{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:50:28Z","timestamp":1781884228820,"version":"3.54.5"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031514","name":"Health Commission of Chengdu Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.biopha.2026.119124","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T21:02:39Z","timestamp":1771448559000},"page":"119124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role of NETO2 in neurological disorders and cancer: From molecular function to clinical relevance"],"prefix":"10.1016","volume":"196","author":[{"given":"Jing","family":"Gou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoli","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-3465","authenticated-orcid":false,"given":"Yongkang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0378-1119(02)00438-9","article-title":"A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain","volume":"286","author":"St\u00f6hr","year":"2002","journal-title":"Gene"},{"issue":"12","key":"10.1016\/j.biopha.2026.119124_bib2","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1523\/JNEUROSCI.2978-16.2017","article-title":"Neto2 assembles with kainate receptors in drg neurons during development and modulates neurite outgrowth in adult sensory neurons","volume":"37","author":"Vernon","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2026.119124_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41594-025-01656-9","article-title":"Activation of kainate receptor GluK2-Neto2 complex","author":"Gangwar","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"7884","key":"10.1016\/j.biopha.2026.119124_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41586-021-03936-y","article-title":"Kainate receptor modulation by NETO2","volume":"599","author":"He","year":"2021","journal-title":"Nature"},{"issue":"Pt 19","key":"10.1016\/j.biopha.2026.119124_bib5","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1113\/jphysiol.2013.256776","article-title":"Modulation of homomeric and heteromeric kainate receptors by the auxiliary subunit Neto1","volume":"591","author":"Fisher","year":"2013","journal-title":"J. Physiol."},{"issue":"37","key":"10.1016\/j.biopha.2026.119124_bib6","doi-asserted-by":"crossref","first-page":"12928","DOI":"10.1523\/JNEUROSCI.2211-12.2012","article-title":"The auxiliary subunits Neto1 and Neto2 REduce Voltage-dependent Inhibition of Recombinant Kainate Receptors","volume":"32","author":"Fisher","year":"2012","journal-title":"J. Neurosci."},{"issue":"37","key":"10.1016\/j.biopha.2026.119124_bib7","doi-asserted-by":"crossref","first-page":"15369","DOI":"10.1074\/jbc.M117.787903","article-title":"Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1","volume":"292","author":"Lomash","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119124_bib8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fncel.2015.00368","article-title":"Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures","volume":"9","author":"Mahadevan","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"9","key":"10.1016\/j.biopha.2026.119124_bib9","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1073\/pnas.1212907110","article-title":"Neto2 is a KCC2 interacting protein required for neuronal Cl\u2212 regulation in hippocampal neurons","volume":"110","author":"Ivakine","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.biopha.2026.119124_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuron.2008.12.014","article-title":"A transmembrane accessory subunit that modulates kainate-type glutamate receptors","volume":"61","author":"Zhang","year":"2009","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib11","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1523\/JNEUROSCI.3098-13.2014","article-title":"Neto auxiliary protein interactions regulate kainate and NMDA receptor subunit localization at mossy fiber-CA3 pyramidal cell synapses","volume":"34","author":"Wyeth","year":"2014","journal-title":"Journal Neuroscience Official Journal Society Neuroscience"},{"issue":"Pt 10","key":"10.1016\/j.biopha.2026.119124_bib12","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1113\/jphysiol.2011.221101","article-title":"Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors","volume":"590","author":"Tomita","year":"2012","journal-title":"J. Physiol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119124_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051433","article-title":"Neto2 interacts with the scaffolding protein grip and regulates synaptic abundance of kainate receptors","volume":"7","author":"Tang","year":"2012","journal-title":"PLoS ONE"},{"issue":"22","key":"10.1016\/j.biopha.2026.119124_bib14","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1523\/JNEUROSCI.0024-11.2011","article-title":"Neto2 modulation of kainate receptors with different subunit compositions","volume":"31","author":"Straub","year":"2011","journal-title":"Journal Neuroscience Official Journal Society Neuroscience"},{"key":"10.1016\/j.biopha.2026.119124_bib15","doi-asserted-by":"crossref","unstructured":"Sheng N., Shi Y.S., Lomash R.M., et al. Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1[J\/OL]. eLife, 4: e11682. DOI:10.7554\/eLife.11682.","DOI":"10.7554\/eLife.11682"},{"issue":"15","key":"10.1016\/j.biopha.2026.119124_bib16","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1074\/jbc.M116.767236","article-title":"A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl\u2212 cotransporter KCC2 in hippocampal neurons","volume":"292","author":"Pressey","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2026.119124_bib17","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/ejn.12519","article-title":"Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors","volume":"39","author":"Zhang","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.biopha.2026.119124_bib18","first-page":"1159","article-title":"Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking","volume":"114","author":"Sheng","year":"2017"},{"issue":"7","key":"10.1016\/j.biopha.2026.119124_bib19","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nn.2837","article-title":"Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1","volume":"14","author":"Straub","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/bcpt.12575","article-title":"Neto2 influences on kainate receptor pharmacology and function","volume":"119","author":"Han","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119124_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2024.108113","article-title":"Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538","volume":"216","author":"Bay","year":"2024","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.biopha.2026.119124_bib22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuropharm.2015.08.018","article-title":"The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors","volume":"99","author":"Fisher","year":"2015","journal-title":"Neuropharmacology"},{"issue":"41","key":"10.1016\/j.biopha.2026.119124_bib23","doi-asserted-by":"crossref","first-page":"25830","DOI":"10.1073\/pnas.1915464117","article-title":"The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation","volume":"117","author":"Kiragasi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"22","key":"10.1016\/j.biopha.2026.119124_bib24","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1113\/JP271103","article-title":"Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2","volume":"593","author":"Griffith","year":"2015","journal-title":"J. Physiol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119124_bib25","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1007\/s12035-019-1612-4","article-title":"NETO1 regulates postsynaptic kainate receptors in ca3 interneurons during circuit maturation","volume":"56","author":"Orav","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.biopha.2026.119124_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003369","article-title":"Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2\/ASF","volume":"3","author":"Sanford","year":"2008","journal-title":"PloS One"},{"issue":"47","key":"10.1016\/j.biopha.2026.119124_bib27","doi-asserted-by":"crossref","first-page":"17889","DOI":"10.1074\/jbc.RA119.008631","article-title":"Neto proteins regulate gating of the kainate-type glutamate receptor GluK2 through two binding sites","volume":"294","author":"Li","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/adt.2015.689","article-title":"Pharmacological modulation of GluK1 and GluK2 by NETO1, NETO2, and PSD95","volume":"14","author":"Li","year":"2016","journal-title":"ASSAY Drug Dev. Technol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119124_bib29","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/cercor\/bhu244","article-title":"Synaptic targeting of kainate receptors","volume":"26","author":"Palacios-Filardo","year":"2016","journal-title":"Cereb. Cortex"},{"issue":"10","key":"10.1016\/j.biopha.2026.119124_bib30","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nrn3335","article-title":"Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function","volume":"13","author":"Copits","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"27","key":"10.1016\/j.biopha.2026.119124_bib31","doi-asserted-by":"crossref","first-page":"10009","DOI":"10.1523\/JNEUROSCI.6617-10.2011","article-title":"Neto1 is an auxiliary subunit of native synaptic kainate receptors[J\/OL]","volume":"31","author":"Tang","year":"2011","journal-title":"J. Neuroscience Official J. Soc. Neuro."},{"issue":"9","key":"10.1016\/j.biopha.2026.119124_bib32","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.celrep.2017.08.017","article-title":"Neto auxiliary subunits regulate interneuron somatodendritic and presynaptic kainate receptors to control network inhibition","volume":"20","author":"Wyeth","year":"2017","journal-title":"Cell Rep."},{"issue":"20","key":"10.1016\/j.biopha.2026.119124_bib33","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.1523\/JNEUROSCI.0100-11.2011","article-title":"Synaptic targeting and functional modulation of gluk1 kainate receptors by the auxiliary neuropilin and tolloid-Like (NETO) proteins","volume":"31","author":"Copits","year":"2011","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.biopha.2026.119124_bib34","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0048-17.2017","article-title":"NETO1 guides development of glutamatergic connectivity in the hippocampus by regulating axonal kainate receptors","volume":"4","author":"Orav","year":"2017","journal-title":"eNeuro"},{"issue":"10172","key":"10.1016\/j.biopha.2026.119124_bib35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"issue":"10503","key":"10.1016\/j.biopha.2026.119124_bib36","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0140-6736(25)00773-1","article-title":"Childhood epilepsy","volume":"406","author":"Menon","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2026.119124_bib37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1755-8166-5-16","article-title":"Juxtaposition of heterochromatic and euchromatic regions by chromosomal translocation mediates a heterochromatic long-range position effect associated with a severe neurological phenotype","volume":"5","author":"Finelli","year":"2012","journal-title":"Mol. Cytogenet."},{"issue":"5","key":"10.1016\/j.biopha.2026.119124_bib38","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/jama.2015.8109","article-title":"JAMA PATIENT PAGE. posttraumatic stress disorder (PTSD)","volume":"314","author":"Spoont","year":"2015","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.biopha.2026.119124_bib39","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/s41386-019-0376-x","article-title":"Heightened fear in the absence of the kainate receptor auxiliary subunit NETO2: implications for PTSD","volume":"44","author":"Sargin","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopha.2026.119124_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cpr.2017.09.001","article-title":"A review of current evidence regarding the ICD-11 proposals for diagnosing PTSD and complex PTSD","volume":"58","author":"Brewin","year":"2017","journal-title":"Clin. Psychol. Rev."},{"issue":"6","key":"10.1016\/j.biopha.2026.119124_bib41","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1176\/appi.ajp.2009.08121799","article-title":"PTSD diagnostic criteria: understanding etiology and treatment","volume":"166","author":"Asmundson","year":"2009","journal-title":"Am. J. Psychiatry"},{"issue":"11","key":"10.1016\/j.biopha.2026.119124_bib42","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1038\/s41386-019-0344-5","article-title":"Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction","volume":"44","author":"Mennesson","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.biopha.2026.119124_bib43","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0541-19.2020","article-title":"Kainate receptor auxiliary subunit NETO2-related cued fear conditioning impairments associate with defects in amygdala development and excitability.","volume":"7","author":"Mennesson","year":"2020","journal-title":"eNeuro"},{"issue":"11","key":"10.1016\/j.biopha.2026.119124_bib44","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J. Clin. Investig."},{"issue":"9164","key":"10.1016\/j.biopha.2026.119124_bib45","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(99)01311-2","article-title":"Pain: an overview[J\/OL]","volume":"353","author":"Loeser","year":"1999","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.biopha.2026.119124_bib46","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1074\/jbc.M116.767236","article-title":"A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl\u2212 cotransporter KCC2 in hippocampal neurons","volume":"292","author":"Pressey","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119124_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137430","article-title":"NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKC\u03b3 activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn","volume":"813","author":"Guo","year":"2023","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.biopha.2026.119124_bib48","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1056\/NEJM199403103301006","article-title":"Schizophrenia","volume":"330","author":"Carpenter","year":"1994","journal-title":"New Engl. J. Med."},{"issue":"9","key":"10.1016\/j.biopha.2026.119124_bib49","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1038\/s41380-023-02293-8","article-title":"Genomic findings in schizophrenia and their implications","volume":"28","author":"Owen","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.biopha.2026.119124_bib50","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ajhg.2013.09.004","article-title":"Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia","volume":"93","author":"Rippey","year":"2013","journal-title":"Am. J. Hum. Genet."},{"issue":"8","key":"10.1016\/j.biopha.2026.119124_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11912-019-0820-4","article-title":"Updates on management of gastric cancer","volume":"21","author":"Johnston","year":"2019","journal-title":"Curr. Oncol. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib52","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41419-025-07991-5","article-title":"MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKK\u03b1 in gastric adenocarcinoma","volume":"16","author":"Du","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2026.119124_bib53","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41419-019-1388-5","article-title":"NETO2 promotes invasion and metastasis of gastric cancer cells via activation of PI3K\/Akt\/NF-\u03baB\/Snail axis and predicts outcome of the patients","volume":"10","author":"Liu","year":"2019","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.biopha.2026.119124_bib54","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3390\/biom13050736","article-title":"Epigenetic and tumor microenvironment for prognosis of patients with gastric cancer","volume":"13","author":"Wu","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.biopha.2026.119124_bib55","article-title":"From biomarkers to mechanisms: deepening the clinical translation of inflammatory indices in colorectal cancer pathogenesis","author":"Yan","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.biopha.2026.119124_bib56","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jproteome.5c00483","article-title":"Plasma proteomic high-performance biomarkers for early diagnosis of colorectal cancer","author":"Jin","year":"2025","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.biopha.2026.119124_bib57","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1186\/s12885-015-2018-y","article-title":"Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma","volume":"15","author":"Hu","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2026.119124_bib58","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12863-017-0581-8","article-title":"Upregulation of NETO2 gene in colorectal cancer","volume":"18","author":"Fedorova","year":"2017","journal-title":"BMC Genet."},{"key":"10.1016\/j.biopha.2026.119124_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.594933","article-title":"NETO2 Is deregulated in breast, prostate, and colorectal cancer and participates in cellular signaling","volume":"11","author":"Fedorova","year":"2020","journal-title":"Front. Genet."},{"issue":"10485","key":"10.1016\/j.biopha.2026.119124_bib60","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.biopha.2026.119124_bib61","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","article-title":"Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors","volume":"18","author":"Klein","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2026.119124_bib62","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.2147\/CMAR.S204260","article-title":"NETO2 promotes pancreatic cancer cell proliferation, invasion and migration via activation of the STAT3 signaling pathway","volume":"11","author":"Li","year":"2019","journal-title":"Cancer Manag. Res."},{"issue":"6","key":"10.1016\/j.biopha.2026.119124_bib63","first-page":"673","article-title":"Precision screening for esophageal squamous cell carcinoma in China","volume":"32","author":"He","year":"2020","journal-title":"Chin. J. Cancer Res. ChungKuo Yen Cheng Yen Chiu"},{"issue":"11","key":"10.1016\/j.biopha.2026.119124_bib64","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/s10038-020-0795-x","article-title":"RNA sequencing-based microRNA expression signature in esophageal squamous cell carcinoma: oncogenic targets by antitumor miR-143-5p and miR-143-3p regulation","volume":"65","author":"Wada","year":"2020","journal-title":"J. Hum. Genet."},{"issue":"22","key":"10.1016\/j.biopha.2026.119124_bib65","doi-asserted-by":"crossref","first-page":"8600","DOI":"10.1002\/cam4.3463","article-title":"Exosomal lncRNA FAM225A accelerates esophageal squamous cell carcinoma progression and angiogenesis by sponging miR-206 to upregulate NETO2 and FOXP1 expression","volume":"9","author":"Zhang","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.biopha.2026.119124_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340038","article-title":"A multiplatform metabolomics reveals possible biomarkers for the early-stage esophageal squamous cell carcinoma","volume":"1220","author":"Zhao","year":"2022","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib67","doi-asserted-by":"crossref","first-page":"259","DOI":"10.7150\/ijbs.53795","article-title":"NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K\/AKT and ERK pathway","volume":"17","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib68","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41572-021-00245-6","volume":"7","author":"Hepatocellular carcinoma","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib69","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12943-024-02101-z","article-title":"Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma","volume":"23","author":"Chan","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib70","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cld.2022.08.004","article-title":"Hepatocellular Carcinoma: New Developments","volume":"27","author":"Ganesan","year":"2023","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.biopha.2026.119124_bib71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12957-025-03717-1","article-title":"Targeting NETO2 suppresses cell proliferation, invasion, and migration and inactivates the STAT3\/C-MYC pathway in hepatocellular carcinoma","volume":"23","author":"He","year":"2025","journal-title":"World J. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119124_bib72","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gutjnl-2014-308483","article-title":"Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. The results from a prospective study","volume":"65","author":"Villa","year":"2016","journal-title":"Gut"},{"issue":"10192","key":"10.1016\/j.biopha.2026.119124_bib73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.biopha.2026.119124_bib74","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/cac2.12218","article-title":"The chinese society of clinical oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma","volume":"41","author":"Tang","year":"2021","journal-title":"Cancer Communications"},{"issue":"4","key":"10.1016\/j.biopha.2026.119124_bib75","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.annonc.2020.12.007","article-title":"Nasopharyngeal carcinoma: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up\u2020","volume":"32","author":"Bossi","year":"2021","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib76","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2019.03.061","article-title":"Reducing NETO2 expression prevents human nasopharyngeal carcinoma (NPC) progression by suppressing metastasis and inducing apoptosis","volume":"513","author":"He","year":"2019","journal-title":"Biochemical Biophysical Res. Commun."},{"key":"10.1016\/j.biopha.2026.119124_bib77","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.omto.2021.11.009","article-title":"TTN-AS1 accelerates the growth and migration of nasopharyngeal carcinoma cells by targeting miR-876-5p\/NETO2","volume":"24","author":"Chen","year":"2021","journal-title":"Mol. Ther. Oncolytics"},{"issue":"7","key":"10.1016\/j.biopha.2026.119124_bib78","doi-asserted-by":"crossref","first-page":"vii320","DOI":"10.1093\/annonc\/mdq276","article-title":"Osteosarcoma","volume":"21","author":"Ritter","year":"2010","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119124_bib79","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrc3838","article-title":"Translational biology of osteosarcoma","volume":"14","author":"Kansara","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biopha.2026.119124_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145292","article-title":"Neuropilin and tolloid-like 2 regulates the progression of osteosarcoma","volume":"768","author":"Wang","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.biopha.2026.119124_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2022.101887","article-title":"TYMSOS-miR-101-3p-NETO2 axis promotes osteosarcoma progression","volume":"67","author":"Zhang","year":"2023","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.biopha.2026.119124_bib82","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.11496","article-title":"Identification of potential gene signatures associated with osteosarcoma by integrated bioinformatics analysis","volume":"9","author":"Jia","year":"2021","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccm.2019.10.001","article-title":"Lung cancer 2020: epidemiology, etiology, and prevention","volume":"41","author":"Bade","year":"2020","journal-title":"Clin. Chest Med."},{"issue":"5","key":"10.1016\/j.biopha.2026.119124_bib84","first-page":"599","article-title":"[Increase in NETO2 gene expression is a potential molecular genetic marker in renal and lung cancers][J]","volume":"48","author":"Oparina","year":"2012","journal-title":"Genetika"},{"key":"10.1016\/j.biopha.2026.119124_bib85","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12935-025-03701-5","article-title":"\u03b15-nAChR\/NETO2 contributed to chronic stress-promoted lung adenocarcinoma progression","volume":"25","author":"Wang","year":"2025","journal-title":"Cancer Cell Int."},{"issue":"3","key":"10.1016\/j.biopha.2026.119124_bib86","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/labinvest.2017.108","article-title":"Identification of a gene expression signature associated with the metastasis suppressor function of NME1: prognostic value in human melanoma","volume":"98","author":"Leonard","year":"2018","journal-title":"Lab. Investig. a J. Tech. Methods Pathol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119124_bib87","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.mcna.2018.12.006","article-title":"Lung Cancer","volume":"103","author":"Nasim","year":"2019","journal-title":"Med. Clin. North Am."},{"issue":"6","key":"10.1016\/j.biopha.2026.119124_bib88","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3892\/ol.2021.13079","article-title":"Long noncoding RNA SNHG17 promotes lung adenocarcinoma progression by targeting the microRNA-193a-5p\/NETO2 axis","volume":"22","author":"Zhang","year":"2021","journal-title":"Oncol. Lett."},{"issue":"18","key":"10.1016\/j.biopha.2026.119124_bib89","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.3390\/ijms20184482","article-title":"Involvement of dual strands of miR-143 (miR-143-5p and miR-143-3p) and their target oncogenes in the molecular pathogenesis of lung adenocarcinoma","volume":"20","author":"Sanada","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.biopha.2026.119124_bib90","doi-asserted-by":"crossref","first-page":"14257","DOI":"10.3390\/ijms232214257","article-title":"Complexities of prostate cancer","volume":"23","author":"Wasim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119124_bib91","unstructured":"Genetics and biology of prostate cancer - PubMed[EB\/OL]. [2025-09-12]. \u3008https:\/\/pubmed.ncbi.nlm.nih.gov\/30181359\/\u3009."},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib92","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tranon.2018.09.003","article-title":"Biomarkers associated with tumor heterogeneity in prostate cancer","volume":"12","author":"Yun","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.biopha.2026.119124_bib93","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.718638","article-title":"Identification of ARHGEF38, NETO2, GOLM1, and SAPCD2 associated with prostate cancer progression by bioinformatic analysis and experimental validation","volume":"9","author":"Sun","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2026.119124_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1535091","article-title":"Machine learning models for predicting prostate cancer recurrence and identifying potential molecular biomarkers","volume":"15","author":"Antunes","year":"2025","journal-title":"Front. Oncol."},{"issue":"9472","key":"10.1016\/j.biopha.2026.119124_bib95","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/S0140-6736(05)66546-4","article-title":"Breast cancer","volume":"365","author":"Veronesi","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2026.119124_bib96","unstructured":"Breast cancer: pathogenesis and treatments - PubMed[EB\/OL]. [2025-09-12]. \u3008https:\/\/pubmed.ncbi.nlm.nih.gov\/39966355\/\u3009."},{"issue":"15","key":"10.1016\/j.biopha.2026.119124_bib97","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1158\/0008-5472.CAN-07-0962","article-title":"Nm23-H1 suppresses tumor cell motility by downregulating the lysophosphatidic acid receptor EDG2","volume":"67","author":"Horak","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2026.119124_bib98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2020.02.002","article-title":"Immunotherapy for glioma: Current management and future application","volume":"476","author":"Xu","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2026.119124_bib99","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12967-019-1908-1","article-title":"Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas","volume":"17","author":"Sun","year":"2019","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib100","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41419-023-05555-z","article-title":"Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2026.119124_bib101","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1127645","article-title":"Glioblastoma survival is associated with distinct proteomic alteration signatures post chemoirradiation in a large-scale proteomic panel","volume":"13","author":"Krauze","year":"2023","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119124_bib102","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12967-019-1908-1","article-title":"Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas","volume":"17","author":"Sun","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119124_bib103","article-title":"Identifying potential diagnostic and therapeutic targets for infantile hemangioma using WGCNA and machine learning algorithms","author":"Wang","year":"2024","journal-title":"Biochem. Genet."},{"issue":"5","key":"10.1016\/j.biopha.2026.119124_bib104","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.2353\/ajpath.2009.080517","article-title":"Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling","volume":"174","author":"Calicchio","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib105","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.18632\/aging.205443","article-title":"Prognostic characteristics of a six-gene signature based on ssGSEA in sarcoma","volume":"16","author":"Liu","year":"2024","journal-title":"Aging"},{"issue":"23","key":"10.1016\/j.biopha.2026.119124_bib106","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.3390\/cancers14235999","article-title":"Correlation of transcriptomics and FDG-PET SUVmax indicates reciprocal expression of stemness-related transcription factor and neuropeptide signaling pathways in glucose metabolism of ewing sarcoma","volume":"14","author":"Prexler","year":"2022","journal-title":"Cancers"},{"issue":"9997","key":"10.1016\/j.biopha.2026.119124_bib107","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2026.119124_bib108","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/ard.2004.033217","article-title":"Psoriasis: epidemiology, clinical features, and quality of life","volume":"64","author":"Langley","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2026.119124_bib109","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13287-019-1159-3","article-title":"Dermal mesenchymal stem cells: a resource of migration-associated function in psoriasis?","volume":"10","author":"Niu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biopha.2026.119124_bib110","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.5527","article-title":"Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood","volume":"6","author":"Tangprasittipap","year":"2018","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.biopha.2026.119124_bib111","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1134\/S0026893318020152","article-title":"Transcription factor SAP30 is involved in the activation of NETO2 gene expression in clear cell renal cell carcinoma","volume":"52","author":"Snezhkina","year":"2018","journal-title":"Mol. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib112","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1947603518764260","article-title":"A membranome-centered approach defines novel biomarkers for cellular subtypes in the intervertebral disc","volume":"11","author":"Van Den Akker","year":"2020","journal-title":"Cartilage"},{"issue":"8","key":"10.1016\/j.biopha.2026.119124_bib113","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.3168\/jds.2025-26361","article-title":"Bayesian fine-mapping and Mendelian randomization leveraging expression quantitative trait loci reveal novel candidate causal genes for body conformation traits in cattle","volume":"108","author":"Teng","year":"2025","journal-title":"J. Dairy Sci."},{"issue":"2","key":"10.1016\/j.biopha.2026.119124_bib114","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11684-022-0935-0","article-title":"NETO2 promotes melanoma progression via activation of the Ca2+\/CaMKII signaling pathway","volume":"17","author":"Zhu","year":"2023","journal-title":"Front. Med."},{"issue":"28","key":"10.1016\/j.biopha.2026.119124_bib115","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1523\/JNEUROSCI.2397-21.2022","article-title":"The antiseizure drug perampanel is a subunit-selective negative allosteric modulator of kainate receptors","volume":"42","author":"Taniguchi","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2026.119124_bib116","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.2147\/CMAR.S204260","article-title":"NETO2 promotes pancreatic cancer cell proliferation, invasion and migration via activation of the STAT3 signaling pathway","volume":"11","author":"Li","year":"2019","journal-title":"CANCER Manag. Res."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226001563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:50:23Z","timestamp":1781880623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226001563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":116,"alternative-id":["S0753332226001563"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119124","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of NETO2 in neurological disorders and cancer: From molecular function to clinical relevance","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119124"}}