{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:02:36Z","timestamp":1783026156510,"version":"3.54.6"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP2\/728\/46"],"award-info":[{"award-number":["RGP2\/728\/46"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004083","name":"Ministry of Science ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2025\\u201302243112"],"award-info":[{"award-number":["RS-2025\\u201302243112"]}],"id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004083","name":"Ministry of Science ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2021R1I1A2060024"],"award-info":[{"award-number":["NRF-2021R1I1A2060024"]}],"id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004083","name":"Ministry of Science ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2024\\u201300461726"],"award-info":[{"award-number":["RS-2024\\u201300461726"]}],"id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.biopha.2026.119059","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:07:05Z","timestamp":1769598425000},"page":"119059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting c-Met and EMT, PI3K\/Akt\/mTOR\/MEK signaling with Dihydropyrimidinone-Piperazine-based scaffold that triggers apoptosis, autophagy, and paraptosis in breast carcinomas"],"prefix":"10.1016","volume":"195","author":[{"given":"Monisha Yadav","family":"H S","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Yun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6879-7835","authenticated-orcid":false,"given":"Narasimha M.","family":"Beeraka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhoomika","family":"B R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doddahosuru M.","family":"Gurudatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav Kumar","family":"Harish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Madegowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh L.","family":"Gaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreeja","family":"Basappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir N.","family":"Nikolenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-0817","authenticated-orcid":false,"given":"Riyaz Ali M.","family":"Osmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchugarakoppal S.","family":"Rangappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-468X","authenticated-orcid":false,"given":"Basappa","family":"Basappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-0612","authenticated-orcid":false,"given":"Kwang Seok","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2026.119059_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.627693","article-title":"Preclinical advances in theranostics for the different molecular subtypes of breast cancer","volume":"12","author":"Fang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119059_bib2","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.3390\/molecules28083450","article-title":"Discovery of pyrimidine-and coumarin-linked hybrid molecules as inducers of JNK Phosphorylation through ROS generation in breast cancer cells","volume":"28","author":"Kim","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2026.119059_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2147\/BCTT.S270799","article-title":"Resistance and overcoming resistance in breast cancer","author":"Luque-Bolivar","year":"2020","journal-title":"Breast Cancer Targets Therapy"},{"issue":"11","key":"10.1016\/j.biopha.2026.119059_bib4","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/s41419-020-03156-8","article-title":"SYK inhibition targets acute myeloid leukemia stem cells by blocking their oxidative metabolism","volume":"11","author":"Polak","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2026.119059_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110433","article-title":"Isoimperatorin down-regulates epithelial mesenchymal transition through modulating NF-\u03baB signaling and CXCR4 expression in colorectal and hepatocellular carcinoma cells","volume":"99","author":"Kim","year":"2022","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/cancers11010049","article-title":"Oxymatrine attenuates tumor growth and deactivates STAT5 signaling in a lung cancer xenograft model","volume":"11","author":"Jung","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.biopha.2026.119059_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biochi.2022.04.014","article-title":"Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells","volume":"198","author":"Jung","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.biopha.2026.119059_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12882-016-0233-7","article-title":"Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTP\u03b5 and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma","volume":"17","author":"Kim","year":"2016","journal-title":"BMC Nephrol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119059_bib9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/ars.2015.6418","article-title":"Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model","volume":"24","author":"Zhang","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2026.119059_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib11","first-page":"57","article-title":"Python: a programming language for software integration and development","volume":"17","author":"Sanner","year":"1999","journal-title":"J. Mol. Graph Model"},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"issue":"15","key":"10.1016\/j.biopha.2026.119059_bib13","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.bmcl.2015.05.047","article-title":"Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2","volume":"25","author":"Srinivas","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.biopha.2026.119059_bib14","article-title":"Identification of a novel 1, 2 oxazine that can induce apoptosis by targeting NF-\u03baB in hepatocellular carcinoma cells","volume":"25","author":"Somu","year":"2020","journal-title":"Biotechnol. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2026.119059_bib15","first-page":"2715","article-title":"Oxazine derivatives of \u03b3-and \u03b4-tocotrienol display enhanced anticancer activity in vivo","volume":"34","author":"Ananthula","year":"2014","journal-title":"Anticancer Res."},{"issue":"17","key":"10.1016\/j.biopha.2026.119059_bib16","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.3390\/molecules24173127","article-title":"Fangchinoline, a bisbenzylisoquinoline alkaloid can modulate cytokine-impelled apoptosis via the dual regulation of NF-\u03baB and AP-1 pathways","volume":"24","author":"Jung","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.biopha.2026.119059_bib17","first-page":"148","article-title":"Targeting MET in cancer therapy","volume":"3","author":"Mo","year":"2017","journal-title":"Chronic Dis. Transl. Med"},{"issue":"2","key":"10.1016\/j.biopha.2026.119059_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrc3205","article-title":"Targeting MET in cancer: rationale and progress","volume":"12","author":"Gherardi","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"16","key":"10.1016\/j.biopha.2026.119059_bib19","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1158\/0008-5472.CAN-07-6782","article-title":"Identification of a novel recepteur d\u2032origine nantais\/c-met small-molecule kinase inhibitor with antitumor activity in vivo","volume":"68","author":"Zhang","year":"2008","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.biopha.2026.119059_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11020254","article-title":"Casticin-induced inhibition of cell growth and survival are mediated through the dual modulation of Akt\/mTOR Signaling Cascade","volume":"11","author":"Lee","year":"2019","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.biopha.2026.119059_bib21","first-page":"1013","article-title":"The roles of hepatocyte growth factor scatter factor and Met receptor in human cancers (Review)","volume":"5","author":"To","year":"1998","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2026.119059_bib22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ejca.2008.01.022","article-title":"Molecular cancer therapy: can our expectation be MET?","volume":"44","author":"Migliore","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.biopha.2026.119059_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00395","article-title":"Judicious Toggling of mTOR activity to combat insulin resistance and cancer: current evidence and perspectives","volume":"7","author":"Ong","year":"2016","journal-title":"Front. Pharm."},{"issue":"4","key":"10.1016\/j.biopha.2026.119059_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153155","article-title":"Trisubstituted-imidazoles induce apoptosis in human breast cancer cells by targeting the oncogenic PI3K\/Akt\/mTOR Signaling Pathway","volume":"11","author":"Mohan","year":"2016","journal-title":"Plos One"},{"issue":"4","key":"10.1016\/j.biopha.2026.119059_bib25","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ijc.20598","article-title":"c-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2\/neu","volume":"113","author":"Lengyel","year":"2005","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12964-025-02033-1","article-title":"Targeting HGF\/c-MET signaling to regulate the tumor microenvironment: implications for counteracting tumor immune evasion","volume":"23","author":"Xia","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"21","key":"10.1016\/j.biopha.2026.119059_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218303","article-title":"Anti-neoplastic effect of Ginkgolide C through Modulating c-met phosphorylation in hepatocellular carcinoma cells","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1_","key":"10.1016\/j.biopha.2026.119059_bib28","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1177\/1758834011422556","article-title":"An overview of the c-MET signaling pathway","volume":"3","author":"Organ","year":"2011","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.biopha.2026.119059_bib29","series-title":"Therapeutic potential of c-MET inhibitors: background and clinical data","author":"Organ","year":"2012"},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib30","article-title":"The emerging role of c-met in carcinogenesis and clinical implications as a possible therapeutic target","volume":"2022","author":"Faiella","year":"2022","journal-title":"J. Oncol."},{"issue":"22","key":"10.1016\/j.biopha.2026.119059_bib31","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1039\/C4OB00364K","article-title":"Design and synthesis of 3,3\u2032-biscoumarin-based c-Met inhibitors","volume":"12","author":"Xu","year":"2014","journal-title":"Org. Biomol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2026.119059_bib32","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3892\/or.2017.5347","article-title":"Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway","volume":"37","author":"Gao","year":"2017","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2026.119059_bib33","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/hep.29496","article-title":"Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma","volume":"67","author":"Bouattour","year":"2018","journal-title":"Hepatology"},{"issue":"33","key":"10.1016\/j.biopha.2026.119059_bib34","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.3748\/wjg.v24.i33.3695","article-title":"Updates on the hepatocyte growth factor\/c-Met axis in hepatocellular carcinoma and its therapeutic implications","volume":"24","author":"Garcia-Vilas","year":"2018","journal-title":"World J. Gastroentero"},{"issue":"9","key":"10.1016\/j.biopha.2026.119059_bib35","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1158\/1078-0432.CCR-12-2791","article-title":"Targeting the HGF\/c-MET pathway in hepatocellular carcinoma","volume":"19","author":"Goyal","year":"2013","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.biopha.2026.119059_bib36","doi-asserted-by":"crossref","first-page":"12831","DOI":"10.18632\/oncotarget.14606","article-title":"A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma","volume":"8","author":"Dai","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/jhet.4742","article-title":"Advances in Biginelli reaction: a comprehensive review","volume":"61","author":"Chandravarkar","year":"2024","journal-title":"J. Heterocycl. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2026.119059_bib38","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s11030-018-9841-4","article-title":"Current progress in asymmetric Biginelli reaction: an update","volume":"22","author":"Heravi","year":"2018","journal-title":"Mol. Divers."},{"issue":"12","key":"10.1016\/j.biopha.2026.119059_bib39","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0223-5234(00)01189-2","article-title":"Biologically active dihydropyrimidones of the Biginelli-type\u2014a literature survey","volume":"35","author":"Kappe","year":"2000","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2026.119059_bib40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jare.2014.10.006","article-title":"A mini-review on Biginelli adducts with notable pharmacological properties","volume":"6","author":"de F\u00e1tima","year":"2015","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.biopha.2026.119059_bib41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejmech.2017.03.025","article-title":"Recent synthetic and medicinal perspectives of dihydropyrimidinones: a review","volume":"132","author":"Kaur","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2026.119059_bib42","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.ejmech.2017.10.073","article-title":"Biological activity of dihydropyrimidinone (DHPM) derivatives: a systematic review","volume":"143","author":"Matos","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2026.119059_bib43","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ejmech.2013.01.031","article-title":"Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents","volume":"62","author":"El-Nassan","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2026.119059_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2022.100718","article-title":"Advances in the discovery of DHPMs as Eg5 inhibitors for the management of breast cancer and glioblastoma: a review","volume":"5","author":"Nikam","year":"2023","journal-title":"Results Chem."},{"key":"10.1016\/j.biopha.2026.119059_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102101","article-title":"Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species\/JNK pathway in human breast cancer cells","volume":"49","author":"Kim","year":"2024","journal-title":"Transl. Oncol."},{"issue":"13","key":"10.1016\/j.biopha.2026.119059_bib46","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.biopha.2026.119059_bib47","unstructured":"BIOVIA DS: Discovery Studio Visualizer 4.5. San diego: Dassault syst\u00e8mes 2021."},{"key":"10.1016\/j.biopha.2026.119059_bib48","series-title":"GaussView Version 5","author":"Dennington","year":"2009"},{"issue":"13","key":"10.1016\/j.biopha.2026.119059_bib49","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1021\/jz300554y","article-title":"A (nearly) universally applicable method for modeling noncovalent interactions using B3LYP","volume":"3","author":"Torres","year":"2012","journal-title":"J. Phys. Chem. Lett."},{"issue":"7","key":"10.1016\/j.biopha.2026.119059_bib50","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional thermochemistry. III. The role of exact exchange","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"issue":"9","key":"10.1016\/j.biopha.2026.119059_bib51","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/acsmedchemlett.9b00276","article-title":"Structural and molecular insight into resistance mechanisms of first generation cMET inhibitors","volume":"10","author":"Collie","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.biopha.2026.119059_bib52","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jcc.20634","article-title":"A semiempirical free energy force field with charge-based desolvation","volume":"28","author":"Huey","year":"2007","journal-title":"J. Comput. Chem."},{"issue":"12","key":"10.1016\/j.biopha.2026.119059_bib53","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrm1261","article-title":"Met, metastasis, motility and more","volume":"4","author":"Birchmeier","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2026.119059_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128948","article-title":"Discovery of a selective c-MET inhibitor with a novel binding mode","volume":"75","author":"Collie","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.biopha.2026.119059_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-017-0753-1","article-title":"Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.biopha.2026.119059_bib56","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s12272-012-0402-6","article-title":"Progress in cancer therapy targeting c-Met signaling pathway","volume":"35","author":"Jung","year":"2012","journal-title":"Arch. pharmacal Res."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib57","first-page":"13","article-title":"Giovannetti E, Biasco G, Peters GJ: c-Met as a target for personalized therapy","volume":"7","author":"Garajov\u00e1","year":"2015","journal-title":"Transl. oncogenomics"},{"issue":"2-3","key":"10.1016\/j.biopha.2026.119059_bib58","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.matchemphys.2012.06.016","article-title":"Multisite luminescence of rare earth doped TiO2 anatase nanoparticles","volume":"135","author":"Anti\u0107","year":"2012","journal-title":"Mater. Chem. Phys."},{"issue":"6","key":"10.1016\/j.biopha.2026.119059_bib59","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1016\/S1452-3981(23)19588-5","article-title":"Synthesis and catalytic activity of TiO2 nanoparticles for photochemical oxidation of concentrated chlorophenols under direct solar radiation","volume":"7","author":"Ba-Abbad","year":"2012","journal-title":"Int. J. Electrochem. Sci."},{"key":"10.1016\/j.biopha.2026.119059_bib60","first-page":"1","article-title":"Probing the hybridized triazole-chalcones: an in-depth investigations of molecular structure journey towards antibacterial potential against DNA gyrase","author":"Kumar Harish","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.biopha.2026.119059_bib61","doi-asserted-by":"crossref","DOI":"10.1039\/D4ME00135D","article-title":"The pivotal role of the carbonyl group in methoxy chalcones: comprehensive analyses of the structure and computational insights into binding affinity towards monoamine oxidase enzymes","author":"Harish","year":"2025","journal-title":"Mol. Syst. Des. Eng."},{"issue":"4","key":"10.1016\/j.biopha.2026.119059_bib62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/cancers9040035","article-title":"Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment","volume":"9","author":"Owusu","year":"2017","journal-title":"Cancers"},{"issue":"13","key":"10.1016\/j.biopha.2026.119059_bib63","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1002\/j.1460-2075.1992.tb05588.x","article-title":"Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor\/scatter factor","volume":"11","author":"Naldini","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.biopha.2026.119059_bib64","unstructured":"Vigna E., Naldini L., Tamagnone L., Longati P., Bardelli A., Maina F., Ponzetto C., Comoglio P.: Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cellular and Molecular Biology (Noisy-le-Grand, France) 1994, 40(5):597-604."},{"issue":"12","key":"10.1016\/j.biopha.2026.119059_bib65","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrm3012","article-title":"MET signalling: principles and functions in development, organ regeneration and cancer","volume":"11","author":"Trusolino","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib66","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12943-018-0796-y","article-title":"Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Cancer"},{"issue":"28","key":"10.1016\/j.biopha.2026.119059_bib67","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1038\/s41388-021-01863-w","article-title":"HGF\/c-MET pathway in cancer: from molecular characterization to clinical evidence","volume":"40","author":"Fu","year":"2021","journal-title":"Oncogene"},{"issue":"15","key":"10.1016\/j.biopha.2026.119059_bib68","first-page":"4277","article-title":"Scatter factor\/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase-and AKT-dependent pathways","volume":"60","author":"Bowers","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2026.119059_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-11-180","article-title":"HGF\/c-met\/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop","volume":"11","author":"Syed","year":"2011","journal-title":"Bmc Cancer"},{"issue":"2","key":"10.1016\/j.biopha.2026.119059_bib70","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1182\/blood-2005-05-1929","article-title":"Functional analysis of HGF\/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma","volume":"107","author":"Tjin","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib71","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3892\/ol.2015.3943","article-title":"Hepatocyte growth factor increases the invasive potential of PC\u20113 human prostate cancer cells via an ERK\/MAPK and Zeb\u20111 signaling pathway","volume":"11","author":"Han","year":"2016","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.biopha.2026.119059_bib72","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.3390\/ijms19113300","article-title":"Extracellular matrix influencing HGF\/c-MET signaling pathway: impact on cancer progression","volume":"19","author":"Noriega-Guerra","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1_","key":"10.1016\/j.biopha.2026.119059_bib73","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1177\/1758834011422557","article-title":"c-MET as a potential therapeutic target and biomarker in cancer","volume":"3","author":"Sierra","year":"2011","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"10","key":"10.1016\/j.biopha.2026.119059_bib74","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4331\/wjbc.v2.i10.232","article-title":"Mechanisms of autophagy and apoptosis: recent developments in breast cancer cells","volume":"2","author":"Esteve","year":"2011","journal-title":"World J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2026.119059_bib75","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1039\/C5TX00043B","article-title":"Autophagy as the effector and player in DNA damage response of cells to genotoxicants","volume":"4","author":"Zhang","year":"2015","journal-title":"Toxicol. Res."},{"issue":"5","key":"10.1016\/j.biopha.2026.119059_bib76","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1667\/RR15099.1","article-title":"Differential radiation sensitivity in p53 wild-type and p53-deficient tumor cells associated with senescence but not apoptosis or (nonprotective) autophagy","volume":"190","author":"Xu","year":"2018","journal-title":"Radiat. Res."},{"key":"10.1016\/j.biopha.2026.119059_bib77","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bcp.2018.01.048","article-title":"The potentially conflicting cell autonomous and cell non-autonomous functions of autophagy in mediating tumor response to cancer therapy","volume":"153","author":"Gewirtz","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119059_bib78","series-title":"Seminars in Cancer Biology: 2020","first-page":"129","article-title":"The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib","author":"Booth","year":"2020"},{"issue":"7","key":"10.1016\/j.biopha.2026.119059_bib79","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/cdd.2008.28","article-title":"No death without life: vital functions of apoptotic effectors","volume":"15","author":"Galluzzi","year":"2008","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.biopha.2026.119059_bib80","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.4049\/jimmunol.177.8.5612","article-title":"Deguelin, an Akt inhibitor, suppresses I\u03baB\u03b1 kinase activation leading to suppression of NF-\u03baB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion","volume":"177","author":"Nair","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2026.119059_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-9966-30-87","article-title":"Apoptosis in cancer: from pathogenesis to treatment","volume":"30","author":"Wong","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2026.119059_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175113","article-title":"Withanolide modulates the potential crosstalk between apoptosis and autophagy in different colorectal cancer cell lines","volume":"928","author":"Jung","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119059_bib83","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2174\/1389200219666180511154722","article-title":"The application of natural products in cancer therapy by targeting apoptosis pathways","volume":"19","author":"Wang","year":"2018","journal-title":"Curr. Drug Metab."},{"issue":"2","key":"10.1016\/j.biopha.2026.119059_bib84","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3390\/cells10020332","article-title":"Brassinin inhibits proliferation in human liver cancer cells via mitochondrial dysfunction","volume":"10","author":"Hong","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.biopha.2026.119059_bib85","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ptr.5010","article-title":"Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K\/Akt\/mTOR\/S6K1 signaling cascades","volume":"28","author":"Kim","year":"2014","journal-title":"Phytother. Res."},{"issue":"7","key":"10.1016\/j.biopha.2026.119059_bib86","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1002\/ptr.7095","article-title":"Brassinin enhances the anticancer actions of paclitaxel by targeting multiple signaling pathways in colorectal cancer cells","volume":"35","author":"Yang","year":"2021","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.biopha.2026.119059_bib87","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/ptr.6233","article-title":"The combined treatment of brassinin and imatinib synergistically downregulated the expression of MMP-9 in SW480 colon cancer cells","volume":"33","author":"Bakar-Ates","year":"2019","journal-title":"Phytother. Res."},{"issue":"33","key":"10.1016\/j.biopha.2026.119059_bib88","doi-asserted-by":"crossref","first-page":"22932","DOI":"10.1074\/jbc.274.33.22932","article-title":"Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis: caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells","volume":"274","author":"Boulares","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib89","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/09603123.2019.1625034","article-title":"Lead acetate induces apoptosis in Leydig cells by activating PPAR\u03b3\/caspase-3\/PARP pathway","volume":"31","author":"Zhou","year":"2021","journal-title":"Int. J. Environ. Health Res."},{"issue":"2","key":"10.1016\/j.biopha.2026.119059_bib90","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/biology12020307","article-title":"Brassinin induces apoptosis, autophagy, and paraptosis via MAPK signaling pathway activation in chronic myelogenous leukemia cells","volume":"12","author":"Yang","year":"2023","journal-title":"Biology"},{"issue":"8","key":"10.1016\/j.biopha.2026.119059_bib91","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib92","article-title":"Tumor suppression and promotion by autophagy","volume":"2014","author":"\u00c1valos","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"15","key":"10.1016\/j.biopha.2026.119059_bib93","doi-asserted-by":"crossref","first-page":"8147","DOI":"10.3390\/ijms22158147","article-title":"Pyrimethamine modulates interplay between apoptosis and autophagy in chronic myelogenous leukemia cells","volume":"22","author":"Jung","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib94","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119059_bib95","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900325","article-title":"Pristimerin Induces Autophagy-Mediated Cell Death in K562 Cells through the ROS\/JNK Signaling Pathway","volume":"16","author":"Liu","year":"2019","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.biopha.2026.119059_bib96","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and Autophagy","author":"Tanida","year":"2008","journal-title":"Autophagosome phagosome"},{"issue":"5","key":"10.1016\/j.biopha.2026.119059_bib97","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1080\/15548627.2020.1752548","article-title":"Autophagy in the physiological endometrium and cancer","volume":"17","author":"Devis-Jauregui","year":"2021","journal-title":"Autophagy"},{"issue":"26","key":"10.1016\/j.biopha.2026.119059_bib98","doi-asserted-by":"crossref","first-page":"14376","DOI":"10.1073\/pnas.97.26.14376","article-title":"An alternative, nonapoptotic form of programmed cell death","volume":"97","author":"Sperandio","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2026.119059_bib99","series-title":"Photodynamic Therapy: Methods and Protocols","first-page":"711","article-title":"Detection of Paraptosis after photodynamic therapy","author":"Kessel","year":"2022"},{"issue":"10","key":"10.1016\/j.biopha.2026.119059_bib100","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.cdd.4401465","article-title":"Paraptosis: mediation by MAP kinases and inhibition by AIP-1\/Alix","volume":"11","author":"Sperandio","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biopha.2026.119059_bib101","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1007\/s00432-017-2464-9","article-title":"ROS-modulated therapeutic approaches in cancer treatment","volume":"143","author":"Raza","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119059_bib102","doi-asserted-by":"crossref","first-page":"10877","DOI":"10.3390\/molecules190810877","article-title":"ROS-dependent antiproliferative effect of brassinin derivative homobrassinin in human colorectal cancer Caco2 cells","volume":"19","author":"Kello","year":"2014","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.biopha.2026.119059_bib103","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10495-020-01655-9","article-title":"Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation","volume":"26","author":"Liu","year":"2021","journal-title":"Apoptosis"},{"issue":"12","key":"10.1016\/j.biopha.2026.119059_bib104","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1002\/jcp.25349","article-title":"Mitochondria and mitochondrial ROS in cancer: novel targets for anticancer therapy","volume":"231","author":"Yang","year":"2016","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.biopha.2026.119059_bib105","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.3390\/molecules29102388","article-title":"Anticancer Potential of Indole Phytoalexins and Their Analogues","volume":"29","author":"Zigov\u00e1","year":"2024","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.biopha.2026.119059_bib106","doi-asserted-by":"crossref","first-page":"25744","DOI":"10.3390\/ijms161025744","article-title":"JNK-Bcl-2\/Bcl-xL-Bax\/Bak pathway mediates the crosstalk between matrine-induced autophagy and apoptosis via interplay with beclin 1","volume":"16","author":"Yang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.biopha.2026.119059_bib107","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.350","article-title":"Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment","volume":"4","author":"Sui","year":"2013","journal-title":"Cell death Dis."},{"issue":"41","key":"10.1016\/j.biopha.2026.119059_bib108","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.3748\/wjg.v24.i41.4643","article-title":"Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma","volume":"24","author":"Huang","year":"2018","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119059_bib109","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/jcmm.13049","article-title":"Matrine induces Akt\/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells","volume":"21","author":"Wu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119059_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118023","article-title":"Targeting VEGF signaling for tumor microenvironment remodeling and metastasis inhibition: Therapeutic strategies and insights","volume":"186","author":"Mahaki","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib111","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1074\/jbc.M804777200","article-title":"Role of Ras signaling in the induction of snail by transforming growth factor-\u03b2","volume":"284","author":"Horiguchi","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib112","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1055-3207(18)30283-7","article-title":"Role of growth factors in pancreatic cancer","volume":"7","author":"Korc","year":"1998","journal-title":"Surg. Oncol. Clin. North Am."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib113","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","article-title":"Angiogenic signaling pathways and anti-angiogenic therapy for cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.biopha.2026.119059_bib114","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.2147\/OTT.S134813","article-title":"Role of matrix metalloproteinase-9 in transforming growth factor-\u03b21-induced epithelial\u2013mesenchymal transition in esophageal squamous cell carcinoma","author":"Bai","year":"2017","journal-title":"OncoTargets Ther."},{"issue":"21","key":"10.1016\/j.biopha.2026.119059_bib115","doi-asserted-by":"crossref","first-page":"14824","DOI":"10.1074\/jbc.M113.451336","article-title":"Transforming growth factor-\u03b21 (TGF-\u03b21)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts","volume":"288","author":"Midgley","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119059_bib116","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12957-020-01958-w","article-title":"Role of MMP-9 in epithelial-mesenchymal transition of thyroid cancer","volume":"18","author":"Li","year":"2020","journal-title":"World J. Surg. Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119059_bib117","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10555-016-9650-0","article-title":"From transformation to metastasis: deconstructing the extracellular matrix in breast cancer","volume":"35","author":"Kaushik","year":"2016","journal-title":"Cancer Metastas.. Rev."},{"issue":"23","key":"10.1016\/j.biopha.2026.119059_bib118","doi-asserted-by":"crossref","first-page":"12783","DOI":"10.3390\/ijms222312783","article-title":"Downregulation of MMP-9 enhances the anti-migratory effect of cyclophosphamide in MDA-MB-231 and MCF-7 breast cancer cell lines","volume":"22","author":"Izdebska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6-7","key":"10.1016\/j.biopha.2026.119059_bib119","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.phymed.2008.11.006","article-title":"Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf\/MEK\/ERK pathway in MCF-7 human breast cancer cells","volume":"16","author":"Kim","year":"2009","journal-title":"Phytomedicine"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226000910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226000910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:35:05Z","timestamp":1773999305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226000910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":119,"alternative-id":["S0753332226000910"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119059","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting c-Met and EMT, PI3K\/Akt\/mTOR\/MEK signaling with Dihydropyrimidinone-Piperazine-based scaffold that triggers apoptosis, autophagy, and paraptosis in breast carcinomas","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119059"}}