{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:22:08Z","timestamp":1788470528037,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2020-NR046282"],"award-info":[{"award-number":["RS-2020-NR046282"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2022-NR070330"],"award-info":[{"award-number":["RS-2022-NR070330"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["26Z9001"],"award-info":[{"award-number":["26Z9001"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.biopha.2026.119019","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T21:09:22Z","timestamp":1770239362000},"page":"119019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Vitisin B, extracted from Vitis vinifera, enhances memory function and neuroprotective effects in scopolamine-induced memory-impaired mice"],"prefix":"10.1016","volume":"196","author":[{"given":"Won Seok","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongyoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Seop","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Eun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4019-1261","authenticated-orcid":false,"given":"Myoung Jin","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-7386","authenticated-orcid":false,"given":"Soo-Jin","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonggi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-0494","authenticated-orcid":false,"given":"Ik-Hyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-9813","authenticated-orcid":false,"given":"Chun Whan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu-Sang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1892-8061","authenticated-orcid":false,"given":"Min Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4589","key":"10.1016\/j.biopha.2026.119019_bib1","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1126\/science.6338589","article-title":"Alzheimer's disease: a disorder of cortical cholinergic innervation","volume":"219","author":"Coyle","year":"1983","journal-title":"Science"},{"issue":"4558","key":"10.1016\/j.biopha.2026.119019_bib2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.biopha.2026.119019_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0896-6273(90)90166-D","article-title":"Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture","volume":"5","author":"Alderson","year":"1990","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.biopha.2026.119019_bib4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1073\/pnas.88.3.961","article-title":"Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3","volume":"88","author":"Kn\u00fcsel","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.biopha.2026.119019_bib5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/1567205016666190315093520","article-title":"Mitigating Alzheimer\u2019s Disease with Natural Polyphenols: A Review","volume":"16","author":"Roger","year":"2019","journal-title":"Curr. Alzheimer Res."},{"issue":"8","key":"10.1016\/j.biopha.2026.119019_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082749","article-title":"Neuroprotective Properties of Resveratrol and Its Derivatives-Influence on Potential Mechanisms Leading to the Development of Alzheimer's Disease","volume":"21","author":"Wici\u0144ski","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2026.119019_bib7","doi-asserted-by":"crossref","first-page":"936","DOI":"10.5114\/aoms.2019.85463","article-title":"Resveratrol and cognitive decline: a clinician perspective","volume":"15","author":"Cicero","year":"2019","journal-title":"Arch. Med Sci."},{"issue":"17","key":"10.1016\/j.biopha.2026.119019_bib8","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.3390\/nu16172856","article-title":"Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders\u2014An Overview of Experimental Evidence","volume":"16","author":"Tseilikman","year":"2024","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.biopha.2026.119019_bib9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.apsb.2022.07.001","article-title":"Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virus-induced oxidative stress","volume":"13","author":"Kwon","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"10.1016\/j.biopha.2026.119019_bib10","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.3390\/app14114534","article-title":"Resveratrol: A Review on the Biological Activity and Applications","volume":"14","author":"Bejenaru","year":"2024","journal-title":"Appl. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119019_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10616-019-00366-7","article-title":"Neuroprotection of SAK3 on scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells","volume":"72","author":"Suthprasertporn","year":"2020","journal-title":"Cytotechnology"},{"key":"10.1016\/j.biopha.2026.119019_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114812","article-title":"The central administration of vitisin a, extracted from Vitis vinifera, improves cognitive function and related signaling pathways in a scopolamine-induced dementia model","volume":"163","author":"Choi","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2026.119019_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114812","article-title":"The central administration of vitisin a, extracted from Vitis vinifera, improves cognitive function and related signaling pathways in a scopolamine-induced dementia model","volume":"163","author":"Choi","year":"2023","journal-title":"Biomed. Pharm."},{"issue":"2","key":"10.1016\/j.biopha.2026.119019_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process"},{"issue":"30","key":"10.1016\/j.biopha.2026.119019_bib15","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1016\/0040-4020(96)00543-1","article-title":"Absolute structures of new hydroxystilbenoids, vitisin C and viniferal, from Vitis vinifera \u2018Kyohou","volume":"52","author":"Ito","year":"1996","journal-title":"Tetrahedron"},{"issue":"3","key":"10.1016\/j.biopha.2026.119019_bib16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/jpet.102.041616","article-title":"The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development","volume":"306","author":"Terry","year":"2003","journal-title":"J. Pharm. Exp. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2026.119019_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/1381612043386509","article-title":"Acetylcholinesterase inhibition in Alzheimer's Disease","volume":"10","author":"Ibach","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2026.119019_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.00103","article-title":"Resveratrol Derivatives as Potential Treatments for Alzheimer\u2019s and Parkinson\u2019s Disease","volume":"12","author":"Arbo","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.biopha.2026.119019_bib19","series-title":"The Benefits of Natural Products for Neurodegenerative Diseases","first-page":"153","article-title":"Role of Plant Polyphenols in Alzheimer\u2019s Disease","author":"Thenmozhi","year":"2016"},{"issue":"24","key":"10.1016\/j.biopha.2026.119019_bib20","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1016\/j.bmcl.2012.09.105","article-title":"Design, synthesis, and evaluation of resveratrol derivatives as A\u00df(\u2081-\u2084\u2082) aggregation inhibitors, antioxidants, and neuroprotective agents","volume":"22","author":"Lu","year":"2012","journal-title":"Bioorg. Med Chem. Lett."},{"issue":"1","key":"10.1016\/j.biopha.2026.119019_bib21","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","article-title":"Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer's Disease: Understanding the Therapeutics Strategies","volume":"53","author":"Kamat","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119019_bib22","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.tiv.2013.12.021","article-title":"Oxidative stress mediated by NMDA, AMPA\/KA channels in acute hippocampal slices: Neuroprotective effect of resveratrol","volume":"28","author":"Quincozes-Santos","year":"2014","journal-title":"Toxicol. Vitr."},{"issue":"2","key":"10.1016\/j.biopha.2026.119019_bib23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/biomedicines10020273","article-title":"Vitisin A, a Resveratrol Tetramer, Improves Scopolamine-Induced Impaired Learning and Memory Functions in Amnesiac ICR Mice","volume":"10","author":"Chen","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.biopha.2026.119019_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031170","article-title":"BDNF as a Promising Therapeutic Agent in Parkinson's Disease","volume":"21","author":"Palasz","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.biopha.2026.119019_bib25","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/sj.cdd.4401662","article-title":"Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways","volume":"12","author":"Almeida","year":"2005","journal-title":"Cell Death Differ."},{"issue":"14","key":"10.1016\/j.biopha.2026.119019_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28145415","article-title":"Polyphenols and Neurodegenerative Diseases: Potential Effects and Mechanisms of Neuroprotection","volume":"28","author":"Arias-S\u00e1nchez","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2026.119019_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2018.04.050","article-title":"Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1\/miR-134 signalling pathway regulates CREB\/BDNF expression in hippocampus in vivo and in vitro","volume":"349","author":"Shen","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.biopha.2026.119019_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114474","article-title":"Therapeutic potential of natural molecules against Alzheimer's disease via SIRT1 modulation","volume":"161","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.biopha.2026.119019_bib29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1254\/jphs.91.267","article-title":"Brain-derived neurotrophic factor\/TrkB signaling in memory processes","volume":"91","author":"Yamada","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2026.119019_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8152373","article-title":"Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1","volume":"2018","author":"Gomes","year":"2018","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.biopha.2026.119019_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00778","article-title":"Targeting Synaptic Plasticity in Experimental Models of Alzheimer\u2019s Disease","volume":"10","author":"Mango","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119019_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104618","article-title":"Resveratrol derivative excited postsynaptic potentiation specifically via PKC\u03b2-NMDA receptor mediation","volume":"152","author":"Tong","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"23","key":"10.1016\/j.biopha.2026.119019_bib33","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.0385-14.2014","article-title":"A. Fl\u00f6el, Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults","volume":"34","author":"Witte","year":"2014","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.biopha.2026.119019_bib34","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1007\/s12035-013-8401-2","article-title":"Neuroprotective Effects of Resveratrol Against A\u03b2 Administration in Rats are Improved by Lipid-Core Nanocapsules","volume":"47","author":"Frozza","year":"2013","journal-title":"Mol. Neurobiol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222600051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222600051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:40:42Z","timestamp":1781880042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333222600051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":34,"alternative-id":["S075333222600051X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119019","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitisin B, extracted from Vitis vinifera, enhances memory function and neuroprotective effects in scopolamine-induced memory-impaired mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119019"}}