{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:33:31Z","timestamp":1789612411322,"version":"build-2803163510"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010032","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["202140282"],"award-info":[{"award-number":["202140282"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key Areas of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1111110003"],"award-info":[{"award-number":["2020B1111110003"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["23ZR1448700"],"award-info":[{"award-number":["23ZR1448700"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.biopha.2023.115643","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T07:25:25Z","timestamp":1697181925000},"page":"115643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Unveiling the dual role of autophagy in vascular remodelling and its related diseases"],"prefix":"10.1016","volume":"168","author":[{"given":"Hangui","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongchen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Najbah","family":"Nik Nabil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2023.115643_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-319-96445-4_4","article-title":"Mechanobiology and vascular remodeling: from membrane to nucleus","volume":"1097","author":"Qi","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115643_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41374-019-0192-2","article-title":"The pathophysiological basis of vascular disease","volume":"99","author":"Lyle","year":"2019","journal-title":"Lab Invest."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molmed.2016.11.005","article-title":"Targeting vascular remodeling to treat pulmonary arterial hypertension","volume":"23","author":"Thompson","year":"2017","journal-title":"Trends Mol. Med"},{"issue":"22","key":"10.1016\/j.biopha.2023.115643_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225694","article-title":"The role of vascular smooth muscle cells in arterial remodeling: focus on calcification-related processes","volume":"20","author":"Jaminon","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2023.115643_bib5","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1161\/ATVBAHA.119.312131","article-title":"Smooth muscle cell phenotypic diversity","volume":"39","author":"Liu","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2023.115643_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/MNH.0b013e328335eec9","article-title":"Role of extracellular matrix in vascular remodeling of hypertension","volume":"19","author":"Briones","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"10","key":"10.1016\/j.biopha.2023.115643_bib7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1089\/ars.2020.8110","article-title":"Vascular extracellular matrix remodeling and hypertension","volume":"34","author":"Cai","year":"2021","journal-title":"Antioxid. Redox Signal"},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41392-023-01430-7","article-title":"Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions","volume":"8","author":"Ma","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.biopha.2023.115643_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehad386","article-title":"Pathogenesis and management of abdominal aortic aneurysm","author":"Golledge","year":"2023","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.biopha.2023.115643_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115643_bib11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41576-022-00562-w","article-title":"Autophagy genes in biology and disease","volume":"24","author":"Yamamoto","year":"2023","journal-title":"Nat. Rev. Genet"},{"issue":"5","key":"10.1016\/j.biopha.2023.115643_bib12","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41419-022-04906-6","article-title":"Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.biopha.2023.115643_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1164\/rccm.201005-0746OC","article-title":"Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension","volume":"183","author":"Lee","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41420-022-00995-6","article-title":"Ibandronate promotes autophagy by inhibiting Rac1-mTOR signaling pathway in vitro and in vivo","volume":"8","author":"Han","year":"2022","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jcp.22709","article-title":"Osteopontin stimulates autophagy via integrin\/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells","volume":"227","author":"Zheng","year":"2012","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.biopha.2023.115643_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2555476","article-title":"Aldehyde dehydrogenase 2 (ALDH2) elicits protection against pulmonary hypertension via inhibition of ERK1\/2-mediated autophagy","volume":"2022","author":"Chang","year":"2022","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.biopha.2023.115643_bib17","first-page":"5","article-title":"Autophagy mediates tumor necrosis factor-\u03b1-induced phenotype switching in vascular smooth muscle A7r5 cell line","volume":"13","author":"Pintus","year":"2018","journal-title":"Plos One"},{"issue":"4","key":"10.1016\/j.biopha.2023.115643_bib18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/cvr\/cvy022","article-title":"Smooth muscle cell fate and plasticity in atherosclerosis","volume":"114","author":"Allahverdian","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"7855","key":"10.1016\/j.biopha.2023.115643_bib19","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2023.115643_bib20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ni.2001","article-title":"The immune system in atherosclerosis","volume":"12","author":"Hansson","year":"2011","journal-title":"Nat. Immunol."},{"issue":"25","key":"10.1016\/j.biopha.2023.115643_bib21","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.jacc.2007.02.059","article-title":"Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior","volume":"49","author":"Chatzizisis","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.biopha.2023.115643_bib22","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/hc0802.104327","article-title":"Relationship between coronary artery remodeling and plaque vulnerability","volume":"105","author":"Varnava","year":"2002","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jcmg.2013.10.007","article-title":"Impact of positive and negative lesion site remodeling on clinical outcomes: insights from PROSPECT","volume":"7","author":"Inaba","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"issue":"11","key":"10.1016\/j.biopha.2023.115643_bib24","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1093\/cvr\/cvab046","article-title":"Vascular smooth muscle cells in atherosclerosis: time for a re-assessment","volume":"117","author":"Grootaert","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.biopha.2023.115643_bib25","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1093\/cvr\/cvab046","article-title":"Vascular smooth muscle cells in atherosclerosis: time for a re-assessment","volume":"117","author":"Grootaert","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"4","key":"10.1016\/j.biopha.2023.115643_bib26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCRESAHA.115.306361","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"118","author":"Bennett","year":"2016","journal-title":"Circ. Res"},{"issue":"4","key":"10.1016\/j.biopha.2023.115643_bib27","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/cvr\/cvy007","article-title":"Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis","volume":"114","author":"Grootaert","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.biopha.2023.115643_bib28","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1080\/15548627.2018.1501132","article-title":"Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis","volume":"14","author":"Osonoi","year":"2018","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.biopha.2023.115643_bib29","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1080\/15548627.2015.1096485","article-title":"Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis","volume":"11","author":"Grootaert","year":"2015","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.biopha.2023.115643_bib30","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1096\/fj.201800975RRR","article-title":"SCAPknockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formationviaup\u2010regulating autophagy inApoE\u2212\/\u2212mice","volume":"33","author":"Li","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2023.115643_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41419-018-1197-2","article-title":"Contribution of p62\/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"9587","key":"10.1016\/j.biopha.2023.115643_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","article-title":"Essential hypertension","volume":"370","author":"Messerli","year":"2007","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.biopha.2023.115643_bib33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/CIRCRESAHA.121.318083","article-title":"Guideline-driven management of hypertension: an evidence-based update","volume":"128","author":"Carey","year":"2021","journal-title":"Circ. Res"},{"issue":"10","key":"10.1016\/j.biopha.2023.115643_bib34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41581-021-00430-6","article-title":"Hypertension-induced cognitive impairment: from pathophysiology to public health","volume":"17","author":"Ungvari","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115643_bib35","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/ajh\/hpaa195","article-title":"Mechanisms of vascular remodeling in hypertension","volume":"34","author":"Humphrey","year":"2021","journal-title":"Am. J. Hypertens."},{"issue":"4","key":"10.1016\/j.biopha.2023.115643_bib36","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/cvr\/cvaa164","article-title":"Single-cell RNA sequencing reveals cell type- and artery type-specific vascular remodelling in male spontaneously hypertensive rats","volume":"117","author":"Cheng","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.biopha.2023.115643_bib37","doi-asserted-by":"crossref","unstructured":"Konukoglu D., Uzun H. Endothelial Dysfunction and Hypertension. Hypertension: From Basic Research to Clinical Practice, Vol 2. 2017;956:511\u2013540.","DOI":"10.1007\/5584_2016_90"},{"issue":"9","key":"10.1016\/j.biopha.2023.115643_bib38","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/ATVBAHA.118.311229","article-title":"Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension","volume":"38","author":"Brown","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3 Pt 2","key":"10.1016\/j.biopha.2023.115643_bib39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/hy09t1.096249","article-title":"Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis","volume":"38","author":"Intengan","year":"2001","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2023.115643_bib40","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.biopha.2023.115643_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105920","article-title":"Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2\/AMPK\/TSC2 pathway","volume":"173","author":"Li","year":"2021","journal-title":"Pharm. Res"},{"issue":"10","key":"10.1016\/j.biopha.2023.115643_bib42","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/CIRCRESAHA.118.314032","article-title":"Endothelial SIRT6 is vital to prevent hypertension and associated cardiorenal injury through targeting Nkx3.2-GATA5 signaling","volume":"124","author":"Guo","year":"2019","journal-title":"Circ. Res"},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118855","article-title":"Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application","volume":"1868","author":"Li","year":"2021","journal-title":"Biochim Biophys. Acta Mol. Cell Res"},{"issue":"8","key":"10.1016\/j.biopha.2023.115643_bib44","doi-asserted-by":"crossref","first-page":"627","DOI":"10.21037\/atm-20-6891","article-title":"Apelin receptor upregulation in spontaneously hypertensive rat contributes to the enhanced vascular smooth muscle cell proliferation by activating autophagy","volume":"9","author":"Xu","year":"2021","journal-title":"Ann. Transl. Med"},{"issue":"9","key":"10.1016\/j.biopha.2023.115643_bib45","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.7150\/thno.41028","article-title":"TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting Bcl-2-p62 complex formation","volume":"10","author":"Lv","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2023.115643_bib46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actbio.2019.01.070","article-title":"The role of tissue remodeling in mechanics and pathogenesis of abdominal aortic aneurysms","volume":"88","author":"Niestrawska","year":"2019","journal-title":"Acta Biomater."},{"issue":"24","key":"10.1016\/j.biopha.2023.115643_bib47","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.023601","article-title":"Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms","volume":"10","author":"Lu","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"17","key":"10.1016\/j.biopha.2023.115643_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176334","article-title":"Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm","volume":"21","author":"Gurung","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib49","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejvs.2009.01.020","article-title":"Gene expression profiling of peripheral blood in patients with abdominal aortic aneurysm","volume":"38","author":"Giusti","year":"2009","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"3","key":"10.1016\/j.biopha.2023.115643_bib50","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jvs.2017.08.086","article-title":"Loss of vascular smooth muscle cell autophagy exacerbates angiotensin II-associated aortic remodeling","volume":"68","author":"Ramadan","year":"2018","journal-title":"J. Vasc. Surg."},{"issue":"3","key":"10.1016\/j.biopha.2023.115643_bib51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000513465","article-title":"Metformin inhibits abdominal aortic aneurysm formation through the activation of the AMPK\/mTOR signaling pathway","volume":"58","author":"He","year":"2021","journal-title":"J. Vasc. Res"},{"key":"10.1016\/j.biopha.2023.115643_bib52","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3389\/fphys.2020.00866","article-title":"Melatonin plays a critical protective role in nicotine-related abdominal aortic aneurysm","volume":"11","author":"Duan","year":"2020","journal-title":"Front Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2023.115643_bib53","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jvs.2004.05.020","article-title":"Rapamycin suppresses experimental aortic aneurysm growth","volume":"40","author":"Lawrence","year":"2004","journal-title":"J. Vasc. Surg."},{"issue":"5","key":"10.1016\/j.biopha.2023.115643_bib54","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ejvs.2014.02.006","article-title":"Rapamycin limits the growth of established experimental abdominal aortic aneurysms","volume":"47","author":"Rouer","year":"2014","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"6","key":"10.1016\/j.biopha.2023.115643_bib55","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202202158RR","article-title":"Mitochondrial quality control in abdominal aortic aneurysm: From molecular mechanisms to therapeutic strategies","volume":"37","author":"Wang","year":"2023","journal-title":"FASEB J."},{"issue":"17","key":"10.1016\/j.biopha.2023.115643_bib56","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15000","article-title":"Defective autophagy in vascular smooth muscle cells enhances the healing of abdominal aortic aneurysm","volume":"9","author":"Mochida","year":"2021","journal-title":"Physiol. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molmed.2016.11.005","article-title":"Targeting vascular remodeling to treat pulmonary arterial hypertension","volume":"23","author":"Thompson","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.biopha.2023.115643_bib58","first-page":"360","article-title":"Pulmonary arterial hypertension: pathogenesis and clinical management","author":"Thenappan","year":"2018","journal-title":"Bmj-Br. Med. J."},{"issue":"9\u201310","key":"10.1016\/j.biopha.2023.115643_bib59","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10495-018-1477-4","article-title":"The role of autophagy in pulmonary hypertension: a double-edge sword","volume":"23","author":"Chen","year":"2018","journal-title":"Apoptosis"},{"issue":"10","key":"10.1016\/j.biopha.2023.115643_bib60","doi-asserted-by":"crossref","first-page":"16755","DOI":"10.1002\/jcp.28531","article-title":"Autophagy in pulmonary hypertension: emerging roles and therapeutic implications","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib61","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3892\/ijmm.2015.2224","article-title":"Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway","volume":"36","author":"Li","year":"2015","journal-title":"Int J. Mol. Med"},{"issue":"4","key":"10.1016\/j.biopha.2023.115643_bib62","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1165\/rcmb.2012-0446OC","article-title":"Adenosine monophosphate-activated protein kinase is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension","volume":"49","author":"Ibe","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115643_bib63","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00408-022-00569-4","article-title":"Activation of autophagy induces monocrotaline-induced pulmonary arterial hypertension by FOXM1-mediated FAK phosphorylation","volume":"200","author":"Zhai","year":"2022","journal-title":"Lung"},{"issue":"7","key":"10.1016\/j.biopha.2023.115643_bib64","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41419-022-05091-2","article-title":"FUNDC1-mediated mitophagy and HIF1alpha activation drives pulmonary hypertension during hypoxia","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2023.115643_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175968","article-title":"Downregulation of PDCD4 through STAT3\/ATF6\/autophagy mediates MIF-induced PASMCs proliferation\/migration and vascular remodeling","volume":"956","author":"Chai","year":"2023","journal-title":"Eur. J. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13578-022-00744-3","article-title":"Ubiquitinated AIF is a major mediator of hypoxia-induced mitochondrial dysfunction and pulmonary artery smooth muscle cell proliferation","volume":"12","author":"Ma","year":"2022","journal-title":"Cell Biosci."},{"issue":"5","key":"10.1016\/j.biopha.2023.115643_bib67","doi-asserted-by":"crossref","first-page":"L899","DOI":"10.1152\/ajplung.00527.2016","article-title":"Endothelial cell-related autophagic pathways in Sugen\/hypoxia-exposed pulmonary arterial hypertensive rats","volume":"313","author":"Kato","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib68","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/HYPERTENSIONAHA.122.19397","article-title":"The novel lysosomal autophagy inhibitor (ROC-325) ameliorates experimental pulmonary hypertension","volume":"80","author":"Bao","year":"2023","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.biopha.2023.115643_bib69","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res"},{"key":"10.1016\/j.biopha.2023.115643_bib70","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2013.06.002","article-title":"A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling","volume":"101\u2013102","author":"Saito","year":"2014","journal-title":"J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2023.115643_bib71","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1161\/HYPERTENSIONAHA.110.157743","article-title":"Learning from the placenta: acute atherosis and vascular remodeling in preeclampsia-novel aspects for atherosclerosis and future cardiovascular health","volume":"56","author":"Staff","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2023.115643_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110699","article-title":"Endovascular trophoblast and spiral artery remodeling","volume":"503","author":"Sato","year":"2020","journal-title":"Mol. Cell Endocrinol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115643_bib73","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4161\/auto.22927","article-title":"Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia","volume":"9","author":"Nakashima","year":"2014","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2022.100712","article-title":"MiR-141-3p promotes hypoxia-induced autophagy in human placental trophoblast cells","volume":"23","author":"Luo","year":"2023","journal-title":"Reprod. Biol."},{"issue":"10","key":"10.1016\/j.biopha.2023.115643_bib75","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1210\/en.2012-1472","article-title":"Hypoxia induces autophagy in primary human trophoblasts","volume":"153","author":"Chen","year":"2012","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.biopha.2023.115643_bib76","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.ajpath.2018.07.021","article-title":"Trophoblast-specific conditional Atg7 knockout mice develop gestational hypertension","volume":"188","author":"Aoki","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2023.115643_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102813","article-title":"The inhibition of protein kinase C beta contributes to the pathogenesis of preeclampsia by activating autophagy","volume":"56","author":"Zhao","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.biopha.2023.115643_bib78","first-page":"1","article-title":"Astaxanthin impact on brain: health potential and market perspective","author":"Cunha","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.biopha.2023.115643_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4629189","article-title":"Astaxanthin attenuates hypertensive vascular remodeling by protecting vascular smooth muscle cells from oxidative stress-induced mitochondrial dysfunction","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"issue":"6374","key":"10.1016\/j.biopha.2023.115643_bib80","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2788","article-title":"Spermidine in health and disease","volume":"359","author":"Madeo","year":"2018","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.biopha.2023.115643_bib81","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014757","article-title":"Spermidine suppresses development of experimental abdominal aortic aneurysms","volume":"9","author":"Liu","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.biopha.2023.115643_bib82","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41419-020-2326-2","article-title":"A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.biopha.2023.115643_bib83","article-title":"Effects of Bcl-2\/Bcl-x(L) inhibitors on pulmonary artery smooth muscle cells","volume":"7","author":"Rybka","year":"2018","journal-title":"Antioxid. (Basel)"},{"issue":"3","key":"10.1016\/j.biopha.2023.115643_bib84","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1042\/BJ20121344","article-title":"PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress","volume":"451","author":"Salabei","year":"2013","journal-title":"Biochem J."},{"issue":"2","key":"10.1016\/j.biopha.2023.115643_bib85","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1039\/D2NH00348A","article-title":"Attenuating endothelial leakiness with self-assembled DNA nanostructures for pulmonary arterial hypertension","volume":"8","author":"Liu","year":"2023","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.biopha.2023.115643_bib86","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejphar.2019.02.008","article-title":"Dacomitinib, a new pan-EGFR inhibitor, is effective in attenuating pulmonary vascular remodeling and pulmonary hypertension","volume":"850","author":"Yu","year":"2019","journal-title":"Eur. J. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib87","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1124\/jpet.117.239921","article-title":"Docetaxel reverses pulmonary vascular remodeling by decreasing autophagy and resolves right ventricular fibrosis","volume":"363","author":"Ibrahim","year":"2017","journal-title":"J. Pharm. Exp. Ther."},{"issue":"8","key":"10.1016\/j.biopha.2023.115643_bib88","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/CIRCRESAHA.111.300483","article-title":"Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation","volume":"112","author":"Long","year":"2013","journal-title":"Circ. Res"},{"issue":"6","key":"10.1016\/j.biopha.2023.115643_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062919","article-title":"Preclinical investigation of trifluoperazine as a novel therapeutic agent for the treatment of pulmonary arterial hypertension","volume":"22","author":"Grobs","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2023.115643_bib90","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1152\/physiol.00039.2019","article-title":"Cellular pathways promoting pulmonary vascular remodeling by hypoxia","volume":"35","author":"Shimoda","year":"2020","journal-title":"Physiology"},{"key":"10.1016\/j.biopha.2023.115643_bib91","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-981-16-2830-6_9","article-title":"Autophagic flux detection: significance and methods involved","volume":"1208","author":"Zhang","year":"2021","journal-title":"Adv. Exp. Med Biol."},{"issue":"5","key":"10.1016\/j.biopha.2023.115643_bib92","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/aps.2012.184","article-title":"Why should autophagic flux be assessed?","volume":"34","author":"Zhang","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2023.115643_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114139","article-title":"How ginseng regulates autophagy: insights from multistep process","volume":"158","author":"Ren","year":"2023","journal-title":"Biomed. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2023.115643_bib94","first-page":"42","article-title":"The regulation of neuronal autophagy and cell survival by MCL1 in Alzheimer's disease","volume":"1","author":"Rezaeian","year":"2022","journal-title":"Acta Mater. Med"},{"issue":"9","key":"10.1016\/j.biopha.2023.115643_bib95","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/s41388-017-0046-6","article-title":"Dual role of autophagy in hallmarks of cancer","volume":"37","author":"Singh","year":"2018","journal-title":"Oncogene"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:26:18Z","timestamp":1779917178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223014415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":95,"alternative-id":["S0753332223014415"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115643","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the dual role of autophagy in vascular remodelling and its related diseases","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115643"}}