{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:38:49Z","timestamp":1791585529926,"version":"4.3.4"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Wroc\u0142aw Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.biopha.2025.118564","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:00:45Z","timestamp":1758582045000},"page":"118564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Corneal endothelial cells decline \u2013 A review of recent findings from molecular and clinical research"],"prefix":"10.1016","volume":"192","author":[{"given":"Dominika","family":"Domaga\u0142a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Muzyka-Wo\u017aniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Penciak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Niebora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Wo\u017aniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-46590-2","article-title":"An effective method for culturing functional human corneal endothelial cells using a xenogeneic free culture medium","volume":"13","author":"Alonso-Alonso","year":"2023","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2025.118564_bib2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/bjophthalmol-2015-307415","article-title":"Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction","volume":"100","author":"Baudouin","year":"2016","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exer.2011.06.004","article-title":"Molecular mechanisms underlying the corneal endothelial pump","volume":"95","author":"Bonanno","year":"2012","journal-title":"Exp. Eye Res."},{"issue":"10","key":"10.1016\/j.biopha.2025.118564_bib4","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/ICO.0000000000000915","article-title":"Treatment of fuchs endothelial dystrophy by descemet stripping without endothelial keratoplasty","volume":"35","author":"Borkar","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.biopha.2025.118564_bib5","doi-asserted-by":"crossref","unstructured":"Catala Quilis, P. (2023). Understanding the complexity of the corneal endothelium for regenerative medicine [maastricht university]. https:\/\/doi.org\/10.26481\/dis.20230913pq.","DOI":"10.26481\/dis.20230913pq"},{"key":"10.1016\/j.biopha.2025.118564_bib6","doi-asserted-by":"crossref","unstructured":"C\u00e1therine Mart\u00ednez Malo, L., & El Bosque, A. (2022). DETERMINATION OF FACTORS ASSOCIATED WITH LONG\u2395TERM ENDOTHELIAL LOSS AND REFRACTIVE RESULT IN PATIENTS WITH ARTISAN PHAKIC LENS.","DOI":"10.31348\/2022\/21"},{"issue":"4","key":"10.1016\/j.biopha.2025.118564_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4274\/tjo.53486","article-title":"Does long-term soft contact lens wear affect corneal and anterior chamber parameters?","volume":"48","author":"\u00c7avdarl\u0131","year":"2018","journal-title":"Turk. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.biopha.2025.118564_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000050858","article-title":"Effects of Contact Lenses on Corneal Endothelium \u2013 A Morphological and Functional Study","volume":"215","author":"Chang","year":"2001","journal-title":"Ophthalmologica"},{"issue":"3","key":"10.1016\/j.biopha.2025.118564_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4103\/ijo.IJO_574_20","article-title":"Specular microscopy in clinical practice","volume":"69","author":"Chaurasia","year":"2021","journal-title":"Indian J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02547-2","article-title":"Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases","volume":"19","author":"Chen","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.biopha.2025.118564_bib11","doi-asserted-by":"crossref","unstructured":"Chew, L.A., Jun, A.S., & Barnett, B.P., 2022. Corneal endothelial transplantation from bench to bedside: A review of animal models and their translational value for therapeutic development. In Experimental Eye Research (Vol. 224). Academic Press. https:\/\/doi.org\/10.1016\/j.exer.2022.109241.","DOI":"10.1016\/j.exer.2022.109241"},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib12","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s42003-023-05005-8","article-title":"In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions","volume":"6","author":"Chiang","year":"2023","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/ajt.15631","article-title":"Regulatory t cells promote corneal endothelial cell survival following transplantation via interleukin-10","volume":"20","author":"Coco","year":"2020","journal-title":"Am. J. Transplant. Off. J. Am. Soc. Transplant. Am. Soc. Transpl. Surg."},{"key":"10.1016\/j.biopha.2025.118564_bib14","article-title":"An update on corneal biomechanics and architecture in diabetes","volume":"2019","author":"Del Buey","year":"2019","journal-title":"J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.biopha.2025.118564_bib15","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/php.12686","article-title":"Damaging effects of ultraviolet radiation on the cornea","volume":"93","author":"Delic","year":"2017","journal-title":"Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/bjophthalmol-2020-316888","article-title":"Two-year outcomes of the MINIject drainage system for uncontrolled glaucoma from the STAR-I first-in-human trial","volume":"106","author":"Denis","year":"2022","journal-title":"Br. J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.biopha.2025.118564_bib17","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ogla.2019.06.001","article-title":"A First-in-Human study of the efficacy and safety of MINIject in patients with medically uncontrolled Open-Angle glaucoma (STAR-I)","volume":"2","author":"Denis","year":"2019","journal-title":"Ophthalmol. Glaucoma"},{"key":"10.1016\/j.biopha.2025.118564_bib18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.exer.2019.02.010","article-title":"Effects of amantadine on corneal endothelium","volume":"181","author":"Dudley","year":"2019","journal-title":"Exp. Eye Res."},{"issue":"9","key":"10.1016\/j.biopha.2025.118564_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111307","article-title":"A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration","volume":"40","author":"Efraim","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00210-019-01711-5","article-title":"Apoptotic effects of norfloxacin on corneal endothelial cells","volume":"393","author":"Fan","year":"2020","journal-title":"NaunynSchmiede \u2019S. Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2025.118564_bib21","article-title":"Corneal endothelial cell dysfunction: etiologies and management","volume":"10","author":"Feizi","year":"2018","journal-title":"Ther. Adv. Ophthalmol."},{"issue":"7","key":"10.1016\/j.biopha.2025.118564_bib22","first-page":"1084","article-title":"GATA6 is essential for endoderm formation from human pluripotent stem cells","volume":"6","author":"Fisher","year":"2017","journal-title":"Biol. Open"},{"key":"10.1016\/j.biopha.2025.118564_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/DDDT.S435522","article-title":"The role of rho kinase inhibitors in corneal diseases","volume":"18","author":"Futterknecht","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2025.118564_bib24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/hep.510260307","article-title":"Ki-67 expression during rat liver regeneration after partial hepatectomy","volume":"26","author":"Gerlach","year":"1997","journal-title":"Hepatology"},{"issue":"20","key":"10.1016\/j.biopha.2025.118564_bib25","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.1128\/MCB.00359-08","article-title":"Oct4\/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells","volume":"28","author":"Greer Card","year":"2008","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.biopha.2025.118564_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.109952","article-title":"Protective effects of curcumin on corneal endothelial cell PANoptosis and monocyte adhesion induced by tumor necrosis factor-alpha and interferon-gamma in rats","volume":"245","author":"Guo","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biopha.2025.118564_bib28","article-title":"Phakic intraocular lens myopia","author":"Hasan","year":"2023","journal-title":"StatPearls"},{"issue":"3","key":"10.1016\/j.biopha.2025.118564_bib29","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1016\/j.jcjo.2016.11.018","article-title":"Corneal edema with a systemic epidermal growth factor receptor inhibitor","volume":"52","author":"H\u00f6llhumer","year":"2017","journal-title":"Can. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1124\/mol.66.2.302","volume":"66","author":"Huang","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biopha.2025.118564_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1093985","article-title":"The role of pyroptosis in endothelial dysfunction induced by diseases","volume":"13","author":"Ju","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2025.118564_bib32","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1177\/112067210501500604","article-title":"Corneal endothelial cells\u2019 protection against thermal injury: influence of ophthalmic viscoelastic substances in experimental study on rabbits","volume":"15","author":"Jurowski","year":"2005","journal-title":"Eur. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.51329\/mehdiophthal1500","article-title":"Cataract surgery in retinitis pigmentosa","volume":"13","author":"Karti","year":"2024","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol."},{"issue":"11","key":"10.1016\/j.biopha.2025.118564_bib34","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMoa1712770","article-title":"Injection of cultured cells with a ROCK inhibitor for bullous keratopathy","volume":"378","author":"Kinoshita","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.biopha.2025.118564_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4274\/tjo.72368","article-title":"Does fluid temperature affect corneal Endothelium-Descemet membrane scroll formation? An in vitro study","volume":"48","author":"Ko\u00e7luk","year":"2018","journal-title":"Turk. J. Ophthalmol."},{"issue":"12","key":"10.1016\/j.biopha.2025.118564_bib36","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004170000223","article-title":"A comparative study of corneal endothelial changes induced by different durations of soft contact lens wear","volume":"239","author":"Lee","year":"2001","journal-title":"Graefe's Arch. Clin. Exp. Ophthalmol."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib38","doi-asserted-by":"crossref","first-page":"C116","DOI":"10.1152\/ajpcell.00095.2016","article-title":"Fluid transport by the cornea endothelium is dependent on buffering lactic acid efflux","volume":"311","author":"Li","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2025.118564_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101417","article-title":"Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells","volume":"30","author":"Lovatt","year":"2020","journal-title":"Redox Biol."},{"issue":"16","key":"10.1016\/j.biopha.2025.118564_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13164760","article-title":"Visual prognosis following cataract surgery in highly myopic patients with prior history of verisyse phakic intraocular lens implantation","volume":"13","author":"Loveless","year":"2024","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ajpath.2021.10.016","article-title":"The neuropeptide Alpha-Melanocyte-Stimulating hormone is critical for corneal endothelial cell protection and graft survival after transplantation","volume":"192","author":"Lu\u017enik Marzidov\u0161ek","year":"2022","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.biopha.2025.118564_bib42","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3390\/antiox12061228","article-title":"Role of NADPH Oxidase 4 in Corneal Endothelial Cells Is Mediated by Endoplasmic Reticulum Stress and Autophagy","volume":"12","author":"Ma","year":"2023","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib43","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0002-9394(14)71541-7","article-title":"Corneal endothelial dysfunction in digoxin toxicity [6]","volume":"113","author":"Madreperla","year":"1992","journal-title":"Am. J. Ophthalmol."},{"issue":"8","key":"10.1016\/j.biopha.2025.118564_bib44","first-page":"1310","article-title":"Wavelength-dependent ultraviolet induction of cyclobutane pyrimidine dimers in the human cornea","volume":"12","author":"Mallet","year":"2013","journal-title":"Photochem. Photobiol. Sci. Off. J. Eur. Photochem. Assoc. Eur. Soc. Photobiol."},{"issue":"4","key":"10.1016\/j.biopha.2025.118564_bib45","doi-asserted-by":"crossref","DOI":"10.1080\/15569527.2024.2422914","article-title":"Effects on corneal endothelium of intravitreal injection of anti-VEGF drugs","volume":"43","author":"Malvasi","year":"2024","journal-title":"Cutan. Ocul. Toxicol."},{"issue":"8","key":"10.1016\/j.biopha.2025.118564_bib46","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/ICO.0000000000001941","article-title":"Corneal edema associated with systemic dopaminergic agents","volume":"38","author":"Mancera","year":"2019","journal-title":"Cornea"},{"issue":"15","key":"10.1016\/j.biopha.2025.118564_bib47","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1167\/iovs.16-20414","article-title":"Corneal endothelial cell migration and proliferation enhanced by rho kinase (ROCK) inhibitors in In vitro and in vivo models","volume":"57","author":"Meekins","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib48","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clae.2020.06.007","article-title":"The morphology of corneal endothelial cells in long term soft contact lens wearers in Kuala Lumpur","volume":"44","author":"Mohd-Ali","year":"2021","journal-title":"Contact Lens Anterior Eye"},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib49","doi-asserted-by":"crossref","DOI":"10.3109\/08830185.2012.737877","article-title":"Corneal transplantation and immune privilege","volume":"32","author":"Niederkorn","year":"2013","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.biopha.2025.118564_bib50","first-page":"1589","article-title":"Corneal endothelial cell loss in patients after minimally invasive glaucoma surgery: current perspectives","volume":"16","author":"Obuchowska","year":"2022"},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib51","article-title":"Increased corneal endothelial cell migration in fuchs endothelial corneal dystrophy: a live cell imaging study","volume":"1","author":"Ong Tone","year":"2021","journal-title":"Ophthalmol. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2025.118564_bib52","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4103\/jovr.jovr_28_17","article-title":"Corneal alterations associated with pseudoexfoliation syndrome and glaucoma: a literature review","volume":"12","author":"Palko","year":"2017","journal-title":"J. Ophthalmic Vis. Res."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010036","article-title":"MiR-302a regenerates human corneal endothelial cells against IFN-\u03b3-Induced cell death","volume":"12","author":"Park","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12886-018-0682-9","article-title":"Short-term effects and safety of an acute increase of intraocular pressure after intravitreal bevacizumab injection on corneal endothelial cells","volume":"18","author":"Park","year":"2018","journal-title":"BMC Ophthalmol."},{"issue":"7","key":"10.1016\/j.biopha.2025.118564_bib55","article-title":"ZO-1 and Na\/K ATPase are expressed in a human-engineered corneal endothelium","volume":"61","author":"Parra","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2025.118564_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/cells12091307","article-title":"Effects of Rho-Associated kinase (Rock) inhibitors (Alternative to Y-27632) on primary human corneal endothelial cells","volume":"12","author":"Peh","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.biopha.2025.118564_bib57","doi-asserted-by":"crossref","first-page":"e779","DOI":"10.1111\/aos.14968","article-title":"PRESERFLO\u2122 MicroShunt versus trabeculectomy: first results on efficacy and safety","volume":"100","author":"Pillunat","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.biopha.2025.118564_bib58","author":"Ponirakis","year":"2025","journal-title":"Assoc. corneal Endothel. Cell Morphol. Neurodegener. mild Cogn. Impair. Dement."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib59","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1167\/iovs.14-16166","article-title":"Understanding the process of corneal endothelial morphological change in vitro","volume":"56","author":"Roy","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.biopha.2025.118564_bib60","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s00417-020-04671-2","article-title":"Structural imaging of conjunctival filtering blebs in XEN gel implantation and trabeculectomy: a confocal and anterior segment optical coherence tomography study","volume":"258","author":"Sacchi","year":"2020","journal-title":"Graefe\u2019S. Arch. Clin. Exp. Ophthalmol."},{"issue":"11","key":"10.1016\/j.biopha.2025.118564_bib61","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1167\/iovs.04-0439","article-title":"Inflammatory cytokines induce apoptosis of corneal endothelium through nitric oxide","volume":"45","author":"Sagoo","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2025.118564_bib62","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ophtha.2019.03.006","article-title":"Prospective, randomized, controlled pivotal trial of an ab interno implanted trabecular Micro-Bypass in primary Open-Angle glaucoma and cataract: Two-Year results","volume":"126","author":"Samuelson","year":"2019","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.biopha.2025.118564_bib63","first-page":"E239","article-title":"Dynamic regulation of barrier integrity of the corneal endothelium","volume":"87","author":"Sangly","year":"2010","journal-title":"Optometry Vision Science Official Publication American Academy Optometry"},{"key":"10.1016\/j.biopha.2025.118564_bib64","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ajo.2020.12.006","article-title":"Potential functional restoration of corneal endothelial cells in fuchs endothelial corneal dystrophy by ROCK inhibitor (Ripasudil)","volume":"224","author":"Schl\u00f6tzer-Schrehardt","year":"2021","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib65","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bbrc.2018.12.139","article-title":"Long noncoding RNA MALAT1 promotes high glucose-induced human endothelial cells pyroptosis by affecting NLRP3 expression through competitively binding miR-22","volume":"509","author":"Song","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.biopha.2025.118564_bib66","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3390\/biomedicines12071439","article-title":"Suppressing Pro-Apoptotic proteins by siRNA in corneal endothelial cells protects against cell death","volume":"12","author":"Staehlke","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.biopha.2025.118564_bib67","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajo.2021.11.012","article-title":"Superiority of mature differentiated cultured human corneal endothelial cell injection therapy for corneal endothelial failure","volume":"237","author":"Ueno","year":"2022","journal-title":"Am. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib68","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2021.11052","article-title":"Risk factors for fluctuations in corneal endothelial cell density (Review)","volume":"23","author":"Vaiciuliene","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.biopha.2025.118564_bib69","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.survophthal.2017.07.004","article-title":"A review of the evidence for in\u00a0vivo corneal endothelial regeneration","volume":"63","author":"Van den Bogerd","year":"2018","journal-title":"Surv. Ophthalmol."},{"issue":"6","key":"10.1016\/j.biopha.2025.118564_bib70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/tvst.8.6.13","article-title":"Corneal Endothelial Cells Over the Past Decade: Are We Missing the Mark(er)?","volume":"8","author":"Van den Bogerd","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.biopha.2025.118564_bib71","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2147\/OPTH.S411454","article-title":"Endothelial cell loss following cataract surgery using continuous curvilinear capsulorhexis or precision pulse capsulotomy","volume":"17","author":"Vital","year":"2023","journal-title":"Clin. Ophthalmol. (Auckl. N. Z. )"},{"key":"10.1016\/j.biopha.2025.118564_bib72","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.exer.2018.02.017","article-title":"A potential role for eph receptor signalling during migration of corneal endothelial cells","volume":"170","author":"Walshe","year":"2018","journal-title":"Exp. Eye Res."},{"issue":"4","key":"10.1016\/j.biopha.2025.118564_bib73","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00417-018-3913-0","article-title":"Inflammatory cytokine TNF-\u03b1 promotes corneal endothelium apoptosis via upregulating TIPE2 transcription during corneal graft rejection","volume":"256","author":"Wang","year":"2018","journal-title":"Graefe\u2019S. Arch. Clin. Exp. Ophthalmol."},{"issue":"13","key":"10.1016\/j.biopha.2025.118564_bib74","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1177\/1535370216640931","article-title":"Cytotoxicity of atropine to human corneal endothelial cells by inducing mitochondrion-dependent apoptosis","volume":"241","author":"Wen","year":"2016","journal-title":"Exp. Biol. Med. (Maywood N. J. )"},{"issue":"9","key":"10.1016\/j.biopha.2025.118564_bib75","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2217\/rme-2020-0202","article-title":"Challenges in corneal endothelial cell culture","volume":"16","author":"Wongvisavavit","year":"2021","journal-title":"Regen. Med."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14131-3","article-title":"Association between corneal endothelial cell densities and elevated cytokine levels in the aqueous humour","volume":"7","author":"Yagi-Yaguchi","year":"2017","journal-title":"Sci. Rep."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2025.118564_bib77","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"15","key":"10.1016\/j.biopha.2025.118564_bib78","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.12998\/wjcc.v7.i15.1978","article-title":"Changes in corneal endothelial cell density in patients with primary open-angle glaucoma","volume":"7","author":"Yu","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.biopha.2025.118564_bib79","doi-asserted-by":"crossref","first-page":"7605","DOI":"10.2147\/IJN.S436038","article-title":"A comprehensive review of small interfering RNAs (siRNAs): mechanism, therapeutic targets, and delivery strategies for cancer therapy","volume":"18","author":"Zhang","year":"2023","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib80","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.preteyeres.2011.10.001","article-title":"Electrical signaling in control of ocular cell behaviors","volume":"31","author":"Zhao","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"issue":"4","key":"10.1016\/j.biopha.2025.118564_bib81","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00445.2019","article-title":"NAD+ precursors protect corneal endothelial cells from UVB-induced apoptosis","volume":"318","author":"Zhao","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2025.118564_bib82","article-title":"Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury","author":"Zidan","year":"2023","journal-title":"Res. Sq."},{"issue":"1","key":"10.1016\/j.biopha.2025.118564_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-025-00396-0","article-title":"Advancements in bioengineering for descemet membrane endothelial keratoplasty (DMEK)","volume":"10","author":"Zwingelberg","year":"2025","journal-title":"Npj Regen. Med."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332225007589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332225007589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:23:03Z","timestamp":1775780583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332225007589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":83,"alternative-id":["S0753332225007589"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2025.118564","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corneal endothelial cells decline \u2013 A review of recent findings from molecular and clinical research","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2025.118564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"118564"}}