{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:14:06Z","timestamp":1785168846678,"version":"3.55.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","award":["xzy012022130"],"award-info":[{"award-number":["xzy012022130"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.biopha.2023.115646","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:08:08Z","timestamp":1696511288000},"page":"115646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Therapeutics of osteoarthritis and pharmacological mechanisms: A focus on RANK\/RANKL signaling"],"prefix":"10.1016","volume":"167","author":[{"given":"Jingqi","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4594-3603","authenticated-orcid":false,"given":"Hongmou","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2023.115646_bib1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2023.115646_bib2","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.biopha.2023.115646_bib3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/1573397113666170807122312","article-title":"Novel Insights into the Pathogenesis of Osteoarthritis","volume":"14","author":"Geyer","year":"2018","journal-title":"Curr. Rheuma Rev."},{"key":"10.1016\/j.biopha.2023.115646_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2023.05.005","article-title":"Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography","author":"Muratovic","year":"2023","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.115646_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109789","article-title":"Signaling pathways affected by mutations causing osteogenesis imperfecta","volume":"76","author":"Etich","year":"2020","journal-title":"Cell Signal"},{"key":"10.1016\/j.biopha.2023.115646_bib6","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/rheumatology\/keab440","article-title":"The role of TNFRSF11B in development of osteoarthritic cartilage","volume":"61","author":"Rodriguez Ruiz","year":"2022","journal-title":"Rheumatology"},{"key":"10.1016\/j.biopha.2023.115646_bib7","article-title":"Current comprehensive understanding of denosumab (the RANKL neutralizing antibody) in the treatment of bone metastasis of malignant tumors, including pharmacological mechanism and clinical trials","volume":"13","author":"Lu","year":"2023","journal-title":"Front Oncol."},{"key":"10.1016\/j.biopha.2023.115646_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.bone.2008.04.006","article-title":"Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors","volume":"43","author":"Tat","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.biopha.2023.115646_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.14348\/molcells.2015.2241","article-title":"MicroRNA-26a regulates RANKL-induced osteoclast formation","volume":"38","author":"Kim","year":"2015","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biopha.2023.115646_bib10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.msec.2017.08.069","article-title":"3D printing hydrogel with graphene oxide is functional in cartilage protection by influencing the signal pathway of Rank\/Rankl\/OPG","volume":"82","author":"Cheng","year":"2018","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"key":"10.1016\/j.biopha.2023.115646_bib11","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/rheumatology\/kep300","article-title":"Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis","volume":"48","author":"Kwan Tat","year":"2009","journal-title":"Rheumatology"},{"key":"10.1016\/j.biopha.2023.115646_bib12","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201600R","article-title":"The STING inhibitor C-176 attenuates osteoclast-related osteolytic diseases by inhibiting osteoclast differentiation","volume":"37","author":"Yu","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2023.115646_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.842538","article-title":"Alpha-7 nicotinic receptor dampens murine osteoblastic response to inflammation and age-related osteoarthritis","volume":"13","author":"Courties","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.biopha.2023.115646_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106376","article-title":"Esculentoside A protects against osteoarthritis by ameliorating inflammation and repressing osteoclastogenesis","volume":"82","author":"Shao","year":"2020","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.biopha.2023.115646_bib15","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.joca.2015.08.015","article-title":"Inflammation in joint injury and post-traumatic osteoarthritis","volume":"23","author":"Lieberthal","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.115646_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41413-021-00183-9","article-title":"IkappaB-zeta signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology","volume":"10","author":"Arra","year":"2022","journal-title":"Bone Res"},{"key":"10.1016\/j.biopha.2023.115646_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106321","article-title":"PD0325901, an ERK inhibitor, attenuates RANKL-induced osteoclast formation and mitigates cartilage inflammation by inhibiting the NF-kappaB and MAPK pathways","volume":"132","author":"Jiang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.biopha.2023.115646_bib18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2015.10.008","article-title":"Osteoclasts are recruited to the subchondral bone in naturally occurring post-traumatic equine carpal osteoarthritis and may contribute to cartilage degradation","volume":"24","author":"Bertuglia","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.115646_bib19","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.joca.2014.07.013","article-title":"Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis","volume":"22","author":"Yan","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.115646_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184653","article-title":"Regulatory effects and interactions of the Wnt and OPG-RANKL-RANK signaling at the bone-cartilage interface in osteoarthritis","volume":"20","author":"Kovacs","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.115646_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bone.2010.09.010","article-title":"Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats","volume":"48","author":"Jiao","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.biopha.2023.115646_bib22","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1172\/JCI200316069","article-title":"Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis","volume":"111","author":"Ritchlin","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2023.115646_bib23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/0022034515576051","article-title":"Wnt5a\/Ror2 mediates temporomandibular joint subchondral bone remodeling","volume":"94","author":"Yang","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.biopha.2023.115646_bib24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/rheumatology\/keac232","article-title":"Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization","volume":"62","author":"Rodriguez Ruiz","year":"2022","journal-title":"Rheumatology"},{"key":"10.1016\/j.biopha.2023.115646_bib25","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/s41401-021-00747-9","article-title":"Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK\/c-fos\/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion","volume":"43","author":"Fang","year":"2022","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.biopha.2023.115646_bib26","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1172\/JCI121561","article-title":"Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain","volume":"129","author":"Zhu","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2023.115646_bib27","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/joor.12649","article-title":"Th1\/Th17\/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: a preliminary report","volume":"45","author":"Monasterio","year":"2018","journal-title":"J. Oral. Rehabil."},{"key":"10.1016\/j.biopha.2023.115646_bib28","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ajpath.2022.02.003","article-title":"Inflammasome activation in the hip synovium of rapidly destructive coxopathy patients and its relationship with the development of synovitis and bone loss","volume":"192","author":"Yokota","year":"2022","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2023.115646_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115616","article-title":"Human dendritic cell-derived osteoclasts with high bone resorption capacity and T cell stimulation ability","volume":"142","author":"Narisawa","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.biopha.2023.115646_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121405","article-title":"Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL\/OPG axis","volume":"316","author":"Mostafa","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2023.115646_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10067-021-05846-w","article-title":"Blockade of adiponectin receptor 1 signaling inhibits synovial inflammation and alleviates joint damage in collagen-induced arthritis","volume":"41","author":"Wang","year":"2022","journal-title":"Clin. Rheuma"},{"key":"10.1016\/j.biopha.2023.115646_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010120","article-title":"Role of synovial exosomes in osteoclast differentiation in inflammatory arthritis","volume":"10","author":"Song","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2023.115646_bib33","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/art.42074","article-title":"Role of lysine-specific demethylase 1 in metabolically integrating osteoclast differentiation and inflammatory bone resorption through hypoxia-inducible factor 1alpha and E2F1","volume":"74","author":"Doi","year":"2022","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.biopha.2023.115646_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2019.07.002","article-title":"Applications of RNA interference in the treatment of arthritis","volume":"214","author":"Rai","year":"2019","journal-title":"Transl. Res"},{"key":"10.1016\/j.biopha.2023.115646_bib35","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1517\/14656566.2013.825606","article-title":"New and emerging treatments for osteoarthritis management: will the dream come true with personalized medicine","volume":"14","author":"Roubille","year":"2013","journal-title":"Expert Opin. Pharm."},{"key":"10.1016\/j.biopha.2023.115646_bib36","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1471-2474-13-154","article-title":"Inhibition of osteoclastogenesis by RNA interference targeting RANK","volume":"13","author":"Ma","year":"2012","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.biopha.2023.115646_bib37","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.joca.2012.08.011","article-title":"In vivo reduction or blockade of interleukin-1beta in primary osteoarthritis influences expression of mediators implicated in pathogenesis","volume":"20","author":"Santangelo","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.115646_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108348","article-title":"MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-kappaB1-RANKL pathway in fibroblast-like synoviocytes","volume":"212","author":"Lee","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.biopha.2023.115646_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.116024","article-title":"The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1\/TNF-alpha\/IL-6 signaling through Mir-149-5p","volume":"151","author":"Chiu","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.biopha.2023.115646_bib40","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/jbmr.4527","article-title":"Melatonin prevents cartilage degradation in early-stage osteoarthritis through activation of miR-146a\/NRF2\/HO-1 axis","volume":"37","author":"Zhou","year":"2022","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.biopha.2023.115646_bib41","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1093\/rheumatology\/keab018","article-title":"Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization","volume":"60","author":"Wang","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.biopha.2023.115646_bib42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm1190","article-title":"Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy","volume":"11","author":"Ito","year":"2005","journal-title":"Nat. Med"},{"key":"10.1016\/j.biopha.2023.115646_bib43","first-page":"2285","article-title":"Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis","volume":"9","author":"Yeh","year":"2015","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.biopha.2023.115646_bib44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.joca.2021.06.014","article-title":"Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice","volume":"30","author":"Lee","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.115646_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176046","article-title":"Emerging gene-editing modalities for osteoarthritis","volume":"21","author":"Tanikella","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.115646_bib46","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/annrheumdis-2018-214724","article-title":"Exploration of CRISPR\/Cas9-based gene editing as therapy for osteoarthritis","volume":"78","author":"Zhao","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2023.115646_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031467","article-title":"Mitochondrial genome editing to treat human osteoarthritis-a narrative review","volume":"23","author":"Zhong","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.115646_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238330","article-title":"Characterization of CRISPR\/Cas9 RANKL knockout mesenchymal stem cell clones based on single-cell printing technology and Emulsion Coupling assay as a low-cellularity workflow for single-cell cloning","volume":"16","author":"Gross","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2023.115646_bib49","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/s41419-018-1225-2","article-title":"Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis","volume":"9","author":"Varela-Eirin","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2023.115646_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.b.35261","article-title":"Anatomy, molecular structures, and hyaluronic acid - Gelatin injectable hydrogels as a therapeutic alternative for hyaline cartilage recovery: a review","author":"Vaca-Gonzalez","year":"2023","journal-title":"J. Biomed. Mater. Res B Appl. Biomater."},{"key":"10.1016\/j.biopha.2023.115646_bib51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.joca.2013.10.013","article-title":"High molecular weight hyaluronic acid regulates osteoclast formation by inhibiting receptor activator of NF-kappaB ligand through Rho kinase","volume":"22","author":"Ariyoshi","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2023.115646_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119667","article-title":"A hyaluronic acid\/platelet-rich plasma hydrogel containing MnO(2) nanozymes efficiently alleviates osteoarthritis in vivo","volume":"292","author":"Zhou","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2023.115646_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120967","article-title":"Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment","volume":"275","author":"Kang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2023.115646_bib54","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1590\/s0102-865020170060000002","article-title":"The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model","volume":"32","author":"Zhang","year":"2017","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.biopha.2023.115646_bib55","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1111\/jcmm.15064","article-title":"Osthole-loaded N-octyl-O-sulfonyl chitosan micelles (NSC-OST) inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in rats","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.biopha.2023.115646_bib56","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jbm.a.35919","article-title":"Formulation and in vitro and in vivo evaluation of a new osteoprotegerin-chitosan gel for bone tissue regeneration","volume":"105","author":"Jayash","year":"2017","journal-title":"J. Biomed. Mater. Res A"},{"key":"10.1016\/j.biopha.2023.115646_bib57","doi-asserted-by":"crossref","first-page":"6717","DOI":"10.7150\/thno.56607","article-title":"Bi-directional regulation functions of lanthanum-substituted layered double hydroxide nanohybrid scaffolds via activating osteogenesis and inhibiting osteoclastogenesis for osteoporotic bone regeneration","volume":"11","author":"Chu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2023.115646_bib58","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s12951-021-01086-x","article-title":"Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.biopha.2023.115646_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41467-021-27738-y","article-title":"PPARalpha-ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis","volume":"13","author":"Park","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2023.115646_bib60","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijbiomac.2022.06.079","article-title":"Chitosan-based biomaterials for the treatment of bone disorders","volume":"215","author":"Rahimi","year":"2022","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2023.115646_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105703","article-title":"Berberine coated mannosylated liposomes curtail RANKL stimulated osteoclastogenesis through the modulation of GSK3beta pathway via upregulating miR-23a","volume":"74","author":"Sujitha","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2023.115646_bib62","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jconrel.2011.03.001","article-title":"Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis","volume":"152","author":"Hofkens","year":"2011","journal-title":"J. Control Release"},{"key":"10.1016\/j.biopha.2023.115646_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102741","article-title":"An Overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions","volume":"20","author":"Ilchovska","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.biopha.2023.115646_bib64","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41584-022-00793-5","article-title":"Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions","volume":"18","author":"Komatsu","year":"2022","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.biopha.2023.115646_bib65","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1152\/physrev.00036.2016","article-title":"Osteoimmunology: the conceptual framework unifying the immune and skeletal systems","volume":"97","author":"Okamoto","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2023.115646_bib66","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.41666","article-title":"Characterization and function of tumor necrosis factor and interleukin-6-induced osteoclasts in rheumatoid arthritis","volume":"73","author":"Yokota","year":"2021","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.biopha.2023.115646_bib67","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2021.08.011","article-title":"Exercise to mend aged-tissue crosstalk in bone targeting osteoporosis & osteoarthritis","volume":"123","author":"Little-Letsinger","year":"2022","journal-title":"Semin Cell Dev. Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:40:32Z","timestamp":1776462032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223014440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":67,"alternative-id":["S0753332223014440"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115646","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutics of osteoarthritis and pharmacological mechanisms: A focus on RANK\/RANKL signaling","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115646","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115646"}}