mice","volume":"39","author":"Telegdy","year":"2013","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.biopha.2023.115437_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdermsci.2017.12.009","article-title":"Skin wound healing in humans and mice: challenges in translational research","volume":"90","author":"Zomer","year":"2018","journal-title":"J. Dermatol. Sci."},{"issue":"13","key":"10.1016\/j.biopha.2023.115437_bib16","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4155\/fmc-2020-0071","article-title":"IGF-1C domain-modified chitosan hydrogel accelerates cutaneous wound healing by promoting angiogenesis","volume":"12","author":"Li","year":"2020","journal-title":"Future Med. Chem."},{"issue":"8","key":"10.1016\/j.biopha.2023.115437_bib17","article-title":"The protective effect of snail secretion filtrate in an experimental model of excisional wounds in mice","volume":"8","author":"Gugliandolo","year":"2021","journal-title":"Vet. Sci."},{"issue":"19","key":"10.1016\/j.biopha.2023.115437_bib18","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1080\/10408398.2021.1884532","article-title":"Therapeutic implications of functional tea ingredients for ameliorating inflammatory bowel disease: a focused review","volume":"62","author":"Huang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.biopha.2023.115437_bib19","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1515\/ntrev-2022-0122","article-title":"Effect of natural-based biological hydrogels combined with growth factors on skin wound healing","volume":"11","author":"Wang","year":"2022","journal-title":"Nanotechnol. Rev."},{"issue":"6","key":"10.1016\/j.biopha.2023.115437_bib20","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1111\/iwj.14075","article-title":"The use of epidermal growth factor in dermatological practice","volume":"20","author":"Shin","year":"2023","journal-title":"Int. Wound J."},{"issue":"3","key":"10.1016\/j.biopha.2023.115437_bib21","first-page":"56","article-title":"Sources of collagen for biomaterials in skin wound healing","volume":"6","author":"Davison-Kotler","year":"2019","journal-title":"Bioeng. (Basel)"},{"key":"10.1016\/j.biopha.2023.115437_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.hermed.2023.100697","article-title":"Herbal medicine used for wound healing by the tribes of the North Eastern States of India: a comprehensive review","author":"Bordoloi","year":"2023","journal-title":"J. Herb. Med."},{"key":"10.1016\/j.biopha.2023.115437_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkaa038","article-title":"Wound healing center establishment and new technology application in improving the wound healing quality in China","volume":"8","author":"Fu","year":"2020","journal-title":"Burns Trauma"},{"issue":"11","key":"10.1016\/j.biopha.2023.115437_bib24","article-title":"Cellular and molecular events of wound healing and the potential of silver based nanoformulations as wound healing agents","volume":"9","author":"Tyavambiza","year":"2022","journal-title":"Bioeng. -Basel"},{"issue":"15","key":"10.1016\/j.biopha.2023.115437_bib25","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.3390\/cells11152439","article-title":"Innovative treatment strategies to accelerate wound healing: trajectory and recent advancements","volume":"11","author":"Kolimi","year":"2022","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.biopha.2023.115437_bib26","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.stem.2022.07.006","article-title":"Wound healing, fibroblast heterogeneity, and fibrosis","volume":"29","author":"Talbott","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.biopha.2023.115437_bib27","first-page":"798","article-title":"Recent advances and future prospects in topical creams from medicinal plants to expedite wound healing: a review","volume":"36","author":"Edoamodu","year":"2022","journal-title":"Biotechnol. Biotech. Equip."},{"issue":"2","key":"10.1016\/j.biopha.2023.115437_bib28","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3390\/pharmaceutics15020634","article-title":"Local drug delivery strategies towards wound healing","volume":"15","author":"Tiwari","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.biopha.2023.115437_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jdds.2016.09.001","article-title":"Critical role of tumor necrosis factor-alpha in the early process of wound healing in skin","volume":"21","author":"Ritsu","year":"2017","journal-title":"J. Dermatol. Dermatol."},{"issue":"12","key":"10.1016\/j.biopha.2023.115437_bib30","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.3390\/biom12121852","article-title":"Silk fibroin biomaterials and their beneficial role in skin wound healing","volume":"12","author":"Mazurek","year":"2022","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.biopha.2023.115437_bib31","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic wound healing: a review of current management and treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv. Ther."},{"issue":"11","key":"10.1016\/j.biopha.2023.115437_bib32","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1080\/17425247.2021.1989407","article-title":"Recent advancements in cellulose-based biomaterials for management of infected wounds","volume":"18","author":"Momin","year":"2021","journal-title":"Expert. Opin. Drug. Del."},{"issue":"4","key":"10.1016\/j.biopha.2023.115437_bib33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/pat.4540","article-title":"Recent advances on herb-derived constituents-incorporated wound-dressing materials: a review","volume":"30","author":"Krishnan","year":"2019","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.biopha.2023.115437_bib34","article-title":"The role of microRNA in the inflammatory response of wound healing","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115437_bib35","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.burns.2021.06.004","article-title":"Promoting effect of pomegranate peel extract on second-degree burn wound-healing through VEGF-A and TGF-beta 1 regulation","volume":"48","author":"Zhang","year":"2022","journal-title":"Burns"},{"key":"10.1016\/j.biopha.2023.115437_bib36","article-title":"Propolis modifies collagen types I and III accumulation in the matrix of burnt tissue","volume":"2013","author":"Olczyk","year":"2013","journal-title":"Evid. -Based Complement. Altern."},{"key":"10.1016\/j.biopha.2023.115437_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jconrel.2014.10.033","article-title":"The topical administration of rhEGF-loaded nanostructured lipid carriers (rhEGF-NLC) improves healing in a porcine full-thickness excisional wound model","volume":"197","author":"Gainza","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biopha.2023.115437_bib38","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.diabres.2018.06.002","article-title":"Topical epidermal growth factor spray for the treatment of chronic diabetic foot ulcers: a phase III multicenter, double-blind, randomized, placebo-controlled trial","volume":"142","author":"Park","year":"2018","journal-title":"Diabetes Res. Clin. Pract."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223012350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223012350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:42:58Z","timestamp":1782369778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223012350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":38,"alternative-id":["S0753332223012350"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115437","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tea polyphenols (TPP) as a promising wound healing agent: TPP exerts multiple and distinct mechanisms at different phases of wound healing in a mouse model","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115437","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115437"}}