{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:32:01Z","timestamp":1777375921312,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["RTG2098"],"award-info":[{"award-number":["RTG2098"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.biopha.2025.118331","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T13:19:40Z","timestamp":1751980780000},"page":"118331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Amitriptyline inhibits Plasmodium development in infected red blood cells by modulating sphingolipid metabolism and glucose uptake"],"prefix":"10.1016","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0746-5591","authenticated-orcid":false,"given":"Matthias","family":"Hose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1417-5405","authenticated-orcid":false,"given":"Anne","family":"Ninnemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-7761","authenticated-orcid":false,"given":"Hanna","family":"Abberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-3275","authenticated-orcid":false,"given":"Fabian","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyad","family":"Naser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopold","family":"Purkart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Korbmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza","family":"Martins Nascentes Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9494-1926","authenticated-orcid":false,"given":"Vivien","family":"Blietschau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Falkenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Kleuser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-852X","authenticated-orcid":false,"given":"Alpaslan","family":"Tasdogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Gulbins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Carpinteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Klopfleisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-1698","authenticated-orcid":false,"given":"Jan","family":"Buer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M.","family":"Westendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-8591","authenticated-orcid":false,"given":"Kai","family":"Matuschewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2025.118331_bib1","unstructured":"WHO, World Malaria Report 2024, Geneva, WHO, 2024."},{"issue":"3","key":"10.1016\/j.biopha.2025.118331_bib2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2016.07.055","article-title":"Malaria: biology and disease","volume":"167","author":"Cowman","year":"2016","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.biopha.2025.118331_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.pt.2004.07.007","article-title":"Sneaking in through the back entrance: the biology of malaria liver stages","volume":"20","author":"Frevert","year":"2004","journal-title":"Trends Parasitol."},{"issue":"4","key":"10.1016\/j.biopha.2025.118331_bib4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cell.2006.02.006","article-title":"Invasion of red blood cells by malaria parasites","volume":"124","author":"Cowman","year":"2006","journal-title":"Cell"},{"issue":"6872","key":"10.1016\/j.biopha.2025.118331_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/415673a","article-title":"The pathogenic basis of malaria","volume":"415","author":"Miller","year":"2002","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2025.118331_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011157","article-title":"Plasmodium schizogony, a chronology of the parasite\u2019s cell cycle in the blood stage","volume":"19","author":"Vo\u00df","year":"2023","journal-title":"PLOS Pathog."},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-micro-041320-020659","article-title":"Plasmodium egress across the parasite life cycle","volume":"76","author":"Dvorin","year":"2022","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.biopha.2025.118331_bib8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.pt.2004.09.006","article-title":"Clinical features and pathogenesis of severe malaria","volume":"20","author":"Mackintosh","year":"2004","journal-title":"Trends Parasitol."},{"issue":"12","key":"10.1016\/j.biopha.2025.118331_bib9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1474-4422(05)70247-7","article-title":"Pathogenesis, clinical features, and neurological outcome of cerebral malaria","volume":"4","author":"Idro","year":"2005","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.biopha.2025.118331_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1056\/NEJMoa1400116","article-title":"Brain swelling and death in children with cerebral malaria","volume":"372","author":"Seydel","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.biopha.2025.118331_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00019-19","article-title":"Plasmodium genomics and genetics: New insights into malaria pathogenesis, drug resistance, epidemiology, and evolution","volume":"32","author":"Su","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"issue":"13","key":"10.1016\/j.biopha.2025.118331_bib12","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1056\/NEJMoa2101746","article-title":"Evidence of artemisinin-resistant malaria in Africa","volume":"385","author":"Balikagala","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2025.118331_bib13","first-page":"204","article-title":"Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology","volume":"80","author":"Langhorne","year":"2002","journal-title":"Chem. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1475-2875-11-104","article-title":"Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling","volume":"11","author":"Fu","year":"2012","journal-title":"Malar. J."},{"issue":"3","key":"10.1016\/j.biopha.2025.118331_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s430-001-8017-8","article-title":"Rodent malarias: the mouse as a model for understanding immune responses and pathology induced by the erythrocytic stages of the parasite","volume":"189","author":"Li","year":"2001","journal-title":"Med. Microbiol. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1128\/IAI.67.1.57-63.1999","article-title":"Murine gamma delta T lymphocytes elicited during Plasmodium yoelii infection respond to Plasmodium heat shock proteins","volume":"67","author":"Kopacz","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biopha.2025.118331_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00671","article-title":"CD4 T cell subsets in malaria: TH1\/TH2 revisited","volume":"5","author":"Perez-Mazliah","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2025.118331_bib18","doi-asserted-by":"crossref","first-page":"1102223","DOI":"10.4049\/jimmunol.1102223","article-title":"Strong impact of CD4+Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection","volume":"188","author":"Abel","year":"2012","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2025.118331_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/imm.12602","article-title":"Plasmodium yoelii infection of BALB\/c mice results in expansion rather than induction of CD4 + Foxp3 + regulatory T cells","volume":"148","author":"Abel","year":"2016","journal-title":"Immunology"},{"issue":"FEB","key":"10.1016\/j.biopha.2025.118331_bib20","first-page":"1","article-title":"DC-derived IL-10 modulates pro-inflammatory cytokine production and promotes induction of CD4+IL-10+ regulatory T cells during Plasmodium yoelii infection","volume":"8","author":"Loevenich","year":"2017","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2025.118331_bib21","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/emmm.201202273","article-title":"Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria","volume":"5","author":"Howland","year":"2013","journal-title":"EMBO Mol. Med."},{"issue":"6","key":"10.1016\/j.biopha.2025.118331_bib22","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.4049\/jimmunol.1000944","article-title":"Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria","volume":"185","author":"Amante","year":"2010","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.biopha.2025.118331_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013124","article-title":"A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria","volume":"5","author":"Carroll","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2025.118331_bib24","article-title":"Sphingolipids and their metabolism in physiology and disease","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.biopha.2025.118331_bib25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2025.118331_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2008.07.030","article-title":"Ceramide-enriched membrane domains-Structure and function","author":"Zhang","year":"2009","journal-title":"Biochim. Et. Biophys. Acta Biomembr."},{"key":"10.1016\/j.biopha.2025.118331_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83073","article-title":"Cell-intrinsic ceramides determine T cell function during melanoma progression","volume":"11","author":"Hose","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.biopha.2025.118331_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01225","article-title":"T cell-specific overexpression of acid sphingomyelinase results in elevated T cell activation and reduced parasitemia during Plasmodium yoelii infection","author":"Hose","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2025.118331_bib29","article-title":"Acid sphingomyelinase (ASM) is a negative regulator of regulatory T cell (Treg) development","author":"Zhou","year":"2016","journal-title":"Cell. Physiol. Biochem"},{"issue":"8","key":"10.1016\/j.biopha.2025.118331_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023852","article-title":"Identification of novel functional inhibitors of acid sphingomyelinase","volume":"6","author":"Kornhuber","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2025.118331_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab020","article-title":"Inhibition of acid sphingomyelinase increases regulatory T cells in humans","author":"Wiese","year":"2021","journal-title":"Brain Commun."},{"key":"10.1016\/j.biopha.2025.118331_bib32","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1600691","article-title":"Inhibition of acid sphingomyelinase allows for selective targeting of CD4+ conventional versus Foxp3+ regulatory T cells","author":"Hollmann","year":"2016","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib33","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/s41598-020-80658-7","article-title":"Erythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum","volume":"11","author":"Sah","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2025.118331_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77975","article-title":"The acid ceramidase\/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis","volume":"11","author":"G\u00fcnther","year":"2022","journal-title":"Elife"},{"issue":"S1","key":"10.1016\/j.biopha.2025.118331_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.33594\/000000183","article-title":"Pharmacological inhibition of acid sphingomyelinase ameliorates experimental autoimmune encephalomyelitis","volume":"27","author":"Walter","year":"2019","journal-title":"Neurosignals"},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pt.2012.10.002","article-title":"Monocytes and macrophages in malaria: protection or pathology?","volume":"29","author":"Chua","year":"2013","journal-title":"Trends Parasitol."},{"issue":"7","key":"10.1016\/j.biopha.2025.118331_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41577-019-0158-z","article-title":"T cell-mediated immunity to malaria","volume":"19","author":"Kurup","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.biopha.2025.118331_bib38","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.4049\/jimmunol.169.11.6369","article-title":"On the pathogenic role of brain-sequestered \u03b1\u03b2 CD8+ T cells in experimental cerebral malaria","volume":"169","author":"Belnoue","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2025.118331_bib39","doi-asserted-by":"crossref","DOI":"10.1159\/000185482","article-title":"Influence of amitriptyline on eryptosis, parasitemia and survival of Plasmodium berghei-infected mice","author":"Brand","year":"2008","journal-title":"Cell. Physiol. Biochem"},{"issue":"4","key":"10.1016\/j.biopha.2025.118331_bib40","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1550-7408.1974.tb03711.x","article-title":"Glucose transport in the malarial (Plasmodium lophurae) infected erythrocyte","volume":"21","author":"Sherman","year":"1974","journal-title":"J. Protozool."},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib41","doi-asserted-by":"crossref","first-page":"12086","DOI":"10.1038\/ncomms12086","article-title":"Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia","volume":"7","author":"Sun","year":"2016","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.biopha.2025.118331_bib42","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1021\/bi991931u","article-title":"ATP-dependent substrate occlusion by the human erythrocyte sugar transporter","volume":"39","author":"Heard","year":"2000","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.biopha.2025.118331_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0166-6851(96)02734-X","article-title":"Glucose uptake in Plasmodium falciparum-infected erythrocytes is an equilibrative not an active process","volume":"82","author":"Kirk","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"issue":"13","key":"10.1016\/j.biopha.2025.118331_bib44","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1073\/pnas.1330865100","article-title":"Validation of the hexose transporter of Plasmodium falciparum as a novel drug target","volume":"100","author":"Jo\u00ebt","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2025.118331_bib45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41579-024-01008-2","article-title":"Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa","volume":"22","author":"Rosenthal","year":"2024","journal-title":"Nat. Rev. Microbiol"},{"issue":"2","key":"10.1016\/j.biopha.2025.118331_bib46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1017\/S0031182017001081","article-title":"Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis","volume":"145","author":"Mina","year":"2018","journal-title":"Parasitology"},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1021\/ml2002136","article-title":"Sphingolipid analogues inhibit development of malaria parasites","volume":"3","author":"Meyer","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"issue":"20","key":"10.1016\/j.biopha.2025.118331_bib48","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1073\/pnas.92.20.9181","article-title":"Sphingolipid synthesis as a target for chemotherapy against malaria parasites","volume":"92","author":"Lauer","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.biopha.2025.118331_bib49","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1515\/hsz-2018-0159","article-title":"CD4+ Foxp3+ regulatory T cell-mediated immunomodulation by anti-depressants inhibiting acid sphingomyelinase","volume":"399","author":"Schneider-Schaulies","year":"2018","journal-title":"Biol. Chem."},{"key":"10.1016\/j.biopha.2025.118331_bib50","doi-asserted-by":"crossref","DOI":"10.1097\/SHK.0000000000000648","article-title":"Amitriptyline usage exacerbates the immune suppression following burn injury","author":"Johnson","year":"2016","journal-title":"Shock"},{"issue":"10","key":"10.1016\/j.biopha.2025.118331_bib51","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/AAC.44.10.2689-2692.2000","article-title":"Role of the neurotransmitter reuptake-blocking activity of antidepressants in reversing chloroquine resistance in vitro in Plasmodium falciparum","volume":"44","author":"Dale","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Pt 3","key":"10.1016\/j.biopha.2025.118331_bib52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/bj3460671","article-title":"Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum","volume":"346","author":"Hanada","year":"2000","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.biopha.2025.118331_bib53","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.chom.2015.08.003","article-title":"Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of Plasmodium falciparum","volume":"18","author":"Gulati","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib54","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41420-018-0075-0","article-title":"Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies","volume":"4","author":"Lewis","year":"2018","journal-title":"Cell Death Discov."},{"issue":"7\u20138","key":"10.1016\/j.biopha.2025.118331_bib55","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2119\/molmed.2010.00214","article-title":"S1P is associated with protection in human and experimental cerebral malaria","volume":"17","author":"Finney","year":"2011","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2025.118331_bib56","doi-asserted-by":"crossref","first-page":"e02766-22","DOI":"10.1128\/spectrum.02766-22","article-title":"Host-erythrocytic sphingosine-1-phosphate regulates Plasmodium histone deacetylase activity and exhibits epigenetic control over cell death and differentiation","volume":"11","author":"Kumar","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"3","key":"10.1016\/j.biopha.2025.118331_bib57","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0024-3205(99)00590-1","article-title":"The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants","volume":"66","author":"Pinkofsky","year":"2000","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.biopha.2025.118331_bib58","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molbiopara.2005.09.007","article-title":"High efficiency transfection of Plasmodium berghei facilitates novel selection procedures","volume":"145","author":"Janse","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.biopha.2025.118331_bib59","article-title":"Antidepressants act by inducing autophagy controlled by sphingomyelin\u2013ceramide","author":"Gulbins","year":"2018","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.biopha.2025.118331_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100631","article-title":"The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells","volume":"65","author":"Prell","year":"2024","journal-title":"J. Lipid Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332225005256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332225005256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T12:00:44Z","timestamp":1754654444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332225005256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":60,"alternative-id":["S0753332225005256"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2025.118331","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amitriptyline inhibits Plasmodium development in infected red blood cells by modulating sphingolipid metabolism and glucose uptake","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2025.118331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"118331"}}