{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:39:51Z","timestamp":1787744391834,"version":"build-2784847793"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["GA UK 190\/54\/251753"],"award-info":[{"award-number":["GA UK 190\/54\/251753"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["SVV 260 523"],"award-info":[{"award-number":["SVV 260 523"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006533","name":"Ministerstvo Zem\u011bd\u011blstv\u00ed","doi-asserted-by":"publisher","award":["311\/1997 Coll."],"award-info":[{"award-number":["311\/1997 Coll."]}],"id":[{"id":"10.13039\/501100006533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010719","name":"Pakistan Agricultural Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.biopha.2023.115447","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T13:59:01Z","timestamp":1694181541000},"page":"115447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Pharmacological effects of mTORC1\/C2 inhibitor in a preclinical model of NASH progression"],"prefix":"10.1016","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-9833","authenticated-orcid":false,"given":"Mahak","family":"Arora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Pavl\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Ku\u010dera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Kozl\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijana","family":"\u0160opin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Vac\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"\u013dupt\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1393-2546","authenticated-orcid":false,"given":"Matthias","family":"Duda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Slana\u0159","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolina","family":"Kutinov\u00e1 Canov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.biopha.2023.115447_bib1","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","article-title":"Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults","volume":"34","author":"Vernon","year":"2011","journal-title":"Aliment Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.biopha.2023.115447_bib3","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/jgh.12212","article-title":"Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches","volume":"28","author":"Schuppan","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/cts.12839","article-title":"Evolving role for pharmacotherapy in NAFLD\/NASH","volume":"14","author":"Attia","year":"2021","journal-title":"Clin. Transl. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2023.115447_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/cld.918","article-title":"Nutrition management strategies for nonalcoholic fatty liver disease: treatment and prevention","volume":"15","author":"Miller","year":"2020","journal-title":"Clin. Liver Dis."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s13679-022-00474-0","article-title":"Anti-obesity medications for the management of nonalcoholic fatty liver disease","volume":"11","author":"Polyzos","year":"2022","journal-title":"Curr. Obes. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/1060028020935105","article-title":"A systematic review of newer antidiabetic agents in the treatment of nonalcoholic fatty liver disease","volume":"55","author":"Dougherty","year":"2021","journal-title":"Ann. Pharmacother."},{"issue":"8","key":"10.1016\/j.biopha.2023.115447_bib9","doi-asserted-by":"crossref","first-page":"G979","DOI":"10.1152\/ajpgi.00169.2012","article-title":"PGC-1\u03b1 overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion","volume":"303","author":"Morris","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"12","key":"10.1016\/j.biopha.2023.115447_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/biology9120419","article-title":"Why hepatic CYP2E1-elevation by itself is insufficient for inciting NAFLD\/NASH: inferences from two genetic knockout mouse models","volume":"9","author":"Correia","year":"2020","journal-title":"Biology"},{"issue":"2","key":"10.1016\/j.biopha.2023.115447_bib11","first-page":"1609","article-title":"SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF\u2011\u03baB pathway in mouse kupffer cells","volume":"18","author":"Niu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2023.115447_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174857","article-title":"mTOR as an eligible molecular target for possible pharmacological treatment of nonalcoholic steatohepatitis","volume":"921","author":"Arora","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"16","key":"10.1016\/j.biopha.2023.115447_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169196","article-title":"mTOR: a potential new target in nonalcoholic fatty liver disease","volume":"23","author":"Feng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2023.115447_bib14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2020.02.070","article-title":"Lipin1 mediates cognitive impairment in fld mice via PKD-ERK pathway","volume":"525","author":"Shang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2023.115447_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2020.170375","article-title":"Liraglutide ameliorates lipotoxicity-induced inflammation through the mTORC1 signalling pathway","volume":"133","author":"Ao","year":"2020","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jcmgh.2021.04.015","article-title":"Sestrin proteins protect against lipotoxicity-induced oxidative stress in the liver via suppression of C-Jun N-terminal kinases","volume":"12","author":"Fang","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.biopha.2023.115447_bib17","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1080\/15548627.2021.1961072","article-title":"Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy","volume":"18","author":"Liu","year":"2022","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ccell.2017.11.011","article-title":"mTORC2 promotes tumorigenesis via lipid synthesis","volume":"32","author":"Guri","year":"2017","journal-title":"Cancer Cell"},{"issue":"20","key":"10.1016\/j.biopha.2023.115447_bib19","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1016\/j.bmcl.2009.08.038","article-title":"The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase","volume":"19","author":"Malagu","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.biopha.2023.115447_bib20","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.9207.1","article-title":"mTOR inhibitors in cancer therapy","volume":"5","author":"Xie","year":"2016","journal-title":"F1000Res"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2013.06.017","article-title":"mTOR kinase inhibitors as potential cancer therapeutic drugs","volume":"340","author":"Sun","year":"2013","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/BJ20090489","article-title":"Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)","volume":"421","author":"Garc\u00eda-Mart\u00ednez","year":"2009","journal-title":"Biochem. J."},{"issue":"13","key":"10.1016\/j.biopha.2023.115447_bib23","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1074\/jbc.M111.304485","article-title":"Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics","volume":"287","author":"Liu","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"37","key":"10.1016\/j.biopha.2023.115447_bib24","doi-asserted-by":"crossref","first-page":"15201","DOI":"10.1073\/pnas.1103746108","article-title":"The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib25","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/jid.2012.483","article-title":"Potent dual inhibitors of TORC1 and TORC2 complexes (KU-0063794 and KU-0068650) demonstrate in vitro and ex vivo anti-keloid scar activity","volume":"133","author":"Syed","year":"2013","journal-title":"J. Investig. Dermatol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054918","article-title":"A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biopha.2023.115447_bib27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/pr.2013.246","article-title":"Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies","volume":"75","author":"Schmid","year":"2014","journal-title":"Pedia Res."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib28","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2015.08.045","article-title":"Autophagy inhibition sensitizes KU-0063794-mediated anti-HepG2 hepatocellular carcinoma cell activity in vitro and in vivo","volume":"465","author":"Yongxi","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2023.115447_bib29","series-title":"Properties and Applications","article-title":"Isolated hepatocytes: preparation, properties and applications: preparation","author":"Berry","year":"1991"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/15376510701738421","article-title":"Modulation of spontaneous and lipopolysaccharide-induced nitric oxide production and apoptosis by d-galactosamine in rat hepatocyte culture: the significance of combinations of different methods","volume":"18","author":"Canov\u00e1","year":"2008","journal-title":"Toxicol. Mech. Methods"},{"issue":"4","key":"10.1016\/j.biopha.2023.115447_bib31","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/01480545.2016.1255953","article-title":"Acetaminophen toxicity in rat and mouse hepatocytes in vitro","volume":"40","author":"Ku\u010dera","year":"2017","journal-title":"Drug Chem. Toxicol."},{"issue":"3\u20134","key":"10.1016\/j.biopha.2023.115447_bib32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.niox.2009.09.004","article-title":"Resveratrol attenuates lipopolysaccharide-induced hepatitis in D-galactosamine sensitized rats: role of nitric oxide synthase 2 and heme oxygenase-1","volume":"21","author":"Farghali","year":"2009","journal-title":"Nitric Oxide"},{"issue":"22","key":"10.1016\/j.biopha.2023.115447_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213824","article-title":"Agomelatine, ketamine and vortioxetine attenuate energy cell metabolism-in vitro study","volume":"23","author":"\u013dupt\u00e1k","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.biopha.2023.115447_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0236612","article-title":"Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling","volume":"15","author":"La\u0111inovi\u0107","year":"2020","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib35","doi-asserted-by":"crossref","first-page":"615","DOI":"10.33549\/physiolres.932761","article-title":"D-galactosamine\/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection","volume":"63","author":"Kemelo","year":"2014","journal-title":"Physiol. Res"},{"issue":"7","key":"10.1016\/j.biopha.2023.115447_bib36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"12","key":"10.1016\/j.biopha.2023.115447_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib38","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2023.115447_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.lfs.2018.04.022","article-title":"Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis","volume":"203","author":"Chen","year":"2018","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12906-019-2671-9","article-title":"Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK\/ACC\/CPT-1A and SREBP-1c\/FAS signaling pathways in LO2 cells","volume":"19","author":"Fang","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"issue":"39","key":"10.1016\/j.biopha.2023.115447_bib41","doi-asserted-by":"crossref","first-page":"41479","DOI":"10.18632\/oncotarget.6286","article-title":"Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis","volume":"6","author":"Mart\u00ednez","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jep.2014.04.011","article-title":"Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPAR\u03b1 pathways in L02 cells and HepG2 cells","volume":"154","author":"Yin","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib43","doi-asserted-by":"crossref","first-page":"C1130","DOI":"10.1152\/ajpcell.00165.2020","article-title":"Inositol-requiring enzyme 1\u03b1 links palmitate-induced mTOR activation and lipotoxicity in hepatocytes","volume":"319","author":"Chen","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"12","key":"10.1016\/j.biopha.2023.115447_bib44","first-page":"733","article-title":"Rapamycin attenuates palmitate-induced lipid aggregation by up-regulating sirt-1 signaling in AML12 hepatocytes","volume":"71","author":"Wang","year":"2016","journal-title":"Pharmazie"},{"key":"10.1016\/j.biopha.2023.115447_bib45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fchem.2020.00407","article-title":"Rapamycin-loaded mPEG-PLGA nanoparticles ameliorate hepatic steatosis and liver injury in non-alcoholic fatty liver disease","volume":"8","author":"Zhao","year":"2020","journal-title":"Front. Chem."},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098759","article-title":"The regulation of lipid deposition by insulin in goose liver cells is mediated by the PI3K-AKT-mTOR signaling pathway","volume":"10","author":"Han","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib47","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S1359-6349(08)72253-5","article-title":"319 POSTER Pharmacodynamics and anti-tumour activity of KU-0063794, a potent and specific inhibitor of mTOR kinase","volume":"12","author":"Davies","year":"2008","journal-title":"Ejc Suppl."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11095-019-2745-x","article-title":"Intraperitoneal route of drug administration: should it be used in experimental animal studies?","volume":"37","author":"Al Shoyaib","year":"2019","journal-title":"Pharm. Res."},{"issue":"12","key":"10.1016\/j.biopha.2023.115447_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126468","article-title":"Atorvastatin modulates bile acid homeostasis in mice with diet-induced nonalcoholic steatohepatitis","volume":"22","author":"Lastuvkova","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.biopha.2023.115447_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136908","article-title":"Western diet decreases the liver mitochondrial oxidative flux of succinate: insight from a murine NAFLD model","volume":"22","author":"Sta\u0148kov\u00e1","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031101","article-title":"Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease","volume":"21","author":"Sta\u0148kov\u00e1","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib52","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1538\/expanim.19-0148","article-title":"High fat diet induced obesity model using four strainsof mice: Kunming, C57BL\/6, BALB\/c and ICR","volume":"69","author":"Li","year":"2020","journal-title":"Exp. Anim."},{"issue":"7","key":"10.1016\/j.biopha.2023.115447_bib53","first-page":"813","article-title":"Sirolimus and mTOR inhibitors: a review of side effects and specific management in solid organ transplantation","volume":"42","author":"Nguyen","year":"2019","journal-title":"Drug Saf."},{"issue":"10","key":"10.1016\/j.biopha.2023.115447_bib54","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/j.1432-2277.2008.00710.x","article-title":"Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients","volume":"21","author":"Rovira","year":"2008","journal-title":"Transpl. Int."},{"issue":"9","key":"10.1016\/j.biopha.2023.115447_bib55","doi-asserted-by":"crossref","first-page":"742","DOI":"10.18632\/aging.100688","article-title":"Rapamycin-induced metabolic defects are reversible in both lean and obese mice","volume":"6","author":"Liu","year":"2014","journal-title":"Aging"},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib56","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/hep.26594","article-title":"High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase","volume":"58","author":"Ishimoto","year":"2013","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib57","first-page":"909","article-title":"Mammalian target of the rapamycin pathway is involved in non-alcoholic fatty liver disease","volume":"3","author":"Wang","year":"2010","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib58","first-page":"2627","article-title":"Co-administration of everolimus and N-acetylcysteine attenuates hepatic stellate cell activation and hepatic fibrosis","volume":"12","author":"Choi","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib59","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/jpen.1173","article-title":"Autophagy may protect against parenteral nutrition-associated liver disease by suppressing endoplasmic reticulum stress","volume":"43","author":"Zhang","year":"2019","journal-title":"JPEN J. Parent. Enter. Nutr."},{"issue":"31","key":"10.1016\/j.biopha.2023.115447_bib60","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026835","article-title":"Decline in serum albumin concentration is a predictor of serious events in nonalcoholic fatty liver disease","volume":"100","author":"Kawaguchi","year":"2021","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-291X(03)00295-X","article-title":"Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system","volume":"303","author":"Ijichi","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.biopha.2023.115447_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006189","article-title":"Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway","volume":"4","author":"Zhang","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib63","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1038\/s41598-022-06614-9","article-title":"Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation","volume":"12","author":"Gallego-Dur\u00e1n","year":"2022","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.biopha.2023.115447_bib64","doi-asserted-by":"crossref","DOI":"10.2215\/CJN.05050610","article-title":"Relationship between Kidney Function and Liver Histology in Subjects with Nonalcoholic Steatohepatitis","volume":"5","author":"Targher","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.biopha.2023.115447_bib65","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/bjc.2012.368","article-title":"Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphoma","volume":"107","author":"Naing","year":"2012","journal-title":"Br. J. Cancer"},{"issue":"8","key":"10.1016\/j.biopha.2023.115447_bib66","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/bjc.2016.59","article-title":"A first in man, dose-finding study of the mTORC1\/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies","volume":"114","author":"Mateo","year":"2016","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib67","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0026-0495(00)90588-2","article-title":"The db\/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of western diet feeding","volume":"49","author":"Kobayashi","year":"2000","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib68","doi-asserted-by":"crossref","first-page":"G1179","DOI":"10.1152\/ajpgi.00411.2004","article-title":"Hepatic triglyceride contents are genetically determined in mice: results of a strain survey","volume":"288","author":"Lin","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2023.115447_bib69","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-nutr-071714-034355","article-title":"The roles of mTOR complexes in lipid metabolism","volume":"35","author":"Caron","year":"2015","journal-title":"Annu Rev. Nutr."},{"issue":"11","key":"10.1016\/j.biopha.2023.115447_bib70","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.metabol.2007.06.016","article-title":"The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes","volume":"56","author":"Brown","year":"2007","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.biopha.2023.115447_bib71","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1254\/jphs.08215FP","article-title":"Rapamycin protects against high fat diet\u2013induced obesity in C57BL\/6J mice","volume":"109","author":"Chang","year":"2009","journal-title":"J. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2023.115447_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.732","article-title":"Chronic everolimus treatment of high-fat diet mice leads to a reduction in obesity but impaired glucose tolerance","volume":"9","author":"Chang","year":"2021","journal-title":"Pharm. Res. Perspect."},{"issue":"8","key":"10.1016\/j.biopha.2023.115447_bib73","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1017\/S1751731116000380","article-title":"Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes","volume":"10","author":"Liu","year":"2016","journal-title":"Animal"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib74","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.hbpd.2022.10.004","article-title":"A mixed blessing for liver transplantation patients \u2014 Rapamycin","volume":"22","author":"Fan","year":"2023","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib75","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.jcmgh.2022.02.015","article-title":"Activation of liver mTORC1 protects against NASH via dual regulation of VLDL-TAG secretion and de novo lipogenesis","volume":"13","author":"Uehara","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib76","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cmet.2012.03.015","article-title":"Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c.","volume":"15","author":"Hagiwara","year":"2012","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib77","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/07315724.1996.10718600","article-title":"Susceptibility to hepatic oxidative stress in rabbits fed different animal and plant fats","volume":"15","author":"Slim","year":"1996","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.biopha.2023.115447_bib78","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.exger.2016.08.002","article-title":"Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice","volume":"83","author":"Mart\u00ednez-Cisuelo","year":"2016","journal-title":"Exp. Gerontol."},{"issue":"11","key":"10.1016\/j.biopha.2023.115447_bib79","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1002\/art.39791","article-title":"Mitochondrial dysfunction in the liver and antiphospholipid antibody production precede disease onset and respond to rapamycin in lupus-prone mice","volume":"68","author":"Oaks","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib80","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/hep.27284","article-title":"Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition","volume":"60","author":"Sapp","year":"2014","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.biopha.2023.115447_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9100995","article-title":"Western diet causes obesity-induced nonalcoholic fatty liver disease development by differentially compromising the autophagic response","volume":"9","author":"Simoes","year":"2020","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib82","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2011.10.003","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis","volume":"52","author":"Rolo","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib83","doi-asserted-by":"crossref","first-page":"939","DOI":"10.14218\/JCTH.2022.00067","article-title":"Reactive oxygen species and oxidative stress in the pathogenesis of MAFLD","volume":"10","author":"Clare","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"4","key":"10.1016\/j.biopha.2023.115447_bib84","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2362.2008.01936.x","article-title":"Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model","volume":"38","author":"Serviddio","year":"2008","journal-title":"Eur. J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib85","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13622","article-title":"Mitochondria, oxidative stress and nonalcoholic fatty liver disease: a complex relationship","volume":"52","author":"Karkucinska-Wieckowska","year":"2022","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.biopha.2023.115447_bib86","doi-asserted-by":"crossref","first-page":"6292630","DOI":"10.1155\/2017\/6292630","article-title":"mTOR inhibition rejuvenates the aging gingival fibroblasts through alleviating oxidative stress","volume":"2017","author":"Xia","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.biopha.2023.115447_bib87","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/CIRCRESAHA.114.303562","article-title":"Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling","volume":"114","author":"Yano","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2023.115447_bib88","first-page":"28","article-title":"The anti-obesity and anti-steatotic effects of chrysin in a rat model of obesity mediated through modulating the hepatic AMPK\/mTOR\/lipogenesis pathways","author":"Oriquat","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2023.115447_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114845","article-title":"Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma","volume":"195","author":"M\u00e1rquez-Quiroga","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2023.115447_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119403","article-title":"A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH","volume":"276","author":"Zhou","year":"2021","journal-title":"Life Sci."},{"issue":"28","key":"10.1016\/j.biopha.2023.115447_bib91","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.3748\/wjg.v18.i28.3635","article-title":"Cellular and molecular mechanisms of intestinal fibrosis","volume":"18","author":"Speca","year":"2012","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.biopha.2023.115447_bib92","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jhep.2010.10.044","article-title":"Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis","volume":"55","author":"Patsenker","year":"2011","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115447_bib93","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jhep.2006.07.030","article-title":"Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis","volume":"45","author":"Neef","year":"2006","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115447_bib94","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0016-5085(99)70406-3","article-title":"Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis","volume":"117","author":"Zhu","year":"1999","journal-title":"Gastroenterology"},{"issue":"69","key":"10.1016\/j.biopha.2023.115447_bib95","doi-asserted-by":"crossref","first-page":"113403","DOI":"10.18632\/oncotarget.15194","article-title":"Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL\/6J mice by inhibiting de-novo lipogenesis","volume":"8","author":"Love","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib96","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cmet.2014.05.001","article-title":"Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition","volume":"20","author":"Umemura","year":"2014","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib97","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11892-021-01377-5","article-title":"Hanley, Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications","volume":"21","author":"Martin","year":"2021","journal-title":"Curr. Diab Rep."},{"key":"10.1016\/j.biopha.2023.115447_bib98","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12967-015-0552-7","article-title":"Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice","volume":"13","author":"Ganz","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2023.115447_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.738512","article-title":"Evidence that C\/EBP-\u03b2 LAP increases fat metabolism and protects against diet-induced obesity in response to mTOR inhibition","volume":"2","author":"Bitto","year":"2021","journal-title":"Front. Aging"},{"issue":"Pt 1","key":"10.1016\/j.biopha.2023.115447_bib100","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BST0370217","article-title":"A complex interplay between Akt, TSC2 and the two mTOR complexes","volume":"37","author":"Huang","year":"2009","journal-title":"Biochem. Soc. Trans."},{"issue":"6590","key":"10.1016\/j.biopha.2023.115447_bib101","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf8271","article-title":"Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1","volume":"376","author":"Gosis","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.biopha.2023.115447_bib102","first-page":"10","article-title":"mTOR activation in liver tumors is associated with metabolic syndrome and non-alcoholic steatohepatitis in both mouse models and humans","author":"Okuno","year":"2018","journal-title":"Cancers"},{"issue":"15","key":"10.1016\/j.biopha.2023.115447_bib103","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158221","article-title":"CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload","volume":"22","author":"Harjum\u00e4ki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.biopha.2023.115447_bib104","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1172\/JCI46243","article-title":"Hepatic Sirt1 deficiency in mice impairs mTorc2\/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance","volume":"121","author":"Wang","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2023.115447_bib105","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/763257","article-title":"Role of the Nrf2-ARE pathway in liver diseases","volume":"2013","author":"Shin","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib106","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.gene.2004.06.015","article-title":"Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model","volume":"340","author":"Kim","year":"2004","journal-title":"Gene"},{"issue":"7","key":"10.1016\/j.biopha.2023.115447_bib107","first-page":"766","article-title":"Inducible nitric oxide synthase in the liver: regulation and function","volume":"63","author":"Taylor","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopha.2023.115447_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113869","article-title":"Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.biopha.2023.115447_bib109","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1034\/j.1600-0676.2001.021003161.x","article-title":"Nitric oxide and the liver","volume":"21","author":"Farzaneh-Far","year":"2001","journal-title":"Liver"},{"issue":"18","key":"10.1016\/j.biopha.2023.115447_bib110","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/ars.2016.6850","article-title":"Inducible nitric oxide synthase in the carcinogenesis of gastrointestinal cancers","volume":"26","author":"de Oliveira","year":"2016","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib111","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jcmgh.2018.09.011","article-title":"Macrophage raptor deficiency-induced lysosome dysfunction exacerbates nonalcoholic steatohepatitis","volume":"7","author":"Liu","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib112","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s42003-022-03653-w","article-title":"mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling","volume":"5","author":"Wang","year":"2022","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115447_bib113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-8-1","article-title":"The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes.","volume":"8","author":"Lisi","year":"2011","journal-title":"J. Neuroinflamm."},{"issue":"4","key":"10.1016\/j.biopha.2023.115447_bib114","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.31557\/APJCP.2019.20.4.1229","article-title":"An in silico approach to identify high affinity small molecule targeting m-TOR inhibitors for the clinical treatment of breast cancer","volume":"20","author":"Patidar","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223012453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223012453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:32:33Z","timestamp":1776461553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223012453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":114,"alternative-id":["S0753332223012453"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115447","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological effects of mTORC1\/C2 inhibitor in a preclinical model of NASH progression","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115447"}}