{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:16:06Z","timestamp":1792106166997,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A04J0471"],"award-info":[{"award-number":["2023A04J0471"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A03J00226"],"award-info":[{"award-number":["2023A03J00226"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515030134"],"award-info":[{"award-number":["2023A1515030134"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.biopha.2024.116597","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:10:16Z","timestamp":1713589816000},"page":"116597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15\/STAT3 pathway"],"prefix":"10.1016","volume":"174","author":[{"given":"Chun-Ling","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1227-6100","authenticated-orcid":false,"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yini","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.biopha.2024.116597_bib1","doi-asserted-by":"crossref","first-page":"10466","DOI":"10.7150\/thno.45211","article-title":"Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8(+) T-cell memory in wild-type and humanized mice","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.biopha.2024.116597_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00281-022-00927-7","article-title":"Tissue-resident memory T cells in the kidney","volume":"44","author":"Asada","year":"2022","journal-title":"Semin Immunopathol."},{"key":"10.1016\/j.biopha.2024.116597_bib3","doi-asserted-by":"crossref","first-page":"1111521","DOI":"10.3389\/fimmu.2023.1111521","article-title":"Tissue-resident memory T cells in renal autoimmune diseases","volume":"14","author":"Ginsberg","year":"2023","journal-title":"Front Immunol."},{"issue":"9","key":"10.1016\/j.biopha.2024.116597_bib4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/ki.2012.242","article-title":"Kidney-infiltrating CD4+ T-cell clones promote nephritis in lupus-prone mice","volume":"82","author":"Okamoto","year":"2012","journal-title":"Kidney Int"},{"issue":"82","key":"10.1016\/j.biopha.2024.116597_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add8454","article-title":"Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15","volume":"8","author":"Tieu","year":"2023","journal-title":"Sci. Immunol."},{"issue":"46","key":"10.1016\/j.biopha.2024.116597_bib6","doi-asserted-by":"crossref","first-page":"E10915","DOI":"10.1073\/pnas.1811615115","article-title":"IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages","volume":"115","author":"Zhang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.biopha.2024.116597_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2567.2008.02878.x","article-title":"Interleukin-15 stimulates macrophages to activate CD4+ T cells: a role in the pathogenesis of rheumatoid arthritis?","volume":"126","author":"R\u00fcckert","year":"2009","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.biopha.2024.116597_bib8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.immuni.2009.09.017","article-title":"Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets","volume":"31","author":"Mortier","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2024.116597_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154495","article-title":"Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics","volume":"108","author":"Zheng","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.biopha.2024.116597_bib10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jep.2010.06.004","article-title":"Zhen-wu-tang, a blended traditional Chinese herbal medicine, ameliorates proteinuria and renal damage of streptozotocin-induced diabetic nephropathy in rats","volume":"131","author":"Cai","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2024.116597_bib11","first-page":"10","article-title":"Clinical and experimental studies of therapeutic effects of Zhen-Wu-Tang on chronic renal failure","volume":"4","author":"Du","year":"1991","journal-title":"Zhong Guo Yi Yao Xue Bao"},{"issue":"21","key":"10.1016\/j.biopha.2024.116597_bib12","first-page":"126","article-title":"Meta-analysis of clinical effects of Zhen-Wu-Tang on chronic kidney disease","volume":"13","author":"Lu","year":"2021","journal-title":"Zhong Guo Lin. Chang Yan Jiu"},{"issue":"09","key":"10.1016\/j.biopha.2024.116597_bib13","first-page":"92","article-title":"Clinical observation on rituximab combined with zhenwu tang for lupus nephritis","volume":"50","author":"Fei","year":"2018","journal-title":"J. N. Chin. Med"},{"issue":"02","key":"10.1016\/j.biopha.2024.116597_bib14","first-page":"858","article-title":"Efficacy observation of Zhenwu Decoction combined with immunosuppressive treatment of spleen and kidney yang deficiency syndrome of lupus nephritis","volume":"34","author":"Bao-lin","year":"2019","journal-title":"China J. Trad. Chin. Med Pharm."},{"key":"10.1016\/j.biopha.2024.116597_bib15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.biopha.2018.02.127","article-title":"Zhen-wu-tang protects against podocyte injury in rats with IgA nephropathy via PPAR\u03b3\/NF-\u03baB pathway","volume":"101","author":"Liu","year":"2018","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2024.116597_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.777670","article-title":"Zhen-Wu-Tang induced mitophagy to protect mitochondrial function in chronic glomerulonephritis via PI3K\/AKT\/mTOR and AMPK pathways","volume":"12","author":"Liu","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.biopha.2024.116597_bib17","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.biopha.2018.10.146","article-title":"Zhen-wu-tang attenuates Adriamycin-induced nephropathy via regulating AQP2 and miR-92b","volume":"109","author":"Liang","year":"2019","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2024.116597_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152913","article-title":"Zhen-wu-tang ameliorates membranous nephropathy rats through inhibiting NF-\u03baB pathway and NLRP3 inflammasome","volume":"59","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2024.116597_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jep.2017.12.013","article-title":"Zhen-wu-tang ameliorates adenine-induced chronic renal failure in rats: regulation of the canonical Wnt4\/beta-catenin signaling in the kidneys","volume":"219","author":"La","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2024.116597_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154901","article-title":"Paeoniflorin suppresses kidney inflammation by regulating macrophage polarization via KLF4-mediated mitophagy","volume":"116","author":"Cao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2024.116597_bib21","first-page":"7008907","article-title":"Anti-inflammatory mechanism of action of benzoylmesaconine in lipopolysaccharide-stimulated RAW264.7 cells","volume":"2022","author":"Zhou","year":"2022","journal-title":"Evid. Based Complement Altern. Med"},{"issue":"5","key":"10.1016\/j.biopha.2024.116597_bib22","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1007\/s10753-021-01478-z","article-title":"Benzoylaconine modulates LPS-induced responses through inhibition of toll-like receptor-mediated NF-\u03baB and MAPK signaling in RAW264.7 cells","volume":"44","author":"Zhou","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.biopha.2024.116597_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114434","article-title":"Paeoniflorin ameliorates murine lupus nephritis by increasing CD4(+)Foxp3(+) Treg cells via enhancing mTNFalpha-TNFR2 pathway","volume":"185","author":"Liang","year":"2021","journal-title":"Biochem Pharm."},{"issue":"8","key":"10.1016\/j.biopha.2024.116597_bib24","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/j.ymthe.2022.04.024","article-title":"Targeting tissue-resident memory CD8(+) T cells in the kidney is a potential therapeutic strategy to ameliorate podocyte injury and glomerulosclerosis","volume":"30","author":"Li","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biopha.2024.116597_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102424","article-title":"JAK\/STAT signaling controls the fate of CD8(+)CD103(+) tissue-resident memory T cell in lupus nephritis","volume":"109","author":"Zhou","year":"2020","journal-title":"J. Autoimmun."},{"issue":"5187","key":"10.1016\/j.biopha.2024.116597_bib26","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1126\/science.7973659","article-title":"Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits","volume":"266","author":"Miyazaki","year":"1994","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.biopha.2024.116597_bib27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/1074-7613(95)90141-8","article-title":"The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15","volume":"2","author":"Lin","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2024.116597_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.681748","article-title":"Macrophage Heterogeneity in Kidney Injury and Fibrosis","volume":"12","author":"Wen","year":"2021","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2024.116597_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.biopha.2024.116597_bib30","article-title":"Application of herbal traditional Chinese medicine in the treatment of lupus nephritis","volume":"13","author":"Liu","year":"2022","journal-title":"Front Pharm."},{"issue":"6","key":"10.1016\/j.biopha.2024.116597_bib31","first-page":"343","article-title":"[Therapy of integrated traditional Chinese medicine and Western medicine on 74 lupus nephritis]","volume":"14","author":"Ye","year":"1994","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"5","key":"10.1016\/j.biopha.2024.116597_bib32","first-page":"276","article-title":"[Lupus nephritis treated with impact therapy of cyclophosphamide and traditional Chinese medicine]","volume":"14","author":"Ruan","year":"1994","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"31","key":"10.1016\/j.biopha.2024.116597_bib33","doi-asserted-by":"crossref","first-page":"11391","DOI":"10.12998\/wjcc.v10.i31.11391","article-title":"Dan Bai Xiao Formula combined with glucocorticoids and cyclophosphamide for pediatric lupus nephritis: a pilot prospective study","volume":"10","author":"Cao","year":"2022","journal-title":"World J. Clin. Cases"},{"issue":"2","key":"10.1016\/j.biopha.2024.116597_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/cells10020409","article-title":"Tissue-resident memory T cells in chronic inflammation-local cells with systemic effects?","volume":"10","author":"Samat","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2024.116597_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.652191","article-title":"Resident memory T cells in autoimmune skin diseases","volume":"12","author":"Ryan","year":"2021","journal-title":"Front Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2024.116597_bib36","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm.3883","article-title":"The emerging role of resident memory T cells in protective immunity and inflammatory disease","volume":"21","author":"Park","year":"2015","journal-title":"Nat. Med"},{"key":"10.1016\/j.biopha.2024.116597_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1600-065X.2008.00604.x","article-title":"Twelve immunotherapy drugs that could cure cancers","volume":"222","author":"Cheever","year":"2008","journal-title":"Immunol. Rev."},{"issue":"12","key":"10.1016\/j.biopha.2024.116597_bib38","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.20020369","article-title":"Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells","volume":"195","author":"Becker","year":"2002","journal-title":"J. Exp. Med"},{"issue":"12","key":"10.1016\/j.biopha.2024.116597_bib39","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat. Immunol."},{"issue":"6284","key":"10.1016\/j.biopha.2024.116597_bib40","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.aad2035","article-title":"Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes","volume":"352","author":"Mackay","year":"2016","journal-title":"Sci. (N. Y., N. Y. )"},{"issue":"9","key":"10.1016\/j.biopha.2024.116597_bib41","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.1502337","article-title":"IL-15-independent maintenance of tissue-resident and boosted effector memory CD8 T cells","volume":"196","author":"Schenkel","year":"2016","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2024.116597_bib42","first-page":"744","article-title":"Identification of low-abundance urinary biomarkers in lupus nephritis using electrochemiluminescence immunoassays","volume":"71","author":"Stanley","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2024.116597_bib43","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/cei.13263","article-title":"Natural killer cell expression of Ki67 is associated with elevated serum IL-15, disease activity and nephritis in systemic lupus erythematosus","volume":"196","author":"Hudspeth","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2024.116597_bib44","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001428","article-title":"Interleukin-15 and cancer: some solved and many unsolved questions","volume":"8","author":"Fiore","year":"2020","journal-title":"J. ImmunoTher. Cancer"},{"issue":"2","key":"10.1016\/j.biopha.2024.116597_bib45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.clim.2015.04.004","article-title":"Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL\/lpr mice","volume":"158","author":"Edwards","year":"2015","journal-title":"Clin. Immunol."},{"issue":"12","key":"10.1016\/j.biopha.2024.116597_bib46","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1177\/0961203319877242","article-title":"T cell-specific STAT3 deficiency abrogates lupus nephritis","volume":"28","author":"Yoshida","year":"2019","journal-title":"Lupus"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332224004815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332224004815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:03:09Z","timestamp":1782342189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332224004815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":46,"alternative-id":["S0753332224004815"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2024.116597","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15\/STAT3 pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2024.116597","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"116597"}}