{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:30:20Z","timestamp":1787243420367,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012546","name":"Chongqing Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021XM2037"],"award-info":[{"award-number":["2021XM2037"]}],"id":[{"id":"10.13039\/100012546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2020jcyj-msxmX0698"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0698"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["cstc2021jcyj-bshX0147"],"award-info":[{"award-number":["cstc2021jcyj-bshX0147"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.biopha.2023.115657","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:42:18Z","timestamp":1697154138000},"page":"115657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["5-Bromo-3,4-dihydroxybenzaldehyde stabilizes diabetic retinal neurovascular units by inhibiting the inflammatory microenvironment"],"prefix":"10.1016","volume":"168","author":[{"given":"Qionghua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-5006","authenticated-orcid":false,"given":"Yanhong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kepeng","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2023.115657_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106292","article-title":"Redoxisome and diabetic retinopathy: Pathophysiology and therapeutic interventions","author":"Sharma","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biopha.2023.115657_bib2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMra1005073","article-title":"Diabetic retinopathy","volume":"13","author":"Antonetti","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2023.115657_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2337\/diabetes.55.03.06.db05-1349","article-title":"Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina","volume":"3","author":"Pannicke","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2023.115657_bib4","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1523\/JNEUROSCI.3483-13.2014","article-title":"Dopamine deficiency contributes to early visual dysfunction in a rodent model of type 1 diabetes","volume":"3","author":"Aung","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2023.115657_bib5","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1167\/iovs.07-0683","article-title":"Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice","volume":"6","author":"Gastinger","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biopha.2023.115657_bib6","article-title":"Post-translational processing of synaptophysin in the rat retina is disrupted by diabetes","volume":"9","author":"D'Cruz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2023.115657_bib7","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1111\/jcmm.15016","article-title":"Treatment of diabetic retinopathy through neuropeptide Y-mediated enhancement of neurovascular microenvironment","volume":"7","author":"Ou","year":"2020","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.biopha.2023.115657_bib8","first-page":"6","article-title":"Diabetic retinopathy: pathophysiology and treatments","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2023.115657_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41433-019-0652-3","article-title":"Anti-VEGF therapy is not a magic bullet for diabetic retinopathy","volume":"4","author":"Zhao","year":"2020","journal-title":"Eye"},{"key":"10.1016\/j.biopha.2023.115657_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583687","article-title":"The role of inflammation in diabetic retinopathy","author":"Forrester","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2023.115657_bib11","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/jcb.25575","article-title":"Angiogenesis and inflammation crosstalk in diabetic retinopathy","volume":"11","author":"Capit\u00e3o","year":"2016","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.biopha.2023.115657_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1039\/C5NP00156K","article-title":"Marine natural products","volume":"3","author":"Blunt","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.biopha.2023.115657_bib13","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/md9071273","article-title":"Bromophenols in marine algae and their bioactivities","volume":"7","author":"Liu","year":"2011","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2023.115657_bib14","article-title":"Progress of bromophenols in marine algae from 2011 to 2020: structure, bioactivities, and applications","volume":"8","author":"Dong","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2023.115657_bib15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/md11020350","article-title":"HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: synthesis and anti-diabetic effects in C57BL\/KsJ-db\/db mice","volume":"2","author":"Shi","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2023.115657_bib16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5487\/TR.2017.33.4.325","article-title":"Anti-inflammatory effect of 3-Bromo-4,5-Dihydroxybenzaldehyde, a component of Polysiphonia morrowii, In Vivo and In Vitro","volume":"4","author":"Kang","year":"2017","journal-title":"Toxicol. Res"},{"key":"10.1016\/j.biopha.2023.115657_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114087","article-title":"5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE\/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice","author":"Han","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2023.115657_bib18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/ptr.6266","article-title":"Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes","volume":"3","author":"Ko","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2023.115657_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113793","article-title":"5-Bromo-3,4-dihydroxybenzaldehyde attenuates endothelial cells injury from high glucose-induced damage","author":"Wang","year":"2022","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2023.115657_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yexcr.2019.04.008","article-title":"Restoring retinal neurovascular health via substance P","volume":"2","author":"Ou","year":"2019","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.biopha.2023.115657_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110818","article-title":"The cells involved in the pathological process of diabetic retinopathy","author":"Yang","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2023.115657_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109767","article-title":"A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications","author":"Huang","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2023.115657_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101799","article-title":"Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","author":"Kang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2023.115657_bib24","first-page":"1919","article-title":"Recent developments of neuroprotective agents for degenerative retinal disorders","volume":"9","author":"Ou","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.biopha.2023.115657_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105960","article-title":"Role of toll-like receptor 4 in diabetic retinopathy","author":"Bayan","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biopha.2023.115657_bib26","first-page":"6782872","article-title":"The beneficial roles of SIRT1 in neuroinflammation-related diseases","author":"Jiao","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.biopha.2023.115657_bib27","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41419-021-04350-y","article-title":"IL-17A injury to retinal ganglion cells is mediated by retinal M\u00fcller cells in diabetic retinopathy","volume":"11","author":"Qiu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2023.115657_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00125-017-4435-8","article-title":"Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond","volume":"1","author":"Hammes","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopha.2023.115657_bib29","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/nrdp.2016.12","article-title":"Diabetic retinopathy","author":"Wong","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.biopha.2023.115657_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.660164","article-title":"Microglial activation is associated with vasoprotection in a rat model of inflammatory retinal vasoregression","author":"Riemann","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2023.115657_bib31","article-title":"Involvement of premacular mast cells in the pathogenesis of macular diseases","volume":"2","author":"Sato","year":"2019","journal-title":"PLoS One"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:42:45Z","timestamp":1779918165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223014555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":31,"alternative-id":["S0753332223014555"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115657","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-Bromo-3,4-dihydroxybenzaldehyde stabilizes diabetic retinal neurovascular units by inhibiting the inflammatory microenvironment","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115657"}}