{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:54:05Z","timestamp":1790009645688,"version":"4.0.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004168","name":"Universit\u00e4t zu L\u00fcbeck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004168","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["KU 1496\/7\\u20133"],"award-info":[{"award-number":["KU 1496\/7\\u20133"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["KU 1496\/7\\u20131"],"award-info":[{"award-number":["KU 1496\/7\\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["INST 392\/141\\u20131 FUGG"],"award-info":[{"award-number":["INST 392\/141\\u20131 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.biopha.2026.119073","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:02:30Z","timestamp":1770429750000},"page":"119073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Amlodipine improves aortic dysfunction in atherosclerotic mice"],"prefix":"10.1016","volume":"196","author":[{"given":"Sophia Marie","family":"Rasch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Fels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Schmalohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Daniel Hernandez","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Peschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Maria","family":"Will","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Bernd","family":"Hoevener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Achner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Klersy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Spiecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-6267","authenticated-orcid":false,"given":"Carl","family":"Vahldieck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-0803","authenticated-orcid":false,"given":"Tobias","family":"Reinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urte","family":"Matschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zouhair","family":"Aherrahrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Kusche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-2997","authenticated-orcid":false,"given":"Walter","family":"Raasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biopha.2026.119073_bib1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.5551\/jat.12450","article-title":"Anti-atherosclerotic potential of dihydropyridine calcium channel blockers","volume":"19","author":"Ishii","year":"2012","journal-title":"J. Atheroscler. Thromb."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/01.fjc.0000195603.65858.27","article-title":"Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden\/hCRP transgenic mice","volume":"47","author":"Trion","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"8698","key":"10.1016\/j.biopha.2026.119073_bib3","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/0140-6736(90)91121-P","article-title":"Retardation of angiographic progression of coronary artery disease by nifedipine. Results of the International Nifedipine Trial on Antiatherosclerotic Therapy (INTACT). INTACT Group Investigators","volume":"335","author":"Lichtlen","year":"1990","journal-title":"Lancet"},{"issue":"13","key":"10.1016\/j.biopha.2026.119073_bib4","first-page":"1503","article-title":"Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events","volume":"102","author":"Pitt","year":"2000","journal-title":"Prev. Invest. Circ."},{"issue":"8","key":"10.1016\/j.biopha.2026.119073_bib5","first-page":"887","article-title":"Long term effects of nisoldipine on the progression of coronary atherosclerosis and the occurrence of clinical events: the NICOLE study","volume":"89","author":"Dens","year":"2003","journal-title":"Heart (Br. Card. Soc. )"},{"issue":"18","key":"10.1016\/j.biopha.2026.119073_bib6","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1001\/jama.292.18.2217","article-title":"Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial","volume":"292","author":"Nissen","year":"2004","journal-title":"Jama"},{"issue":"6","key":"10.1016\/j.biopha.2026.119073_bib7","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/01.CIR.82.6.1940","article-title":"A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis","volume":"82","author":"Waters","year":"1990","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ijcard.2009.05.019","article-title":"Calcium channel regulation in vascular smooth muscle cells: synergistic effects of statins and calcium channel blockers","volume":"139","author":"Clunn","year":"2010","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119073_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/01.RES.58.2.305","article-title":"Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110","volume":"58","author":"Habib","year":"1986","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0021-9150(98)00019-7","article-title":"Reduction in infarct size by chronic amlodipine treatment in cholesterol-fed rabbits","volume":"138","author":"Hoshida","year":"1998","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/01.HYP.32.1.16","article-title":"Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension","volume":"32","author":"Higashi","year":"1998","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.biopha.2026.119073_bib12","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/ATVBAHA.109.202309","article-title":"Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice","volume":"30","author":"Ishii","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119073_bib13","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1161\/CIRCRESAHA.114.302937","article-title":"Induction of atherosclerosis in mice and hamsters without germline genetic engineering","volume":"114","author":"Bjorklund","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2026.119073_bib14","article-title":"The anti-atherosclerotic effect of chronic AT1 receptor blocker treatment also depends on the ACE2\/Ang(1-7)\/Mas axis","volume":"186","author":"Klersy","year":"2025","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/ATVBAHA.114.303617","article-title":"Induction of sustained hypercholesterolemia by single adeno-associated virus-mediated gene transfer of mutant hPCSK9","volume":"35","author":"Roche-Molina","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biopha.2026.119073_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101713","article-title":"Deletion of NoxO1 limits atherosclerosis development in female mice","volume":"37","author":"Buchmann","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2026.119073_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s00424-022-02710-x","article-title":"AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9(DY) atherosclerosis mouse model","author":"Achner","year":"2022","journal-title":"Pflug. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.biopha.2026.119073_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1338458","article-title":"Incidence of microvascular dysfunction is increased in hyperlipidemic mice leading to a reduction in cerebral blood flow and an impairment of long-term memory","volume":"15","author":"Hernandez Torres","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119073_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/HYPERTENSIONAHA.110.163444","article-title":"C-reactive protein makes human endothelium stiff and tight","volume":"57","author":"Kusche-Vihrog","year":"2011","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.biopha.2026.119073_bib20","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/01.CIR.0000124061.78478.94","article-title":"Irbesartan but not amlodipine suppresses diabetes-associated atherosclerosis","volume":"109","author":"Candido","year":"2004","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.biopha.2026.119073_bib21","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1161\/HYPERTENSIONAHA.108.110932","article-title":"Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine","volume":"51","author":"Nussberger","year":"2008","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.biopha.2026.119073_bib22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1291\/hypres.27.517","article-title":"Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model","volume":"27","author":"Takai","year":"2004","journal-title":"Hypertens. Res. Off. J. Jpn. Soc. Hypertens."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2006.11.030","article-title":"Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species","volume":"195","author":"Doran","year":"2007","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.biopha.2026.119073_bib24","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ajpath.2022.12.009","article-title":"Endothelial glycocalyx and cardiomyocyte damage is prevented by recombinant syndecan-1 in acute myocardial infarction","volume":"193","author":"Vahldieck","year":"2023","journal-title":"Am. J. Pathol."},{"issue":"23","key":"10.1016\/j.biopha.2026.119073_bib25","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.1128\/JVI.05359-11","article-title":"The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes","volume":"85","author":"Sonntag","year":"2011","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119073_bib26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/hgtb.2017.192","article-title":"Protocol for efficient generation and characterization of adeno-associated viral vectors","volume":"28","author":"Jungmann","year":"2017","journal-title":"Hum. gene Ther. Methods"},{"issue":"16","key":"10.1016\/j.biopha.2026.119073_bib27","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1111\/bph.15193","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"177","author":"Percie du Sert","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib28","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/bph.12510","article-title":"Chronic blockade of angiotensin AT\u2081 receptors improves cardinal symptoms of metabolic syndrome in diet-induced obesity in rats","volume":"171","author":"M\u00fcller-Fielitz","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119073_bib29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0002-9149(97)89205-3","article-title":"Sex- and age-related antihypertensive effects of amlodipine. the amlodipine cardiovascular community trial study group","volume":"77","author":"Kloner","year":"1996","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.biopha.2026.119073_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-3-642-30726-3_11","article-title":"Sex and gender differences in cardiovascular drug therapy","volume":"214","author":"Seeland","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/HJH.0000000000003901","article-title":"Differences in sex and age response to single pill combination based antihypertensive therapy reflecting in blood pressure and arterial stiffness","volume":"43","author":"Brguljan Hitij","year":"2025","journal-title":"J. Hypertens."},{"issue":"8","key":"10.1016\/j.biopha.2026.119073_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.123.015227","article-title":"Sex differences in coronary atherosclerotic phenotype and healing pattern on optical coherence tomography imaging","volume":"16","author":"Seegers","year":"2023","journal-title":"Circ. Cardiovasc. Imaging"},{"issue":"5","key":"10.1016\/j.biopha.2026.119073_bib33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.phrs.2004.11.006","article-title":"Assessment of sex differences in pharmacokinetics and pharmacodynamics of amlodipine in a bioequivalence study","volume":"51","author":"Abad-Santos","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00005344-200307000-00010","article-title":"Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice","volume":"42","author":"Delsing","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119073_bib35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/FJC.0b013e3181b76713","article-title":"Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine","volume":"54","author":"Kang","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1536\/ihj.17-265","article-title":"Amlodipine inhibits vascular cell senescence and protects against atherogenesis through the mechanism independent of calcium channel blockade","volume":"59","author":"Kayamori","year":"2018","journal-title":"Int. Heart J."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0021-9150(02)00055-2","article-title":"Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice","volume":"164","author":"van de Poll","year":"2002","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.biopha.2026.119073_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1291\/hypres.29.457","article-title":"Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions","volume":"29","author":"Yoshii","year":"2006","journal-title":"Hypertens. Res. Off. J. Jpn. Soc. Hypertens."},{"issue":"11","key":"10.1016\/j.biopha.2026.119073_bib39","article-title":"Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice","volume":"8","author":"Chen","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib40","doi-asserted-by":"crossref","first-page":"8792","DOI":"10.1038\/s41598-020-65601-0","article-title":"CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development","volume":"10","author":"Aherrahrou","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119073_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1426526","article-title":"Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axis","volume":"15","author":"Vahldieck","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.atherosclerosis.2014.08.033","article-title":"Non-invasive assessment of pulse wave velocity in mice by means of ultrasound images","volume":"237","author":"Di Lascio","year":"2014","journal-title":"Atherosclerosis"},{"issue":"120","key":"10.1016\/j.biopha.2026.119073_bib43","article-title":"Ultrasound-based Pulse Wave Velocity Evaluation in Mice","author":"Di Lascio","year":"2017","journal-title":"J. Vis. Exp. JoVE"},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib44","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1038\/s41598-018-24228-y","article-title":"Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation","volume":"8","author":"Bauer","year":"2018","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib45","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0735-1097(99)00599-9","article-title":"Restenosis and clinical outcome in patients treated with amlodipine after angioplasty: results from the Coronary AngioPlasty Amlodipine REStenosis Study (CAPARES)","volume":"35","author":"J\u00f8rgensen","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"issue":"21","key":"10.1016\/j.biopha.2026.119073_bib46","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.biopha.2026.119073_bib47","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events: the Framingham Heart Study","volume":"121","author":"Mitchell","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2026.119073_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2021.07.006","article-title":"Arterial biomarkers in the evaluation, management and prognosis of aortic stenosis","volume":"332","author":"Gardikioti","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2026.119073_bib49","doi-asserted-by":"crossref","DOI":"10.1007\/s10456-024-09933-9","article-title":"Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE(-\/-) mice","author":"Br\u00fcckner","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biopha.2026.119073_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.874015","article-title":"Aortic Stiffness in L-NAME Treated C57Bl\/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction","volume":"13","author":"De Moudt","year":"2022","journal-title":"Front. Physiol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119073_bib51","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1177\/2047487320919895","article-title":"Abdominal aortic calcification: from ancient friend to modern foe","volume":"28","author":"Bartstra","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119073_bib52","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1161\/ATVBAHA.114.303916","article-title":"Cross-sectional relations of arterial stiffness, pressure pulsatility, wave reflection, and arterial calcification","volume":"34","author":"Tsao","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/138945008783755575","article-title":"Progression and disruption of advanced atherosclerotic plaques in murine models","volume":"9","author":"Rosenfeld","year":"2008","journal-title":"Curr. Drug Targets"},{"issue":"2","key":"10.1016\/j.biopha.2026.119073_bib54","first-page":"213","article-title":"Modulation of renal superoxide dismutase by telmisartan therapy in C57BL\/6-Ins2(Akita) diabetic mice, Hypertension research","volume":"35","author":"Fujita","year":"2012","journal-title":"Off. J. Jpn. Soc. Hypertens."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib55","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.amjhyper.2004.10.012","article-title":"Risk reduction therapy for syndrome X: comparison of several treatments","volume":"18","author":"Oron-Herman","year":"2005","journal-title":"Am. J. Hypertens."},{"issue":"9","key":"10.1016\/j.biopha.2026.119073_bib56","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/oby.2006.183","article-title":"Angiotensin-converting enzyme inhibition reduces lipid deposits in myocardium and improves left ventricular function of obese zucker rats","volume":"14","author":"Toblli","year":"2006","journal-title":"Obes. (Silver Spring Md. )"},{"issue":"6","key":"10.1016\/j.biopha.2026.119073_bib57","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/FJC.0b013e3181583d80","article-title":"Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR\/NDmcr-cp rats, spontaneously hypertensive obese rats","volume":"50","author":"Kagota","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/ajh\/hpt138","article-title":"The effects of amlodipine and S(-)-amlodipine on vascular endothelial function in patients with hypertension","volume":"27","author":"He","year":"2014","journal-title":"Am. J. Hypertens."},{"issue":"8","key":"10.1016\/j.biopha.2026.119073_bib59","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1007\/s11095-007-9491-1","article-title":"Synergistic effect of amlodipine and atorvastatin in reversing LDL-induced endothelial dysfunction","volume":"25","author":"Mason","year":"2008","journal-title":"Pharm. Res."},{"issue":"2","key":"10.1016\/j.biopha.2026.119073_bib60","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/01.fjc.0000205497.90765.b0","article-title":"Comparative effects of azelnidipine and other Ca2+-channel blockers on the induction of inducible nitric oxide synthase in vascular smooth muscle cells","volume":"47","author":"Ma","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib61","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbrc.2003.10.036","article-title":"A calcium channel blocker activates both ecto-5(')-nucleotidase and NO synthase in HUVEC","volume":"311","author":"Asano","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2026.119073_bib62","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.biopha.2017.08.092","article-title":"\u03b2-Elemene attenuates atherosclerosis in apolipoprotein E-deficient mice via restoring NO levels and alleviating oxidative stress","volume":"95","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"key":"10.1016\/j.biopha.2026.119073_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108453","article-title":"Dietary nitrate attenuated endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for NADPH oxidase","volume":"689","author":"Peng","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.biopha.2026.119073_bib64","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/HYPERTENSIONAHA.109.142190","article-title":"Arterial stiffness is regulated by nitric oxide and endothelium-derived hyperpolarizing factor during changes in blood flow in humans","volume":"55","author":"Bellien","year":"2010","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2026.119073_bib65","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/hc2901.091399","article-title":"Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E\/endothelial nitric oxide synthase double-knockout mice","volume":"104","author":"Kuhlencordt","year":"2001","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.biopha.2026.119073_bib66","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1161\/hc4501.099729","article-title":"Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e\/endothelial nitric oxide synthase double knockout mice","volume":"104","author":"Chen","year":"2001","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.biopha.2026.119073_bib67","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1001\/jama.283.21.2810","article-title":"Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease","volume":"283","author":"Iribarren","year":"2000","journal-title":"Jama"},{"issue":"2","key":"10.1016\/j.biopha.2026.119073_bib68","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0735-1097(96)00479-2","article-title":"Determinants and correlates of target lesion calcium in coronary artery disease: a clinical, angiographic and intravascular ultrasound study","volume":"29","author":"Mintz","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119073_bib69","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/01.ATV.19.8.1852","article-title":"Noncollagenous bone matrix proteins, calcification, and thrombosis in carotid artery atherosclerosis","volume":"19","author":"Bini","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119073_bib70","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s12975-012-0198-1","article-title":"Anti-inflammatory effect of amlodipine plus atorvastatin treatment on carotid atherosclerosis in zucker metabolic syndrome rats","volume":"3","author":"Zhang","year":"2012","journal-title":"Transl. Stroke Res."},{"issue":"45","key":"10.1016\/j.biopha.2026.119073_bib71","doi-asserted-by":"crossref","first-page":"17024","DOI":"10.1073\/pnas.0606539103","article-title":"Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit","volume":"103","author":"Tiwari","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.biopha.2026.119073_bib72","doi-asserted-by":"crossref","first-page":"690","DOI":"10.5551\/jat.41798","article-title":"Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel","volume":"25","author":"Komoda","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.biopha.2026.119073_bib73","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/463527","article-title":"Cav1.2, cell proliferation, and new target in atherosclerosis","volume":"2013","author":"Soldatov","year":"2013","journal-title":"ISRN Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119073_bib74","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00360-019-01252-6","article-title":"Functional and structural changes in aorta of mice divergently selected for basal metabolic rate","volume":"190","author":"Sawicka","year":"2020","journal-title":"J. Comp. Physiol. B Biochem. Syst. Environ. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119073_bib75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/10641960903254414","article-title":"Anti-inflammatory properties of azelnidipine, a dihydropyridine-based calcium channel blocker","volume":"32","author":"Komoda","year":"2010","journal-title":"Clin. Exp. Hypertens."},{"issue":"5","key":"10.1016\/j.biopha.2026.119073_bib76","doi-asserted-by":"crossref","first-page":"568","DOI":"10.5551\/jat.1628","article-title":"Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy","volume":"16","author":"Sasaki","year":"2009","journal-title":"J. Atheroscler. Thromb."},{"issue":"7","key":"10.1016\/j.biopha.2026.119073_bib77","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s12272-001-1243-0","article-title":"Effects of calcium channel blockers on hyaluronidase-induced capillary vascular permeability","volume":"31","author":"Halici","year":"2008","journal-title":"Arch. pharmacal Res."},{"key":"10.1016\/j.biopha.2026.119073_bib78","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fcvm.2020.00109","article-title":"Dare to compare. development of atherosclerotic lesions in human, mouse, and zebrafish","volume":"7","author":"Vedder","year":"2020","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:42:10Z","timestamp":1781880130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226001058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":78,"alternative-id":["S0753332226001058"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119073","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amlodipine improves aortic dysfunction in atherosclerotic mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119073"}}