{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:03Z","timestamp":1787771943723,"version":"build-2784847793"},"reference-count":141,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.biopha.2026.119239","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T16:41:17Z","timestamp":1775752877000},"page":"119239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Electrical conditioning strategies in myocardial ischemia-reperfusion injury"],"prefix":"10.1016","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-1699","authenticated-orcid":false,"given":"Mark F.A.","family":"Bierhuizen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorik H.","family":"Amesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier C.","family":"Manintveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"Kluin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja M.S.","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick J.H.J.","family":"Taverne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6868","key":"10.1016\/j.biopha.2026.119239_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation-contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063005","article-title":"Bioengineering Clinically Relevant Cardiomyocytes and Cardiac Tissues from Pluripotent Stem Cells","volume":"22","author":"James","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0008-6363(98)00033-9","article-title":"A fresh look at reperfusion injury","volume":"38","author":"Piper","year":"1998","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/cvr\/cvp110","article-title":"The use of controlled reperfusion strategies in cardiac surgery to minimize ischaemia\/reperfusion damage","volume":"83","author":"Beyersdorf","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"22","key":"10.1016\/j.biopha.2026.119239_bib5","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.jacc.2024.02.056","article-title":"Reperfusion Injury in Patients With Acute Myocardial Infarction: JACC Scientific Statement","volume":"83","author":"Welt","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119239_bib6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med"},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib7","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrcardio.2016.5","article-title":"Ischaemic conditioning and reperfusion injury","volume":"13","author":"Hausenloy","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00395-005-0523-x","article-title":"Postconditioning--A new link in nature's armor against myocardial ischemia-reperfusion injury","volume":"100","author":"Vinten-Johansen","year":"2005","journal-title":"Basic Res Cardiol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052519","article-title":"Pharmacological Conditioning of the Heart: An Update on Experimental Developments and Clinical Implications","volume":"22","author":"Roth","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119239_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2019.101421","article-title":"Potential therapeutic roles of stem cells in ischemia-reperfusion injury","volume":"37","author":"Barzegar","year":"2019","journal-title":"Stem Cell Res"},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib12","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jcmg.2014.01.017","article-title":"Clinical pacing post-conditioning during revascularization after AMI","volume":"7","author":"Waltenberger","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"issue":"15","key":"10.1016\/j.biopha.2026.119239_bib13","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jcin.2017.04.036","article-title":"Low-Level Tragus Stimulation for the Treatment of Ischemia and Reperfusion Injury in Patients With ST-Segment Elevation Myocardial Infarction: A Proof-of-Concept Study","volume":"10","author":"Yu","year":"2017","journal-title":"JACC Cardiovasc Inter."},{"issue":"7","key":"10.1016\/j.biopha.2026.119239_bib14","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1111\/jcmm.15127","article-title":"E.-C.C. Action, Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury","volume":"24","author":"Davidson","year":"2020","journal-title":"J. Cell Mol. Med"},{"issue":"12","key":"10.1016\/j.biopha.2026.119239_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biopha.2026.119239_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-bioeng-071114-040647","article-title":"Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form","volume":"19","author":"Levin","year":"2017","journal-title":"Annu Rev. Biomed. Eng."},{"issue":"9","key":"10.1016\/j.biopha.2026.119239_bib17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/bies.950190912","article-title":"Physiological electrical fields modify cell behaviour","volume":"19","author":"McCaig","year":"1997","journal-title":"Bioessays"},{"key":"10.1016\/j.biopha.2026.119239_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fbioe.2016.00055","article-title":"Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine","volume":"4","author":"Pietak","year":"2016","journal-title":"Front Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1152\/advan.00105.2016","article-title":"Cardiac electrophysiology: normal and ischemic ionic currents and the ECG","volume":"41","author":"Klabunde","year":"2017","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.biopha.2026.119239_bib20","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3389\/fphar.2020.00872","article-title":"Targeting Calcium Homeostasis in Myocardial Ischemia\/Reperfusion Injury: An Overview of Regulatory Mechanisms and Therapeutic Reagents","volume":"11","author":"Wang","year":"2020","journal-title":"Front Pharm."},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib21","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ajpath.2019.08.019","article-title":"Glycocalyx Degradation in Ischemia-Reperfusion Injury","volume":"190","author":"Abassi","year":"2020","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.biopha.2026.119239_bib22","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","article-title":"Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes","volume":"192","author":"Zorov","year":"2000","journal-title":"J. Exp. Med"},{"issue":"13","key":"10.1016\/j.biopha.2026.119239_bib23","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.1016\/S0021-9258(19)50355-6","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization","volume":"267","author":"Bernardi","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.biopha.2026.119239_bib24","first-page":"12295","article-title":"On the voltage dependence of the mitochondrial permeability transition pore","volume":"272","author":"Scorrano","year":"1997","journal-title":"A Crit. Apprais. J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-5793(93)80273-W","article-title":"The mitochondrial permeability transition pore may comprise VDAC molecules. I. Binary structure and voltage dependence of the pore","volume":"330","author":"Szabo","year":"1993","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00395-023-01002-4","article-title":"Preventing mitochondrial reverse electron transport as a strategy for cardioprotection","volume":"118","author":"Prag","year":"2023","journal-title":"Basic Res Cardiol."},{"issue":"10","key":"10.1016\/j.biopha.2026.119239_bib27","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/s42255-019-0126-8","article-title":"Voltage-energized Calcium-sensitive ATP Production by Mitochondria","volume":"1","author":"Wescott","year":"2019","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2004.04.013","article-title":"Myocardial ischemia\/reperfusion-injury, a clinical view on a complex pathophysiological process","volume":"100","author":"Moens","year":"2005","journal-title":"Int J. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molmed.2019.10.007","article-title":"Regulation of Mitochondrial ATP Production: Ca(2+) Signaling and Quality Control","volume":"26","author":"Boyman","year":"2020","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.biopha.2026.119239_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2024.106650","article-title":"Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies","volume":"175","author":"Wu","year":"2024","journal-title":"Int J. Biochem Cell Biol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/MOT.0000000000001015","article-title":"Mitochondria and ischemia reperfusion injury","volume":"27","author":"Panconesi","year":"2022","journal-title":"Curr. Opin. Organ Transpl."},{"key":"10.1016\/j.biopha.2026.119239_bib32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem"},{"issue":"10","key":"10.1016\/j.biopha.2026.119239_bib33","article-title":"The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury","volume":"8","author":"Kuznetsov","year":"2019","journal-title":"Antioxid. (Basel)"},{"issue":"2 Pt 1","key":"10.1016\/j.biopha.2026.119239_bib34","doi-asserted-by":"crossref","first-page":"C313","DOI":"10.1152\/ajpcell.1994.267.2.C313","article-title":"Mitochondrial calcium transport: physiological and pathological relevance","volume":"267","author":"Gunter","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"5-6","key":"10.1016\/j.biopha.2026.119239_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1054\/ceca.2000.0168","article-title":"Mitochondrial calcium transport: mechanisms and functions","volume":"28","author":"Gunter","year":"2000","journal-title":"Cell Calcium"},{"key":"10.1016\/j.biopha.2026.119239_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102894","article-title":"Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection","volume":"67","author":"Heusch","year":"2023","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib37","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7555\/JBR.37.20230021","article-title":"Do reactive oxygen species damage or protect the heart in ischemia and reperfusion? Analysis on experimental and clinical data","volume":"37","author":"Maslov","year":"2023","journal-title":"J. Biomed. Res"},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib38","doi-asserted-by":"crossref","first-page":"C12","DOI":"10.1152\/ajpcell.00131.2021","article-title":"Mitochondrial redox regulation and myocardial ischemia-reperfusion injury","volume":"322","author":"Chen","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2026.119239_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/862423","article-title":"Reactive oxygen species and the cardiovascular system","author":"Taverne","year":"2013","journal-title":"Oxid. Med Cell Longev. 2013"},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib40","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00395-013-0392-7","article-title":"Redox balance and cardioprotection","volume":"108","author":"Tullio","year":"2013","journal-title":"Basic Res Cardiol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib41","doi-asserted-by":"crossref","first-page":"H1115","DOI":"10.1152\/ajpheart.00879.2009","article-title":"Role of the gap junction in ischemic preconditioning in the heart","volume":"298","author":"Miura","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2026.119239_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-60761-198-1_5","article-title":"Electrotaxis and wound healing: experimental methods to study electric fields as a directional signal for cell migration","volume":"571","author":"Tai","year":"2009","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119239_bib43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/bioe.2021.0021","article-title":"Myocardial Edema Revisited in a New Paradigm of Cardiac Electrical Microcurrent Application in Heart Failure","volume":"3","author":"Rame","year":"2021","journal-title":"Bioelectricity"},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jtv.2021.12.002","article-title":"Electrical microcurrent stimulation therapy for wound healing: A meta-analysis of randomized clinical trials","volume":"31","author":"Avenda\u00f1o-Coy","year":"2022","journal-title":"J. Tissue Viability"},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25063268","article-title":"Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration","volume":"25","author":"Bachamanda Somesh","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119239_bib46","article-title":"The Coronary Microcirculation Re-explored: Pathophysiological Insights and Clinical Implications","volume":"20","author":"Elamin","year":"2025","journal-title":"Eur. Cardiol."},{"issue":"13","key":"10.1016\/j.biopha.2026.119239_bib47","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1073\/pnas.1922095117","article-title":"ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart","volume":"117","author":"Zhao","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib48","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202313451","article-title":"Electro-metabolic signaling","volume":"156","author":"Longden","year":"2024","journal-title":"J. Gen. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00395-019-0756-8","article-title":"Coronary microvascular obstruction: the new frontier in cardioprotection","volume":"114","author":"Heusch","year":"2019","journal-title":"Basic Res Cardiol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib50","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biopha.2026.119239_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front Pharm."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib52","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/cvr\/cvp065","article-title":"Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation","volume":"83","author":"Kasseckert","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"2 Pt 2","key":"10.1016\/j.biopha.2026.119239_bib53","first-page":"H886","article-title":"Cholinergic and alpha-adrenergic coronary vasomotion [corrected] with increasing ischemia-reperfusion injury","volume":"268","author":"Ehring","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.biopha.2026.119239_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2018.04.005","article-title":"A brain within the heart: A review on the intracardiac nervous system","volume":"119","author":"Dur\u00e3es Campos","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib55","article-title":"The Intrinsic Cardiac Nervous System: From Pathophysiology to Therapeutic Implications","volume":"13","author":"Giannino","year":"2024","journal-title":"Biol. (Basel)"},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib56","article-title":"The Intrinsic Cardiac Nervous System and Its Role in Cardiac Pacemaking and Conduction","volume":"7","author":"Fedele","year":"2020","journal-title":"J. Cardiovasc Dev. Dis."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib57","doi-asserted-by":"crossref","first-page":"PL13","DOI":"10.1016\/0024-3205(93)90617-C","article-title":"Zaprinast, cicletanine, and verapamil attenuate overdrive pacing-induced myocardial ischemia in conscious rabbits","volume":"53","author":"Szilvassy","year":"1993","journal-title":"Life Sci."},{"issue":"1-2","key":"10.1016\/j.biopha.2026.119239_bib58","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.autneu.2008.11.007","article-title":"Spatially divergent cardiac responses to nicotinic stimulation of ganglionated plexus neurons in the canine heart","volume":"145","author":"Cardinal","year":"2009","journal-title":"Auton. Neurosci."},{"issue":"1-2","key":"10.1016\/j.biopha.2026.119239_bib59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.autneu.2013.01.004","article-title":"Effects of low-intensity atrial ganglionated plexi stimulation on ventricular electrophysiology and arrhythmogenesis","volume":"174","author":"He","year":"2013","journal-title":"Auton. Neurosci."},{"issue":"8","key":"10.1016\/j.biopha.2026.119239_bib60","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tcm.2019.10.011","article-title":"Hype or hope: Vagus nerve stimulation against acute myocardial ischemia-reperfusion injury","volume":"30","author":"Chen","year":"2020","journal-title":"Trends Cardiovasc Med"},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib61","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsycho.2005.11.013","article-title":"The role of vagal function in the risk for cardiovascular disease and mortality","volume":"74","author":"Thayer","year":"2007","journal-title":"Biol. Psychol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib62","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/HYPERTENSIONAHA.109.142042","article-title":"Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart","volume":"55","author":"Levick","year":"2010","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.biopha.2026.119239_bib63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/cvr\/13.9.523","article-title":"Rapid activation of the sympathetic nervous system following coronary artery occlusion: relationship to infarct size, site, and haemodynamic impact","volume":"13","author":"Karlsberg","year":"1979","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib64","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5493\/wjem.v8.i1.8","article-title":"Autonomic function and ventricular tachyarrhythmias during acute myocardial infarction","volume":"8","author":"Kolettis","year":"2018","journal-title":"World J. Exp. Med"},{"issue":"9101","key":"10.1016\/j.biopha.2026.119239_bib65","first-page":"478","article-title":"Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction","volume":"351","author":"Rovere","year":"1998","journal-title":"ATRAMI (Auton. Tone Reflex. Myocard. Infarct. ) Invest. Lancet"},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00395-017-0662-x","article-title":"The RISK pathway and beyond","volume":"113","author":"Rossello","year":"2018","journal-title":"Basic Res Cardiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tcm.2005.03.001","article-title":"The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning","volume":"15","author":"Hausenloy","year":"2005","journal-title":"Trends Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib68","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.005975","article-title":"Activation of cGMP\/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling","volume":"2","author":"Inserte","year":"2013","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00395-018-0670-5","article-title":"The SAFE pathway for cardioprotection: is this a promising target?","volume":"113","author":"Hadebe","year":"2018","journal-title":"Basic Res Cardiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib70","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cardiores.2006.02.020","article-title":"Insulin protects cardiomyocytes against reoxygenation-induced hypercontracture by a survival pathway targeting SR Ca2+ storage","volume":"70","author":"Abdallah","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.biopha.2026.119239_bib71","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.biocel.2005.09.017","article-title":"Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection","volume":"38","author":"Davidson","year":"2006","journal-title":"Int J. Biochem Cell Biol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib72","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00395-023-01003-3","article-title":"Perspective: mitochondrial STAT3 in cardioprotection","volume":"118","author":"Kleinbongard","year":"2023","journal-title":"Basic Res Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib73","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00395-021-00898-0","article-title":"Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function","volume":"116","author":"Comit\u00e0","year":"2021","journal-title":"Basic Res Cardiol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119239_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092466","article-title":"Revisiting the Cardioprotective Effects of Acetylcholine Receptor Activation against Myocardial Ischemia\/Reperfusion Injury","volume":"19","author":"Intachai","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib75","doi-asserted-by":"crossref","first-page":"H1289","DOI":"10.1152\/ajpheart.00286.2017","article-title":"Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms","volume":"314","author":"Buchholz","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119239_bib76","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00011-012-0527-6","article-title":"Postconditioning with vagal stimulation attenuates local and systemic inflammatory responses to myocardial ischemia reperfusion injury in rats","volume":"61","author":"Wang","year":"2012","journal-title":"Inflamm. Res"},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib77","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00395-018-0683-0","article-title":"Vagus nerve stimulation exerts cardioprotection against myocardial ischemia\/reperfusion injury predominantly through its efferent vagal fibers","volume":"113","author":"Nuntaphum","year":"2018","journal-title":"Basic Res Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib78","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jcmm.12938","article-title":"Vagal nerve stimulation improves mitochondrial dynamics via an M(3) receptor\/CaMKKbeta\/AMPK pathway in isoproterenol-induced myocardial ischaemia","volume":"21","author":"Xue","year":"2017","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.biopha.2026.119239_bib79","article-title":"Electroacupuncture Pretreatment Regulates Apoptosis of Myocardial Ischemia-Reperfusion Injury in Rats Through RhoA\/p38MAPK Pathway Mediated by miR-133a-5p","author":"Han","year":"2021","journal-title":"Evid. Based Complement Altern. Med 2021"},{"issue":"9","key":"10.1016\/j.biopha.2026.119239_bib80","doi-asserted-by":"crossref","first-page":"H1818","DOI":"10.1152\/ajpheart.00030.2012","article-title":"Cardioprotection of electroacupuncture against myocardial ischemia-reperfusion injury by modulation of cardiac norepinephrine release","volume":"302","author":"Zhou","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2026.119239_bib81","article-title":"ERK1\/2-Egr-1 Signaling Pathway-Mediated Protective Effects of Electroacupuncture in a Mouse Model of Myocardial Ischemia-Reperfusion","author":"Zhang","year":"2014","journal-title":"Evid. Based Complement Altern. Med 2014"},{"key":"10.1016\/j.biopha.2026.119239_bib82","article-title":"STAT3 but Not STAT5 Contributes to the Protective Effect of Electroacupuncture Against Myocardial Ischemia\/Reperfusion Injury in Mice","volume":"8","author":"Guo","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.biopha.2026.119239_bib83","article-title":"Electroacupuncture Pretreatment Mitigates Myocardial Ischemia\/Reperfusion Injury via XBP1\/GRP78\/Akt Pathway","volume":"8","author":"Wang","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib84","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/FJC.0b013e31822b7204","article-title":"Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion","volume":"58","author":"Calvillo","year":"2011","journal-title":"J. Cardiovasc Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib85","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jtcvs.2008.08.020","article-title":"Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect","volume":"137","author":"Katare","year":"2009","journal-title":"J. Thorac. Cardiovasc Surg."},{"issue":"7","key":"10.1016\/j.biopha.2026.119239_bib86","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00424-014-1591-2","article-title":"Changes in the loading conditions induced by vagal stimulation modify the myocardial infarct size through sympathetic-parasympathetic interactions","volume":"467","author":"Buchholz","year":"2015","journal-title":"Pflug. Arch."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib87","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/jce.12850","article-title":"Low-Level Vagus Nerve Stimulation Attenuates Myocardial Ischemic Reperfusion Injury by Antioxidative Stress and Antiapoptosis Reactions in Canines","volume":"27","author":"Chen","year":"2016","journal-title":"J. Cardiovasc Electro"},{"issue":"11","key":"10.1016\/j.biopha.2026.119239_bib88","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.hrthm.2013.08.009","article-title":"Low-amplitude, left vagus nerve stimulation significantly attenuates ventricular dysfunction and infarct size through prevention of mitochondrial dysfunction during acute ischemia-reperfusion injury","volume":"10","author":"Shinlapawittayatorn","year":"2013","journal-title":"Heart Rhythm"},{"issue":"12","key":"10.1016\/j.biopha.2026.119239_bib89","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.hrthm.2014.08.001","article-title":"Vagus nerve stimulation initiated late during ischemia, but not reperfusion, exerts cardioprotection via amelioration of cardiac mitochondrial dysfunction","volume":"11","author":"Shinlapawittayatorn","year":"2014","journal-title":"Heart Rhythm"},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib90","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00395-015-0508-3","article-title":"Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow","volume":"110","author":"Uitterdijk","year":"2015","journal-title":"Basic Res Cardiol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119239_bib91","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.ijcard.2011.12.082","article-title":"Preischemic efferent vagal stimulation increases the size of myocardial infarction in rabbits. Role of the sympathetic nervous system","volume":"155","author":"Buchholz","year":"2012","journal-title":"Int J. Cardiol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119239_bib92","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00011-014-0775-8","article-title":"Optimal intervention time of vagal stimulation attenuating myocardial ischemia\/reperfusion injury in rats","volume":"63","author":"Wang","year":"2014","journal-title":"Inflamm. Res"},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib93","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/CIRCHEARTFAILURE.114.001564","article-title":"Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve improves left ventricular remodeling in conscious dogs with healed myocardial infarction","volume":"7","author":"Wang","year":"2014","journal-title":"Circ. Heart Fail"},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14061866","article-title":"Low-Frequency Electrical Stimulation of the Auricular Branch of the Vagus Nerve in Patients with ST-Elevation Myocardial Infarction: A Randomized Clinical Trial","volume":"14","author":"Kruchinova","year":"2025","journal-title":"J. Clin. Med"},{"issue":"ement_1","key":"10.1016\/j.biopha.2026.119239_bib95","article-title":"Vagal nerve stimulation improves myocardial recovery after STEMI: a randomized trial","volume":"46","author":"Dyab","year":"2025","journal-title":"Eur. Heart J."},{"issue":"9","key":"10.1016\/j.biopha.2026.119239_bib96","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4103\/1673-5374.237124","article-title":"Electroacupuncture modulates the activity of the hippocampus-nucleus tractus solitarius-vagus nerve pathway to reduce myocardial ischemic injury","volume":"13","author":"Cui","year":"2018","journal-title":"Neural Regen. Res"},{"issue":"3","key":"10.1016\/j.biopha.2026.119239_bib97","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.athoracsur.2009.12.003","article-title":"Cardioprotective effects of electroacupuncture pretreatment on patients undergoing heart valve replacement surgery: a randomized controlled trial","volume":"89","author":"Yang","year":"2010","journal-title":"Ann. Thorac. Surg."},{"issue":"8","key":"10.1016\/j.biopha.2026.119239_bib98","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1460-9592.2012.03822.x","article-title":"Cardioprotective effect of transcutaneous electric acupoint stimulation in the pediatric cardiac patients: a randomized controlled clinical trial","volume":"22","author":"Ni","year":"2012","journal-title":"Paediatr. Anaesth."},{"key":"10.1016\/j.biopha.2026.119239_bib99","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijcard.2015.05.043","article-title":"Efficacy of electroacupuncture pretreatment for myocardial injury in patients undergoing percutaneous coronary intervention: A randomized clinical trial with a 2-year follow-up","volume":"194","author":"Wang","year":"2015","journal-title":"Int J. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12871-022-01611-x","article-title":"Effects of transcutaneous electrical nerve stimulation on myocardial protection in patients undergoing aortic valve replacement: a randomized clinical trial","volume":"22","author":"Cho","year":"2022","journal-title":"BMC Anesth."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib101","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s42234-024-00153-6","article-title":"Vagal nerve stimulation in myocardial ischemia\/reperfusion injury: from bench to bedside","volume":"10","author":"Giannino","year":"2024","journal-title":"Bioelectron. Med"},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib102","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1142\/S0192415X04002557","article-title":"Electroacupuncture on PC6 (Neiguan) attenuates ischemia\/reperfusion injury in rat hearts","volume":"32","author":"Tsou","year":"2004","journal-title":"Am. J. Chin. Med"},{"issue":"3","key":"10.1016\/j.biopha.2026.119239_bib103","first-page":"455","article-title":"Electroacupuncture Pretreatment at Neiguan (PC6) attenuates autophagy in rats with myocardial ischemia reperfusion through the phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin pathway","volume":"41","author":"Han","year":"2021","journal-title":"J. Tradit. Chin. Med"},{"key":"10.1016\/j.biopha.2026.119239_bib104","article-title":"Cardioprotective Effect of Electroacupuncture Pretreatment on Myocardial Ischemia\/Reperfusion Injury via Antiapoptotic Signaling","author":"Lu","year":"2016","journal-title":"Evid. Based Complement Altern. Med 2016"},{"issue":"11","key":"10.1016\/j.biopha.2026.119239_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165777","article-title":"The Interplay between the Renin Angiotensin System and Pacing Postconditioning Induced Cardiac Protection","volume":"11","author":"Babiker","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib106","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00395-010-0095-2","article-title":"Long-term protection and mechanism of pacing-induced postconditioning in the heart","volume":"105","author":"Babiker","year":"2010","journal-title":"Basic Res Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib107","doi-asserted-by":"crossref","first-page":"H372","DOI":"10.1152\/ajpheart.2002.282.1.H372","article-title":"Effects of single- and biventricular pacing on temporal and spatial dynamics of ventricular contraction","volume":"282","author":"Wyman","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib108","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s13105-016-0535-z","article-title":"Understanding pacing postconditioning-mediated cardiac protection: a role of oxidative stress and a synergistic effect of adenosine","volume":"73","author":"Babiker","year":"2017","journal-title":"J. Physiol. Biochem"},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4196\/kjpp.2010.14.1.1","article-title":"Mechanical Stretch-Induced Protection against Myocardial Ischemia-Reperfusion Injury Involves AMP-Activated Protein Kinase","volume":"14","author":"Hao","year":"2010","journal-title":"Korean J. Physiol. Pharm."},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00395-016-0568-z","article-title":"Co-dependence of the neural and humoral pathways in the mechanism of remote ischemic conditioning","volume":"111","author":"Pickard","year":"2016","journal-title":"Basic Res Cardiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib111","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00395-017-0601-x","article-title":"Intrinsic cardiac ganglia and acetylcholine are important in the mechanism of ischaemic preconditioning","volume":"112","author":"Pickard","year":"2017","journal-title":"Basic Res Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib112","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ehjci\/jew334","article-title":"Synergistic prognostic implications of left ventricular mechanical dyssynchrony and impaired cardiac sympathetic nerve activity in heart failure patients with reduced left ventricular ejection fraction","volume":"19","author":"Doi","year":"2018","journal-title":"Eur. Heart J. Cardiovasc Imaging"},{"issue":"20","key":"10.1016\/j.biopha.2026.119239_bib113","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.jacc.2022.08.801","article-title":"Neurometabolism and Ventricular Dyssynchrony in Patients With Heart Failure and Reduced Ejection Fraction","volume":"80","author":"Bai","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib114","first-page":"I264","article-title":"Pacing-induced dys-synchrony preconditions rabbit myocardium against ischemia\/reperfusion injury","volume":"114","author":"Vanagt","year":"2006","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.biopha.2026.119239_bib115","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.jacc.2007.01.070","article-title":"Pacing-induced dyssynchrony during early reperfusion reduces infarct size","volume":"49","author":"Vanagt","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib116","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12265-012-9390-7","article-title":"Pacing postconditioning: impact of pacing algorithm, gender, and diabetes on its myocardial protective effects","volume":"5","author":"Babiker","year":"2012","journal-title":"J. Cardiovasc Transl. Res"},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib117","first-page":"83","article-title":"Ventricular fibrillation: are swine a sensitive species?","volume":"42","author":"Walcott","year":"2015","journal-title":"J. Inter. Card. Electro"},{"issue":"10","key":"10.1016\/j.biopha.2026.119239_bib118","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1006\/jmcc.1996.0201","article-title":"Time course of the protection against ischaemia and reperfusion-induced ventricular arrhythmias resulting from brief periods of cardiac pacing","volume":"28","author":"Kaszala","year":"1996","journal-title":"J. Mol. Cell Cardiol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119239_bib119","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00395-016-0588-8","article-title":"Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery","volume":"111","author":"Hausenloy","year":"2016","journal-title":"Basic Res Cardiol."},{"issue":"1-2","key":"10.1016\/j.biopha.2026.119239_bib120","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11010-012-1467-8","article-title":"Time course analysis of cardiac pacing-induced gene expression changes in the canine heart","volume":"372","author":"Kovacs","year":"2013","journal-title":"Mol. Cell Biochem"},{"issue":"7","key":"10.1016\/j.biopha.2026.119239_bib121","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/sj.bjp.0702695","article-title":"Pacing-induced delayed protection against arrhythmias is attenuated by aminoguanidine, an inhibitor of nitric oxide synthase","volume":"127","author":"Kis","year":"1999","journal-title":"Br. J. Pharm."},{"issue":"5 Pt 2","key":"10.1016\/j.biopha.2026.119239_bib122","first-page":"H2033","article-title":"Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning","volume":"266","author":"Szilvassy","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib123","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00019501-199305000-00008","article-title":"Cicletanine attenuates overdrive pacing-induced global myocardial ischemia in rabbits: possible role of cardiac cyclic nucleotides","volume":"4","author":"Szilvassy","year":"1993","journal-title":"Coron. Artery Dis."},{"issue":"7","key":"10.1016\/j.biopha.2026.119239_bib124","first-page":"573","article-title":"Protective effect of pacing on reperfusion-induced ventricular arrhythmias in isolated rat hearts","volume":"11","author":"Takeda","year":"1995","journal-title":"Can. J. Cardiol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119239_bib125","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/cvr\/25.12.1051","article-title":"Transient ischaemia induced by rapid cardiac pacing results in myocardial preconditioning","volume":"25","author":"Vegh","year":"1991","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib126","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.CIR.93.1.178","article-title":"Rapid ventricular pacing produces myocardial protection by nonischemic activation of KATP+ channels","volume":"93","author":"Koning","year":"1996","journal-title":"Circulation"},{"issue":"10207","key":"10.1016\/j.biopha.2026.119239_bib127","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(19)32039-2","article-title":"Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): a single-blind randomised controlled trial","volume":"394","author":"Hausenloy","year":"2019","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib128","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ahj.2015.01.015","article-title":"Long-term effects of ischemic postconditioning on clinical outcomes: 1-year follow-up of the POST randomized trial","volume":"169","author":"Hahn","year":"2015","journal-title":"Am. Heart J."},{"issue":"3","key":"10.1016\/j.biopha.2026.119239_bib129","article-title":"Microcurrent Therapy as a Therapeutic Modality for Musculoskeletal Pain: A Systematic Review Accelerating the Translation From Clinical Trials to Patient Care","volume":"3","author":"Iijima","year":"2021","journal-title":"Arch. Rehabil. Res Clin. Transl."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib130","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/ehf2.13242","article-title":"Cardio-microcurrent device for chronic heart failure: first-in-human clinical study","volume":"8","author":"Kosevic","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"4","key":"10.1016\/j.biopha.2026.119239_bib131","doi-asserted-by":"crossref","first-page":"S361","DOI":"10.1016\/j.healun.2020.01.436","article-title":"Animal Model of Cardiac Reperfusion Injury to Evaluate the Effects of Electrical Microcurrent Application: Preliminary Results","volume":"39","author":"Mariani","year":"2020","journal-title":"J. Heart Lung Transplant."},{"issue":"3","key":"10.1016\/j.biopha.2026.119239_bib132","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ehf2.12169","article-title":"Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components","volume":"4","author":"Macfelda","year":"2017","journal-title":"ESC Heart Fail"},{"issue":"20","key":"10.1016\/j.biopha.2026.119239_bib133","doi-asserted-by":"crossref","first-page":"13990","DOI":"10.1074\/jbc.M512334200","article-title":"Mitochondrial membrane potential is dependent on the oligomeric state of F1F0-ATP synthase supracomplexes","volume":"281","author":"Bornhovd","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119239_bib134","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.msec.2014.08.045","article-title":"Iontophoresis with gold nanoparticles improves mitochondrial activity and oxidative stress markers of burn wounds","volume":"44","author":"Silveira","year":"2014","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"issue":"7101","key":"10.1016\/j.biopha.2026.119239_bib135","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature04925","article-title":"Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN","volume":"442","author":"Zhao","year":"2006","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.biopha.2026.119239_bib136","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091924","article-title":"Microcurrent Stimulation Triggers MAPK Signaling and TGF-beta1 Release in Fibroblast and Osteoblast-Like Cell Lines","volume":"9","author":"Konstantinou","year":"2020","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib137","doi-asserted-by":"crossref","first-page":"265","DOI":"10.33549\/physiolres.933992","article-title":"MENS-associated increase of muscular protein content via modulation of caveolin-3 and TRIM72","volume":"68","author":"Ohno","year":"2019","journal-title":"Physiol. Res"},{"issue":"5","key":"10.1016\/j.biopha.2026.119239_bib138","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052508","article-title":"Micro-Current Stimulation Suppresses Inflammatory Responses in Peptidoglycan-Treated Raw 264.7 Macrophages and Propionibacterium acnes-Induced Skin Inflammation via TLR2\/NF-kappaB Signaling Pathway","volume":"23","author":"Lee","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2026.119239_bib139","doi-asserted-by":"crossref","first-page":"806","DOI":"10.21037\/apm-21-3286","article-title":"Role of the PI3K\/Akt signaling pathway in liver ischemia reperfusion injury: a narrative review","volume":"11","author":"Wang","year":"2022","journal-title":"Ann. Palliat. Med"},{"key":"10.1016\/j.biopha.2026.119239_bib140","article-title":"International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)","volume":"14","author":"Farmer","year":"2020","journal-title":"Front Hum. Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119239_bib141","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00395-021-00893-5","article-title":"C.C.A.C. on behalf of the European Union, IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action","volume":"116","author":"Lecour","year":"2021","journal-title":"Basic Res Cardiol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226002726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226002726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:35:24Z","timestamp":1779244524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226002726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":141,"alternative-id":["S0753332226002726"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119239","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrical conditioning strategies in myocardial ischemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119239"}}