{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:04:11Z","timestamp":1790859851847,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Provincial Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["202304016"],"award-info":[{"award-number":["202304016"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["202103021223233"],"award-info":[{"award-number":["202103021223233"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["202203021212363"],"award-info":[{"award-number":["202203021212363"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017338","name":"Key Program of NSFC-Tongyong Union Foundation","doi-asserted-by":"publisher","award":["82073909"],"award-info":[{"award-number":["82073909"]}],"id":[{"id":"10.13039\/100017338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010010","name":"Shanxi Province Science Foundation for Youths","doi-asserted-by":"publisher","award":["2023XM022"],"award-info":[{"award-number":["2023XM022"]}],"id":[{"id":"10.13039\/501100010010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100026734","name":"Development Fund for Black Students in Science and Technology","doi-asserted-by":"publisher","award":["YDZJSX20231A059"],"award-info":[{"award-number":["YDZJSX20231A059"]}],"id":[{"id":"10.13039\/100026734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100026734","name":"Development Fund for Black Students in Science and Technology","doi-asserted-by":"publisher","award":["YDZJSX2022A059"],"award-info":[{"award-number":["YDZJSX2022A059"]}],"id":[{"id":"10.13039\/100026734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.biopha.2024.117293","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T20:33:19Z","timestamp":1723581199000},"page":"117293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Repositioning fluphenazine as a cuproptosis-dependent anti-breast cancer drug candidate based on TCGA database"],"prefix":"10.1016","volume":"178","author":[{"given":"Xiaoli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-3127","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-5804","authenticated-orcid":false,"given":"Yunfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2024.117293_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: a Cancer J. Clin."},{"key":"10.1016\/j.biopha.2024.117293_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106535","article-title":"Breast cancer: biology, biomarkers, and treatments","volume":"84","author":"Barzaman","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2024.117293_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104806","article-title":"Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer - A comprehensive review from chemotherapy to immunotherapy","volume":"156","author":"Jabbarzadeh Kaboli","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2024.117293_bib4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41568-020-0266-x","article-title":"Key steps for effective breast cancer prevention","volume":"20","author":"Britt","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biopha.2024.117293_bib5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","article-title":"Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research","volume":"15","author":"Tong","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.biopha.2024.117293_bib6","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.biopha.2024.117293_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","article-title":"Cuproptosis: a copper-triggered modality of mitochondrial cell death","volume":"32","author":"Tang","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.biopha.2024.117293_bib8","doi-asserted-by":"crossref","first-page":"2733232","DOI":"10.1155\/2023\/2733232","article-title":"Construction of a prognostic model for predicting colorectal cancer prognosis and response to immunotherapy based on cuproptosis-associated lncRNAs","volume":"2023","author":"Yang","year":"2023","journal-title":"J. Oncol."},{"key":"10.1016\/j.biopha.2024.117293_bib9","doi-asserted-by":"crossref","first-page":"3419401","DOI":"10.1155\/2023\/3419401","article-title":"A novel cuproptosis-associated gene signature to predict prognosis in patients with pancreatic cancer","volume":"2023","author":"Du","year":"2023","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.biopha.2024.117293_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13062-023-00358-w","article-title":"Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma","volume":"18","author":"Chen","year":"2023","journal-title":"Biol. Direct"},{"key":"10.1016\/j.biopha.2024.117293_bib11","doi-asserted-by":"crossref","first-page":"1082974","DOI":"10.3389\/fimmu.2023.1082974","article-title":"Construction and validation of a cuproptosis-related prognostic model for glioblastoma","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2024.117293_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/imr.13276","article-title":"Copper homeostasis and cuproptosis in cancer immunity and therapy","volume":"321","author":"Liu","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biopha.2024.117293_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14235771","article-title":"Prognostic significance of cuproptosis-related gene signatures in breast cancer based on transcriptomic data analysis","volume":"14","author":"Zhou","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.biopha.2024.117293_bib14","doi-asserted-by":"crossref","first-page":"1029092","DOI":"10.3389\/fimmu.2022.1029092","article-title":"Cross-talk between cuproptosis and ferroptosis regulators defines the tumor microenvironment for the prediction of prognosis and therapies in lung adenocarcinoma","volume":"13","author":"Shen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2024.117293_bib15","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.drudis.2019.06.014","article-title":"Drug repurposing: a promising tool to accelerate the drug discovery process","volume":"24","author":"Parvathaneni","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.biopha.2024.117293_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71880","article-title":"A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer","volume":"11","author":"Yang","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.biopha.2024.117293_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad142","article-title":"Decoding connectivity map-based drug repurposing for oncotherapy","volume":"24","author":"Zhao","year":"2023","journal-title":"Brief. Bioinforma."},{"key":"10.1016\/j.biopha.2024.117293_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114830","article-title":"The molecular mechanisms of cuproptosis and its relevance to cardiovascular disease","volume":"163","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2024.117293_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.149211","article-title":"UK-5099, a mitochondrial pyruvate carrier inhibitor, recovers impaired neutrophil maturation caused by AK2 deficiency in human pluripotent stem cell models","volume":"687","author":"Wang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2024.117293_bib20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/BS9.0000000000000117","article-title":"Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis","volume":"4","author":"Nie","year":"2022","journal-title":"Blood Sci."},{"key":"10.1016\/j.biopha.2024.117293_bib21","doi-asserted-by":"crossref","first-page":"C588","DOI":"10.1152\/ajpcell.00054.2010","article-title":"Acquisition of dietary copper: a role for anion transporters in intestinal apical copper uptake","volume":"300","author":"Zimnicka","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2024.117293_bib22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s12859-022-04894-6","article-title":"High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases","volume":"23","author":"Li","year":"2022","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.biopha.2024.117293_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10142-023-01210-0","article-title":"Cuproptosis-related gene SLC31A1 expression correlates with the prognosis and tumor immune microenvironment in glioma","volume":"23","author":"Wang","year":"2023","journal-title":"Funct. Integr. Genom."},{"key":"10.1016\/j.biopha.2024.117293_bib24","doi-asserted-by":"crossref","first-page":"1194046","DOI":"10.3389\/fmed.2023.1194046","article-title":"A ceRNA network-mediated over-expression of cuproptosis-related gene SLC31A1 correlates with poor prognosis and positive immune infiltration in breast cancer","volume":"10","author":"Lian","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.biopha.2024.117293_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.930041","article-title":"Comprehensive analysis of cuproptosis-related genes in immune infiltration and prognosis in melanoma","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2024.117293_bib26","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000034741","article-title":"Cuproptosis-related prognostic signatures predict the prognosis and immunotherapy in HCC patients","volume":"102","author":"Peng","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/j.biopha.2024.117293_bib27","article-title":"The expression of cuproptosis-related genes in hepatocellular carcinoma and their relationships with prognosis","volume":"12","author":"Zhao","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biopha.2024.117293_bib28","first-page":"3521","article-title":"Expression of ATP7A in esophageal squamous cell carcinoma (ESCC) and its clinical significance","volume":"12","author":"Li","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biopha.2024.117293_bib29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tox.2016.06.003","article-title":"Tyrosine phosphorylation of dihydrolipoamide dehydrogenase as a potential cadmium target and its inhibitory role in regulating mouse sperm motility","volume":"358","author":"Li","year":"2016","journal-title":"Toxicology, 357-"},{"key":"10.1016\/j.biopha.2024.117293_bib30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3892\/ol.2023.13800","article-title":"Oncogenic role of copper\u2011induced cell death\u2011associated protein DLD in human cancer: a pan\u2011cancer analysis and experimental verification","volume":"25","author":"Qi","year":"2023","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2024.117293_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103007","article-title":"Inhibiting the compensatory elevation of xCT collaborates with disulfiram\/copper-induced GSH consumption for cascade ferroptosis and cuproptosis","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2024.117293_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202370152","article-title":"Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with \u03b1PD-L1 for enhanced cancer immunotherapy","volume":"35","author":"Guo","year":"2023","journal-title":"Adv. Mater. (Deerfield Beach, Fla. )"},{"key":"10.1016\/j.biopha.2024.117293_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28083393","article-title":"Improvement of the in vitro cytotoxic effect on HT-29 colon cancer cells by combining 5-fluorouacil and fluphenazine with green, red or brown propolis","volume":"28","author":"Falc\u00e3o","year":"2023","journal-title":"Mol."},{"key":"10.1016\/j.biopha.2024.117293_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22605","article-title":"Repurposing fluphenazine as an autophagy modulator for treating liver cancer","volume":"9","author":"Su","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.biopha.2024.117293_bib35","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.21873\/anticanres.11172","article-title":"Highly Halaven-resistant KBV20C cancer cells can be sensitized by Co-treatment with fluphenazine","volume":"36","author":"Cheon","year":"2016","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biopha.2024.117293_bib36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.18632\/oncotarget.26725","article-title":"AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer","volume":"10","author":"Goyette","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2024.117293_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.isci.2023.108218","article-title":"Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332224011776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332224011776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:49:10Z","timestamp":1777862950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332224011776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":37,"alternative-id":["S0753332224011776"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2024.117293","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repositioning fluphenazine as a cuproptosis-dependent anti-breast cancer drug candidate based on TCGA database","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2024.117293","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"117293"}}