{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:49:13Z","timestamp":1789080553310,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.biopha.2025.118481","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:32:15Z","timestamp":1755649935000},"page":"118481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Synergistic enhancement of anticancer effects by periodontal ligament stem cell exosomes and oxaliplatin via apoptosis induction and protein modulation"],"prefix":"10.1016","volume":"191","author":[{"given":"Jarunya","family":"Ngamkham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-3330","authenticated-orcid":false,"given":"Wararat","family":"Chiangjong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-3661","authenticated-orcid":false,"given":"Pei-Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9389-4194","authenticated-orcid":false,"given":"Dar-Bin","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thainsang","family":"Phansri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-3918","authenticated-orcid":false,"given":"Hathaitip","family":"Sritanaudomchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2025.118481_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.biopha.2025.118481_bib2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/annonc\/mdw028","article-title":"Periodontal disease and risk of all cancers among Male never smokers: an updated analysis of the health professionals Follow-up study","volume":"27","author":"Michaud","year":"2016","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.biopha.2025.118481_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdent.2009.10.007","article-title":"The association between periodontal disease and cancer: a review of the literature","volume":"38","author":"Fitzpatrick","year":"2010","journal-title":"J. Dent."},{"key":"10.1016\/j.biopha.2025.118481_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12091797","article-title":"Oral microbiome: a review of its impact on oral and systemic health","volume":"12","author":"Rajasekaran","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.biopha.2025.118481_bib5","article-title":"Liquid biopsy in colorectal cancer-current status and potential clinical applications","volume":"9","author":"Norcic","year":"2018","journal-title":"Micro (Basel)"},{"key":"10.1016\/j.biopha.2025.118481_bib6","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1200\/JCO.2010.31.7883","article-title":"Increasing incidence of oral tongue squamous cell carcinoma in young White women, age 18 to 44 years","volume":"29","author":"Patel","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.biopha.2025.118481_bib7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4240\/wjgs.v15.i4.495","article-title":"Current and emerging therapeutic approaches for colorectal cancer: a comprehensive review","volume":"15","author":"Kumar","year":"2023","journal-title":"World J. Gastrointest. Surg."},{"key":"10.1016\/j.biopha.2025.118481_bib8","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2025.118481_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1200\/JCO.2004.09.046","article-title":"A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer","volume":"22","author":"Goldberg","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.biopha.2025.118481_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15061653","article-title":"Combination therapy as a promising way to fight oral cancer","volume":"15","author":"Silva","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biopha.2025.118481_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101838","article-title":"Nanostructures for site-specific delivery of oxaliplatin cancer therapy: versatile nanoplatforms in synergistic cancer therapy","volume":"39","author":"Bagheri","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.biopha.2025.118481_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.biopha.2025.118481_bib13","first-page":"103","article-title":"Embryonic-maternal cross-talk via exosomes: potential implications","volume":"8","author":"Saadeldin","year":"2015","journal-title":"Stem Cells Cloning"},{"key":"10.1016\/j.biopha.2025.118481_bib14","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.12998\/wjcc.v9.i18.4467","article-title":"Roles of exosomes in diagnosis and treatment of colorectal cancer","volume":"9","author":"Umwali","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.biopha.2025.118481_bib15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biopha.2025.118481_bib16","doi-asserted-by":"crossref","first-page":"e84256","DOI":"10.1371\/journal.pone.0084256","article-title":"Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2025.118481_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.canlet.2011.10.002","article-title":"Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo","volume":"315","author":"Zhu","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2025.118481_bib18","doi-asserted-by":"crossref","DOI":"10.1177\/20417314211008626","article-title":"Defined MSC exosome with high yield and purity to improve regenerative activity","volume":"12","author":"Kim","year":"2021","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.biopha.2025.118481_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-021-01037-x","article-title":"Challenges and advances in clinical applications of mesenchymal stromal cells","volume":"14","author":"Zhou","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.biopha.2025.118481_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/srep38498","article-title":"Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells","volume":"6","author":"Reza","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2025.118481_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s13402-017-0335-7","article-title":"MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR\/HIF-1alpha\/VEGF signaling axis in breast cancer cells","volume":"40","author":"Pakravan","year":"2017","journal-title":"Cell Oncol. (Dordr.)"},{"key":"10.1016\/j.biopha.2025.118481_bib22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41598-018-36855-6","article-title":"Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma","volume":"9","author":"Rosenberger","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2025.118481_bib23","article-title":"Exosomes as drug carriers in Anti-Cancer therapy","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2025.118481_bib24","doi-asserted-by":"crossref","first-page":"10809","DOI":"10.2147\/CMAR.S277324","article-title":"Antitumor activity of cabazitaxel and MSC-TRAIL derived extracellular vesicles in drug-resistant oral squamous cell carcinoma","volume":"12","author":"Qiu","year":"2020","journal-title":"Cancer Manag Res."},{"key":"10.1016\/j.biopha.2025.118481_bib25","article-title":"Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells","volume":"18","author":"Ru","year":"2023","journal-title":"Open Life Sci."},{"key":"10.1016\/j.biopha.2025.118481_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1225449","article-title":"Curcumin-primed periodontal ligament stem cells-derived extracellular vesicles improve osteogenic ability through the Wnt\/beta-catenin pathway","volume":"11","author":"Lan","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2025.118481_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/nano11071858","article-title":"Periodontal and dental pulp Cell-Derived small extracellular vesicles: a review of the current status","volume":"11","author":"Hua","year":"2021","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.biopha.2025.118481_bib28","doi-asserted-by":"crossref","first-page":"558","DOI":"10.7150\/ijms.40918","article-title":"PDLSCs regulate angiogenesis of periodontal ligaments via VEGF transferred by exosomes in periodontitis","volume":"17","author":"Zhang","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.biopha.2025.118481_bib29","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3389\/fgene.2020.00582","article-title":"Extracellular vesicles of human periodontal ligament stem cells contain MicroRNAs associated to Proto-Oncogenes: implications in cytokinesis","volume":"11","author":"Chiricosta","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2025.118481_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ajoms.2023.08.006","article-title":"Stem cell therapy based on human periodontal ligament stem cells preactivated with TNF-\u03b1 as for human head and neck squamous cell carcinoma","volume":"36","author":"Ohara","year":"2024","journal-title":"J. Oral. Maxillofac. Surg. Med. Pathol."},{"key":"10.1016\/j.biopha.2025.118481_bib31","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.3892\/mmr.2017.6333","article-title":"High glucose promotes the osteogenic differentiation capability of human periodontal ligament fibroblasts","volume":"15","author":"Seubbuk","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2025.118481_bib32","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2022-0427","article-title":"Stem cell-derived exosomes from human exfoliated deciduous teeth promote angiogenesis in hyperglycemic-induced human umbilical vein endothelial cells","volume":"31","author":"Sunartvanichkul","year":"2023","journal-title":"J. Appl. Oral. Sci."},{"key":"10.1016\/j.biopha.2025.118481_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33280-7","article-title":"Multiplex biomarker screening assay for urinary extracellular vesicles study: a targeted Label-Free proteomic approach","volume":"8","author":"Chutipongtanate","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2025.118481_bib34","article-title":"ALA-A2 is a novel anticancer peptide inspired by Alpha-Lactalbumin: a discovery from a computational peptide library, in silico anticancer peptide screening and in vitro experimental validation","volume":"7","author":"Lerksuthirat","year":"2023","journal-title":"Glob. Chall."},{"key":"10.1016\/j.biopha.2025.118481_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-020-2227-7","article-title":"Mouse models of neutropenia reveal progenitor-stage-specific defects","volume":"582","author":"Muench","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2025.118481_bib36","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/aps.2017.12","article-title":"Engineering exosomes as refined biological nanoplatforms for drug delivery","volume":"38","author":"Luan","year":"2017","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.biopha.2025.118481_bib37","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jconrel.2020.03.039","article-title":"Extracellular vesicles for tumor targeting delivery based on five features principle","volume":"322","author":"Yong","year":"2020","journal-title":"J. Control Release"},{"key":"10.1016\/j.biopha.2025.118481_bib38","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.7150\/thno.45028","article-title":"Engineering blood exosomes for tumor-targeting efficient gene\/chemo combination therapy","volume":"10","author":"Zhan","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2025.118481_bib39","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extra Vesicles"},{"key":"10.1016\/j.biopha.2025.118481_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030316","article-title":"Exosome as a delivery vehicle for cancer therapy","volume":"11","author":"Moon","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2025.118481_bib41","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1089\/scd.2016.0093","article-title":"microRNA-145 mediates the inhibitory effect of adipose Tissue-Derived stromal cells on prostate cancer","volume":"25","author":"Takahara","year":"2016","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.biopha.2025.118481_bib42","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/jemt.23236","article-title":"Effects of human umbilical cord mesenchymal stem cells on co-cultured ovarian carcinoma cells","volume":"82","author":"Li","year":"2019","journal-title":"Microsc. Res Tech."},{"key":"10.1016\/j.biopha.2025.118481_bib43","article-title":"Microvesicles derived from human umbilical cord wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo","volume":"8","author":"Wu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2025.118481_bib44","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.2147\/OTT.S159829","article-title":"Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect","volume":"11","author":"Shen","year":"2018","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.biopha.2025.118481_bib45","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2025.118481_bib46","article-title":"Exosomes in cancer progression and therapy resistance: molecular insights and therapeutic opportunities","volume":"13","author":"Wandrey","year":"2023","journal-title":"Life (Basel)"},{"key":"10.1016\/j.biopha.2025.118481_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102617","article-title":"Exosomes in the tumor microenvironment: from biology to clinical applications","volume":"10","author":"da Costa","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2025.118481_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101448","article-title":"Oxaliplatin enhances the apoptotic effect of mesenchymal stem cells, delivering soluble TRAIL in chemoresistant colorectal cancer","volume":"16","author":"Quiroz-Reyes","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.biopha.2025.118481_bib49","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1111\/cas.13697","article-title":"Exosomes in cancer development and clinical applications","volume":"109","author":"Tai","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.biopha.2025.118481_bib50","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4251\/wjgo.v8.i8.583","article-title":"Apoptotic pathways as a therapeutic target for colorectal cancer treatment","volume":"8","author":"Abraha","year":"2016","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.biopha.2025.118481_bib51","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1189\/jlb.69.6.912","article-title":"Functional classification of interferon-stimulated genes identified using microarrays","volume":"69","author":"de Veer","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2025.118481_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fimmu.2017.00029","article-title":"Canonical and Non-Canonical aspects of JAK-STAT signaling: lessons from interferons for cytokine responses","volume":"8","author":"Majoros","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2025.118481_bib53","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/bjc.2013.335","article-title":"IRF-1 responsiveness to IFN-gamma predicts different cancer immune phenotypes","volume":"109","author":"Murtas","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biopha.2025.118481_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.952231","article-title":"IL12 immune therapy clinical trial review: novel strategies for avoiding CRS-associated cytokines","volume":"13","author":"Jia","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.biopha.2025.118481_bib55","doi-asserted-by":"crossref","first-page":"788024","DOI":"10.3389\/fonc.2021.788024","article-title":"\u03b2-tubulin isotype, TUBB4B,regulates the maintenance of cancer stem cells","volume":"11","author":"Dharmapal","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biopha.2025.118481_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.558","article-title":"Intracellular annexin A2 regulates NF-kappaB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer","volume":"6","author":"Jung","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2025.118481_bib57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3892\/or.2016.5234","article-title":"Annexin A1 is involved in resistance to 5-FU in colon cancer cells","volume":"37","author":"Onozawa","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2025.118481_bib58","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1021\/acs.biochem.1c00126","article-title":"Annexins A1 and A2 accumulate and are immobilized at Cross-Linked Membrane-Membrane interfaces","volume":"60","author":"Berg Klenow","year":"2021","journal-title":"Biochemistry"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332225006754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332225006754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:20:43Z","timestamp":1772806843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332225006754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":58,"alternative-id":["S0753332225006754"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2025.118481","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic enhancement of anticancer effects by periodontal ligament stem cell exosomes and oxaliplatin via apoptosis induction and protein modulation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2025.118481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"118481"}}