{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T23:22:24Z","timestamp":1787440944830,"version":"build-2736575974"},"reference-count":297,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.biopha.2026.119480","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:37:34Z","timestamp":1779089854000},"page":"119480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Crosstalk of pathogenic signaling pathways in intervertebral disc degeneration: Epigenetic regulation and therapeutic implications"],"prefix":"10.1016","volume":"200","author":[{"given":"Xinhui","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/annrheumdis-2017-212056","article-title":"Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein [J]","volume":"77","author":"Cheng","year":"2018","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.joca.2013.10.019","article-title":"Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study [J]","volume":"22","author":"Teraguchi","year":"2014","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00007632-198704000-00013","article-title":"Descriptive epidemiology of low-back pain and its related medical care in the United States [J]","volume":"12","author":"Deyo","year":"1987","journal-title":"Spine"},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41419-019-1978-2","article-title":"CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p\/SIRT1 axis [J]","volume":"10","author":"Xie","year":"2019","journal-title":"Cell death & Dis."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/rheumatology\/ken396","article-title":"The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain [J]","volume":"48","author":"Freemont","year":"2009","journal-title":"Rheumatol. (Oxf. Engl. )"},{"key":"10.1016\/j.biopha.2026.119480_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00003086-200003000-00018","article-title":"The disproportionate impact of chronic arthralgia and arthritis among women [J]","volume":"372","author":"Buckwalter","year":"2000","journal-title":"Clin. Orthop. Relat. Res"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib7","first-page":"18","article-title":"Intervertebral disc: anatomy-physiology-pathophysiology-treatment [J]","volume":"8","author":"Raj","year":"2008","journal-title":"Pain. Pract. Off. J. World Inst. Pain."},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103601","article-title":"MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology [J]","volume":"21","author":"Cazzanelli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/joa.12022","article-title":"Factors regulating viable cell density in the intervertebral disc: blood supply in relation to disc height [J]","volume":"222","author":"Boubriak","year":"2013","journal-title":"J. Anat."},{"key":"10.1016\/j.biopha.2026.119480_bib10","article-title":"Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration [J]","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2026.119480_bib11","first-page":"1289","article-title":"Molecular mechanisms of biological aging in intervertebral discs [J]","volume":"34","author":"Vo","year":"2016"},{"key":"10.1016\/j.biopha.2026.119480_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2020.04.016","article-title":"Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function [J]","volume":"508","author":"Zhang","year":"2020","journal-title":"Clin. Chim. Acta"},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib13","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/term.1866","article-title":"Treatment of the degenerated intervertebral disc; closure, repair and regeneration of the annulus fibrosus [J]","volume":"9","author":"Sharifi","year":"2015","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.biopha.2026.119480_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.spinee.2004.07.007","article-title":"Adjacent segment degeneration and adjacent segment disease: the consequences of spinal fusion? [J]","volume":"4","author":"Hilibrand","year":"2004","journal-title":"Spine J. Off. J. North Am. Spine Soc."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00109-018-1712-z","article-title":"Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8\/CINC-1 through TLR2-NF-\u03baB p65 pathway [J]","volume":"97","author":"Jiao","year":"2019","journal-title":"J. Mol. Med. (Berl. Ger. )"},{"key":"10.1016\/j.biopha.2026.119480_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112717","article-title":"Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K\/AKT\/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo [J]","volume":"139","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119480_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13677","article-title":"p300 arrests intervertebral disc degeneration by regulating the FOXO3\/Sirt1\/Wnt\/\u03b2-catenin axis [J","volume":"21","author":"Hao","year":"2022","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib18","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s10753-017-0508-6","article-title":"IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-\u03b1 Through the JAK-STAT Signaling Pathway [J]","volume":"40","author":"Chen","year":"2017","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.biopha.2026.119480_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13438","article-title":"Roles of p38 MAPK signalling in intervertebral disc degeneration [J]","volume":"56","author":"Shi","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.biopha.2026.119480_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176298","article-title":"Fisetin suppresses ferroptosis through Nrf2 and attenuates intervertebral disc degeneration in rats [J]","volume":"964","author":"Li","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119480_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111918","article-title":"Oxidative stress promotes intervertebral disc degeneration through NAT10-mediated IKK\u03b2 N4-acetylcytidine modification [J]","volume":"134","author":"Wang","year":"2025","journal-title":"Cell Signal"},{"key":"10.1016\/j.biopha.2026.119480_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/bs.ircmb.2016.08.002","article-title":"Epigenetic Control of Gene Expression in Maize [J]","volume":"328","author":"Huang","year":"2017","journal-title":"Int Rev. Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2026.119480_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101902","article-title":"Epigenetic modifications of inflammation in intervertebral disc degeneration [J]","volume":"87","author":"Kang","year":"2023","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.biopha.2026.119480_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115654","article-title":"Quercetin alleviates intervertebral disc degeneration by disrupting CEBPB-HMGA1 interaction to suppress TNFA production and reduce ECM degradation [J]","volume":"167","author":"Liu","year":"2025","journal-title":"Int Immunopharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/cpr.12121","article-title":"Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies [J]","volume":"47","author":"Wang","year":"2014","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12542","article-title":"Nuclear factor-kappa B-dependent X-box binding protein 1 signalling promotes the proliferation of nucleus pulposus cells under tumour necrosis factor alpha stimulation [J]","volume":"52","author":"Chen","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.biopha.2026.119480_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cca.2015.06.023","article-title":"MMPs and ADAMTSs in intervertebral disc degeneration [J]","volume":"448","author":"Wang","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"14","key":"10.1016\/j.biopha.2026.119480_bib28","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2174\/1381612824666180327165604","article-title":"Signaling Pathways in Inflammation and Anti-inflammatory Therapies [J]","volume":"24","author":"Yeung","year":"2018","journal-title":"Curr. Pharm. Des."},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib29","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1515\/hsz-2014-0164","article-title":"Inflammatory outcomes of apoptosis, necrosis and necroptosis [J]","volume":"395","author":"Davidovich","year":"2014","journal-title":"Biol. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2026.119480_bib30","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.joca.2018.04.002","article-title":"Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-\u03b1\/NF-\u03baB-Wnt5a negative-feedback loop [J]","volume":"26","author":"Li","year":"2018","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content [J]","volume":"10","author":"Risbud","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"issue":"21","key":"10.1016\/j.biopha.2026.119480_bib32","doi-asserted-by":"crossref","first-page":"E1291","DOI":"10.1097\/BRS.0b013e3182a42bc2","article-title":"Substance P stimulates production of inflammatory cytokines in human disc cells [J]","volume":"38","author":"Kepler","year":"2013","journal-title":"Spine"},{"key":"10.1016\/j.biopha.2026.119480_bib33","first-page":"608","article-title":"Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells [J]","volume":"31","author":"Yamamoto","year":"2013"},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib34","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s11999-014-3774-8","article-title":"Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? [J]","volume":"473","author":"Kadow","year":"2015","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.biopha.2026.119480_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110660","article-title":"The role of IL-1\u03b2 and TNF-\u03b1 in intervertebral disc degeneration [J]","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed. & Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/nyas.13551","article-title":"Inflammatory biomarkers of low back pain and disc degeneration: a review [J]","volume":"1410","author":"Khan","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib37","first-page":"492","article-title":"Catabolic cytokine expressions in patients with degenerative disc disease [J]","volume":"20","author":"Akyol","year":"2010","journal-title":"Turk. Neurosurg."},{"key":"10.1016\/j.biopha.2026.119480_bib38","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cca.2015.08.029","article-title":"Interleukin-1\u03b2 in intervertebral disk degeneration [J]","volume":"450","author":"Yang","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2026.119480_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.22203\/eCM.v030a08","article-title":"Disc in flames: Roles of TNF-\u03b1 and IL-1\u03b2 in intervertebral disc degeneration","volume":"30","author":"Johnson Z","year":"2015","journal-title":"J. ]. Eur. Cells & Mater."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib40","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/rheumatology\/ken056","article-title":"Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc [J]","volume":"47","author":"Hoyland","year":"2008","journal-title":"Rheumatol. (Oxf. Engl. )"},{"key":"10.1016\/j.biopha.2026.119480_bib41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13018-015-0296-3","article-title":"IL-1\u03b2 promotes ADAMTS enzyme-mediated aggrecan degradation through NF-\u03baB in human intervertebral disc [J]","volume":"10","author":"Sun","year":"2015","journal-title":"J. Orthop. Surg. Res."},{"issue":"14","key":"10.1016\/j.biopha.2026.119480_bib42","doi-asserted-by":"crossref","first-page":"E817","DOI":"10.1097\/BRS.0000000000001982","article-title":"Potential Involvement of the IL-6\/JAK\/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration [J]","volume":"42","author":"Suzuki","year":"2017","journal-title":"Spine"},{"key":"10.1016\/j.biopha.2026.119480_bib43","first-page":"900","article-title":"Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6\/STAT3 Signaling Pathway in Human Intervertebral Disc Degeneration [J]","volume":"31","author":"Ji","year":"2016"},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41434-018-0004-0","article-title":"Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review [J]","volume":"25","author":"Sampara","year":"2018","journal-title":"Gene Ther."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arr.2007.08.001","article-title":"The cell biology of intervertebral disc aging and degeneration [J]","volume":"6","author":"Zhao","year":"2007","journal-title":"Ageing Res. Rev."},{"issue":"13","key":"10.1016\/j.biopha.2026.119480_bib46","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1080\/15384101.2016.1152433","article-title":"Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways [J]","volume":"15","author":"Feng","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biopha.2026.119480_bib47","first-page":"1745","article-title":"TNF-\u03b1 suppresses SHOX2 expression via NF-\u03baB signaling pathway and promotes intervertebral disc degeneration and related pain in a rat model [J]","volume":"39","author":"Ye","year":"2021"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcm.2017.09.003","article-title":"Cytokine Involvement in Biological Inflammation Related to Degenerative Disorders of the Intervertebral Disk: A Narrative Review [J]","volume":"17","author":"De Geer","year":"2018","journal-title":"J. Chiropr. Med."},{"key":"10.1016\/j.biopha.2026.119480_bib49","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine [J]","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2026.119480_bib50","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s13075-015-0834-8","article-title":"Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration [J]","volume":"17","author":"Suzuki","year":"2015","journal-title":"Arthritis Res. & Ther."},{"key":"10.1016\/j.biopha.2026.119480_bib51","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2166817","article-title":"The Role of Oxidative Stress in Intervertebral Disc Degeneration [J]","volume":"2022","author":"Cao","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2026.119480_bib52","first-page":"658","article-title":"Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs [J]","volume":"9","author":"Kim","year":"2009"},{"key":"10.1016\/j.biopha.2026.119480_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3565127","article-title":"ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases [J]","volume":"2016","author":"Davalli","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2026.119480_bib54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.22203\/eCM.v030a07","article-title":"Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells","volume":"30","author":"Dimozi","year":"2015","journal-title":"J. ]. Eur. Cells & Mater."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib55","first-page":"1133","article-title":"Apoptosis (programmed cell death) and its signals - A review [J]","volume":"81","author":"Obeng","year":"2021","journal-title":"Braz. J. Biol. = Rev. brasleira De. Biol."},{"issue":"22","key":"10.1016\/j.biopha.2026.119480_bib56","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1097\/00007632-200111150-00004","article-title":"The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc [J]","volume":"26","author":"Ariga","year":"2001","journal-title":"Spine"},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib57","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/01.brs.0000154652.96975.1f","article-title":"Occurrence and regional distribution of apoptosis in scoliotic discs [J]","volume":"30","author":"Chen","year":"2005","journal-title":"Spine"},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091137","article-title":"Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review [J]","volume":"10","author":"Kim","year":"2018","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib59","first-page":"771","article-title":"WANG J Y J. Cell Death Response to DNA Damage [J]","volume":"92","year":"2019","journal-title":"Yale J. Biol. Med."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib60","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.joca.2015.09.019","article-title":"Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration [J]","volume":"24","author":"Wang","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib61","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10495-012-0708-3","article-title":"Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells [J]","volume":"17","author":"Ding","year":"2012","journal-title":"Apoptosis international journal programmed cell death"},{"key":"10.1016\/j.biopha.2026.119480_bib62","article-title":"The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis [J]","volume":"2022","author":"Li","year":"2022","journal-title":"Anal. Cell. Pathol. (Amst. )"},{"key":"10.1016\/j.biopha.2026.119480_bib63","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.redox.2018.09.006","article-title":"Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration [J]","volume":"19","author":"Song","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2026.119480_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153366","article-title":"Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs [J]","volume":"220","author":"Wu","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.biopha.2026.119480_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110660","article-title":"The role of IL-1\u03b2 and TNF-\u03b1 in intervertebral disc degeneration [J]","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed. Pharm."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib66","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI118884","article-title":"The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration [J]","volume":"98","author":"Antoniou","year":"1996","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2026.119480_bib67","first-page":"S810","article-title":"Age-related changes in human cervical, thoracal and lumbar intervertebral disc exhibit a strong intra-individual correlation [J]","volume":"21","author":"Weiler","year":"2012"},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031715","article-title":"The Proteolysis of ECM in Intervertebral Disc Degeneration [J]","volume":"23","author":"Liang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119480_bib69","first-page":"331","article-title":"Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration [J]","volume":"13","author":"Vo","year":"2013"},{"key":"10.1016\/j.biopha.2026.119480_bib70","first-page":"385","article-title":"Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration--an in vivo study on the New Zealand white rabbit [J]","volume":"24","author":"Omlor","year":"2006"},{"issue":"46","key":"10.1016\/j.biopha.2026.119480_bib71","doi-asserted-by":"crossref","first-page":"31493","DOI":"10.1074\/jbc.R109.052340","article-title":"A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms [J]","volume":"284","author":"Apte","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119480_bib72","first-page":"24","article-title":"Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics [J]","volume":"44-46","author":"Dubail","year":"2015"},{"key":"10.1016\/j.biopha.2026.119480_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174447","article-title":"Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: a review [J]","volume":"910","author":"He","year":"2021","journal-title":"Eur. J. Pharm."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib74","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1007\/s11033-022-07542-7","article-title":"OXR1 signaling pathway as a possible mechanism of elastase-induced oxidative damage in pulmonary cells: the protective role of ellagic acid [J]","volume":"49","author":"Bayati","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib75","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1038\/s41467-020-16597-8","article-title":"CYCLIN-B1\/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment [J]","volume":"11","author":"Hagey","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054607","article-title":"Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective [J]","volume":"24","author":"Zulkefli","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.biopha.2026.119480_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28166070","article-title":"Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice [J]","volume":"28","author":"Chen","year":"2023","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib78","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s11064-024-04099-8","article-title":"Orientin Modulates Nrf2-ARE, PI3K\/Akt, JNK-ERK1\/2, and TLR4\/NF-kB Pathways to Produce Neuroprotective Benefits in Parkinson's Disease [J]","volume":"49","author":"Vasudevan Sajini","year":"2024","journal-title":"Neurochem. Res"},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib79","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/ijc.11651","article-title":"Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma [J]","volume":"108","author":"Fukuchi","year":"2004","journal-title":"Int. J. Cancer"},{"issue":"12","key":"10.1016\/j.biopha.2026.119480_bib80","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrc1753","article-title":"Oncogenic PI3K deregulates transcription and translation [J]","volume":"5","author":"Bader","year":"2005","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib81","first-page":"206","article-title":"Knockdown of Ski decreases osteosarcoma cell proliferation and migration by suppressing the PI3K\/Akt signaling pathway [J]","volume":"56","author":"Zhao","year":"2020","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib82","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s13277-013-1293-y","article-title":"Effects of tetrandrine on glioma cell malignant phenotype via inhibition of ADAM17 [J]","volume":"35","author":"Wu","year":"2014","journal-title":"Tumour Biol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119480_bib83","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0968-0004(01)01958-2","article-title":"Ten years of protein kinase B signalling: a hard Akt to follow [J]","volume":"26","author":"Brazil","year":"2001","journal-title":"Trends Biochem Sci."},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib84","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/phar.2173","article-title":"Current and Investigational Agents Targeting the Phosphoinositide 3-Kinase Pathway [J]","volume":"38","author":"Tang","year":"2018","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.biopha.2026.119480_bib85","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pharmthera.2015.11.013","article-title":"AKT signaling in ERBB2-amplified breast cancer [J]","volume":"158","author":"Carmona","year":"2016","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.biopha.2026.119480_bib86","article-title":"The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment [J]","author":"Li","year":"2026","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.biopha.2026.119480_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113941","article-title":"Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K\/Akt signaling pathway [J]","volume":"156","author":"Liu","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib88","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22887","article-title":"Activation of PI3K\/PKB\/GSK-3\u03b2 signaling by sciadopitysin protects cardiomyocytes against high glucose-induced oxidative stress and apoptosis [J]","volume":"35","author":"Zhang","year":"2021","journal-title":"J. Biochem Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib89","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.joca.2008.05.007","article-title":"IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways [J]","volume":"17","author":"Zhang","year":"2009","journal-title":"Osteoarthr. Cartil."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib90","first-page":"2309","article-title":"Regulation of insulin-like growth factor 1 receptor signaling by microRNA-4458 in the development of lumbar disc degeneration [J]","volume":"8","author":"Liu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.biopha.2026.119480_bib91","doi-asserted-by":"crossref","unstructured":"Baffi M.O., Slattery E., Sohn P., et al. Conditional deletion of the TGF-\u03b2 type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones [J]. 2004, 276(1): 124\u2013142.","DOI":"10.1016\/j.ydbio.2004.08.027"},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib92","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cyto.2014.07.249","article-title":"The effect of transforming growth factor \u03b21 on the crosstalk between autophagy and apoptosis in the annulus fibrosus cells under serum deprivation [J]","volume":"70","author":"Ni","year":"2014","journal-title":"Cytokine"},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075251","article-title":"MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K [J]","volume":"8","author":"Liu","year":"2013","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib94","first-page":"465","article-title":"[Mechanism of chlorogenic acid on apoptosis of rat nucleus pulposus cells induced by oxidative stress] [J]","volume":"37","author":"Xie R","year":"2014","journal-title":"Zhong yao cai = Zhongyaocai = J. Chin. Med. Mater."},{"key":"10.1016\/j.biopha.2026.119480_bib95","first-page":"1184","article-title":"Hepatocyte growth factor regulates HIF-1\u03b1-induced nucleus pulposus cell proliferation through MAPK-, PI3K\/Akt-, and STAT3-mediated signaling [J]","volume":"39","author":"Itsuji","year":"2021"},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib96","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.3390\/ijms15034007","article-title":"miR-21 promotes human nucleus pulposus cell proliferation through PTEN\/AKT signaling [J]","volume":"15","author":"Liu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119480_bib97","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.wneu.2016.01.024","article-title":"MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1 [J]","volume":"97","author":"Li","year":"2017","journal-title":"World Neurosurg."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12020467","article-title":"Dual PI3K\/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining [J]","volume":"12","author":"Sch\u00f6tz","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib99","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41419-020-2296-4","article-title":"A cathelicidin-related antimicrobial peptide suppresses cardiac hypertrophy induced by pressure overload by regulating IGFR1\/PI3K\/AKT and TLR9\/AMPK\u03b1 [J]","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2026.119480_bib100","article-title":"Intervertebral disc cell fate during aging and degeneration: apoptosis, senescence, and autophagy [J]","volume":"14","author":"Yurube","year":"2023","journal-title":"N. Am. Spine Soc. J."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.1082","article-title":"Autophagy and mTOR signaling during intervertebral disc aging and degeneration [J]","volume":"3","author":"Yurube","year":"2020","journal-title":"JOR Spine"},{"key":"10.1016\/j.biopha.2026.119480_bib102","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9941253","article-title":"Role of PI3K\/AKT Signaling Pathway in Nucleus Pulposus Cells [J]","volume":"2021","author":"Xiao","year":"2021","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.biopha.2026.119480_bib103","article-title":"Cyclic Mechanical Stretch Ameliorates the Degeneration of Nucleus Pulposus Cells through Promoting the ITGA2\/PI3K\/AKT Signaling Pathway [J]","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid. Med Cell Longev."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib104","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease [J]","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"issue":"28","key":"10.1016\/j.biopha.2026.119480_bib105","doi-asserted-by":"crossref","first-page":"16690","DOI":"10.1073\/pnas.1910547117","article-title":"Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation [J]","volume":"117","author":"Ma","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107540","article-title":"GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation [J]","volume":"31","author":"Choi","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.biopha.2026.119480_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120128","article-title":"Assembly of lung progenitors into developmentally-inspired geometry drives differentiation via cellular tension [J]","volume":"254","author":"Soleas","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib108","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s13075-019-1986-8","article-title":"Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt\/\u03b2-catenin pathway [J]","volume":"21","author":"Zhan","year":"2019","journal-title":"Arthritis Res. & Ther."},{"issue":"8","key":"10.1016\/j.biopha.2026.119480_bib109","doi-asserted-by":"crossref","first-page":"E513","DOI":"10.1097\/BRS.0b013e3181f52cb5","article-title":"Intervertebral disc development is regulated by Wnt\/\u03b2-catenin signaling [J]","volume":"36","author":"Kondo","year":"2011","journal-title":"Spine"},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib110","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1002\/art.27599","article-title":"Enhancement of intervertebral disc cell senescence by WNT\/\u03b2-catenin signaling-induced matrix metalloproteinase expression [J]","volume":"62","author":"Hiyama","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib111","doi-asserted-by":"crossref","first-page":"14185","DOI":"10.18632\/aging.203036","article-title":"Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt\/\u03b2-catenin signaling in intervertebral disc degeneration [J]","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.biopha.2026.119480_bib112","first-page":"133","article-title":"SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt\/\u03b2-catenin pathway and ameliorates disc degeneration [J]","volume":"27","author":"Wu","year":"2022"},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib113","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3892\/ijmm.2016.2470","article-title":"Aquaporin 3 protects against lumbar intervertebral disc degeneration via the Wnt\/\u03b2-catenin pathway [J]","volume":"37","author":"Xie","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib114","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12906-019-2607-4","article-title":"Velvet antler polypeptide partially rescue facet joint osteoarthritis-like phenotype in adult \u03b2-catenin conditional activation mice [J]","volume":"19","author":"Xie","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib115","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1186\/ar4379","article-title":"A complex interaction between Wnt signaling and TNF-\u03b1 in nucleus pulposus cells [J]","volume":"15","author":"Hiyama","year":"2013","journal-title":"Arthritis Res. & Ther."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib116","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70431","article-title":"ZIP8 Regulates Inflammation and Macrophage Polarisation in Intervertebral Disc Degeneration via the Wnt\/\u03b2-Catenin Pathway [J]","volume":"29","author":"Xu","year":"2025","journal-title":"J. Cell Mol. Med"},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib117","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1167\/iovs.66.4.67","article-title":"Microglia-Derived IL-6 Promotes M\u00fcller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration [J]","volume":"66","author":"Xu","year":"2025","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"29","key":"10.1016\/j.biopha.2026.119480_bib118","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024562118","article-title":"MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate [J]","volume":"118","author":"Gutierrez-Prat","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib119","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/hep.31274","article-title":"Functional Consequences of Metabolic Zonation in Murine Livers: Insights for an Old Story [J]","volume":"73","author":"Berndt","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119480_bib120","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.632956","article-title":"Mechanobiology of Autophagy: The Unexplored Side of Cancer [J]","volume":"11","author":"Hern\u00e1ndez-C\u00e1ceres","year":"2021","journal-title":"Front Oncol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib121","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.cell.2006.12.005","article-title":"SnapShot: NF-kappaB signaling pathways [J","volume":"127","author":"Hayden","year":"2006","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib122","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1002\/jcp.28504","article-title":"NF-\u03baB targeting for overcoming tumor resistance and normal tissues toxicity [J]","volume":"234","author":"Mortezaee","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib123","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling [J]","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2026.119480_bib124","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.blre.2018.11.003","article-title":"The impact of NF-\u03baB signaling on pathogenesis and current treatment strategies in multiple myeloma [J]","volume":"34","author":"Vr\u00e1bel","year":"2019","journal-title":"Blood Rev."},{"key":"10.1016\/j.biopha.2026.119480_bib125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.0105-2896.2005.00329.x","article-title":"Role of nuclear factor-kappaB in the immune system and bone [J]","volume":"208","author":"Jimi","year":"2005","journal-title":"Immunol. Rev."},{"issue":"7","key":"10.1016\/j.biopha.2026.119480_bib126","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13057","article-title":"NF-\u03baB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration [J]","volume":"54","author":"Zhang","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.biopha.2026.119480_bib127","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7426458","article-title":"Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-\u03baB Pathways [J","volume":"2017","author":"Feng","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib128","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12941","article-title":"Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration [J]","volume":"54","author":"Zhao","year":"2021","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib129","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00007632-200101150-00005","article-title":"Nitric oxide mediates the change of proteoglycan synthesis in the human lumbar intervertebral disc in response to hydrostatic pressure [J]","volume":"26","author":"Liu","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.biopha.2026.119480_bib130","first-page":"3056","article-title":"MicroRNA-194 Inhibits Lipopolysaccharide-Induced Inflammatory Response in Nucleus Pulposus Cells of the Intervertebral Disc by Targeting TNF Receptor-Associated Factor 6 (TRAF6) [J]","volume":"24","author":"Kong","year":"2018"},{"issue":"11","key":"10.1016\/j.biopha.2026.119480_bib131","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/CS20110496","article-title":"IL-17\/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential [J]","volume":"122","author":"Zhu","year":"2012","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2026.119480_bib132","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.intimp.2019.04.012","article-title":"PPAR-\u03b3 agonist pioglitazone protects against IL-17 induced intervertebral disc inflammation and degeneration via suppression of NF-\u03baB signaling pathway [J]","volume":"72","author":"Liu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2026.119480_bib133","article-title":"Naringin Inhibits Apoptosis Induced by Cyclic Stretch in Rat Annular Cells and Partially Attenuates Disc Degeneration by Inhibiting the ROS\/NF-\u03baB Pathway [J]","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2026.119480_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119874","article-title":"17\u03b2-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-\u03baB signal pathway [J]","volume":"284","author":"Wang","year":"2021","journal-title":"Life Sci."},{"issue":"3-4","key":"10.1016\/j.biopha.2026.119480_bib135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000503281","article-title":"Overexpression of miR-150 Inhibits the NF-\u03baB Signal Pathway in Intervertebral Disc Degeneration through Targeting P2X7 [J]","volume":"207","author":"Zhang","year":"2019","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.biopha.2026.119480_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119324","article-title":"Chlorogenic Acid retards cartilaginous endplate degeneration and ameliorates intervertebral disc degeneration via suppressing NF-\u03baB signaling [J]","volume":"274","author":"Ge","year":"2021","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.biopha.2026.119480_bib137","doi-asserted-by":"crossref","first-page":"825","DOI":"10.4252\/wjsc.v13.i7.825","article-title":"Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair [J]","volume":"13","author":"Menarim","year":"2021","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.biopha.2026.119480_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153164","article-title":"Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-\u03baB signaling pathway [J]","volume":"67","author":"Li","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2026.119480_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119499","article-title":"Interplay between MAPK\/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression [J]","volume":"278","author":"Asl","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2026.119480_bib140","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fendo.2019.00330","article-title":"The MAPK Pathway-Based Drug Therapeutic Targets in Pituitary Adenomas [J]","volume":"10","author":"Lu","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib141","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00432-020-03460-y","article-title":"MAPK signaling pathway-targeted marine compounds in cancer therapy [J]","volume":"147","author":"Wei","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.biopha.2026.119480_bib142","first-page":"50","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases [J]","volume":"75","author":"Cargnello","year":"2011"},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib143","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update [J]","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2026.119480_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112170","article-title":"MAPK \/ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration [J]","volume":"143","author":"Zhang","year":"2021","journal-title":"Biomed. Pharm."},{"issue":"7","key":"10.1016\/j.biopha.2026.119480_bib145","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/1535370218760774","article-title":"The long non-coding RNA NEAT1 contributes to extracellular matrix degradation in degenerative human nucleus pulposus cells [J]","volume":"243","author":"Ruan","year":"2018","journal-title":"Exp. Biol. Med. (Maywood NJ)"},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib146","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1016\/j.ajpath.2014.06.006","volume":"184","author":"Wang","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2026.119480_bib147","article-title":"Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy [J]","volume":"2021","author":"Zhang","year":"2021","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.biopha.2026.119480_bib148","article-title":"Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1\/NF-\u03baB and MAPK Signaling [J]","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib149","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190126","article-title":"Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro [J]","volume":"39","author":"Li","year":"2019","journal-title":"Biosci. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib150","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181451","article-title":"Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MAPK pathway [J]","volume":"38","author":"Fu","year":"2018","journal-title":"Biosci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib151","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/21623945.2021.1910155","article-title":"Visfatin promotes intervertebral disc degeneration by inducing IL-6 expression through the ERK\/JNK\/p38 signalling pathways [J]","volume":"10","author":"Cui","year":"2021","journal-title":"Adipocyte"},{"issue":"8","key":"10.1016\/j.biopha.2026.119480_bib152","first-page":"5114","article-title":"HtrA1 upregulates the expression of ADAMTS-5 in HNPCs via the ERK\/NF-\u03baB\/JNK signaling pathway [J]","volume":"11","author":"Li","year":"2019","journal-title":"Am. J. Transl. Res."},{"issue":"12","key":"10.1016\/j.biopha.2026.119480_bib153","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1080\/15548627.2021.1900498","article-title":"Combination of autophagy and NFE2L2\/NRF2 activation as a treatment approach for neuropathic pain [J]","volume":"17","author":"Li","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.biopha.2026.119480_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2024.102368","article-title":"The mitogen-activated protein kinase network, wired to dynamically function at multiple scales [J]","volume":"88","author":"Gagliardi","year":"2024","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biopha.2026.119480_bib155","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.671499","article-title":"The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders [J]","volume":"13","author":"Saxena","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.biopha.2026.119480_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.116679","article-title":"Attenuation of paraquat-induced inflammation by inhibitors of phosphorylation of mitogen-activated protein kinases in BV(2) microglial cells [J]","volume":"410","author":"Wang","year":"2020","journal-title":"J. Neurol. Sci."},{"issue":"17","key":"10.1016\/j.biopha.2026.119480_bib157","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional Regulation by Nrf2 [J]","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. & Redox Signal."},{"key":"10.1016\/j.biopha.2026.119480_bib158","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pharmthera.2015.11.003","article-title":"Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases [J]","volume":"157","author":"Buendia","year":"2016","journal-title":"Pharmacol. & Ther."},{"key":"10.1016\/j.biopha.2026.119480_bib159","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2020.06.028","article-title":"Transcription factor NRF2 as a promising therapeutic target for Alzheimer's disease [J]","volume":"159","author":"Qu","year":"2020","journal-title":"Free Radic. Biol. & Med."},{"issue":"19","key":"10.1016\/j.biopha.2026.119480_bib160","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1111\/febs.14379","article-title":"The role of Nrf2 signaling in counteracting neurodegenerative diseases [J]","volume":"285","author":"Dinkova-Kostova","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.biopha.2026.119480_bib161","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ijbiomac.2018.11.190","article-title":"Involvement of Nrf2 in myocardial ischemia and reperfusion injury [J]","volume":"125","author":"Shen","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib162","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40001-021-00481-2","article-title":"LncRNA NEAT1 promotes nucleus pulposus cell matrix degradation through regulating Nrf2\/ARE axis [J]","volume":"26","author":"Li","year":"2021","journal-title":"Eur. J. Med. Res."},{"issue":"8","key":"10.1016\/j.biopha.2026.119480_bib163","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","article-title":"The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights [J]","volume":"54","author":"Xiang","year":"2022","journal-title":"Exp. & Mol. Med."},{"key":"10.1016\/j.biopha.2026.119480_bib164","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6645005","article-title":"Long Noncoding RNA ANPODRT Overexpression Protects Nucleus Pulposus Cells from Oxidative Stress and Apoptosis by Activating Keap1-Nrf2 Signaling [J]","volume":"2021","author":"Kang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib165","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41413-020-00125-x","article-title":"Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions [J]","volume":"9","author":"Lyu","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.biopha.2026.119480_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101394","article-title":"The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review [J]","volume":"70","author":"Cheng","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"15","key":"10.1016\/j.biopha.2026.119480_bib167","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1080\/15384101.2021.1949839","article-title":"Platelet-rich plasma attenuates intervertebral disc degeneration via delivering miR-141-3p-containing exosomes [J]","volume":"20","author":"Xu","year":"2021","journal-title":"Cell cycle (Georgetown Tex)"},{"key":"10.1016\/j.biopha.2026.119480_bib168","article-title":"Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2\/HO-1 Pathway in Intervertebral Disc Degeneration [J]","volume":"2021","author":"Wang","year":"2021","journal-title":"Comput. Math. Methods Med."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib169","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3892\/etm.2020.9399","article-title":"Dimethyl fumarate protects nucleus pulposus cells from inflammation and oxidative stress and delays the intervertebral disc degeneration [J]","volume":"20","author":"Zhu","year":"2020","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.biopha.2026.119480_bib170","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5558687","article-title":"Ulinastatin Ameliorates IL-1\u03b2-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2\/NF-\u03baB Pathway [J]","volume":"2021","author":"Luo","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib171","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8040433","article-title":"Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro [J]","volume":"8","author":"Cherif","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.biopha.2026.119480_bib172","article-title":"Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress [J]","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.biopha.2026.119480_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2020.101559","article-title":"Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway [J]","volume":"51","author":"Lu","year":"2020","journal-title":"Mol. Cell Probes"},{"key":"10.1016\/j.biopha.2026.119480_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174993","article-title":"Targeting NRF2 in Type 2 diabetes mellitus and depression: Efficacy of natural and synthetic compounds [J]","volume":"925","author":"Subba","year":"2022","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.biopha.2026.119480_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122007","article-title":"The crosstalk between Nrf2 and NF-\u03baB pathways in coronary artery disease: Can it be regulated by SIRT6? [J]","volume":"330","author":"Casper","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2026.119480_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113171","article-title":"Mono-n-butyl phthalate regulates nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B pathway in an ovalbumin-induced asthma mouse model [J]","volume":"166","author":"Quoc","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2026.119480_bib177","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1101\/sqb.2009.74.028","article-title":"The dawn of developmental signaling in the metazoa [J]","volume":"74","author":"Richards","year":"2009","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib178","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch Signaling in Development, Tissue Homeostasis, and Disease [J]","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev."},{"issue":"386","key":"10.1016\/j.biopha.2026.119480_bib179","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaa3792","article-title":"A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis [J]","volume":"8","author":"Liu","year":"2015","journal-title":"Sci. Signal."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib180","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.joca.2015.10.015","article-title":"Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance [J]","volume":"24","author":"Liu","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib181","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/cdd.2011.114","article-title":"Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation [J]","volume":"19","author":"Haller","year":"2012","journal-title":"Cell death Differ."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib182","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00774-003-0428-4","article-title":"Suppression of differentiation and proliferation of early chondrogenic cells by Notch [J]","volume":"21","author":"Watanabe","year":"2003","journal-title":"J. Bone Miner. Metab."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib183","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1615\/CritRevEukarGeneExpr.v21.i1.30","article-title":"Notochordal cells in the adult intervertebral disc: new perspective on an old question [J]","volume":"21","author":"Risbud","year":"2011","journal-title":"Crit. Rev. Eukaryot. gene Expr."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib184","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/s12891-020-03505-w","article-title":"Correlation between the HIF-1\u03b1\/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain [J]","volume":"21","author":"Xiong","year":"2020","journal-title":"BMC Musculoskelet. Disord."},{"issue":"23","key":"10.1016\/j.biopha.2026.119480_bib185","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1073\/pnas.1206044109","article-title":"Notch controls the magnitude of T helper cell responses by promoting cellular longevity [J]","volume":"109","author":"Helbig","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib186","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13075-019-1990-z","article-title":"JAG2\/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix [J]","volume":"21","author":"Long","year":"2019","journal-title":"Arthritis Res. & Ther."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib187","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1002\/art.30246","article-title":"Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease [J]","volume":"63","author":"Hiyama","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"23","key":"10.1016\/j.biopha.2026.119480_bib188","doi-asserted-by":"crossref","first-page":"16761","DOI":"10.1074\/jbc.M112.446633","article-title":"Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration [J]","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2026.119480_bib189","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1002\/jcp.26385","article-title":"Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration [J]","volume":"233","author":"Zheng","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib190","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1177\/0022034520924656","article-title":"Notch Regulates Fibrocartilage Stem Cell Fate and Is Upregulated in Inflammatory TMJ Arthritis [J]","volume":"99","author":"Ruscitto","year":"2020","journal-title":"J. Dent. Res"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib191","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics [J]","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib192","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112137","article-title":"The PI3K\/AKT pathway promotes fracture healing through its crosstalk with Wnt\/\u03b2-catenin [J]","volume":"394","author":"Dong","year":"2020","journal-title":"Exp. Cell Res"},{"issue":"189","key":"10.1016\/j.biopha.2026.119480_bib193","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.24976\/Discov.Med.202436189.188","article-title":"SIRT2 Alleviates Inflammatory Response, Apoptosis, and ECM Degradation in Osteoarthritic Chondrocytes by Stabilizing PCK1 [J]","volume":"36","author":"Zhong","year":"2024","journal-title":"Discov. Med"},{"issue":"7","key":"10.1016\/j.biopha.2026.119480_bib194","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/jcb.24490","article-title":"Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2\/PI3K signaling [J]","volume":"114","author":"Gui","year":"2013","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.biopha.2026.119480_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101865","article-title":"Polydatin inhibits IL-1\u03b2-mediated chondrocyte inflammation and ameliorates cartilage degradation: Involvement of the NF-\u03baB and Wnt\/\u03b2-catenin pathways [J]","volume":"78","author":"Hu","year":"2022","journal-title":"Tissue Cell"},{"key":"10.1016\/j.biopha.2026.119480_bib196","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111277","article-title":"POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt\/\u03b2-catenin and NF-\u03baB signal pathway in intervertebral disc degeneration [J]","volume":"121","author":"Zhu","year":"2024","journal-title":"Cell Signal"},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib197","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12664","article-title":"miR-640 aggravates intervertebral disc degeneration via NF-\u03baB and WNT signalling pathway [J]","volume":"52","author":"Dong","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.biopha.2026.119480_bib198","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.fct.2013.02.013","article-title":"A 35 kD Phyllanthus niruri protein modulates iron mediated oxidative impairment to hepatocytes via the inhibition of ERKs, p38 MAPKs and activation of PI3k\/Akt pathway [J]","volume":"56","author":"Bhattacharyya","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib199","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cbi.2008.09.006","article-title":"Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappaB pathway: role of a novel plant protein [J]","volume":"177","author":"Ghosh","year":"2009","journal-title":"Chem. Biol. Inter."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107655","article-title":"Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K\/Akt\/NF-kB pathway [J]","volume":"9","author":"Zha","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biopha.2026.119480_bib201","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e31106","article-title":"Poria acid inhibit the growth and metastasis of renal cell carcinoma by inhibiting the PI3K\/akt\/NF-\u03bab signaling pathway [J]","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon"},{"issue":"1-2","key":"10.1016\/j.biopha.2026.119480_bib202","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/ars.2006.8.43","article-title":"Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt\/ERK MAP kinase signaling in pulmonary epithelial cells [J]","volume":"8","author":"Papaiahgari","year":"2006","journal-title":"Antioxid. Redox Signal"},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib203","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1139\/bcb-2020-0641","article-title":"Low-dose lipopolysaccharide protects nerve cells against spinal cord injury via regulating the PI3K-AKT-Nrf2 signaling pathway [J]","volume":"99","author":"Li","year":"2021","journal-title":"Biochem Cell Biol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib204","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/02656736.2016.1155762","article-title":"Punicalagin induces Nrf2 translocation and HO-1 expression via PI3K\/Akt, protecting rat intestinal epithelial cells from oxidative stress [J]","volume":"32","author":"Xu","year":"2016","journal-title":"Int J. Hyperth."},{"key":"10.1016\/j.biopha.2026.119480_bib205","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1016\/j.wneu.2023.05.010","article-title":"N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K\/AKT Signaling Pathway [J]","volume":"176","author":"Yidian","year":"2023","journal-title":"World Neurosurg."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib206","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165575","article-title":"Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2 [J]","volume":"1866","author":"Hua","year":"2020","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2026.119480_bib207","first-page":"880","article-title":"The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases [J]","volume":"24","author":"Jomova","year":"2025","journal-title":"Excli J."},{"key":"10.1016\/j.biopha.2026.119480_bib208","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2018.02.002","article-title":"Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-\u03baB pathways regulated by MAPKs [J]","volume":"288","author":"Pan","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib209","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2174\/011574888X302174240420165019","article-title":"Albiflorin Inhibits Advanced Glycation End Products-Induced ROS and MMP-1 Expression in Gingival Fibroblasts [J]","volume":"20","author":"Gao","year":"2025","journal-title":"Curr. Stem Cell Res Ther."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib210","first-page":"373","article-title":"[Cellular sources of reactive oxygen and nitrogen species. Roles in signal transcription pathways] [J]","volume":"64","author":"Beaudeux J","year":"2006","journal-title":"Ann. Pharm. Fr."},{"issue":"7","key":"10.1016\/j.biopha.2026.119480_bib211","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/jor.25492","article-title":"Procyanidin B2 alleviates oxidative stress-induced nucleus pulposus cells apoptosis through upregulating Nrf2 via PI3K-Akt pathway [J]","volume":"41","author":"Zou","year":"2023","journal-title":"J. Orthop. Res"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib212","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s13365-015-0369-4","article-title":"The immune response in the CNS in Theiler's virus induced demyelinating disease switches from an early adaptive response to a chronic innate-like response [J]","volume":"22","author":"Gilli","year":"2016","journal-title":"J. Neurovirol"},{"key":"10.1016\/j.biopha.2026.119480_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117483","article-title":"Research advances in signaling pathways related to the malignant progression of HSIL to invasive cervical cancer: A review [J]","volume":"180","author":"Wang","year":"2024","journal-title":"Biomed. Pharm."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib214","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.intimp.2014.12.037","article-title":"Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-\u03baB- and MAPK-dependent manner [J]","volume":"24","author":"Reddy","year":"2015","journal-title":"Int Immunopharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib215","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.intimp.2015.02.015","article-title":"Gamma-irradiated resveratrol negatively regulates LPS-induced MAPK and NF-\u03baB signaling through TLR4 in macrophages [J]","volume":"25","author":"Byun","year":"2015","journal-title":"Int Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib216","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41420-022-00856-2","article-title":"Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578 [J]","volume":"8","author":"Yan","year":"2022","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib217","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1051\/medsci\/200723167","article-title":"Innate immunity: structure and function of TLRs] [J]","volume":"23","author":"Delneste","year":"2007","journal-title":"Med Sci. (Paris)"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib218","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clim.2009.07.016","article-title":"Innate immune signals in atherosclerosis [J]","volume":"134","author":"Lundberg","year":"2010","journal-title":"Clin. Immunol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib219","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1074\/jbc.M111.310375","article-title":"Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1\/2-mediated nuclear factor \u03baB activation [J]","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib220","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41583-019-0121-9","article-title":"How the epigenome integrates information and reshapes the synapse [J]","volume":"20","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib221","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/CIRCRESAHA.118.310998","article-title":"Epigenomics: Technologies and Applications [J]","volume":"122","author":"Wang","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2026.119480_bib222","article-title":"Epigenetic Regulation in the Pathogenesis of Rheumatoid Arthritis [J]","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2026.119480_bib223","doi-asserted-by":"crossref","DOI":"10.1177\/25168657231205679","article-title":"Subacute and Chronic Spinal Cord Injury: A Scoping Review of Epigenetics and Secondary Health Conditions [J]","volume":"16","author":"Graves","year":"2023","journal-title":"Epigenetics Insights"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib224","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13072-019-0311-8","article-title":"The role of cigarette smoke-induced epigenetic alterations in inflammation [J]","volume":"12","author":"Zong","year":"2019","journal-title":"Epigenetics & chromatin"},{"key":"10.1016\/j.biopha.2026.119480_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101902","article-title":"Epigenetic modifications of inflammation in intervertebral disc degeneration [J]","volume":"87","author":"Kang","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib226","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41392-023-01331-9","article-title":"Signaling pathways in rheumatoid arthritis: implications for targeted therapy [J]","volume":"8","author":"Ding","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib227","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.765","article-title":"m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency [J]","volume":"12","author":"Li","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119480_bib228","article-title":"SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3-HELZ2\/PPAR\u03b1-HIF1\u03b1 Axis to Drive Intervertebral Disc Degeneration [J]","author":"Fu","year":"2026","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib229","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2026.13823","article-title":"Epigenetic crossroads in intervertebral disc degeneration: Unlocking novel therapeutic avenues (Review) [J]","volume":"33","author":"Hou","year":"2026","journal-title":"Mol. Med Rep."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib230","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/10409238.2022.2088684","article-title":"Hypoxia-regulated microRNAs: the molecular drivers of tumor progression [J]","volume":"57","author":"Sawai","year":"2022","journal-title":"Crit. Rev. Biochem Mol. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib231","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10555-023-10104-3","article-title":"Oncogenic signaling-mediated regulation of chromatin during tumorigenesis [J]","volume":"42","author":"Alam","year":"2023","journal-title":"Cancer Metastas-.-. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib232","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function [J]","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib233","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1947601910393957","article-title":"DNA methylation: superior or subordinate in the epigenetic hierarchy?","volume":"2","author":"Jin","year":"2011","journal-title":"J. ]. Genes & Cancer"},{"key":"10.1016\/j.biopha.2026.119480_bib234","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1302886","article-title":"Epigenetic regulation and therapeutic strategies in ulcerative colitis [J]","volume":"14","author":"Yan","year":"2023","journal-title":"Front. Genet."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222188","article-title":"Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration [J]","volume":"14","author":"Ikuno","year":"2019","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib236","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, inflammation, and metabolic disease [J]","volume":"13","author":"Baker","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2026.119480_bib237","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3389\/fimmu.2018.02167","article-title":"CARD14\/CARMA2 Signaling and its Role in Inflammatory Skin Disorders [J]","volume":"9","author":"Zotti","year":"2018","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib238","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18048","article-title":"DNMT3a-mediated methylation of PPAR\u03b3 promote intervertebral disc degeneration by regulating the NF-\u03baB pathway [J]","volume":"28","author":"Cheng","year":"2024","journal-title":"J. Cell Mol. Med"},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib239","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways [J]","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib240","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/ar4157","article-title":"Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies [J]","volume":"15","author":"Smolders L","year":"2013","journal-title":"Arthritis Res. & Ther."},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib241","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13129","article-title":"Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines [J]","volume":"19","author":"Huang","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.biopha.2026.119480_bib242","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104703","article-title":"Epigenetic histone modulations of PPAR\u03b3 and related pathways contribute to olanzapine-induced metabolic disorders [J]","volume":"155","author":"Su","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib243","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s10753-024-02096-1","article-title":"EZH2-H3K27me3-Mediated Epigenetic Silencing of DKK1 Induces Nucleus Pulposus Cell Pyroptosis in Intervertebral Disc Degeneration by Activating NLRP3 and NAIP\/NLRC4 [J]","volume":"48","author":"Yao","year":"2025","journal-title":"Inflammation"},{"issue":"15","key":"10.1016\/j.biopha.2026.119480_bib244","doi-asserted-by":"crossref","first-page":"16323","DOI":"10.1002\/cam4.6255","article-title":"Recent insights into the SWI\/SNF complex and the molecular mechanism of hSNF5 deficiency in rhabdoid tumors [J]","volume":"12","author":"Kuwahara","year":"2023","journal-title":"Cancer Med"},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib245","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation [J]","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib246","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation [J]","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib247","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yexcr.2017.02.023","article-title":"Sirtuin 6 prevents matrix degradation through inhibition of the NF-\u03baB pathway in intervertebral disc degeneration [J]","volume":"352","author":"Kang","year":"2017","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib248","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2008.10.052","article-title":"SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span [J]","volume":"136","author":"Kawahara","year":"2009","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib249","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1142\/S0192415X24500320","article-title":"Rutaecarpine Alleviates Early Brain Injury-Induced Inflammatory Response Following Subarachnoid Hemorrhage via SIRT6\/NF-[Formula: see text]B Pathway [J]","volume":"52","author":"Xu","year":"2024","journal-title":"Am. J. Chin. Med"},{"key":"10.1016\/j.biopha.2026.119480_bib250","doi-asserted-by":"crossref","DOI":"10.1177\/20417314211021679","article-title":"microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation [J]","volume":"12","author":"Cui","year":"2021","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.biopha.2026.119480_bib251","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cbpa.2020.06.001","article-title":"Domain cross-talk in regulation of histone modifications: Molecular mechanisms and targeting opportunities [J]","volume":"57","author":"Longbotham","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.biopha.2026.119480_bib252","first-page":"245","article-title":"Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases [J]","volume":"55","author":"Zhang","year":"2025","journal-title":"J. Orthop. Transl."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib253","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.cell.2019.10.017","article-title":"The Role of Non-coding RNAs in Oncology [J]","volume":"179","author":"Slack","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2026.119480_bib254","article-title":"Non-Coding RNAs as Novel Regulators of Neuroinflammation in Alzheimer's Disease [J]","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094956","article-title":"Epigenetic Regulation of Neuroinflammation in Parkinson's Disease [J]","volume":"22","author":"Rasheed","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib256","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1007\/s12035-023-03411-x","article-title":"The NF-\u03baB Pathway: a Focus on Inflammatory Responses in Spinal Cord Injury [J]","volume":"60","author":"Ding","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib257","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2217\/rme-2020-0125","article-title":"Research progress on the regulatory role of microRNAs in spinal cord injury [J]","volume":"16","author":"Guo","year":"2021","journal-title":"Regen. Med."},{"key":"10.1016\/j.biopha.2026.119480_bib258","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105520","article-title":"Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications [J]","volume":"170","author":"Lu","year":"2021","journal-title":"Pharm. Res"},{"key":"10.1016\/j.biopha.2026.119480_bib259","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.ircmb.2023.12.001","article-title":"The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications [J]","volume":"386","author":"Shekhar","year":"2024","journal-title":"Int Rev. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib260","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1002\/jcp.29171","article-title":"MicroRNA-181a exerts anti-inflammatory effects via inhibition of the ERK pathway in mice with intervertebral disc degeneration [J]","volume":"235","author":"Sun","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119480_bib261","first-page":"793","article-title":"Overexpression of miR-140-5p inhibits lipopolysaccharide-induced human intervertebral disc inflammation and degeneration by downregulating toll-like receptor 4 [J]","volume":"40","author":"Zhang","year":"2018","journal-title":"Oncol. Rep."},{"issue":"12","key":"10.1016\/j.biopha.2026.119480_bib262","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10123145","article-title":"Hyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey [J]","volume":"10","author":"Lindenmann","year":"2022","journal-title":"Biomedicines"},{"issue":"12","key":"10.1016\/j.biopha.2026.119480_bib263","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1007\/s10072-025-08419-w","article-title":"MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies-advances and challenges [J]","volume":"46","author":"Azam","year":"2025","journal-title":"Neurol. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib264","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2217\/epi-2022-0277","article-title":"Modifications of miRNAs in intervertebral disc degeneration: a key to the future development of genetic-based therapies [J]","volume":"15","author":"Ghaffarpasand","year":"2023","journal-title":"Epigenomics"},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib265","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41419-020-2543-8","article-title":"The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC [J]","volume":"11","author":"Guo","year":"2020","journal-title":"Cell death & Dis."},{"issue":"3","key":"10.1016\/j.biopha.2026.119480_bib266","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.3192","article-title":"The landscape of long noncoding RNAs in the human transcriptome [J]","volume":"47","author":"Iyer","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biopha.2026.119480_bib267","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1480-9222-16-11","article-title":"The functional role of long non-coding RNAs and epigenetics [J]","volume":"16","author":"Cao","year":"2014","journal-title":"Biol. Proced. Online"},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib268","first-page":"2220","article-title":"Long non\u2011coding RNA MALAT1 promotes high glucose\u2011induced rat cartilage endplate cell apoptosis via the p38\/MAPK signalling pathway [J]","volume":"21","author":"Jiang","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib269","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13364-6","article-title":"Long non-coding HCG18 promotes intervertebral disc degeneration by sponging miR-146a-5p and regulating TRAF6 expression [J]","volume":"7","author":"Xi","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib270","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70322","article-title":"Upregulated CEMIP promotes intervertebral disc degeneration via AP-1-mediated change in chromatin accessibility [J]","volume":"15","author":"Shu","year":"2025","journal-title":"Clin. Transl. Med"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib271","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2546670","article-title":"METTL3-mediated m(6)A modification promotes intervertebral disc degeneration [J]","volume":"57","author":"Yang","year":"2025","journal-title":"Ann. Med"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib272","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s41467-022-28990-6","article-title":"WTAP-mediated m(6)A modification of lncRNA NORAD promotes intervertebral disc degeneration [J]","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2026.119480_bib273","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1055808","article-title":"N (6)-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications [J]","volume":"10","author":"Li","year":"2022","journal-title":"Front Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib274","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1016\/j.ymthe.2025.05.021","article-title":"Targeting RNA adenosine editing and modification enzymes for RNA therapeutics [J]","volume":"33","author":"Vlachogiannis","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biopha.2026.119480_bib275","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.actbio.2025.07.033","article-title":"A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration [J]","volume":"203","author":"Wang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2026.119480_bib276","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111024","article-title":"Anionic versus neutral Pt((II)) complexes: The relevance of the charge for human serum albumin binding [J]","volume":"206","author":"Ricciardi","year":"2020","journal-title":"J. Inorg. Biochem"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib277","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41420-025-02515-8","article-title":"ELF1-mediated transactivation of METTL3\/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration [J]","volume":"11","author":"Liu","year":"2025","journal-title":"Cell Death Discov."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib278","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/15592294.2021.1939477","article-title":"Epigenetic Editing in Prostate Cancer: Challenges and Opportunities [J]","volume":"17","author":"Pacheco","year":"2022","journal-title":"Epigenetics"},{"issue":"Pt 4","key":"10.1016\/j.biopha.2026.119480_bib279","article-title":"Lentinan attenuates histone deacetylation of SOCS1 promoter to remodel autophagy via JAK2\/STAT3 pathway for the prevention of intervertebral disc degeneration [J]","volume":"321","author":"Song","year":"2025","journal-title":"Int J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.biopha.2026.119480_bib280","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1002\/jcb.29191","article-title":"Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK\/MAPK axis [J]","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell Biochem"},{"issue":"9","key":"10.1016\/j.biopha.2026.119480_bib281","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1111\/jcmm.14525","article-title":"Down-regulation of insulin-like growth factor binding protein 5 is involved in intervertebral disc degeneration via the ERK signalling pathway [J]","volume":"23","author":"Chen","year":"2019","journal-title":"J. Cell Mol. Med"},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib282","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1186\/s13018-025-06075-6","article-title":"Co-morbid mechanisms of intervertebral disc degeneration and osteoporosis: biomechanical coupling and molecular pathways synergistically driving degenerative lesions [J]","volume":"20","author":"Ling","year":"2025","journal-title":"J. Orthop. Surg. Res"},{"issue":"6","key":"10.1016\/j.biopha.2026.119480_bib283","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/1346-8138.15754","article-title":"Long-term safety of combination treatment with methotrexate and tumor necrosis factor (TNF)-\u03b1 antagonists versus TNF-\u03b1 antagonists alone in psoriatic patients [J]","volume":"48","author":"Hoffmann","year":"2021","journal-title":"J. Dermatol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119480_bib284","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.1076","article-title":"Pathomechanism of intervertebral disc degeneration [J]","volume":"3","author":"Oichi","year":"2020","journal-title":"JOR Spine"},{"key":"10.1016\/j.biopha.2026.119480_bib285","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1120815","article-title":"Epigenetic regulation of stem cells in lung cancer oncogenesis and therapy resistance [J]","volume":"14","author":"Wu","year":"2023","journal-title":"Front Genet"},{"key":"10.1016\/j.biopha.2026.119480_bib286","article-title":"The epigenetic landscape of mesenchymal stem cell and extracellular vesicle therapy [J]","author":"Zhang","year":"2025","journal-title":"Trends Cell Biol."},{"issue":"22","key":"10.1016\/j.biopha.2026.119480_bib287","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216024","article-title":"Enhanced Intervertebral Disc Repair via Genetically Engineered Mesenchymal Stem Cells with Tetracycline Regulatory System [J]","volume":"24","author":"Kim","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2026.119480_bib288","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/jor.25742","article-title":"Glucose depletion decreases cell viability without triggering degenerative changes in a physiological nucleus pulposus explant model [J]","volume":"42","author":"Padrona","year":"2024","journal-title":"J. Orthop. Res"},{"issue":"12","key":"10.1016\/j.biopha.2026.119480_bib289","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acssynbio.7b00246","article-title":"Control of Adipogenic Differentiation in Mesenchymal Stem Cells via Endogenous Gene Activation Using CRISPR-Cas9 [J]","volume":"6","author":"Furuhata","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.biopha.2026.119480_bib290","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2020.101944","article-title":"Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation [J]","volume":"48","author":"Schoger","year":"2020","journal-title":"Stem Cell Res"},{"issue":"4","key":"10.1016\/j.biopha.2026.119480_bib291","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041579","article-title":"Genetic Therapy for Intervertebral Disc Degeneration [J]","volume":"22","author":"Roh","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119480_bib292","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1563635","article-title":"Immune microenvironment in intervertebral disc degeneration: pathophysiology and therapeutic potential [J]","volume":"16","author":"Ren","year":"2025","journal-title":"Front Immunol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119480_bib293","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.7150\/ijbs.17421","article-title":"CRISPR-Cas9: from Genome Editing to Cancer Research [J]","volume":"12","author":"Chen","year":"2016","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.biopha.2026.119480_bib294","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-0716-2679-5_4","article-title":"CRISPR Gene Editing of Hematopoietic Stem and Progenitor Cells [J]","volume":"2567","author":"Shahbazi","year":"2023","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.biopha.2026.119480_bib295","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11082168","article-title":"Progress and Prospects of Gene Editing in Pluripotent Stem Cells [J]","volume":"11","author":"Zhang","year":"2023","journal-title":"Biomedicines"},{"issue":"186","key":"10.1016\/j.biopha.2026.119480_bib296","doi-asserted-by":"crossref","DOI":"10.3791\/64064","article-title":"CRISPR\/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications [J]","author":"Venkatesan","year":"2022","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.biopha.2026.119480_bib297","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exphem.2021.12.399","article-title":"Hematopoietic stem cell gene editing and expansion: State-of-the-art technologies and recent applications [J]","volume":"107","author":"Haltalli","year":"2022","journal-title":"Exp. Hematol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226005160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226005160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:49:58Z","timestamp":1787438998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226005160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":297,"alternative-id":["S0753332226005160"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119480","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk of pathogenic signaling pathways in intervertebral disc degeneration: Epigenetic regulation and therapeutic implications","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119480"}}