{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:02:08Z","timestamp":1784764928877,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020784","name":"Gannan Medical University","doi-asserted-by":"publisher","award":["NX202022"],"award-info":[{"award-number":["NX202022"]}],"id":[{"id":"10.13039\/501100020784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20212BAB206004"],"award-info":[{"award-number":["20212BAB206004"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060420"],"award-info":[{"award-number":["82060420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.biopha.2024.117396","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:55:31Z","timestamp":1725422131000},"page":"117396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Resveratrol as a potential therapeutic agent for sarcopenic obesity: Insights from in vivoperiments"],"prefix":"10.1016","volume":"179","author":[{"given":"Yi","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-6135","authenticated-orcid":false,"given":"Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbiao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2024.117396_bib1","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1016\/j.clnu.2021.01.005","article-title":"Prevalence of sarcopenic obesity and sarcopenic overweight in the general population: the lifelines cohort study","volume":"40","author":"Wagenaar","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.biopha.2024.117396_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/oby.2004.107","article-title":"Sarcopenic obesity: the confluence of two epidemics","volume":"12","author":"Roubenoff","year":"2004","journal-title":"Obes. Res."},{"key":"10.1016\/j.biopha.2024.117396_bib3","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1056\/NEJMsa0900459","article-title":"Forecasting the effects of obesity and smoking on U.S. life expectancy","volume":"361","author":"Stewart","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2024.117396_bib4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/oby.21356","article-title":"Mid-adulthood cardiometabolic risk factor profiles of sarcopenic obesity","volume":"24","author":"Ma","year":"2016","journal-title":"Obesity"},{"key":"10.1016\/j.biopha.2024.117396_bib5","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ijo.2017.122","article-title":"Adiposity and grip strength as long-term predictors of objectively measured physical activity in 93,015 adults: the UK Biobank study","volume":"41","author":"Kim","year":"2017","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biopha.2024.117396_bib6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.semcancer.2020.06.014","article-title":"Phytochemicals in cancer cell chemosensitization: current knowledge and future perspectives","volume":"80","author":"Khatoon","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.biopha.2024.117396_bib7","doi-asserted-by":"crossref","first-page":"8176","DOI":"10.1038\/s41598-024-58375-2","article-title":"Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model","volume":"14","author":"Ye","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2024.117396_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ph14080806","article-title":"Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus","volume":"14","author":"Blahova","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.biopha.2024.117396_bib9","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1111\/bph.15625","article-title":"Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3-mediated muscle wasting in cancer cachexia mice","volume":"178","author":"Niu","year":"2021","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.biopha.2024.117396_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195912","article-title":"Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle","volume":"13","author":"Lettieri-Barbato","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2024.117396_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20071523","article-title":"Resveratrol and its effects on the vascular system","volume":"20","author":"Breuss","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2024.117396_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jphs.2023.04.001","article-title":"Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice","volume":"152","author":"Hosoda","year":"2023","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2024.117396_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.imr.2014.09.004","article-title":"Exercise-induced PGC-1\u03b1 transcriptional factors in skeletal muscle","volume":"3","author":"Jung","year":"2014","journal-title":"Integr. Med. Res."},{"key":"10.1016\/j.biopha.2024.117396_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1017\/S002966511500169X","article-title":"Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity","volume":"74","author":"Wannamethee","year":"2015","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.biopha.2024.117396_bib15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jgr.2021.10.003","article-title":"Gintonin-enriched fraction protects against sarcopenic obesity by promoting energy expenditure and attenuating skeletal muscle atrophy in high-fat diet-fed mice","volume":"46","author":"Jin","year":"2022","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.biopha.2024.117396_bib16","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.18632\/aging.101910","article-title":"Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA\/LKB1\/AMPK pathway","volume":"11","author":"Huang","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.biopha.2024.117396_bib17","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3389\/fphar.2019.01185","article-title":"Integrating network pharmacology and pharmacological evaluation for deciphering the action mechanism of herbal formula Zuojin Pill in suppressing hepatocellular carcinoma","volume":"10","author":"Guo","year":"2019","journal-title":"Front. Pharm."},{"key":"10.1016\/j.biopha.2024.117396_bib18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fphar.2020.00425","article-title":"Deciphering the pharmacological mechanisms of Taohe-Chengqi decoction extract against renal fibrosis through integrating network pharmacology and experimental validation in vitro and in vivo","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Pharm."},{"key":"10.1016\/j.biopha.2024.117396_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/biom9080362","article-title":"The methodological trends of traditional herbal medicine employing network pharmacology","volume":"9","author":"Lee","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.biopha.2024.117396_bib20","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1039\/D1SC05613A","article-title":"wSDTNBI: a novel network-based inference method for virtual screening","volume":"13","author":"Wu","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.biopha.2024.117396_bib21","doi-asserted-by":"crossref","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","article-title":"PubChem 2019 update: improved access to chemical data","volume":"47","author":"Kim","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biopha.2024.117396_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.amjmed.2005.10.049","article-title":"Inflammatory markers and loss of muscle mass (sarcopenia) and strength","volume":"119","author":"Schaap","year":"2006","journal-title":"Am. J. Med."},{"key":"10.1016\/j.biopha.2024.117396_bib23","doi-asserted-by":"crossref","first-page":"14458","DOI":"10.1096\/fj.202000965RR","article-title":"Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK\/STAT signaling pathways","volume":"34","author":"Abid","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2024.117396_bib24","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1096\/fj.02-0187fje","article-title":"Physiological role of tumor necrosis factor alpha in traumatic muscle injury","volume":"16","author":"Warren","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2024.117396_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.maturitas.2016.11.006","article-title":"Inflammation and sarcopenia: a systematic review and meta-analysis","volume":"96","author":"Bano","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.biopha.2024.117396_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrendo.2016.135","article-title":"PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD","volume":"13","author":"Gross","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biopha.2024.117396_bib27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2024.117396_bib28","doi-asserted-by":"crossref","DOI":"10.23736\/S0391-1977.16.02563-3","article-title":"Adipose tissue, obesity and non-alcoholic fatty liver disease","volume":"42","author":"Polyzos","year":"2017","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.biopha.2024.117396_bib29","doi-asserted-by":"crossref","first-page":"414","DOI":"10.14218\/JCTH.2020.00065","article-title":"Skeletal muscle dysfunction in the development and progression of nonalcoholic fatty liver disease","volume":"8","author":"Altajar","year":"2020","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.biopha.2024.117396_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2174\/156652409787847191","article-title":"Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines","volume":"9","author":"Polyzos","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.biopha.2024.117396_bib31","article-title":"Association between sarcopenia level and metabolic syndrome","volume":"16","author":"Kim","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2024.117396_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5009\/gnl18070","article-title":"Age-related decrease in skeletal muscle mass is an independent risk factor for incident nonalcoholic fatty liver disease: a 10-year retrospective cohort study","volume":"13","author":"Lee","year":"2019","journal-title":"Gut Liver"},{"key":"10.1016\/j.biopha.2024.117396_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11912-016-0546-5","article-title":"Clinical implications of sarcopenic obesity in cancer","volume":"18","author":"Carneiro","year":"2016","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.biopha.2024.117396_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jacl.2020.01.002","article-title":"Skeletal muscle area and density are associated with lipid and lipoprotein cholesterol levels: the Multi-Ethnic Study of Atherosclerosis","volume":"14","author":"Vella","year":"2020","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.biopha.2024.117396_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100980","article-title":"Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis","volume":"56","author":"Livshits","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.biopha.2024.117396_bib36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/path.4674","article-title":"Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway","volume":"238","author":"Chiu","year":"2016","journal-title":"J. Pathol."},{"issue":"1985","key":"10.1016\/j.biopha.2024.117396_bib37","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.biopha.2024.117396_bib38","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.tem.2021.03.007","article-title":"Cancer-mediated muscle cachexia: etiology and clinical management","volume":"32","author":"Siff","year":"2021","journal-title":"Trends Endocrinol. Metab.: TEM"},{"key":"10.1016\/j.biopha.2024.117396_bib39","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/ajcn\/nqy162","article-title":"Adipose tissue and skeletal muscle insulin-mediated glucose uptake in insulin resistance: role of blood flow and diabetes","volume":"108","author":"Ferrannini","year":"2018","journal-title":"Am. J. Clin. Nutr."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332224012812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332224012812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:18:55Z","timestamp":1784762335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332224012812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":39,"alternative-id":["S0753332224012812"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2024.117396","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol as a potential therapeutic agent for sarcopenic obesity: Insights from in vivoperiments","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2024.117396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"117396"}}