{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:10:12Z","timestamp":1785859812154,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873041"],"award-info":[{"award-number":["81873041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030124"],"award-info":[{"award-number":["82030124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20405"],"award-info":[{"award-number":["U20A20405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.biopha.2023.115683","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T03:00:19Z","timestamp":1696993219000},"page":"115683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Role of senkyunolide I in the promotion of neural stem\/progenitor cell proliferation via the Akt\/\u03b2-catenin pathway"],"prefix":"10.1016","volume":"168","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Horinokita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Iwatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-guo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-xun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.biopha.2023.115683_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.biopha.2023.115683_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033118","article-title":"Clinical neurology and epidemiology of the major neurodegenerative diseases","volume":"10","author":"Erkkinen","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115683_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12975-016-0460-z","article-title":"Neurogenesis in stroke recovery","volume":"8","author":"Koh","year":"2017","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.biopha.2023.115683_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainresbull.2018.09.002","article-title":"Depression and adult neurogenesis: positive effects of the antidepressant fluoxetine and of physical exercise","volume":"143","author":"Micheli","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.biopha.2023.115683_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00441-017-2675-z","article-title":"Neural stem cells and epilepsy: functional roles and disease-in-a-dish models","volume":"371","author":"Thodeson","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.biopha.2023.115683_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.conb.2018.07.006","article-title":"Regulation of neurogenesis in the adult and aging brain","volume":"53","author":"Katsimpardi","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.biopha.2023.115683_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/1073858414563616","article-title":"Injury-induced neurogenesis: mechanisms and relevance","volume":"22","author":"Yu","year":"2016","journal-title":"Neuroscientist"},{"issue":"10","key":"10.1016\/j.biopha.2023.115683_bib8","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1007\/s12035-016-0290-8","article-title":"Involvement of GSK-3beta phosphorylation through PI3-K\/Akt in cerebral ischemia-induced neurogenesis in rats","volume":"54","author":"Kisoh","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.biopha.2023.115683_bib9","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/jcbfm.2014.130","article-title":"Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here","volume":"34","author":"Tobin","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"9","key":"10.1016\/j.biopha.2023.115683_bib10","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/bmc.3420","article-title":"Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS: application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract","volume":"29","author":"Zhao","year":"2015","journal-title":"Biomed. Chromatogr."},{"issue":"19","key":"10.1016\/j.biopha.2023.115683_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24193536","article-title":"Identification of chemical markers for the discrimination of radix angelica sinensis grown in geoherb and non-geoherb regions using UHPLC-QTOF-MS\/MS based metabolomics","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.biopha.2023.115683_bib12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cbi.2009.11.029","article-title":"Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1","volume":"183","author":"Qi","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"Pt A","key":"10.1016\/j.biopha.2023.115683_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.brainres.2016.08.012","article-title":"Senkyunolide I attenuates oxygen-glucose deprivation\/reoxygenation-induced inflammation in microglial cells","volume":"1649","author":"Hu","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.biopha.2023.115683_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112385","article-title":"Ligusticum chuanxiong exerts neuroprotection by promoting adult neurogenesis and inhibiting inflammation in the hippocampus of ME cerebral ischemia rats","volume":"249","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115683_bib15","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jep.2012.05.047","article-title":"Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae)","volume":"142","author":"He","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2023.115683_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fnmol.2016.00135","article-title":"Protective effect of minocycline against ketamine-induced injury in neural stem cell: involvement of PI3K\/Akt and Gsk-3 beta pathway","volume":"9","author":"Lu","year":"2016","journal-title":"Front. Mol. Neurosci."},{"issue":"47","key":"10.1016\/j.biopha.2023.115683_bib17","doi-asserted-by":"crossref","first-page":"28540","DOI":"10.1074\/jbc.M115.652586","article-title":"Ethosuximide induces hippocampal neurogenesis and reverses cognitive deficits in an amyloid-beta toxin-induced Alzheimer rat model via the phosphatidylinositol 3-kinase (PI3K)\/Akt\/Wnt\/beta-catenin pathway","volume":"290","author":"Tiwari","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2023.115683_bib18","doi-asserted-by":"crossref","first-page":"15321","DOI":"10.1038\/s41598-017-15662-5","article-title":"Radial extracorporeal shock wave therapy enhances the proliferation and differentiation of neural stem cells by notch, PI3K\/AKT, and Wnt\/beta-catenin signaling","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2023.115683_bib19","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1096\/fj.201900014R","article-title":"Adenosine A2A receptor (A2AR) activation triggers Akt signaling and enhances nuclear localization of beta-catenin in osteoblasts","volume":"33","author":"Borhani","year":"2019","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.biopha.2023.115683_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1021\/nn405077y","article-title":"Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt\/beta-catenin pathway","volume":"8","author":"Tiwari","year":"2014","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.biopha.2023.115683_bib21","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1007\/s12035-018-1216-4","article-title":"Possible involvement of PI3-K\/Akt-dependent GSK-3beta signaling in proliferation of neural progenitor cells after hypoxic exposure","volume":"56","author":"Kisoh","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.biopha.2023.115683_bib22","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuron.2013.10.037","article-title":"Neural stem cells: generating and regenerating the brain","volume":"80","author":"Gage","year":"2013","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.biopha.2023.115683_bib23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/embor.2011.16","article-title":"JAM-A regulates epithelial proliferation through Akt\/beta-catenin signalling","volume":"12","author":"Nava","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biopha.2023.115683_bib24","doi-asserted-by":"crossref","first-page":"14091","DOI":"10.1038\/ncomms14091","article-title":"Macrophages induce AKT\/beta-catenin-dependent Lgr5(+) stem cell activation and hair follicle regeneration through TNF","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.biopha.2023.115683_bib25","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","article-title":"The cell biology of neurogenesis","volume":"6","author":"Gotz","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.biopha.2023.115683_bib26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrn4021","article-title":"Proliferation control in neural stem and progenitor cells","volume":"16","author":"Homem","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.biopha.2023.115683_bib27","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.18632\/aging.101519","article-title":"Neural stem cell spacing questions their self-renewal","volume":"10","author":"Mineyeva","year":"2018","journal-title":"Aging"},{"issue":"12","key":"10.1016\/j.biopha.2023.115683_bib28","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.3727\/096368914X679354","article-title":"BDNF pretreatment of human embryonic-derived neural stem cells improves cell survival and functional recovery after transplantation in hypoxic-ischemic stroke","volume":"24","author":"Rosenblum","year":"2015","journal-title":"Cell Transpl."},{"issue":"13","key":"10.1016\/j.biopha.2023.115683_bib29","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1073\/pnas.1422448112","article-title":"Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF","volume":"112","author":"Kirby","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332223014816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:05:31Z","timestamp":1779915931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332223014816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":29,"alternative-id":["S0753332223014816"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115683","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of senkyunolide I in the promotion of neural stem\/progenitor cell proliferation via the Akt\/\u03b2-catenin pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2023.115683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"115683"}}