{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:30:41Z","timestamp":1792690241852,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010609","name":"Medical University of Gda\u0144sk","doi-asserted-by":"publisher","award":["01-65025"],"award-info":[{"award-number":["01-65025"]}],"id":[{"id":"10.13039\/501100010609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.biopha.2026.119006","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T17:48:35Z","timestamp":1770313715000},"page":"119006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Natural inhibitors of PTP1B: Caffeic acid, cinnamic acid, and cinnamaldehyde as promising agents against triple-negative breast cancer"],"prefix":"10.1016","volume":"196","author":[{"given":"Micha\u0142","family":"Suchecki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0401-0640","authenticated-orcid":false,"given":"Maria Denise","family":"Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Herkt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Vergilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-5268","authenticated-orcid":false,"given":"Francesca","family":"Rappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Gorska-Ponikowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-5013","authenticated-orcid":false,"given":"Alicja","family":"Kuban-Jankowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.biopha.2026.119006_bib1","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.3390\/cancers13174287","article-title":"Breast cancer\u2014epidemiology, risk factors, classification, prognostic markers, and current treatment strategies\u2014an updated review","volume":"13","author":"\u0141ukasiewicz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.biopha.2026.119006_bib2","unstructured":"Cancer Today. Accessed 2025. \u3008https:\/\/gco.iarc.fr\/today\/en\/dataviz\/tables?mode=population&cancers=20&group_populations=0&multiple_populations=1\u3009."},{"issue":"5","key":"10.1016\/j.biopha.2026.119006_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.6004\/jnccn.2024.0035","article-title":"Breast cancer, version 3.2024","volume":"22","author":"Gradishar","year":"2024","journal-title":"JNCCN J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.biopha.2026.119006_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.582719","article-title":"Targets and mechanism used by cinnamaldehyde, the main active ingredient in cinnamon, in the treatment of breast cancer","volume":"11","author":"Liu","year":"2020","journal-title":"Front Pharm."},{"issue":"3","key":"10.1016\/j.biopha.2026.119006_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ph17030361","article-title":"Natural compounds and breast cancer: chemo-preventive and therapeutic capabilities of chlorogenic acid and cinnamaldehyde","volume":"17","author":"Olayiwola","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.biopha.2026.119006_bib6","first-page":"588","article-title":"Caffeic acid and diseases\u2014mechanisms of action","volume":"24","author":"Cal","year":"2022","journal-title":"Int. J. Mol. Sci. 2023"},{"issue":"2","key":"10.1016\/j.biopha.2026.119006_bib7","first-page":"173","article-title":"Anticancer potential and molecular mechanisms of cinnamaldehyde and its congeners present in the cinnamon Plant","volume":"3","author":"Cancela","year":"2023","journal-title":"Physiologia 2023"},{"key":"10.1016\/j.biopha.2026.119006_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113532","article-title":"Application of cinnamic acid in the structural modification of natural products: a review","volume":"206","author":"Deng","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.biopha.2026.119006_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.focha.2023.100239","article-title":"Scientific evidences of anticancer potential of medicinal plants","volume":"2","author":"Chandra","year":"2023","journal-title":"Food Chem. Adv."},{"issue":"9","key":"10.1016\/j.biopha.2026.119006_bib10","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2174\/1871520620666200807222248","article-title":"Exploring the molecular mechanism of cinnamic acid-mediated cytotoxicity in triple negative MDA-MB-231 breast cancer cells","volume":"21","author":"Pal","year":"2020","journal-title":"Anticancer Agents Med Chem."},{"issue":"10","key":"10.1016\/j.biopha.2026.119006_bib11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.chembiol.2007.08.012","article-title":"A class of small molecules that inhibit TNF\u03b1-induced survival and death pathways via prevention of interactions between TNF\u03b1RI, TRADD, and RIP1","volume":"14","author":"Gururaja","year":"2007","journal-title":"Chem. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119006_bib12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/carcin\/bgp292","article-title":"Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling","volume":"31","author":"Lu","year":"2009","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.biopha.2026.119006_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26051335","article-title":"The pluripotent activities of caffeic acid phenethyl ester","volume":"26","author":"Olgierd","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.biopha.2026.119006_bib14","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/molecules18010845","article-title":"Chamaejasmine arrests cell cycle, induces apoptosis and inhibits nuclear NF-\u03baB translocation in the human breast cancer cell line MDA-MB-231","volume":"18","author":"Zhang","year":"2013","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.biopha.2026.119006_bib15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.freeradbiomed.2008.10.025","article-title":"The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth","volume":"46","author":"Cabello","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.biopha.2026.119006_bib16","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.7150\/ijbs.89942","article-title":"The PI3K\/Akt pathway and glucose metabolism: a dangerous liaison in cancer","volume":"20","author":"Fontana","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2026.119006_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188442","article-title":"Role of tyrosine phosphorylation in modulating cancer cell metabolism","volume":"1874","author":"Taddei","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA) Reviews Cancer"},{"issue":"2","key":"10.1016\/j.biopha.2026.119006_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188442","article-title":"Role of tyrosine phosphorylation in modulating cancer cell metabolism","volume":"1874","author":"Taddei","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"11","key":"10.1016\/j.biopha.2026.119006_bib19","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211994","article-title":"Recent advances in PTP1B signaling in metabolism and cancer","volume":"41","author":"Villamar-Cruz","year":"2021","journal-title":"Biosci. Rep."},{"issue":"12","key":"10.1016\/j.biopha.2026.119006_bib20","first-page":"1","article-title":"Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2\/AMPK\/mTOC1 pathway","volume":"10","author":"Xu","year":"2019","journal-title":"Cell Death Dis. 2019"},{"issue":"5","key":"10.1016\/j.biopha.2026.119006_bib21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.molcel.2014.02.015","article-title":"SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells","volume":"53","author":"Keller","year":"2014","journal-title":"Mol. Cell"},{"issue":"22","key":"10.1016\/j.biopha.2026.119006_bib22","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.3390\/ijms20225622","article-title":"Knockdown of pyruvate kinase M2 inhibits cell proliferation, metabolism, and migration in renal cell carcinoma","volume":"20","author":"Dey","year":"2019","journal-title":"Int. J. Mol. Sci. 2019"},{"issue":"3","key":"10.1016\/j.biopha.2026.119006_bib23","first-page":"1997","article-title":"ERK\/MAPK signalling pathway and tumorigenesis (Review)","volume":"19","author":"Guo","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"8","key":"10.1016\/j.biopha.2026.119006_bib24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tibs.2010.03.004","article-title":"PTP1B: a double agent in metabolism and oncogenesis","volume":"35","author":"Yip","year":"2010","journal-title":"Trends Biochem. Sci."},{"issue":"14","key":"10.1016\/j.biopha.2026.119006_bib25","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1073\/pnas.86.14.5257","article-title":"cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family","volume":"86","author":"Cool","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"42","key":"10.1016\/j.biopha.2026.119006_bib26","doi-asserted-by":"crossref","first-page":"40607","DOI":"10.1074\/jbc.M306772200","article-title":"Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts","volume":"278","author":"Dadke","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.biopha.2026.119006_bib27","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211994","article-title":"Recent advances in PTP1B signaling in metabolism and cancer","volume":"41","author":"Villamar-Cruz","year":"2021","journal-title":"Biosci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2026.119006_bib28","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1158\/2159-8290.CD-21-0694","article-title":"PTP1B Is an intracellular checkpoint that limits T-cell and CAR T-cell antitumor immunity","volume":"12","author":"Wiede","year":"2022","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.biopha.2026.119006_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-023-05020-9","article-title":"Structure guided studies of the interaction between PTP1B and JAK","volume":"6","author":"Morris","year":"2023","journal-title":"Commun. Biol."},{"issue":"13","key":"10.1016\/j.biopha.2026.119006_bib30","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.3390\/ijms23137027","article-title":"Human protein tyrosine phosphatase 1B (PTP1B): from structure to clinical inhibitor perspectives","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.biopha.2026.119006_bib31","doi-asserted-by":"crossref","first-page":"14052","DOI":"10.1021\/acsomega.4c11062","article-title":"In silico and in vivo investigation of the anti-hyperglycemic effects of caffeic acid","volume":"10","author":"Ratnawati","year":"2025","journal-title":"ACS Omega"},{"issue":"2","key":"10.1016\/j.biopha.2026.119006_bib32","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11418-012-0674-7","article-title":"Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum","volume":"67","author":"Saifudin","year":"2013","journal-title":"J. Nat. Med."},{"issue":"9","key":"10.1016\/j.biopha.2026.119006_bib33","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2174\/1871520620666200807222248","article-title":"Exploring the molecular mechanism of cinnamic acid-mediated cytotoxicity in triple negative MDA-MB-231 breast cancer cells","volume":"21","author":"Pal","year":"2020","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.biopha.2026.119006_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.582719","article-title":"Targets and mechanism used by cinnamaldehyde, the main active ingredient in cinnamon, in the treatment of breast cancer","volume":"11","author":"Liu","year":"2020","journal-title":"Front Pharm."},{"issue":"13","key":"10.1016\/j.biopha.2026.119006_bib35","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.3390\/ijms23137027","article-title":"Human protein tyrosine phosphatase 1B (PTP1B): from structure to clinical inhibitor perspectives","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119006_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112376","article-title":"Recent advance on PTP1B inhibitors and their biomedical applications","volume":"199","author":"Sharma","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"W1","key":"10.1016\/j.biopha.2026.119006_bib37","doi-asserted-by":"crossref","first-page":"W324","DOI":"10.1093\/nar\/gkae300","article-title":"SwissDock 2024: major enhancements for small-molecule docking with attracting cavities and AutoDock Vina","volume":"52","author":"Bugnon","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.biopha.2026.119006_bib38","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model"},{"issue":"5","key":"10.1016\/j.biopha.2026.119006_bib39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.18632\/oncotarget.496","article-title":"Targeting protein-tyrosine phosphatases in breast cancer","volume":"3","author":"Aceto","year":"2012","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.biopha.2026.119006_bib40","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1158\/1541-7786.MCR-11-0198","article-title":"Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2\/Neu but is not essential for tumor maintenance","volume":"9","author":"Balavenkatraman","year":"2011","journal-title":"Mol. Cancer Res."},{"issue":"24","key":"10.1016\/j.biopha.2026.119006_bib41","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1080\/14786419.2023.2177992","article-title":"Novel synthetic derivatives of cinnamic and p-coumaric acids with antiproliferative effect on breast MCF-7 tumor cells","volume":"37","author":"Rodrigues","year":"2023","journal-title":"Nat. Prod. Res."},{"issue":"12","key":"10.1016\/j.biopha.2026.119006_bib42","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.bcp.2003.07.014","article-title":"Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells","volume":"66","author":"Lee","year":"2003","journal-title":"Biochem. Pharm."},{"issue":"2","key":"10.1016\/j.biopha.2026.119006_bib43","doi-asserted-by":"crossref","first-page":"745","DOI":"10.21873\/anticanres.13171","article-title":"Curcumin and cinnamaldehyde as PTP1B inhibitors with antidiabetic and anticancer potential","volume":"39","author":"Kostrzewa","year":"2019","journal-title":"Anticancer Res"},{"issue":"9","key":"10.1016\/j.biopha.2026.119006_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22091554","article-title":"Comparison of two components of propolis: caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231","volume":"22","author":"Kaba\u0142a-Dzik","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2026.119006_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpet.2025.103654","article-title":"Cinnamic acid enhances vinorelbine-induced cytotoxicity in MDA-MB-231 cells through modulation of PTEN and ATG5 expression","author":"Al Mulla Hummadi","year":"2025","journal-title":"J. Pharm. Exp. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2026.119006_bib46","doi-asserted-by":"crossref","DOI":"10.5812\/gct-126544","article-title":"Synergistic effect of taxol and vincristine against MCF-7 cell line","volume":"10","author":"Zandi","year":"2023","journal-title":"Gene Cell Tissue"},{"issue":"1","key":"10.1016\/j.biopha.2026.119006_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12645-025-00315-4","article-title":"PEG-functionalized UiO-66 MOFs for targeted vincristine delivery: enhanced cytotoxicity in breast and ovarian cancer cell lines","volume":"16","author":"Sadeghi Jam","year":"2025","journal-title":"Cancer Nanotechnol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119006_bib48","doi-asserted-by":"crossref","DOI":"10.5812\/gct-126544","article-title":"Synergistic effect of taxol and vincristine against MCF-7 cell line","volume":"10","author":"Zandi","year":"2023","journal-title":"Gene Cell Tissue"},{"issue":"1","key":"10.1016\/j.biopha.2026.119006_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12645-025-00315-4","article-title":"PEG-functionalized UiO-66 MOFs for targeted vincristine delivery: enhanced cytotoxicity in breast and ovarian cancer cell lines","volume":"16","author":"Sadeghi Jam","year":"2025","journal-title":"Cancer Nanotechnol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226000387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226000387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:47:49Z","timestamp":1781880469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226000387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"alternative-id":["S0753332226000387"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119006","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural inhibitors of PTP1B: Caffeic acid, cinnamic acid, and cinnamaldehyde as promising agents against triple-negative breast cancer","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119006"}}