{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:35:42Z","timestamp":1793734542658,"version":"4.6.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2023-00262747"],"award-info":[{"award-number":["RS-2023-00262747"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.biopha.2026.119094","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:34:23Z","timestamp":1770752063000},"page":"119094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["De novo identification of potent ingredients for proteasome activation in MT101-5 using an AI-driven approach"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3987-910X","authenticated-orcid":false,"given":"Sinyeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3944-6015","authenticated-orcid":false,"given":"Manyoung","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9295-1393","authenticated-orcid":false,"given":"Se Woong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-9527","authenticated-orcid":false,"given":"Jin Gyu","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-2636","authenticated-orcid":false,"given":"Sang Cheol","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-7608","authenticated-orcid":false,"given":"Soo In","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-7458","authenticated-orcid":false,"given":"Miwon","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-4316","authenticated-orcid":false,"given":"Doheon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.14108","article-title":"Parkinson disease","volume":"27","author":"Balestrino","year":"2020","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119094_bib2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol."},{"issue":"6645","key":"10.1016\/j.biopha.2026.119094_bib3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"issue":"33","key":"10.1016\/j.biopha.2026.119094_bib4","doi-asserted-by":"crossref","first-page":"9927","DOI":"10.1021\/bi002952n","article-title":"Membrane binding and self-association of alpha-synucleins","volume":"40","author":"Narayanan","year":"2001","journal-title":"Biochemistry"},{"issue":"14","key":"10.1016\/j.biopha.2026.119094_bib5","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1021\/bi972776r","article-title":"Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins","volume":"37","author":"Jenco","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopha.2026.119094_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.neuro.26.010302.081142","article-title":"Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders","volume":"26","author":"Caughey","year":"2003","journal-title":"Annu Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.biopha.2026.119094_bib7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nm0602-600","article-title":"Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease","volume":"8","author":"Xu","year":"2002","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.biopha.2026.119094_bib8","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jmb.2005.06.060","article-title":"Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease","volume":"351","author":"Flower","year":"2005","journal-title":"J. Mol. Biol."},{"issue":"13","key":"10.1016\/j.biopha.2026.119094_bib9","doi-asserted-by":"crossref","first-page":"12924","DOI":"10.1074\/jbc.M306390200","article-title":"Proteasomal inhibition by alpha-synuclein filaments and oligomers","volume":"279","author":"Lindersson","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"37","key":"10.1016\/j.biopha.2026.119094_bib10","doi-asserted-by":"crossref","first-page":"10328","DOI":"10.1073\/pnas.1604645113","article-title":"Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of alpha-synuclein aggregation","volume":"113","author":"Flagmeier","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"33","key":"10.1016\/j.biopha.2026.119094_bib11","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1021\/acs.biochem.8b00321","article-title":"The Familial alpha-Synuclein A53E mutation enhances cell death in response to environmental toxins due to a larger population of oligomers","volume":"57","author":"Mohite","year":"2018","journal-title":"Biochemistry"},{"issue":"35","key":"10.1016\/j.biopha.2026.119094_bib12","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1021\/acs.biochem.8b00314","article-title":"Comparison of kinetics, toxicity, oligomer formation, and membrane binding capacity of alpha-synuclein familial mutations at the A53 site, including the newly discovered A53V mutation","volume":"57","author":"Mohite","year":"2018","journal-title":"Biochemistry"},{"issue":"24","key":"10.1016\/j.biopha.2026.119094_bib13","doi-asserted-by":"crossref","first-page":"9549","DOI":"10.1523\/JNEUROSCI.21-24-09549.2001","article-title":"Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death","volume":"21","author":"Stefanis","year":"2001","journal-title":"J. Neurosci."},{"issue":"33","key":"10.1016\/j.biopha.2026.119094_bib14","doi-asserted-by":"crossref","first-page":"8014","DOI":"10.1021\/bi900619j","article-title":"A cellular model to monitor proteasome dysfunction by alpha-synuclein","volume":"48","author":"Nonaka","year":"2009","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.biopha.2026.119094_bib15","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1073\/pnas.1905057117","article-title":"Translation of the intrinsically disordered protein alpha-synuclein is inhibited by a small molecule targeting its structured mRNA","volume":"117","author":"Zhang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2026.119094_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.705407","article-title":"\"A phase II study to evaluate the safety and efficacy of prasinezumab in early Parkinson's disease (PASADENA): rationale, design, and baseline data","volume":"12","author":"Pagano","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.biopha.2026.119094_bib17","first-page":"2","article-title":"Targeting neurons in the gastrointestinal tract to treat Parkinson's disease","volume":"1","author":"Hauser","year":"2019","journal-title":"Clin. Park Relat. Disord."},{"key":"10.1016\/j.biopha.2026.119094_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113637","article-title":"\"Inhibition of \u03b1-synuclein aggregation by MT101-5 is neuroprotective in mouse models of Parkinson\u2019s disease","volume":"154","author":"Kim","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.biopha.2026.119094_bib19","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.neubiorev.2012.06.007","article-title":"The Parkinson's disease-related genes act in mitochondrial homeostasis","volume":"36","author":"Sai","year":"2012","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.biopha.2026.119094_bib20","doi-asserted-by":"crossref","first-page":"10331","DOI":"10.1038\/ncomms10331","article-title":"Network-based in silico drug efficacy screening","volume":"7","author":"Guney","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2026.119094_bib21","first-page":"439","article-title":"Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks","volume":"25","author":"Pham","year":"2020","journal-title":"Pac. Symp. Biocomput"},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib23","article-title":"Drug repurposing for Parkinson's disease by biological pathway based edge-weighted network proximity analysis","volume":"14","author":"Han","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119094_bib24","doi-asserted-by":"crossref","first-page":"58106","DOI":"10.1109\/ACCESS.2018.2874089","article-title":"A data-driven approach for identifying medicinal combinations of natural products","volume":"6","author":"Yoo","year":"2018","journal-title":"IEEE Access"},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib25","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.1038\/s41598-017-07448-6","article-title":"CODA: Integrating multi-level context-oriented directed associations for analysis of drug effects","volume":"7","author":"Yu","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.biopha.2026.119094_bib26","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1016\/j.bmc.2006.01.055","article-title":"Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I","volume":"14","author":"Zhang","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"10.1016\/j.biopha.2026.119094_bib27","first-page":"835","article-title":"Studies on the active principles of the root Yuan-hua \u2162. Isolation and structure of Yuanhuafine","volume":"40","author":"Wang Cheng-Rui","year":"1982","journal-title":"Acta Chim. Sin."},{"issue":"2","key":"10.1016\/j.biopha.2026.119094_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1248\/cpb.58.234","article-title":"Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa","volume":"58","author":"Hong","year":"2010","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"4","key":"10.1016\/j.biopha.2026.119094_bib29","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1021\/acs.jnatprod.0c00003","article-title":"Daphnane diterpenoids from daphne genkwa inhibit PI3K\/Akt\/mTOR signaling and induce cell cycle arrest and apoptosis in human colon cancer cells","volume":"83","author":"Pan","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"7","key":"10.1016\/j.biopha.2026.119094_bib30","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"issue":"16","key":"10.1016\/j.biopha.2026.119094_bib31","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1111\/bph.15178","article-title":"ARRIVE 2.0 and the British Journal of Pharmacology: updated guidance for 2020","volume":"177","author":"Lilley","year":"2020","journal-title":"Br. J. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nprot.2006.342","article-title":"Protocol for the MPTP mouse model of Parkinson's disease","volume":"2","author":"Jackson-Lewis","year":"2007","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib33","article-title":"Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease","volume":"11","author":"Watanabe","year":"2005","journal-title":"Med. Sci. Monit."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib34","first-page":"35","article-title":"Mechanisms of MPTP toxicity","volume":"13","author":"Przedborski","year":"1998","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib35","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1038\/s41467-023-39970-9","article-title":"An optimized Nurr1 agonist provides disease-modifying effects in Parkinson's disease models","volume":"14","author":"Kim","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2026.119094_bib36","doi-asserted-by":"crossref","first-page":"17807","DOI":"10.1038\/srep17807","article-title":"Resveratrol treatment after status epilepticus restrains neurodegeneration and abnormal neurogenesis with suppression of oxidative stress and inflammation","volume":"5","author":"Mishra","year":"2015","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2026.119094_bib37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ccell.2016.03.026","article-title":"Tight junction protein 1 modulates proteasome capacity and proteasome inhibitor sensitivity in multiple myeloma via EGFR\/JAK1\/STAT3 signaling","volume":"29","author":"Zhang","year":"2016","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.biopha.2026.119094_bib38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ncb1441","article-title":"A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling","volume":"8","author":"Fallon","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119094_bib39","doi-asserted-by":"crossref","first-page":"10146","DOI":"10.18632\/oncotarget.3380","article-title":"Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer","volume":"6","author":"Bae","year":"2015","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.biopha.2026.119094_bib40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41419-019-1601-6","article-title":"AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells","volume":"10","author":"Kim","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2026.119094_bib41","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fchem.2020.00064","article-title":"Reporter-based screens for the ubiquitin\/proteasome system","volume":"8","author":"Gierisch","year":"2020","journal-title":"Front Chem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jpbs.JPBS_175_19","article-title":"Preparation of medicinal plants: basic extraction and fractionation procedures for experimental purposes","volume":"12","author":"Abubakar","year":"2020","journal-title":"J. Pharm. Bioallied Sci."},{"issue":"2","key":"10.1016\/j.biopha.2026.119094_bib43","first-page":"145","article-title":"Daphnane-type diterpenes from genus Daphne and their anti-tumor activity","volume":"13","author":"Hou","year":"2021","journal-title":"Chin. Herb. Med"},{"key":"10.1016\/j.biopha.2026.119094_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119088","article-title":"The inhibitive effects of proteasome inhibitor MG-132 on pterygium fibroblasts in vitro and the potential key regulators involved","volume":"270","author":"Zhao","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neures.2008.10.009","article-title":"Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis","volume":"63","author":"Cheng","year":"2009","journal-title":"Neurosci. Res"},{"issue":"10","key":"10.1016\/j.biopha.2026.119094_bib46","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1111\/j.1742-4658.2011.08093.x","article-title":"Modulation of alpha-synuclein aggregation by dopamine in the presence of MPTP and its metabolite","volume":"278","author":"Jethva","year":"2011","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.biopha.2026.119094_bib47","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/acs.jnatprod.6b00110","article-title":"Daphnane diterpenes from daphne genkwa activate Nurr1 and have a neuroprotective effect in an animal model of Parkinson's disease","volume":"79","author":"Han","year":"2016","journal-title":"J. Nat. Prod."},{"issue":"12","key":"10.1016\/j.biopha.2026.119094_bib48","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1248\/bpb.b17-00641","article-title":"Daphnane and phorbol diterpenes, anti-neuroinflammatory compounds with Nurr1 activation from the roots and stems of Daphne genkwa","volume":"40","author":"Han","year":"2017","journal-title":"Biol. Pharm. Bull."},{"issue":"10","key":"10.1016\/j.biopha.2026.119094_bib49","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2026.119094_bib50","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s12035-012-8368-4","article-title":"Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL\/6 wild-type and GSTP knockout mice","volume":"47","author":"Carvalho","year":"2013","journal-title":"Mol. Neurobiol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119094_bib51","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1073\/pnas.0409713102","article-title":"Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein","volume":"102","author":"Fornai","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.biopha.2026.119094_bib52","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","article-title":"Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations","volume":"20","author":"Bernheimer","year":"1973","journal-title":"J. Neurol. Sci."},{"issue":"17","key":"10.1016\/j.biopha.2026.119094_bib53","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1523\/JNEUROSCI.21-17-06853.2001","article-title":"Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease","volume":"21","author":"Bezard","year":"2001","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.biopha.2026.119094_bib54","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/brain\/awab446","article-title":"Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state","volume":"145","author":"Smajic","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.biopha.2026.119094_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.910988","article-title":"Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure","volume":"14","author":"Brandi","year":"2022","journal-title":"Front Aging Neurosci."},{"issue":"3","key":"10.1016\/j.biopha.2026.119094_bib56","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"T. International Natural Product Sciences, C.T. Supuran, Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.biopha.2026.119094_bib57","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1039\/C5NP00005J","article-title":"Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products","volume":"32","author":"Kibble","year":"2015","journal-title":"Nat. Prod. Rep."},{"issue":"7","key":"10.1016\/j.biopha.2026.119094_bib58","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tins.2005.05.002","article-title":"To die or grow: Parkinson's disease and cancer","volume":"28","author":"West","year":"2005","journal-title":"Trends Neurosci."},{"issue":"9","key":"10.1016\/j.biopha.2026.119094_bib59","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9","article-title":"Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary","volume":"88","author":"Bruening","year":"2000","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/genes9010016","article-title":"SNCA is a functionally low-expressed gene in lung adenocarcinoma","volume":"9","author":"Yan","year":"2018","journal-title":"Genes (Basel)"},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib61","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1038\/s41598-021-84443-y","article-title":"Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth","volume":"11","author":"Shekoohi","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng.491","article-title":"Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies","volume":"42","author":"Veeriah","year":"2010","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.biopha.2026.119094_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/cells7100154","article-title":"The interplay among PINK1\/PARKIN\/Dj-1 network during mitochondrial quality control in cancer biology: protein interaction analysis","volume":"7","author":"Salazar","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119094_bib64","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40035-015-0043-z","article-title":"The associations between Parkinson's disease and cancer: the plot thickens","volume":"4","author":"Feng","year":"2015","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.biopha.2026.119094_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.127821","article-title":"Dihydroquinazolines enhance 20S proteasome activity and induce degradation of alpha-synuclein, an intrinsically disordered protein associated with neurodegeneration","volume":"36","author":"Fiolek","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.biopha.2026.119094_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-26148-4","article-title":"Molecular and metabolic alterations of 2,3-dihydroquinazolin-4(1H)-one derivatives in prostate cancer cell lines","volume":"12","author":"Dahabiyeh","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2026.119094_bib67","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s13206-014-8205-0","article-title":"Identifying transcription factor NURR1 expression-level specific pathways with gene signaling networks","volume":"8","author":"Do","year":"2014","journal-title":"BioChip J."},{"issue":"10","key":"10.1016\/j.biopha.2026.119094_bib68","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1038\/s41401-024-01337-1","article-title":"Author Correction: CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK\/AKT-Nurr1 signal pathways","volume":"45","author":"Han","year":"2024","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.biopha.2026.119094_bib69","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neulet.2013.11.033","article-title":"Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons","volume":"559","author":"Tokuoka","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.biopha.2026.119094_bib70","doi-asserted-by":"crossref","first-page":"768","DOI":"10.2174\/187152712803581155","article-title":"Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease","volume":"11","author":"Zhang","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"51","key":"10.1016\/j.biopha.2026.119094_bib71","doi-asserted-by":"crossref","first-page":"39550","DOI":"10.1074\/jbc.M603950200","article-title":"p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition","volume":"281","author":"Nair","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.biopha.2026.119094_bib72","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1158\/1541-7786.MCR-08-0533","article-title":"NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity","volume":"7","author":"Zhang","year":"2009","journal-title":"Mol. Cancer Res."},{"issue":"1-2","key":"10.1016\/j.biopha.2026.119094_bib73","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2008.06.007","article-title":"Decreased NURR1 gene expression in patients with Parkinson's disease","volume":"273","author":"Le","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.biopha.2026.119094_bib74","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fnagi.2018.00392","article-title":"Alterations of NURR1 and cytokines in the peripheral blood mononuclear cells: combined biomarkers for Parkinson's disease","volume":"10","author":"Li","year":"2018","journal-title":"Front Aging Neurosci."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:45:02Z","timestamp":1781880302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226001265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":74,"alternative-id":["S0753332226001265"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119094","relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.174060381.18927227\/v1","asserted-by":"object"}]},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"De novo identification of potent ingredients for proteasome activation in MT101-5 using an AI-driven approach","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119094"}}