{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:28:24Z","timestamp":1794479304434,"version":"4.9.1"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009827","name":"Alexandria University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.biopha.2026.119436","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:21:29Z","timestamp":1777317689000},"page":"119436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Empagliflozin mitigated cisplatin induced renal endothelial dysfunction in rats via repressing oxidative, inflammatory, apoptotic and fibrotic signals"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8724-5945","authenticated-orcid":false,"given":"Rasha M.","family":"Gaballah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Y.","family":"Sallam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar S.","family":"Elblehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar M.","family":"El-Gowilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9793-8376","authenticated-orcid":false,"given":"Elham A.","family":"Afify","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2026.119436_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.17219\/acem\/58970","article-title":"Protective effects of molsidomine against cisplatin-induced nephrotoxicity","volume":"24","author":"Karakoc","year":"2015","journal-title":"Adv. Clin. Exp. Med. Off. Organ Wroclaw Med. Univ."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.32725\/jab.2019.003","article-title":"Pre-treatment with empagliflozin ameliorates cisplatin induced acute kidney injury by suppressing apoptosis","volume":"17","author":"Abd Elmaaboud","year":"2019","journal-title":"J. Appl. Biomed."},{"issue":"7","key":"10.1016\/j.biopha.2026.119436_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071407","article-title":"Nephroprotective effects of saponins from leaves of panax quinquefolius against cisplatin-induced acute kidney injury","volume":"18","author":"Ma","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119436_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146293","article-title":"TGF-\u03b21, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: Comparative modulating role of Melatonin, Vit. E and Ozone","volume":"820","author":"Abdel-Rahman Mohamed","year":"2022","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib5","doi-asserted-by":"crossref","first-page":"F726","DOI":"10.1152\/ajprenal.2000.278.5.F726","article-title":"Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis","volume":"278","author":"Shiraishi","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2012.07.003","article-title":"Subcellular targets of cisplatin cytotoxicity: an integrated view","volume":"136","author":"Sancho-Mart\u00ednez","year":"2012","journal-title":"Pharm. Ther."},{"issue":"4","key":"10.1016\/j.biopha.2026.119436_bib7","first-page":"879","article-title":"Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice","volume":"28","author":"van Angelen","year":"2013","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"issue":"9","key":"10.1016\/j.biopha.2026.119436_bib8","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1139\/cjpp-2022-0126","article-title":"Endothelin system expression in the kidney following cisplatin-induced acute kidney injury in male and female mice","volume":"100","author":"Gales","year":"2022","journal-title":"Can. J. Physiol. Pharm."},{"issue":"8","key":"10.1016\/j.biopha.2026.119436_bib9","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00204-012-0821-7","article-title":"Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update","volume":"86","author":"Dos Santos","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119436_bib10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/jhh.2017.8","article-title":"Protective effects of nebivolol from oxidative stress to prevent hypertension-related target organ damage","volume":"31","author":"Coats","year":"2017","journal-title":"J. Hum. Hypertens."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib11","doi-asserted-by":"crossref","first-page":"F166","DOI":"10.1152\/ajprenal.00401.2004","article-title":"p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice","volume":"289","author":"Ramesh","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12291-016-0564-y","article-title":"Transforming Growth Factor-\u03b21\/Smad3 Signaling and Redox Status in Experimentally Induced Nephrotoxicity: Impact of Carnosine","volume":"32","author":"Keshk","year":"2017","journal-title":"Indian J. Clin. Biochem. IJCB"},{"issue":"6","key":"10.1016\/j.biopha.2026.119436_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179137","article-title":"The protective effects of Zhen-Wu-Tang against cisplatin-induced acute kidney injury in rats","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1159\/000512986","article-title":"Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Programmed Cell Death and Inflammation via a NOX4-Dependent Mechanism","volume":"7","author":"Yang","year":"2021","journal-title":"Kidney Dis."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13020-022-00574-y","article-title":"Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3\/TGF-\u03b21 and Smad3\/p38 MAPK pathways","volume":"17","author":"Wei","year":"2022","journal-title":"Chin. Med"},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11936-017-0522-x","article-title":"Promise of SGLT2 Inhibitors in Heart Failure: Diabetes and Beyond","volume":"19","author":"Martens","year":"2017","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119436_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116650","article-title":"Cardiovascular outcomes and molecular targets for the cardiac effects of Sodium-Glucose Cotransporter 2 Inhibitors: A systematic review","volume":"175","author":"Madonna","year":"2024","journal-title":"Biomed. & Pharmacother."},{"issue":"15","key":"10.1016\/j.biopha.2026.119436_bib18","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","article-title":"Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure","volume":"383","author":"Packer","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.biopha.2026.119436_bib19","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/HYPERTENSIONAHA.123.20598","article-title":"Functional and Clinical Importance of SGLT2-inhibitors in Frailty: From the Kidney to the Heart","volume":"80","author":"Santulli","year":"2023","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib20","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1124\/jpet.118.253666","article-title":"Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats","volume":"368","author":"Oshima","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2026.119436_bib21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10787-021-00797-9","article-title":"Anti-inflammatory potential of Empagliflozin","volume":"29","author":"Pirklbauer","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/fcp.12548","article-title":"Empagliflozin attenuates transient cerebral ischemia\/reperfusion injury in hyperglycemic rats via repressing oxidative-inflammatory-apoptotic pathway","volume":"34","author":"Amin","year":"2020","journal-title":"Fundam. & Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119436_bib23","article-title":"Empagliflozin Ameliorates Diabetic Cardiomyopathy via Attenuating Oxidative Stress and Improving Mitochondrial Function","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib24","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/dom.13648","article-title":"Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis","volume":"21","author":"Toyama","year":"2019","journal-title":"Diabetes Obes. & Metab."},{"key":"10.1016\/j.biopha.2026.119436_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176066","article-title":"Reversal of fibrosis and portal hypertension by Empagliflozin treatment of CCl(4)-induced liver fibrosis: Emphasis on gal-1\/NRP-1\/TGF-\u03b2 and gal-1\/NRP-1\/VEGFR2 pathways","volume":"959","author":"Noah","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib26","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.kint.2021.01.008","article-title":"Reversing endothelial dysfunction with empagliflozin to improve cardiomyocyte function in cardiorenal syndrome","volume":"99","author":"Dou","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.biopha.2026.119436_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122354","article-title":"Empagliflozin protects against isoprenaline-induced fibrosis in rat heart through modulation of TGF-\u03b2\/SMAD pathway","volume":"337","author":"Elsayed","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s43094-024-00669-3","article-title":"Empagliflozin mitigates methotrexate-induced nephrotoxicity in male albino rats: insights on the crosstalk of AMPK\/Nrf2 signaling pathway","volume":"10","author":"Mishriki","year":"2024","journal-title":"Future J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2026.119436_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153879","article-title":"Targeting Nrf2\/HO-1 and NF-\u03baB\/TNF-\u03b1 signaling pathways with empagliflozin protects against atrial fibrillation-induced acute kidney injury in rats","volume":"506","author":"Badreldin","year":"2024","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.biopha.2026.119436_bib30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/cpdd.16","article-title":"Empagliflozin (BI 10773), a Potent and Selective SGLT2 Inhibitor, Induces Dose-Dependent Glucosuria in Healthy Subjects","volume":"2","author":"Seman","year":"2013","journal-title":"Clin. Pharm. Drug Dev."},{"issue":"2","key":"10.1016\/j.biopha.2026.119436_bib31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s13300-013-0030-2","article-title":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple rising doses of empagliflozin in patients with type 2 diabetes mellitus","volume":"4","author":"Heise","year":"2013","journal-title":"Diabetes Ther."},{"issue":"7","key":"10.1016\/j.biopha.2026.119436_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/dom.12073","article-title":"Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks' treatment with empagliflozin once daily in patients with type 2 diabetes","volume":"15","author":"Heise","year":"2013","journal-title":"Diabetes Obes. Metab."},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib33","first-page":"1","article-title":"Pharmacokinetics, biotransformation, distribution and excretion of empagliflozin, a sodium-glucose co-transporter (SGLT 2) Inhibitor, Mice, Rats, and Dogs","volume":"3","author":"Chen","year":"2015","journal-title":"J. Pharm. & Drug Dev."},{"issue":"2","key":"10.1016\/j.biopha.2026.119436_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"11","key":"10.1016\/j.biopha.2026.119436_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112394","article-title":"The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity","volume":"9","author":"Oelze","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.biopha.2026.119436_bib36","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrneph.2017.113","article-title":"Diabetes mellitus: Cardiovascular and renal benefits of SGLT2 inhibition: insights from CANVAS","volume":"13","author":"Vallon","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib37","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12882-017-0601-y","article-title":"Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats","volume":"18","author":"Alhoshani","year":"2017","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.biopha.2026.119436_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103907","article-title":"Protective effect of empagliflozin on gentamicin-induced acute renal injury via regulation of SIRT1\/NF-\u03baB signaling pathway","volume":"94","author":"Botros","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2-3","key":"10.1016\/j.biopha.2026.119436_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ejphar.2008.04.048","article-title":"Pharmacological characterization of cellular mechanisms of the renal vasodilatory effect of nicotine in rats","volume":"588","author":"El-Mas","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.01.018","article-title":"Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling","volume":"284","author":"El-Mas","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(03)01720-5","article-title":"Testosterone depletion contributes to cyclosporine-induced chronic impairment of acetylcholine renovascular relaxations","volume":"468","author":"El-Mas","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119436_bib42","series-title":"Practical Clinical Biochemistry","author":"Varley","year":"1980"},{"key":"10.1016\/j.biopha.2026.119436_bib43","article-title":"Spectrophotometric and colorimetric determination of protein concentration","volume":"10","author":"Simonian","year":"2006","journal-title":"Curr. Protoc. Mol. Biol. Chapter"},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib44","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic. Biol. & Med."},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib45","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12305","article-title":"MicroRNA\u201193 inhibits the apoptosis and inflammatory response of tubular epithelial cells via the PTEN\/AKT\/mTOR pathway in acute kidney injury","volume":"24","author":"Zhan","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2026.119436_bib46","first-page":"211","article-title":"Analysis of immunostaining and western blotting of endothelin 1 and its receptors in mitral stenosis","volume":"30","author":"Le\u00e3o","year":"2015","journal-title":"Rev. Bras. De. Cir. Cardiovasc."},{"key":"10.1016\/j.biopha.2026.119436_bib47","series-title":"Bancroft's theory and practice of histological techniques","author":"Suvarna","year":"2018"},{"issue":"4","key":"10.1016\/j.biopha.2026.119436_bib48","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000515528","article-title":"The Association between Glomerular Diameter and Secondary Focal Segmental Glomerulosclerosis in Chronic Kidney Disease","volume":"46","author":"Zamami","year":"2021","journal-title":"Kidney & blood Press. Res."},{"issue":"10","key":"10.1016\/j.biopha.2026.119436_bib49","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1007\/s00210-023-02632-0","article-title":"Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis, Naunyn-Schmiedeberg's","volume":"396","author":"Dil","year":"2023","journal-title":"Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119436_bib50","article-title":"Early diagnostic biomarkers for acute kidney injury using cisplatin-induced nephrotoxicity in rat model","volume":"5","author":"Jana","year":"2023","journal-title":"Curr. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib51","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41598-023-27923-7","article-title":"The renin-angiotensin system modulates endotoxic postconditioning of exacerbated renal vasoconstriction in preeclamptic offspring","volume":"13","author":"Morgaan","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119436_bib52","series-title":"The Design and Statistical Analysis of Animal Experiments","author":"Bate","year":"2014"},{"issue":"8","key":"10.1016\/j.biopha.2026.119436_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.xphs.2025.103881","article-title":"Protein-bound cisplatin could exhibit an efficient antitumor effect in vivo","volume":"114","author":"Matsuo","year":"2025","journal-title":"J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2026.119436_bib54","first-page":"364","article-title":"Empagliflozin (Jardiance): A Novel SGLT2 Inhibitor for the Treatment of Type-2 Diabetes","volume":"40","author":"Ndefo","year":"2015","journal-title":"P & T a peer-Rev. J. Formul. Manag."},{"key":"10.1016\/j.biopha.2026.119436_bib55","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119436_bib56","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/bs.acr.2022.03.005","article-title":"Nephrotoxicity in cancer treatment: An update","volume":"155","author":"Chen","year":"2022","journal-title":"Adv. Cancer Res"},{"issue":"14","key":"10.1016\/j.biopha.2026.119436_bib57","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s40265-019-01182-1","article-title":"Prevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis","volume":"79","author":"Hamroun","year":"2019","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib58","article-title":"Proton pump inhibitors may increase the risk of cisplatin-induced acute kidney injury in patients with nasopharyngeal carcinoma: a prospective cohort study","volume":"14","author":"Luo","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2026.119436_bib59","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/cvr\/cvaa123","article-title":"Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase G\u03b1 oxidation","volume":"117","author":"Kolijn","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.biopha.2026.119436_bib60","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1056\/NEJMoa1515920","article-title":"Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes","volume":"375","author":"Wanner","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1871529X1401140724093505","article-title":"Renal endothelial dysfunction in acute kidney ischemia reperfusion injury","volume":"14","author":"Basile","year":"2014","journal-title":"Cardiovasc. & Hematol. Disord. Drug Targets"},{"issue":"6","key":"10.1016\/j.biopha.2026.119436_bib62","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/FJC.0b013e318231166f","article-title":"Metoprolol ameliorates cyclosporine a-induced hypertension and nephrotoxicity in rats","volume":"58","author":"El-Gowilly","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119436_bib63","first-page":"939","article-title":"Investigating the Role of Empagliflozin in the Pathological Progress of Ischemia-Reperfusion Injury in Rat Kidneys: The Involvement of Nitric Oxide","volume":"15","author":"Hasanvand","year":"2025","journal-title":"Adv. Pharm. Bull."},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib64","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00395-024-01067-9","article-title":"Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2","volume":"119","author":"Chen","year":"2024","journal-title":"Basic Res Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12933-020-00997-7","article-title":"Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat","volume":"19","author":"Park","year":"2020","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.biopha.2026.119436_bib66","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.redox.2017.12.019","article-title":"Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission","volume":"15","author":"Zhou","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2026.119436_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173040","article-title":"Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice","volume":"875","author":"Ganbaatar","year":"2020","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.biopha.2026.119436_bib68","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/2277-9175.156642","article-title":"Role of endothelin-1 antagonist; bosentan, against cisplatin-induced nephrotoxicity in male and female rats","volume":"4","author":"Jokar","year":"2015","journal-title":"Adv. Biomed. Res."},{"issue":"7","key":"10.1016\/j.biopha.2026.119436_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13071572","article-title":"Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations","volume":"13","author":"McSweeney","year":"2021","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib70","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1046\/j.1523-1755.2002.00233.x","article-title":"Nitric oxide in acute renal failure: NOS versus NOS","volume":"61","author":"Goligorsky","year":"2002","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib71","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/hep.21384","article-title":"Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide","volume":"44","author":"Zheng","year":"2006","journal-title":"Hepatol. (Baltim. Md. )"},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib72","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.kint.2020.12.013","article-title":"Empagliflozin restores chronic kidney disease\u2013induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction","volume":"99","author":"Juni","year":"2021","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.biopha.2026.119436_bib73","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4049\/immunohorizons.2300077","article-title":"Sodium-Glucose Cotransporter-2 Inhibitor, Empagliflozin, Suppresses the Inflammatory Immune Response to Influenza Infection","volume":"7","author":"Constantinesco","year":"2023","journal-title":"ImmunoHorizons"},{"key":"10.1016\/j.biopha.2026.119436_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115213","article-title":"Dapagliflozin prevents oxidative stress-induced endothelial dysfunction via sirtuin 1 activation","volume":"165","author":"Zhou","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2026.119436_bib75","doi-asserted-by":"crossref","unstructured":"R.M. El-Gohary, A. Abdeen, H.A. Ibrahim, E.S. Taher, M.M. Ghabrial, R.L. Younis, H. Khattab, M.A. Seleem, K.M. Alwutayed, O. Mihaela, B.D. Ioan, M. El-Nablaway, A.A. Aldarmahi, A.M. Ibrahim, R.H. Al-Serwi, A.A. GhalwashEmpagliflozin impact on experimentally induced acetaminophen toxicity: Imprint of mitochondrial dynamics, biogenesis, and cGAS\/STING signal in amending liver insult, Faseb j 38(14) (2024) e23816. doi:10.1096\/fj.202400254RRR2024, e2381610.1096\/fj.202400254RRR.","DOI":"10.1096\/fj.202400254RRR"},{"key":"10.1016\/j.biopha.2026.119436_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104870","article-title":"Empagliflozin protects heart from inflammation and energy depletion via AMPK activation","volume":"158","author":"Koyani","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.biopha.2026.119436_bib77","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4196\/kjpp.2008.12.4.149","article-title":"Expression of endothelin-1 and its receptors in Cisplatin-induced acute renal failure in mice","volume":"12","author":"Lee","year":"2008","journal-title":"Korean J. Physiol. & Pharmacol. Off. J. Korean Physiol. Soc. Korean Soc. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119436_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111255","article-title":"CGS-21680 defers cisplatin-induced AKI-CKD transition in C57\/BL6 mice","volume":"403","author":"Elbrolosy","year":"2024","journal-title":"Chem. Biol. Inter."},{"issue":"21","key":"10.1016\/j.biopha.2026.119436_bib79","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.3390\/ijms21218189","article-title":"Empagliflozin Inhibits Basal and IL-1\u03b2-Mediated MCP-1\/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells","volume":"21","author":"Pirklbauer","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2026.119436_bib80","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41419-023-06125-z","article-title":"miR-92a-3p regulates cisplatin-induced cancer cell death","volume":"14","author":"Larrue","year":"2023","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib81","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1039\/C3FO60501A","article-title":"C-phycocyanin prevents cisplatin-induced nephrotoxicity through inhibition of oxidative stress","volume":"5","author":"Fern\u00e1ndez-Rojas","year":"2014","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.biopha.2026.119436_bib82","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.mehy.2015.08.019","article-title":"Inflammasome, mTORC1 activation, and metabolic derangement contribute to the susceptibility of diabetics to infections","volume":"85","author":"Krakauer","year":"2015","journal-title":"Med Hypotheses"},{"issue":"12","key":"10.1016\/j.biopha.2026.119436_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20123011","article-title":"Recent Advances in Models, Mechanisms, Biomarkers, and Interventions in Cisplatin-Induced Acute Kidney Injury","volume":"20","author":"Holditch","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.biopha.2026.119436_bib84","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1681\/ASN.V12122683","article-title":"Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide","volume":"12","author":"Davis","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib85","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/oxygen2030022","article-title":"Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury","volume":"2","author":"Yoshikawa","year":"2022","journal-title":"Oxygen"},{"issue":"2-3","key":"10.1016\/j.biopha.2026.119436_bib86","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0005-2728(99)00027-4","article-title":"Nitric oxide and lipid peroxidation","volume":"1411","author":"Hogg","year":"1999","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.biopha.2026.119436_bib87","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/00004872-200406000-00015","article-title":"Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells","volume":"22","author":"Touyz","year":"2004","journal-title":"J. Hypertens."},{"issue":"7","key":"10.1016\/j.biopha.2026.119436_bib88","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK signaling pathways in apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2026.119436_bib89","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s10495-007-0082-8","article-title":"Apoptosis by cisplatin requires p53 mediated p38\u03b1 MAPK activation through ROS generation","volume":"12","author":"Bragado","year":"2007","journal-title":"Apoptosis"},{"issue":"9","key":"10.1016\/j.biopha.2026.119436_bib90","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.freeradbiomed.2011.08.006","article-title":"Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury","volume":"51","author":"Mukhopadhyay","year":"2011","journal-title":"Free Radic. Biol. & Med."},{"issue":"9","key":"10.1016\/j.biopha.2026.119436_bib91","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.freeradbiomed.2005.12.025","article-title":"Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity","volume":"40","author":"Mishima","year":"2006","journal-title":"Free Radic. Biol. & Med."},{"issue":"10","key":"10.1016\/j.biopha.2026.119436_bib92","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s10495-007-0110-8","article-title":"Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin","volume":"12","author":"Yano","year":"2007","journal-title":"Apoptosis international journal programmed cell death"},{"key":"10.1016\/j.biopha.2026.119436_bib93","article-title":"The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis","volume":"129","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib94","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/jpet.121.001251","article-title":"Empagliflozin Improves the MicroRNA Signature of Endothelial Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Diabetes","volume":"384","author":"Mone","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"11","key":"10.1016\/j.biopha.2026.119436_bib95","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/ijc.23192","article-title":"Chronic inflammation and oxidative stress in human carcinogenesis","volume":"121","author":"Federico","year":"2007","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.biopha.2026.119436_bib96","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.3390\/biomedicines10112863","article-title":"The Role of NF-\u03baB and Bax\/Bcl-2\/Caspase-3 Signaling Pathways in the Protective Effects of Sacubitril\/Valsartan (Entresto) against HFD\/STZ-Induced Diabetic Kidney Disease","volume":"10","author":"Mohany","year":"2022","journal-title":"Biomedicines"},{"issue":"10","key":"10.1016\/j.biopha.2026.119436_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105721","article-title":"Therapeutic Potential of Pretreatment with Exosomes Derived from Stem Cells from the Apical Papilla against Cisplatin-Induced Acute Kidney Injury","volume":"23","author":"Huang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2026.119436_bib98","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3892\/br.2021.1414","article-title":"Ginaton injection alleviates cisplatin-induced renal interstitial fibrosis in rats via inhibition of apoptosis through regulation of the p38MAPK\/TGF-\u03b21 and p38MAPK\/HIF-1\u03b1 pathways","volume":"14","author":"Liang","year":"2021","journal-title":"Biomed. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2026.119436_bib99","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/cvr\/cvad009","article-title":"Empagliflozin inhibits excessive autophagy through the AMPK\/GSK3\u03b2 signalling pathway in diabetic cardiomyopathy","volume":"119","author":"Madonna","year":"2023","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.biopha.2026.119436_bib100","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/15548627.2024.2410621","article-title":"Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules","volume":"21","author":"Matsui","year":"2025","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.biopha.2026.119436_bib101","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12933-019-0816-2","article-title":"SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart","volume":"18","author":"Li","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.biopha.2026.119436_bib102","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fphys.2015.00082","article-title":"TGF-\u03b2\/Smad signaling in renal fibrosis","volume":"6","author":"Meng","year":"2015","journal-title":"Front Physiol."},{"key":"10.1016\/j.biopha.2026.119436_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178375","article-title":"Empagliflozin alleviates iron accumulation and ferroptosis to mitigate bleomycin-induced pulmonary fibrosis through TFEB-mediated regulation of ACSL4 and GPX4","volume":"1010","author":"Li","year":"2026","journal-title":"Eur. J. Pharmacol."},{"issue":"32","key":"10.1016\/j.biopha.2026.119436_bib104","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1074\/jbc.272.32.19943","article-title":"Tissue-specific pattern of stress kinase activation in ischemic\/reperfused heart and kidney","volume":"272","author":"Yin","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119436_bib105","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.procbio.2019.05.001","article-title":"Nephroprotective effects of Lachnum melanin against acute kidney injury induced by cisplatin in mice","volume":"83","author":"Yang","year":"2019","journal-title":"Process Biochem."},{"key":"10.1016\/j.biopha.2026.119436_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107374","article-title":"Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-\u03b2\/Smad signaling","volume":"93","author":"Shentu","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"50","key":"10.1016\/j.biopha.2026.119436_bib107","doi-asserted-by":"crossref","first-page":"46707","DOI":"10.1074\/jbc.M106176200","article-title":"Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity","volume":"276","author":"Bhowmick","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2026.119436_bib108","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ymthe.2023.12.009","article-title":"Therapeutic potential for renal fibrosis by targeting Smad3-dependent noncoding RNAs","volume":"32","author":"Gu","year":"2024","journal-title":"Mol. Ther."},{"issue":"7","key":"10.1016\/j.biopha.2026.119436_bib109","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.7150\/ijbs.71595","article-title":"Smad3 Signatures in Renal Inflammation and Fibrosis","volume":"18","author":"Wu","year":"2022","journal-title":"Int J. Biol. Sci."},{"issue":"7","key":"10.1016\/j.biopha.2026.119436_bib110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK Signaling Pathways in Apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226004725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226004725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:43:06Z","timestamp":1794476586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226004725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":110,"alternative-id":["S0753332226004725"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119436","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Empagliflozin mitigated cisplatin induced renal endothelial dysfunction in rats via repressing oxidative, inflammatory, apoptotic and fibrotic signals","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119436"}}