{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:46:06Z","timestamp":1794008766792,"version":"4.8.0"},"reference-count":375,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007052","name":"University of Verona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.biopha.2026.119607","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:59:47Z","timestamp":1781672387000},"page":"119607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Unifying and unique roles of non-coding RNA biomarkers in liver and heart fibrosis"],"prefix":"10.1016","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4633-6058","authenticated-orcid":false,"given":"Veronika","family":"Boichenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Frolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Voellenkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germana","family":"Zaccagnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Paolo","family":"Bassareo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Luciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gorelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-7738","authenticated-orcid":false,"given":"Fabio","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2026.119607_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2026.119607_bib2","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib4","article-title":"The cardiohepatic axis in metabolic disease: liver to heart","volume":"10","author":"Hakeem","year":"2025","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115665","article-title":"The liver in heart failure: from biomarkers to clinical risk","volume":"24","author":"Aspromonte","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2018.11.050","article-title":"Nonalcoholic fatty liver disease and the heart: JACC state-of-the-art review","volume":"73","author":"Stahl","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-023-04690-7","article-title":"The impact of fibrotic diseases on global mortality from 1990 to 2019","volume":"21","author":"Mutsaers","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cells14070553","article-title":"Circulating non-coding RNAs as indicators of fibrosis and heart failure severity","volume":"14","author":"Boichenko","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.125.326799","article-title":"Interleukin 11-induced microRNAs as functional mediators and circulating biomarkers of cardiac fibrosis","volume":"138","author":"Tikhomirov","year":"2026","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib11","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jacc.2020.11.044","article-title":"Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction","volume":"77","author":"Frisk","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010242","article-title":"Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding","volume":"9","author":"Simmonds","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib14","article-title":"Association between matrix metalloproteinase-9 and worsening heart failure events in patients with chronic heart failure","volume":"4","author":"Morishita","year":"2017","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2016.07.150","article-title":"Differences in biochemical and genetic biomarkers in patients with heart failure of various etiologies","volume":"221","author":"Bielecka-Dabrowa","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119671","article-title":"Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities","volume":"24","author":"Pei","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151736","article-title":"Extracellular matrix molecular remodeling in human liver fibrosis evolution","volume":"11","author":"Baiocchini","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib18","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v22.i4.1348","article-title":"Hepatic non-parenchymal cells: master regulators of alcoholic liver disease?","volume":"22","author":"Seo","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2026.119607_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","volume":"20","author":"Hammerich","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147873","article-title":"Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells","volume":"25","author":"Akk\u0131z","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib21","doi-asserted-by":"crossref","DOI":"10.21037\/tgh.2020.02.21","article-title":"Fibrosis and hepatic regeneration mechanism","volume":"7","author":"Zu\u00f1iga-Aguilar","year":"2022","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib22","doi-asserted-by":"crossref","DOI":"10.1007\/s43152-021-00030-3","article-title":"Extracellular matrix remodeling in chronic liver disease","volume":"2","author":"Ortiz","year":"2021","journal-title":"Curr. Tissue Microenviron. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41569-026-01257-z","article-title":"HFpEF and MASLD: converging mechanisms and clinical implications","author":"Capone","year":"2026","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.125.325492","article-title":"Decoding the liver-heart axis in cardiometabolic diseases","volume":"136","author":"Capone","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s12968-018-0511-6","article-title":"The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction: a cardiovascular magnetic resonance study","volume":"20","author":"Mahmod","year":"2018","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.biopha.2026.119607_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.630","article-title":"Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and meta-analysis","volume":"18","author":"Gorter","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000560","article-title":"Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association","volume":"137","author":"Konstam","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2026.119607_bib28","doi-asserted-by":"crossref","DOI":"10.3909\/ricm0602","article-title":"Contribution of right ventricular dysfunction to heart failure mortality: a meta-analysis","volume":"13","author":"Iglesias-Garriz","year":"2012","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030567","article-title":"Relationship between heart disease and liver disease: a two-way street","volume":"9","author":"El Hadi","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib30","article-title":"From congestive hepatopathy to hepatocellular carcinoma, how can we improve patient management","volume":"3","author":"Sessa","year":"2021","journal-title":"JHEP Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib31","doi-asserted-by":"crossref","DOI":"10.1053\/jhep.2003.50062","article-title":"Cardiac hepatopathy: clinical, hemodynamic, and histologic characteristics and correlations","volume":"37","author":"Myers","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehy620","article-title":"The clinical spectrum of Fontan-associated liver disease: Results from a prospective multimodality screening cohort","volume":"40","author":"Munsterman","year":"2019","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biopha.2026.119607_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/jmri.25126","article-title":"Evaluation of liver stiffness with magnetic resonance elastography in patients with constrictive pericarditis: preliminary findings","volume":"44","author":"Fenstad","year":"2016","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.biopha.2026.119607_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/thx.26.3.240","article-title":"Surgical repair of tricuspid atresia","volume":"26","author":"Fontan","year":"1971","journal-title":"Thorax"},{"key":"10.1016\/j.biopha.2026.119607_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2020-001434","article-title":"Myocardial fibrosis, diastolic dysfunction and elevated liver stiffness in the Fontan circulation","volume":"7","author":"Alsaied","year":"2020","journal-title":"Open Heart"},{"key":"10.1016\/j.biopha.2026.119607_bib36","doi-asserted-by":"crossref","DOI":"10.1097\/SLA.0000000000005581","article-title":"Evaluation of fontan-associated liver disease and ethnic disparities in long-term survivors of the fontan procedure: a population-based study","volume":"276","author":"Emamaullee","year":"2022","journal-title":"Ann. Surg."},{"key":"10.1016\/j.biopha.2026.119607_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/0016-5085(78)90853-3","article-title":"Incidence and clinical significance of sinusoidal dilatation in liver biopsies","volume":"75","author":"Bruguera","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2026.119607_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics15212774","article-title":"Diagnosis of portal hypertension","volume":"15","author":"M\u00f8ller","year":"2025","journal-title":"Diagnostics"},{"key":"10.1016\/j.biopha.2026.119607_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12020516","article-title":"Cardiac hepatopathy: new perspectives on old problems through a prism of endogenous metabolic regulations by hepatokines","volume":"12","author":"Berezin","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.biopha.2026.119607_bib40","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002553","article-title":"Identification of a novel heart-liver axis: matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate lipid metabolism and inflammation in the liver","volume":"4","author":"Hernandez-Anzaldo","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.biopha.2026.119607_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41569-020-0433-5","article-title":"Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications","volume":"18","author":"Matyas","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib42","doi-asserted-by":"crossref","DOI":"10.1177\/20420188221145549","article-title":"MAFLD: a multisystem disease","volume":"14","author":"Pipitone","year":"2023","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2026.119607_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-023-01842-3","article-title":"Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems","volume":"22","author":"Spinetti","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.biopha.2026.119607_bib44","article-title":"Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure","volume":"377","author":"Cao","year":"2022","journal-title":"Science (1979)"},{"key":"10.1016\/j.biopha.2026.119607_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade4110","article-title":"An IL-6\/STAT3\/MR\/FGF21 axis mediates heart-liver cross-talk after myocardial infarction","volume":"9","author":"Sun","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biopha.2026.119607_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.125.326264","article-title":"Cell type\u2013specific secretome analysis reveals liver-heart crosstalk in HFpEF","volume":"136","author":"Sch\u00fctte","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.15420\/cfr.2018.27.2","article-title":"Biomarkers in routine heart failure clinical care","volume":"5","author":"Nadar","year":"2019","journal-title":"Card. Fail. Rev."},{"key":"10.1016\/j.biopha.2026.119607_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20112629","article-title":"Natriuretic peptides in heart failure with preserved left ventricular ejection fraction: from molecular evidences to clinical implications","volume":"20","author":"Tanase","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib49","doi-asserted-by":"crossref","DOI":"10.1007\/s11897-024-00684-8","article-title":"Biomarkers of hemodynamic congestion in heart failure","volume":"21","author":"Brann","year":"2024","journal-title":"Curr. Heart Fail. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib50","article-title":"Higher BNP\/NT-pro BNP levels stratify prognosis equally well in patients with and without heart failure: a meta-analysis","volume":"9","author":"Hendricks","year":"2022","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/eurjhf\/hfq210","article-title":"Serial changes in high-sensitive troponin i predict outcome in patients with decompensated heart failure","volume":"13","author":"Xue","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib52","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.117.031560","article-title":"Prognostic value of high-sensitivity troponin T in chronic heart failure an individual patient data meta-analysis","volume":"137","author":"Aimo","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2026.119607_bib53","doi-asserted-by":"crossref","DOI":"10.1080\/08037051.2019.1645587","article-title":"Relation of the renin\u2013angiotensin\u2013aldosterone system with potential cardiac injury and remodelling: the SABPA study","volume":"29","author":"Gafane-Matemane","year":"2020","journal-title":"Blood Press."},{"key":"10.1016\/j.biopha.2026.119607_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/biom11020166","article-title":"Galectin-3 and sst2 as prognosticators for heart failure requiring extracorporeal life support: Jack N\u2019 Jill","volume":"11","author":"Bi","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.biopha.2026.119607_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjcard.2016.09.019","article-title":"Meta-analysis of the usefulness of plasma galectin-3 to predict the risk of mortality in patients with heart failure and in the general population","volume":"119","author":"Imran","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib56","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/jpcs.jpcs_19_23","article-title":"A narrative review on serum biomarkers of cardiac fibrosis","volume":"9","author":"Kumari","year":"2023","journal-title":"J. Pract. Cardiovasc. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.926378","article-title":"Detection of myocardial fibrosis: where we stand","volume":"9","author":"Zhu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/S2468-1253(23)00017-1","article-title":"Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study","volume":"8","author":"Vali","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib59","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2018-317593","article-title":"Advances in non-invasive assessment of hepatic fibrosis","volume":"69","author":"Loomba","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2026.119607_bib60","doi-asserted-by":"crossref","DOI":"10.3904\/kjim.2017.317","article-title":"Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension","volume":"33","author":"Shim","year":"2018","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib61","doi-asserted-by":"crossref","DOI":"10.1111\/liv.14498","article-title":"Non-invasive detection of portal hypertension by enhanced liver fibrosis score in patients with different aetiologies of advanced chronic liver disease","volume":"40","author":"Simbrunner","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.biopha.2026.119607_bib62","doi-asserted-by":"crossref","DOI":"10.1097\/MEG.0000000000001385","article-title":"Serum cytokeratin-18 and its relation to liver fibrosis and steatosis diagnosed by FibroScan and controlled attenuation parameter in nonalcoholic fatty liver disease and hepatitis C virus patients","volume":"31","author":"Darweesh","year":"2019","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib63","doi-asserted-by":"crossref","DOI":"10.1080\/00365521.2017.1392596","article-title":"PRO-C3: a new and more precise collagen marker for liver fibrosis in patients with chronic hepatitis C","volume":"53","author":"Hansen","year":"2018","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.biopha.2026.119607_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12111073","article-title":"Nonalcoholic fatty liver disease\u2014a concise review of noninvasive tests and biomarkers","volume":"12","author":"Bassal","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.biopha.2026.119607_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2023.04.002","article-title":"Using the ELF test, FIB-4 and NAFLD fibrosis score to screen the population for liver disease","volume":"79","author":"Kjaergaard","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9121920","article-title":"Systematic review with meta-analysis: diagnostic accuracy of pro-c3 for hepatic fibrosis in patients with non-alcoholic fatty liver disease","volume":"9","author":"Mak","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.biopha.2026.119607_bib67","doi-asserted-by":"crossref","DOI":"10.1007\/s10238-024-01423-y","article-title":"Serum cytokeratin-18 levels as a prognostic biomarker in advanced liver disease: a comprehensive meta-analysis","volume":"24","author":"Zhang","year":"2024","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib68","article-title":"Serum\/plasma proteome in non-malignant liver disease","volume":"25","author":"Fu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib69","doi-asserted-by":"crossref","DOI":"10.1007\/s00246-012-0315-7","article-title":"The precarious state of the liver after a fontan operation: summary of a multidisciplinary symposium","volume":"33","author":"Rychik","year":"2012","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib70","doi-asserted-by":"crossref","DOI":"10.1053\/jhep.2001.22172","article-title":"A model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib71","doi-asserted-by":"crossref","DOI":"10.1007\/s00246-016-1428-1","article-title":"MELD-XI scores correlate with post-fontan hepatic biopsy fibrosis scores","volume":"37","author":"Evans","year":"2016","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/lt.20906","article-title":"MELD-XI: a rational approach to \u201cSickest first\u201d liver transplantation in cirrhotic patients requiring anticoagulant therapy","volume":"13","author":"Heuman","year":"2007","journal-title":"Liver Transplant."},{"key":"10.1016\/j.biopha.2026.119607_bib73","article-title":"Non-invasive biomarkers of Fontan-associated liver disease","volume":"3","author":"Emamaullee","year":"2021","journal-title":"JHEP Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib74","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000580","article-title":"Clinical predictors and noninvasive imaging in Fontan-associated liver disease: a systematic review and meta-analysis","volume":"8","author":"Seol","year":"2024","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.biopha.2026.119607_bib75","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/cit245","article-title":"Noninvasive serum fibrosis markers for screening and staging chronic hepatitis C virus patients in a large US cohort","volume":"57","author":"Holmberg","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/sj.ejhg.5201459","article-title":"The amazing complexity of the human transcriptome","volume":"13","author":"Frith","year":"2005","journal-title":"Eur. J. Human. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41576-018-0017-y","article-title":"Towards a complete map of the human long non-coding RNA transcriptome","volume":"19","author":"Uszczynska-Ratajczak","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib78","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv940","article-title":"CircNet: a database of circular RNAs derived from transcriptome sequencing data","volume":"44","author":"Liu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biopha.2026.119607_bib79","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1016\/j.cell.2024.10.024","article-title":"Small and long non-coding RNAs: past, present, and future","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2026.119607_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111430","article-title":"Noncoding RNA network crosstalk in organ fibrosis","volume":"124","author":"Ling","year":"2024","journal-title":"Cell Signal."},{"key":"10.1016\/j.biopha.2026.119607_bib81","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvab117","article-title":"Dissecting the transcriptome in cardiovascular disease","volume":"118","author":"Robinson","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib82","article-title":"Regulatory RNAs in heart failure","volume":"141","author":"da Costa Gomes","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2026.119607_bib83","article-title":"Plasma miR-22-5p, miR-132-5p, and miR-150-3p are associated with acute myocardial infarction","volume":"2019","author":"Li","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.biopha.2026.119607_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2013.09.041","article-title":"Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy","volume":"63","author":"Roncarati","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib85","article-title":"Serum miR-21 correlates with the histological stage of chronic hepatitis B-associated liver fibrosis","volume":"12","author":"Wu","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biopha.2026.119607_bib86","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/eurjhf\/hfr155","article-title":"Serum levels of microRNAs in patients with heart failure","volume":"14","author":"Goren","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib87","article-title":"Diagnostic potential and pathogenic performance of circulating miR-146b, miR-194, and miR-214 in liver fibrosis","volume":"8","author":"Aghajanzadeh","year":"2023","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.biopha.2026.119607_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.223","article-title":"Critical effects of long non-coding RNA on fibrosis diseases","volume":"50","author":"Zhang","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib89","article-title":"The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis","volume":"9","author":"Jiang","year":"2024","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.biopha.2026.119607_bib90","doi-asserted-by":"crossref","DOI":"10.1002\/poh2.56","article-title":"MicroRNAs as critical regulators in liver fibrosis","volume":"2","author":"Wang","year":"2023","journal-title":"Portal Hypertens. Cirrhosis"},{"key":"10.1016\/j.biopha.2026.119607_bib91","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvab327","article-title":"Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: a position paper from the EU-CardioRNA COST action CA17129","volume":"118","author":"Vanhaverbeke","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan microRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2026.119607_bib93","doi-asserted-by":"crossref","DOI":"10.1038\/nrg2455","article-title":"Biological principles of microRNA-mediated regulation: Shared themes amid diversity","volume":"9","author":"Flynt","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib94","article-title":"Large-scale screens of miRNA-mRNA interactions unveiled that the 3\u2032UTR of a gene is targeted by multiple miRNAs","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062589","article-title":"Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer","volume":"8","author":"Hashimoto","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib96","doi-asserted-by":"crossref","DOI":"10.1002\/ame2.70076","article-title":"Advances in miRNA research: unraveling the complexities of gene regulation","volume":"8","author":"Zheng","year":"2025","journal-title":"Anim. Model. Exp. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib97","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28854-4","article-title":"Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers","volume":"8","author":"L\u00f3pez-Riera","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-00070-6","article-title":"Serum microRNA-1 and microRNA-133a levels reflect myocardial steatosis in uncomplicated type 2 diabetes","volume":"7","author":"De Gonzalo-Calvo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib99","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153497","article-title":"Association of circulating serum MIR-34a and MIR-122 with dyslipidemia among patients with non-alcoholic fatty liver disease","volume":"11","author":"Salvoza","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2013.03.014","article-title":"MicroRNA-21 activates hepatic stellate cells via PTEN\/Akt signaling","volume":"67","author":"Wei","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2026.119607_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/labinvest.2010.126","article-title":"Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans","volume":"90","author":"Marquez","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.biopha.2026.119607_bib102","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00346.2014","article-title":"Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis","volume":"308","author":"Dattaroy","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib103","article-title":"MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2012.08.019","article-title":"A novel reciprocal loop between microRNA-21 and TGF\u03b2RIII is involved in cardiac fibrosis","volume":"44","author":"Liang","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib105","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-017-0520-7","article-title":"miR-21 enhances cardiac fibrotic remodeling and fibroblast proliferation via CADM1\/STAT3 pathway","volume":"17","author":"Cao","year":"2017","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.biopha.2026.119607_bib106","article-title":"miR-21 promotes cardiac fibroblast-to-myofibroblast transformation and myocardial fibrosis by targeting Jagged1","volume":"22","author":"liang Zhou","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib107","doi-asserted-by":"crossref","DOI":"10.2147\/JIR.S285714","article-title":"Microrna-21 mediates a positive feedback on angiotensin ii-induced myofibroblast transformation","volume":"13","author":"Li","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib108","doi-asserted-by":"crossref","DOI":"10.1080\/15384101.2021.1875665","article-title":"LncRNA Neat1 expedites the progression of liver fibrosis in mice through targeting miR-148a-3p and miR-22-3p to upregulate Cyth3","volume":"20","author":"Huang","year":"2021","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biopha.2026.119607_bib109","doi-asserted-by":"crossref","DOI":"10.1177\/15353702221108379","article-title":"MiR-22-3p and miR-29a-3p synergistically inhibit hepatic stellate cell activation by targeting AKT3","volume":"247","author":"Wang","year":"2022","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib110","doi-asserted-by":"crossref","DOI":"10.1159\/000430276","article-title":"MiR-22 suppresses BMP7 in the development of cirrhosis","volume":"36","author":"Ji","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib111","doi-asserted-by":"crossref","DOI":"10.1159\/000487732","article-title":"Abnormal downregulation of caveolin-3 mediates the pro-fibrotic action of microRNA-22 in a model of myocardial infarction","volume":"45","author":"Zhang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib112","article-title":"MiR-30b-5p and miR-22-3p restrain the fibrogenesis of post-myocardial infarction in mice via targeting PTAFR","volume":"24","author":"Zhao","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib113","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-012-9407-9","article-title":"MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart","volume":"35","author":"Jazbutyte","year":"2013","journal-title":"Age"},{"key":"10.1016\/j.biopha.2026.119607_bib114","doi-asserted-by":"crossref","DOI":"10.1159\/000453187","article-title":"MiR-22 may suppress fibrogenesis by targeting TGF\u03b2R i in cardiac fibroblasts","volume":"40","author":"Hong","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib115","article-title":"MiR-22 inhibits myocardial fibrosis in rats with myocardial infarction by targeting PTEN\/Akt\/mTOR signaling pathway","volume":"70","author":"Li","year":"2024","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178107","article-title":"MicroRNA-29a attenuates inflammation and fibrosis in an animal model of NASH through MCJ inhibition and hippo pathway regulation","volume":"1005","author":"Yang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib117","article-title":"microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K\/AKT pathway","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2026.119607_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01737-4","article-title":"Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling","volume":"8","author":"Sassi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2026.119607_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2017.07.004","article-title":"Activation of AMPK attenuated cardiac fibrosis by inhibiting CDK2 via p21\/p27 and miR-29 family pathways in rats","volume":"8","author":"Qi","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biopha.2026.119607_bib120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158657","article-title":"Activation of the miR-34a\/SIRT1\/p53 signaling pathway contributes to the progress of liver fibrosis via inducing apoptosis in hepatocytes but not in HSCs","volume":"11","author":"Tian","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2018.03.005","article-title":"MiR-34a\/miR-93 target c-Ski to modulate the proliferaton of rat cardiac fibroblasts and extracellular matrix deposition in vivo and in vitro","volume":"46","author":"Zhang","year":"2018","journal-title":"Cell Signal."},{"key":"10.1016\/j.biopha.2026.119607_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2012.11.011","article-title":"MiR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression","volume":"58","author":"Li","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib123","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.3652","article-title":"Identification of a novel TGF-\u03b2-miR-122-fibronectin 1\/serum response factor signaling cascade and its implication in hepatic fibrogenesis","volume":"6","author":"Zeng","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2026.119607_bib124","doi-asserted-by":"crossref","DOI":"10.1172\/JCI63455","article-title":"MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis","volume":"122","author":"Tsai","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2026.119607_bib125","doi-asserted-by":"crossref","DOI":"10.1007\/s12265-022-10214-3","article-title":"MicroRNA-122-5p aggravates angiotensin II-mediated myocardial fibrosis and dysfunction in hypertensive rats by regulating the elabela\/apelin-APJ and ACE2-GDF15-porimin signaling","volume":"15","author":"Song","year":"2022","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib126","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.21928","article-title":"Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p\/155-5p expressions","volume":"83","author":"Wang","year":"2022","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib127","doi-asserted-by":"crossref","DOI":"10.1042\/CS20130538","article-title":"microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-\u03b21 up-regulation","volume":"126","author":"Beaumont","year":"2014","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2012.11.022","article-title":"MiR-133a mediates TGF-\u03b2-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis","volume":"58","author":"Roderburg","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib129","doi-asserted-by":"crossref","first-page":"235","DOI":"10.61186\/ibj.4357","article-title":"Unraveling the exosome-miR-133a axis: targeting TGF-\u03b2 signaling via WJ-MSC-derived exosomes for anti-fibrotic therapy in liver fibrosis","volume":"28","author":"Saki","year":"2024","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.biopha.2026.119607_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109842","article-title":"Pentoxifylline alleviated cardiac injury via modulating the cardiac expression of lncRNA-00654-miR-133a-SOX5 mRNA in the rat model of ischemia-reperfusion","volume":"124","author":"Matboli","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2026.119607_bib131","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.12218","article-title":"Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes","volume":"18","author":"Chen","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib132","article-title":"Role of MIR-133a in regulating TGF-\u03b21 signaling pathway in myocardial fibrosis after acute myocardial infarction in rats","volume":"23","author":"Yu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174587","article-title":"MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet","volume":"912","author":"Zhao","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib134","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1186\/s12967-025-06880-x","article-title":"Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation","volume":"23","author":"Zhao","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib135","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-0752-1","article-title":"MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression","volume":"9","author":"Ma","year":"2018","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib136","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00140.2015","article-title":"Suppression of fibrogenic signaling in hepatic stellate cells by twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of twist1","volume":"309","author":"Chen","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib137","doi-asserted-by":"crossref","DOI":"10.1042\/CS20190203","article-title":"The deficiency of MIR-214-3p exacerbates cardiac fibrosis via MIR-214-3p\/NLRC5 axis","volume":"133","author":"Yang","year":"2019","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib138","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.13048","article-title":"Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts","volume":"7","author":"Zhu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2026.119607_bib139","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-1029-4","article-title":"Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy","volume":"9","author":"Yang","year":"2018","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib140","doi-asserted-by":"crossref","DOI":"10.1007\/s13577-021-00653-6","article-title":"The miR-214-3p\/c-Ski axis modulates endothelial\u2013mesenchymal transition in human coronary artery endothelial cells in vitro and in mice model in vivo","volume":"35","author":"Wang","year":"2022","journal-title":"Hum. Cell"},{"key":"10.1016\/j.biopha.2026.119607_bib141","doi-asserted-by":"crossref","DOI":"10.1172\/JCI59327","article-title":"MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca 2+ overload and cell death","volume":"122","author":"Aurora","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2026.119607_bib142","doi-asserted-by":"crossref","DOI":"10.1002\/ar.23396","article-title":"MicroRNA-214 exerts a cardio-protective effect by inhibition of fibrosis","volume":"299","author":"Dong","year":"2016","journal-title":"Anat. Rec."},{"key":"10.1016\/j.biopha.2026.119607_bib143","doi-asserted-by":"crossref","DOI":"10.1038\/srep18351","article-title":"MicroRNA-214 mediates isoproterenol-induced proliferation and collagen synthesis in cardiac fibroblasts","volume":"5","author":"Sun","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib144","article-title":"Long noncoding RNAs in cardiac development and ageing","volume":"12","author":"Devaux","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib145","doi-asserted-by":"crossref","DOI":"10.1101\/gr.6036807","article-title":"Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs","volume":"17","author":"Ponjavic","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.biopha.2026.119607_bib146","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib147","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ncrna.2025.01.004","article-title":"Long non-coding RNAs in humans: classification, genomic organization and function","volume":"11","author":"Chodurska","year":"2025","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.biopha.2026.119607_bib148","article-title":"Long non-coding RNA HOTAIR mediates the switching of histone H3 lysine 27 acetylation to methylation to promote epithelial-to-mesenchymal transition in gastric cancer","volume":"54","author":"Song","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biopha.2026.119607_bib149","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1803725115","article-title":"Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells","volume":"115","author":"Ahmed","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2026.119607_bib150","doi-asserted-by":"crossref","DOI":"10.1038\/ng.3673","article-title":"An inducible long noncoding RNA amplifies DNA damage signaling","volume":"48","author":"Schmitt","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib151","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20123079","article-title":"Long noncoding competing endogenous RNA networks in age-associated cardiovascular diseases","volume":"20","author":"Greco","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib152","article-title":"MIAT is a pro-fibrotic long non-coding RNA governing cardiac fibrosis in post-infarct myocardium","volume":"7","author":"Qu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib153","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.117.310624","article-title":"Inhibition of the cardiac fibroblast-enriched lncRNA Meg3 prevents cardiac fibrosis and diastolic dysfunction","volume":"121","author":"Piccoli","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib154","doi-asserted-by":"crossref","DOI":"10.7150\/thno.20846","article-title":"LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d","volume":"8","author":"Liang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2026.119607_bib155","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-021-00854-y","article-title":"SAIL: a new conserved anti-fibrotic lncRNA in the heart","volume":"116","author":"Luo","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib156","article-title":"LncRNA H19: a novel biomarker in cardiovascular disease","volume":"40","author":"Li","year":"2024","journal-title":"Acta Cardiol. Sin."},{"key":"10.1016\/j.biopha.2026.119607_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109208","article-title":"Long non-coding RNAs H19, MALAT1 and MIAT as potential novel biomarkers for diagnosis of acute myocardial infarction","volume":"118","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2026.119607_bib158","article-title":"Lncrna malat1: a potential fibrosis biomarker and therapeutic target","volume":"11","author":"Li","year":"2021","journal-title":"Crystals"},{"key":"10.1016\/j.biopha.2026.119607_bib159","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.734643","article-title":"Long Non-coding RNA MALAT1: a key player in liver diseases","volume":"8","author":"Lu","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib160","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.27656","article-title":"H19\/miR-148a\/USP4 axis facilitates liver fibrosis by enhancing TGF-\u03b2 signaling in both hepatic stellate cells and hepatocytes","volume":"234","author":"Zhu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib161","doi-asserted-by":"crossref","DOI":"10.1038\/s41401-023-01145-z","article-title":"LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles","volume":"44","author":"Li","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2026.119607_bib162","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2018.07.013","article-title":"DNMT1 controls LncRNA H19\/ERK signal pathway in hepatic stellate cell activation and fibrosis","volume":"295","author":"Yang","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2026.119607_bib163","doi-asserted-by":"crossref","DOI":"10.14348\/molcells.2021.0066","article-title":"LncRNA H19 drives proliferation of cardiac fibroblasts and collagen production via suppression of the miR-29a-3p\/miR-29b-3pVEGFA\/TGF-\u03b2 axis","volume":"45","author":"Guo","year":"2022","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2016.05.005","article-title":"Long noncoding RNA H19 controls DUSP5\/ERK1\/2 axis in cardiac fibroblast proliferation and fibrosis","volume":"25","author":"Tao","year":"2016","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.biopha.2026.119607_bib165","doi-asserted-by":"crossref","DOI":"10.1089\/dna.2017.3799","article-title":"Long Noncoding RNA H19 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-455 in cardiac fibrosis","volume":"36","author":"Huang","year":"2017","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib166","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-1068-x","article-title":"LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212","volume":"9","author":"Yu","year":"2018","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174462","article-title":"LncRNA MEG3 reverses CCl4-induced liver fibrosis by targeting NLRC5","volume":"911","author":"Wu","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib168","article-title":"Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis","volume":"1842","author":"He","year":"2014","journal-title":"Boichim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib169","article-title":"lncRNA MEG3 modulates hepatic stellate cell activation by sponging miR-145 to regulate PPAR\u03b3","volume":"25","author":"Qin","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib170","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-022-00889-7","article-title":"LncRNA MEG3 up-regulates SIRT6 by ubiquitinating EZH2 and alleviates nonalcoholic fatty liver disease","volume":"8","author":"Zou","year":"2022","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.biopha.2026.119607_bib171","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2023.2224607","article-title":"Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure","volume":"28","author":"Mi","year":"2023","journal-title":"Redox Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib172","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1538059","article-title":"LncRNA MEG3 exacerbates diabetic cardiomyopathy via activating pyroptosis signaling pathway","volume":"16","author":"Zhuo","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib173","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.5048","article-title":"MALAT1 promotes liver fibrosis by sponging miR-181a and activating TLR4-NF-\u03baB signaling","volume":"48","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib174","doi-asserted-by":"crossref","DOI":"10.1080\/15384101.2015.1120917","article-title":"Malat1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis","volume":"14","author":"Yu","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biopha.2026.119607_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.trsl.2017.09.001","article-title":"Altered expression of MALAT1 lncRNA in nonalcoholic steatohepatitis fibrosis regulates CXCL5 in hepatic stellate cells","volume":"190","author":"Leti","year":"2017","journal-title":"Transl. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib176","article-title":"Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model","volume":"234","author":"Huang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib177","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201902692R","article-title":"Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1\/miR-141-mediated NLRP3 inflammasome and TGF-\u03b21\/Smads signaling in diabetic cardiomyopathy","volume":"34","author":"Che","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2026.119607_bib178","doi-asserted-by":"crossref","DOI":"10.1007\/s00109-017-1586-5","article-title":"NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6","volume":"95","author":"Yu","year":"2017","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib179","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-021-00632-8","article-title":"miR-139-5p sponged by LncRNA NEAT1 regulates liver fibrosis via targeting \u03b2-catenin\/SOX9\/TGF-\u03b21 pathway","volume":"7","author":"Wang","year":"2021","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.biopha.2026.119607_bib180","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.563265","article-title":"Downregulated microRNA-129-5p by long non-coding RNA NEAT1 upregulates PEG3 expression to aggravate non-alcoholic steatohepatitis","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib181","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116902","article-title":"The lncRNA NEAT1\/miR-29b\/Atg9a axis regulates IGFBPrP1-induced autophagy and activation of mouse hepatic stellate cells","volume":"237","author":"Kong","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib182","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-021-03211-8","article-title":"Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter region","volume":"20","author":"Ge","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib183","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3390\/toxics12120883","article-title":"Circ_0000284 is involved in arsenite-induced hepatic insulin resistance through blocking the plasma membrane translocation of GLUT4 in hepatocytes via IGF2BP2\/PPAR-\u03b3","volume":"12","author":"Xu","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.biopha.2026.119607_bib184","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.9796","article-title":"CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p\/TGF-\u03b22 axis under hypoxia","volume":"8","author":"Liu","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.biopha.2026.119607_bib185","doi-asserted-by":"crossref","DOI":"10.1261\/rna.035667.112","article-title":"Circular RNAs are abundant, conserved, and associated with ALU repeats","volume":"19","author":"Jeck","year":"2013","journal-title":"RNA"},{"key":"10.1016\/j.biopha.2026.119607_bib186","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-020-0243-y","article-title":"The expanding regulatory mechanisms and cellular functions of circular RNAs","volume":"21","author":"Chen","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib187","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-04262-3","article-title":"Mechanisms of circular RNA degradation","volume":"5","author":"Ren","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib188","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113454","article-title":"Circular RNAs in muscle function and disease","volume":"19","author":"Greco","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib189","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ajg.2024.11.003","article-title":"Correlation of local and serum CircHIPK3 expressions with the progression of liver fibrosis\/cirrhosis","volume":"26","author":"Hou","year":"2025","journal-title":"Arab. J. Gastroenterol."},{"key":"10.1016\/j.biopha.2026.119607_bib190","article-title":"Circular RNA regulatory role in pathological cardiac remodelling","author":"Bibi","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib191","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.13789","article-title":"Circular RNAs: methodological challenges and perspectives in cardiovascular diseases","volume":"22","author":"Carrara","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib192","article-title":"Targeting circular RNAs as a therapeutic approach: current strategies and challenges","volume":"6","author":"He","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib193","article-title":"CircHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma","volume":"9","author":"Chen","year":"2018","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib194","doi-asserted-by":"crossref","DOI":"10.7150\/ijbs.36149","article-title":"Circ-hipk3 strengthens the effects of adrenaline in heart failure by mir-17-3p-adcy6 axis","volume":"15","author":"Deng","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib195","doi-asserted-by":"crossref","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2026.119607_bib196","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1820","article-title":"Regulation of microRNA by circular RNA","volume":"15","author":"Singh","year":"2024","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.biopha.2026.119607_bib197","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-023-01051-1","article-title":"CircRNAs: versatile players and new targets in organ fibrosis","volume":"21","author":"Wei","year":"2023","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.biopha.2026.119607_bib198","article-title":"Overview of circRNAs roles and mechanisms in liver fibrosis","volume":"13","author":"Wang","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.biopha.2026.119607_bib199","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020561","article-title":"Challenges in using circulating micro-rnas as biomarkers for cardiovascular diseases","volume":"21","author":"Felekkis","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024145","article-title":"Haemolysis during sample preparation alters microRNA content of plasma","volume":"6","author":"Kirschner","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib201","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2010.157198","article-title":"Analysis of circulating microRNA: preanalytical and analytical challenges","volume":"57","author":"McDonald","year":"2011","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2026.119607_bib202","doi-asserted-by":"crossref","DOI":"10.1007\/s40291-016-0221-4","article-title":"Specific miRNA disease biomarkers in blood, serum and plasma: challenges and prospects","volume":"20","author":"Backes","year":"2016","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib203","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2012.199505","article-title":"Heparin selectively affects the quantification of micrornas in human blood samples","volume":"59","author":"Boeckel","year":"2013","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2026.119607_bib204","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0609.2009.01348.x","article-title":"The role of microRNAs in normal and malignant hematopoiesis","volume":"84","author":"Vasilatou","year":"2010","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.biopha.2026.119607_bib205","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.116.308434","article-title":"Circulating noncoding RNAs as biomarkers of cardiovascular disease and injury","volume":"120","author":"Viereck","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib206","doi-asserted-by":"crossref","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib207","doi-asserted-by":"crossref","DOI":"10.1038\/nrg.2016.114","article-title":"Detecting circular RNAs: bioinformatic and experimental challenges","volume":"17","author":"Szabo","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib208","doi-asserted-by":"crossref","DOI":"10.1038\/s44324-025-00063-4","article-title":"ECM formation and degradation during fibrosis, repair, and regeneration","volume":"3","author":"Mayorca-Guiliani","year":"2025","journal-title":"NPJ Metab. Health Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153588","article-title":"MicroRNAs in organ fibrosis: from molecular mechanisms to potential therapeutic targets","volume":"225","author":"Zhao","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.biopha.2026.119607_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112132","article-title":"Role of miRNA and lncRNAs in organ fibrosis and aging","volume":"143","author":"Ghafouri-Fard","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2026.119607_bib211","doi-asserted-by":"crossref","DOI":"10.2174\/1381612820666141226095701","article-title":"Microrna-21: a central regulator of fibrotic diseases via various targets","volume":"21","author":"Huang","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2026.119607_bib212","article-title":"Critical role of microRNA-21 in the pathogenesis of liver diseases","volume":"7","author":"Zhang","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120304","article-title":"The role of miR-21 as a biomarker and therapeutic target in cardiovascular disease","volume":"574","author":"He","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2026.119607_bib214","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2017.05.007","article-title":"LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN\/MMP-2 signaling pathway","volume":"386","author":"Tao","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2026.119607_bib215","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1056134","article-title":"MicroRNA-21 mediated cross-talk between cardiomyocytes and fibroblasts in patients with atrial fibrillation","volume":"10","author":"Pradhan","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib216","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jacc.2018.11.060","article-title":"Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtypes","volume":"73","author":"Wong","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib217","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/ejhf.517","article-title":"The transcardiac gradient of cardio-microRNAs in the failing heart","volume":"18","author":"Marques","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib218","article-title":"Circulating miRNA-21 is a promising biomarker for heart failure","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib219","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2020.03.003","article-title":"The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics","volume":"20","author":"Bautista-S\u00e1nchez","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biopha.2026.119607_bib220","doi-asserted-by":"crossref","first-page":"14674","DOI":"10.3892\/ol.2024.14674","article-title":"Advances in the study of the mechanism of action of miR-22 in liver lesions (review)","volume":"28","author":"Wang","year":"2024","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2026.119607_bib221","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcm.2014.07.005","article-title":"MiR-22 in cardiac remodeling and disease","volume":"24","author":"Huang","year":"2014","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib222","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00003","article-title":"New microRNA biomarkers for drug-induced steatosis and their potential to predict the contribution of drugs to non-alcoholic fatty liver disease","volume":"8","author":"L\u00f3pez-Riera","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib223","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-016-0929-x","article-title":"MicroRNAs in fibrosis: opportunities and challenges","volume":"18","author":"O\u2019Reilly","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib224","doi-asserted-by":"crossref","DOI":"10.1002\/hep.23922","article-title":"Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis","volume":"53","author":"Roderburg","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib225","doi-asserted-by":"crossref","DOI":"10.1007\/s13105-021-00814-z","article-title":"Role of the microRNA-29 family in myocardial fibrosis","volume":"77","author":"Li","year":"2021","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib226","doi-asserted-by":"crossref","DOI":"10.1111\/1751-2980.12185","article-title":"Serum microRNA-29 levels correlate with disease progression in patients with chronic hepatitis B virus infection","volume":"15","author":"Huang","year":"2014","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib227","doi-asserted-by":"crossref","DOI":"10.1186\/s43162-025-00511-z","article-title":"Circulating microRNAs as potential non-invasive biomarkers for diagnosis and severity assessment of metabolic dysfunction-associated steatotic liver disease: a case\u2013control study","volume":"37","author":"Nafeh","year":"2025","journal-title":"Egypt. J. Intern. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib228","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.112.001207","article-title":"MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation","volume":"127","author":"Dawson","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2026.119607_bib229","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.619083","article-title":"MicroRNA-29b\/c-3p indicate advanced liver fibrosis\/cirrhosis in univentricular heart patients with and without fontan palliation","volume":"7","author":"Abu-Halima","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib230","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/s41565-023-01479-z","article-title":"Nanopore sequencing of DNA-barcoded probes for highly multiplexed detection of microRNA, proteins and small biomarkers","volume":"18","author":"Koch","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biopha.2026.119607_bib231","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.895242","article-title":"MicroRNA-34a: a novel therapeutic target in fibrosis","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib232","doi-asserted-by":"crossref","DOI":"10.3390\/ijms15045774","article-title":"Circulating miR-208b and miR-34a are associated with left ventricular remodeling after acute myocardial infarction","volume":"15","author":"Lv","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib233","doi-asserted-by":"crossref","DOI":"10.21037\/atm-21-5005","article-title":"MiR-34a promotes fibrosis of hepatic stellate cells via the TGF-\u03b2 pathway","volume":"9","author":"Zhang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib234","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.3390\/ijms26062392","article-title":"Expression analysis of circulating miR-21, miR-34a and miR-122 and Redox Status Markers in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients with and Without Type 2 Diabetes","volume":"26","author":"Erceg","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123966","article-title":"MiRNA signature in NAFLD: a turning point for a non-invasive diagnosis","volume":"19","author":"Dongiovanni","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib236","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting","volume":"3","author":"Esau","year":"2006","journal-title":"Cell. Metab."},{"key":"10.1016\/j.biopha.2026.119607_bib237","doi-asserted-by":"crossref","DOI":"10.1002\/hep.23547","article-title":"MicroRNAs control hepatocyte proliferation during liver regeneration","volume":"51","author":"Song","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib238","doi-asserted-by":"crossref","DOI":"10.1007\/s12012-020-09603-4","article-title":"Roles of microRNA-122 in cardiovascular fibrosis and related diseases","volume":"20","author":"Liu","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.biopha.2026.119607_bib239","doi-asserted-by":"crossref","DOI":"10.3390\/genes15101313","article-title":"Role of circulating microRNAs in liver disease and HCC: focus on miR-122","volume":"15","author":"Colaianni","year":"2024","journal-title":"Genes"},{"key":"10.1016\/j.biopha.2026.119607_bib240","doi-asserted-by":"crossref","DOI":"10.1159\/000519995","article-title":"Dynamics of circulating miR-122 predict liver cancer and mortality in Japanese patients with histopathologically confirmed NAFLD and severe fibrosis stage","volume":"100","author":"Akuta","year":"2022","journal-title":"Oncology"},{"key":"10.1016\/j.biopha.2026.119607_bib241","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2018.08.008","article-title":"miRNAs in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"69","author":"Liu","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2026.119607_bib242","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70817","article-title":"A comparison of novel serum markers of liver health in adolescents with metabolic dysfunction-associated steatotic liver disease","volume":"29","author":"Bade","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib243","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.122.060258","article-title":"Circulating microRNA-122-5p is associated with a lack of improvement in left ventricular function after transcatheter aortic valve replacement and regulates viability of cardiomyocytes through extracellular vesicles","volume":"146","author":"Hosen","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2026.119607_bib244","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-024-03715-2","article-title":"Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miR-133a expression in diabetic cardiomyopathy","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib245","article-title":"Expression of circulating microRNAs in patients with ST segment elevation acute myocardial infarction","volume":"63","author":"Ji","year":"2015","journal-title":"Minerva Cardioangiol."},{"key":"10.1016\/j.biopha.2026.119607_bib246","article-title":"Circulating microRNAs are new and sensitive biomarkers of myocardial infarction","volume":"31","author":"D\u2019Alessandra","year":"2010","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biopha.2026.119607_bib247","doi-asserted-by":"crossref","DOI":"10.1159\/000328869","article-title":"Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples","volume":"118","author":"Gidl\u00f6f","year":"2011","journal-title":"Cardiology"},{"key":"10.1016\/j.biopha.2026.119607_bib248","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000899","article-title":"Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study","volume":"5","author":"McAloon","year":"2018","journal-title":"Open. Heart"},{"key":"10.1016\/j.biopha.2026.119607_bib249","doi-asserted-by":"crossref","DOI":"10.1111\/j.1549-8719.2011.00154.x","article-title":"miR-210: the master hypoxamir","volume":"19","author":"Chan","year":"2012","journal-title":"Microcirculation"},{"key":"10.1016\/j.biopha.2026.119607_bib250","article-title":"The role of miR-210 in the biological system: a current overview","volume":"84","author":"Hui","year":"2020","journal-title":"Hum. Hered."},{"key":"10.1016\/j.biopha.2026.119607_bib251","article-title":"Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia","volume":"12","author":"Zaccagnini","year":"2021","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib252","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ncrna.2025.01.009","article-title":"miR-210 overexpression increases pressure overload-induced cardiac fibrosis","volume":"12","author":"Zaccagnini","year":"2025","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.biopha.2026.119607_bib253","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0320365","article-title":"Association of microRNA-210-3p with NT-proBNP, sST2, and Galectin-3 in heart failure patients with preserved and reduced ejection fraction: a cross-sectional study","volume":"20","author":"Arul","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib254","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1002\/ehf2.13371","article-title":"Identification of novel circulating microRNAs in advanced heart failure by next-generation sequencing","volume":"8","author":"Galluzzo","year":"2021","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib255","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2015.00209","article-title":"The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis","volume":"6","author":"Lambrecht","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib256","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70282","article-title":"miR-210-3p ameliorates metabolic dysfunction\u2013associated steatohepatitis-related fibrosis by targeting ISCU and induces ferroptosis","volume":"45","author":"Dai","year":"2025","journal-title":"Liver Int."},{"key":"10.1016\/j.biopha.2026.119607_bib257","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123274","article-title":"MicroRNA-214 in health and disease","volume":"10","author":"Amin","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib258","doi-asserted-by":"crossref","DOI":"10.1007\/s00383-021-05009-7","article-title":"Elevation of microRNA-214 is associated with progression of liver fibrosis in patients with biliary atresia","volume":"38","author":"Yoneyama","year":"2022","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.biopha.2026.119607_bib259","doi-asserted-by":"crossref","DOI":"10.2174\/0122115366359521250122115511","article-title":"MicroRNAs in metabolic dysfunction-associated steatotic liver disease: a systematic review of clinical studies","author":"Antoniou","year":"2025","journal-title":"Microrna"},{"key":"10.1016\/j.biopha.2026.119607_bib260","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s13105-025-01110-w","article-title":"The use of circulating miRNAs for the diagnosis, prognosis, and personalized treatment of MASLD","volume":"81","author":"Tobaruela-Resola","year":"2025","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib261","article-title":"Carvedilol alters circulating mir-1 and mir-214 in heart failure","volume":"13","author":"Shirazi-Tehrani","year":"2020","journal-title":"Pharmgenom. Pers. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib262","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000041838","article-title":"Expression and clinical significance of serum lncRNA H19 in patients with metabolic dysfunction-associated fatty liver disease","volume":"104","author":"Xiong","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.biopha.2026.119607_bib263","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.120.047626","article-title":"Identification of long noncoding RNA H19 as a new biomarker and therapeutic target in right ventricular failure in pulmonary arterial hypertension","volume":"142","author":"Omura","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2026.119607_bib264","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111243","article-title":"The mechanism of lncRNA H19 in fibrosis and its potential as novel therapeutic target","volume":"188","author":"Jiang","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.biopha.2026.119607_bib265","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfaa097","article-title":"A novel Sox9\/lncRNA H19 axis contributes to hepatocyte death and liver fibrosis","volume":"177","author":"Wang","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib266","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24771","article-title":"A novel circulating biomarker lnc-MALAT1 for acute myocardial infarction: its relationship with disease risk, features, cytokines, and major adverse cardiovascular events","volume":"36","author":"Li","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.biopha.2026.119607_bib267","doi-asserted-by":"crossref","DOI":"10.1007\/s12291-024-01203-1","article-title":"Crosstalk between long non-coding RNA MALAT1, miRNA-181a, and IL-17 in cirrhotic patients and their possible correlation SIRT1\/NF-\u0198\u03b2 axis","volume":"40","author":"Khalaf","year":"2025","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib268","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2015.09.028","article-title":"Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion","volume":"289","author":"Wu","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib269","article-title":"Diagnostic value of LncRNA-MEG3 as a serum biomarker in patients with hepatitis B complicated with liver fibrosis","volume":"23","author":"Chen","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib270","doi-asserted-by":"crossref","first-page":"279","DOI":"10.5830\/CVJA-2023-044","article-title":"Correlation between maternally expressed gene 3 expression and heart rate variability in heart failure patients with ventricular arrhythmia","volume":"35","author":"Lin","year":"2024","journal-title":"Cardiovasc. J. Afr."},{"key":"10.1016\/j.biopha.2026.119607_bib271","doi-asserted-by":"crossref","DOI":"10.1016\/j.ydbio.2019.07.005","article-title":"Meg3-DMR, not the Meg3 gene, regulates imprinting of the Dlk1-Dio3 locus","volume":"455","author":"Zhu","year":"2019","journal-title":"Dev. Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib272","doi-asserted-by":"crossref","DOI":"10.1038\/s41434-018-0045-4","article-title":"Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction","volume":"25","author":"Wu","year":"2018","journal-title":"Gene Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib273","article-title":"STAT3-induced upregulation of lncRNA MEG3 regulates the growth of cardiac hypertrophy through miR-361-5p\/HDAC9 axis","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib274","doi-asserted-by":"crossref","DOI":"10.1210\/en.2009-0657","article-title":"Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions","volume":"151","author":"Zhang","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2026.119607_bib275","doi-asserted-by":"crossref","DOI":"10.1007\/s10238-023-01191-1","article-title":"The mechanisms and therapeutic potential of long noncoding RNA NEAT1 in fibrosis","volume":"23","author":"Jiang","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib276","doi-asserted-by":"crossref","DOI":"10.1684\/ecn.2019.0432","article-title":"lncRNA NEAT1 regulates fibrosis and inflammatory response induced by nonalcoholic fatty liver by regulating miR-506\/GLI3","volume":"30","author":"Jin","year":"2019","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.biopha.2026.119607_bib277","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-020-02577-5","article-title":"LncRNA NEAT1\/microRNA-129-5p\/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis","volume":"18","author":"Ye","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib278","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030560","article-title":"LncRNA and circRNA in patients with non-alcoholic fatty liver disease: a systematic review","volume":"13","author":"Zeng","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.biopha.2026.119607_bib279","doi-asserted-by":"crossref","DOI":"10.1007\/s11010-021-04269-0","article-title":"Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p\/GRIA3","volume":"477","author":"Hu","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib280","first-page":"2593","article-title":"The correlation between lncRNA NEAT1 and serum hepcidin in the peripheral blood of non-alcoholic fatty liver disease patients","volume":"14","author":"Zhou","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib281","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1536\/ihj.23-368","article-title":"LncRNA NEAT1\/miR-211\/IL-10 axis regulates inflammation of peripheral blood mononuclear cells in acute myocardial infarction","volume":"65","author":"Hou","year":"2024","journal-title":"Int. Heart J."},{"key":"10.1016\/j.biopha.2026.119607_bib282","article-title":"CircHIPK3 Plays Vital Roles in Cardiovascular Disease","volume":"8","author":"Zhang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib283","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13101066","article-title":"Circulating exosomal circRNAs as diagnostic biomarkers for chronic coronary syndrome","volume":"13","author":"Liu","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.biopha.2026.119607_bib284","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.117.001720","article-title":"Carotid plaque rupture is accompanied by an increase in the ratio of serum circR-284 to miR-221 levels","volume":"10","author":"Bazan","year":"2017","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib285","doi-asserted-by":"crossref","DOI":"10.1038\/s41440-022-01140-7","article-title":"Circ_0000284: a risk factor and potential biomarker for prehypertension and hypertension","volume":"46","author":"Chen","year":"2023","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib286","article-title":"Circulating miR-210 and miR-22 combined with ALT predict the virological response to interferon-alpha therapy of CHB patients","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib287","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2015.08.022","article-title":"Serum microRNA-210 levels in different groups of chronic hepatitis B patients","volume":"450","author":"Yu","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2026.119607_bib288","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-022-03617-y","article-title":"Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation","volume":"20","author":"Hao","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib289","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030592","article-title":"Exosomes: from potential culprits to new therapeutic promise in the setting of cardiac fibrosis","volume":"9","author":"Tikhomirov","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib290","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-024-01209-y","article-title":"Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer","volume":"56","author":"Lee","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib291","doi-asserted-by":"crossref","DOI":"10.1002\/biot.202100646","article-title":"Exosomes: biogenesis, targeting, characterization and their potential as \u201cPlug & Play\u201d vaccine platforms","volume":"17","author":"Dyball","year":"2022","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.biopha.2026.119607_bib292","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M112.446831","article-title":"Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic micrornas regulate cancer cell metastasis","volume":"288","author":"Kosaka","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119607_bib293","doi-asserted-by":"crossref","DOI":"10.1186\/1745-6150-8-12","article-title":"Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3\u2032-untranslated regions","volume":"8","author":"Batagov","year":"2013","journal-title":"Biol. Direct"},{"key":"10.1016\/j.biopha.2026.119607_bib294","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-022-00460-3","article-title":"Challenges and directions in studying cell\u2013cell communication by extracellular vesicles","volume":"23","author":"van Niel","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2026.119607_bib295","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1408301111","article-title":"Quantitative and stoichiometric analysis of the microRNA content of exosomes","volume":"111","author":"Chevillet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2026.119607_bib296","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00659.2021","article-title":"Extracellular vesicle-mediated bidirectional communication between heart and other organs","volume":"322","author":"Gabisonia","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib297","article-title":"Roles and mechanisms of exosomal non-coding RNAs in human health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib298","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13092601","article-title":"Role and applications of experimental animal models of fontan circulation","volume":"13","author":"Jalal","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib299","doi-asserted-by":"crossref","DOI":"10.1093\/icvts\/ivz022","article-title":"Creation of the Fontan circulation in sheep: a survival model","volume":"29","author":"Van Puyvelde","year":"2019","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"10.1016\/j.biopha.2026.119607_bib300","doi-asserted-by":"crossref","DOI":"10.1007\/BF01707667","article-title":"Functional deterioration of the liver by elevated inferior vena cava pressure: a proposed upper safety limit of pressure for maintaining liver viability in dogs","volume":"20","author":"Higashiyama","year":"1994","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.biopha.2026.119607_bib301","doi-asserted-by":"crossref","DOI":"10.1016\/j.vesic.2022.100013","article-title":"Computational analysis of serum-derived extracellular vesicle miRNAs in juvenile sheep model of single stage Fontan procedure","volume":"1","author":"Park","year":"2022","journal-title":"Extracell. Vesicle"},{"key":"10.1016\/j.biopha.2026.119607_bib302","doi-asserted-by":"crossref","DOI":"10.1038\/s44325-024-00039-1","article-title":"Transcriptomic analysis of circulating extracellular vesicles during the perioperative period of Fontan and Glenn surgery","volume":"1","author":"Takaesu","year":"2024","journal-title":"Npj Cardiovasc. Health"},{"key":"10.1016\/j.biopha.2026.119607_bib303","doi-asserted-by":"crossref","DOI":"10.1042\/CS20190558","article-title":"Exosomal microRNA-122 mediates obesity-related cardiomyopathy through suppressing mitochondrial ADP-ribosylation factor-like 2","volume":"133","author":"Wang","year":"2019","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib304","article-title":"Comprehensive profiling of serum microRNAs in normal and non-alcoholic fatty liver disease (NAFLD) patients","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib305","doi-asserted-by":"crossref","DOI":"10.1172\/JCI70577","article-title":"Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy","volume":"124","author":"Bang","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2026.119607_bib306","doi-asserted-by":"crossref","DOI":"10.1186\/s41065-022-00241-0","article-title":"Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K\/AKT\/mTOR pathway","volume":"159","author":"Xie","year":"2022","journal-title":"Hereditas"},{"key":"10.1016\/j.biopha.2026.119607_bib307","article-title":"Hepatocellular carcinoma cell-derived exosomal miR-21-5p induces macrophage M2 polarization by targeting RhoB","volume":"24","author":"Yu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib308","article-title":"Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22","volume":"9","author":"Feng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2026.119607_bib309","article-title":"Microneedle patch loaded with exosomes containing MicroRNA-29b prevents cardiac fibrosis after myocardial infarction","volume":"12","author":"Yuan","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.biopha.2026.119607_bib310","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178209","article-title":"Bone marrow MSCs-derived exosomes (BM-MSCs-Exo) expressed mir-181, mir-24, mir-9, mir-29, mir-338, and mir-486 ameliorated hepatic fibrosis in male rats via altering the expression of Menin-1\/TGF-\u03b2\/smad pathway","volume":"1007","author":"Khamis","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119607_bib311","doi-asserted-by":"crossref","DOI":"10.1186\/s40824-023-00410-w","article-title":"Exosomes derived from mir-214-3p overexpressing mesenchymal stem cells promote myocardial repair","volume":"27","author":"Zhu","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib312","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.109907","article-title":"Selenium alleviates high-fat diet induced hepatocyte lipid accumulation via exosome miR-22\/FGFR1 pathway in grass carp","volume":"141","author":"Wang","year":"2025","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2026.119607_bib313","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-020-01737-0","article-title":"Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis","volume":"11","author":"Cheng","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib314","doi-asserted-by":"crossref","DOI":"10.1002\/hep.26768","article-title":"Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells","volume":"59","author":"Chen","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib315","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001293","article-title":"PD-1 inhibitor inducing exosomal miR-34a-5p expression mediates the cross talk between cardiomyocyte and macrophage in immune checkpoint inhibitor-related cardiac dysfunction","volume":"8","author":"Xia","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.biopha.2026.119607_bib316","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2025.03.033","article-title":"Adipose tissue macrophages in metabolic dysfunction\u2013associated steatohepatitis secrete extracellular vesicles that activate liver fibrosis in obese male mice","volume":"169","author":"Rohm","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2026.119607_bib317","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-018-0153-7","article-title":"Role of miR-223 in the pathophysiology of liver diseases","volume":"50","author":"Ye","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib318","doi-asserted-by":"crossref","DOI":"10.1002\/hep.22569","article-title":"Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression","volume":"48","author":"Cheung","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib319","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"Van Rooij","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2026.119607_bib320","doi-asserted-by":"crossref","DOI":"10.1002\/hep.30506","article-title":"The role of innate immune cells in nonalcoholic steatohepatitis","volume":"70","author":"Cai","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib321","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141513","article-title":"Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis","volume":"131","author":"He","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2026.119607_bib322","doi-asserted-by":"crossref","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"Calvente","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biopha.2026.119607_bib323","article-title":"Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells","volume":"13","author":"Boonkaew","year":"2025","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.biopha.2026.119607_bib324","doi-asserted-by":"crossref","DOI":"10.1002\/hep.31658","article-title":"Myeloid-cell\u2013specific IL-6 signaling promotes microRNA-223-enriched exosome production to attenuate NAFLD-associated fibrosis","volume":"74","author":"Hou","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2026.119607_bib325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms161024965","article-title":"miR-223 inhibits lipid deposition and inflammation by suppressing toll-like receptor 4 signaling in macrophages","volume":"16","author":"Wang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib326","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaf183","article-title":"Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging","volume":"80","author":"He","year":"2025","journal-title":"J. Gerontol. - Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib327","doi-asserted-by":"crossref","DOI":"10.1007\/s40846-024-00902-7","article-title":"MiR-223-3p-loaded exosomes derived from bone marrow mesenchymal stem cells ameliorate mouse myocardial infarction injury through inhibiting NLRP3 inflammasome activation","volume":"44","author":"Wang","year":"2024","journal-title":"J. Med. Biol. Eng."},{"key":"10.1016\/j.biopha.2026.119607_bib328","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2019.09.003","article-title":"Long noncoding RNA-enriched vesicles secreted by hypoxic cardiomyocytes drive cardiac fibrosis","volume":"18","author":"Kenneweg","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biopha.2026.119607_bib329","article-title":"Macrophage-derived exosomal MALAT1 regulates autophagy through miR-204-5p\/ATG7 axis in H9C2 cardiomyocytes and diabetic rat heart","volume":"41","author":"Shyu","year":"2025","journal-title":"Acta Cardiol. Sin."},{"key":"10.1016\/j.biopha.2026.119607_bib330","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2019.09.008","article-title":"Exosomal MALAT1 derived from hepatic cells is involved in the activation of hepatic stellate cells via miRNA-26b in fibrosis induced by arsenite","volume":"316","author":"Dai","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2026.119607_bib331","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-022-01036-y","article-title":"METTL3-mediated macrophage exosomal NEAT1 contributes to hepatic fibrosis progression through Sp1\/TGF-\u03b21\/Smad signaling pathway","volume":"8","author":"Shu","year":"2022","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.biopha.2026.119607_bib332","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.02.029","article-title":"Reassessment of exosome composition","volume":"177","author":"Jeppesen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2026.119607_bib333","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.biopha.2026.119607_bib334","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2026.119607_bib335","article-title":"Effect of chronic western diets on non-alcoholic fatty liver of male mice modifying the ppar-\u03b3 pathway via mir-27b-5p regulation","volume":"22","author":"Zhang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib336","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-021-04972-3","article-title":"MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-\u03b2\/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7","volume":"14","author":"Zhou","year":"2021","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.biopha.2026.119607_bib337","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-07652-7","article-title":"Circular PVT1 promotes cardiac fibroblast activation interacting with miR-30a-5p and miR-125b-5p","volume":"16","author":"Bibi","year":"2025","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.biopha.2026.119607_bib338","article-title":"The emerging roles of CircPVT1 in cancer progression","volume":"26","author":"Wu","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.biopha.2026.119607_bib339","doi-asserted-by":"crossref","DOI":"10.3390\/cells12212578","article-title":"circRNA-miRNA-mRNA deregulated network in ischemic heart failure patients","volume":"12","author":"Mad\u00e8","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib340","article-title":"miR-26a limits muscle wasting and cardiac fibrosis through exosome-mediated microRNA transfer in chronic kidney disease","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2026.119607_bib341","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.120.16598","article-title":"Urinary-and plasma-derived exosomes reveal a distinct microRNA signature associated with albuminuria in hypertension","volume":"77","author":"Perez-Hernandez","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2026.119607_bib342","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.700959","article-title":"Serum miR-214 serves as a biomarker for prodromal Parkinson\u2019s disease","volume":"13","author":"Li","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.biopha.2026.119607_bib343","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ejhf.244","article-title":"MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure","volume":"17","author":"Watson","year":"2015","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib344","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315226","article-title":"Systems biology in chronic heart failure\u2014identification of potential miRNA regulators","volume":"23","author":"Vilella-Figuerola","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib345","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.009446","article-title":"The association of protein biomarkers with incident heart failure with preserved and reduced ejection fraction","volume":"16","author":"Takvorian","year":"2023","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.biopha.2026.119607_bib346","doi-asserted-by":"crossref","DOI":"10.1042\/ETLS20243003","article-title":"The impact of artificial intelligence on biomarker discovery","volume":"8","author":"Javaid","year":"2025","journal-title":"Emerg. Top. Life Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib347","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15143749","article-title":"Machine learning identifies a signature of nine exosomal RNAs that predicts hepatocellular carcinoma","volume":"15","author":"Yap","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.biopha.2026.119607_bib348","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.595699","article-title":"Identification and analysis of the blood lncRNA signature for liver cirrhosis and hepatocellular carcinoma","volume":"11","author":"Xia","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2026.119607_bib349","doi-asserted-by":"crossref","DOI":"10.5501\/wjv.v14.i2.101976","article-title":"Micro RNAs as a potential biomarker for predicting liver fibrosis severity in hepatitis C virus affected patients","volume":"14","author":"Kaur","year":"2025","journal-title":"World J. Virol."},{"key":"10.1016\/j.biopha.2026.119607_bib350","doi-asserted-by":"crossref","DOI":"10.1016\/j.livres.2024.05.003","article-title":"Plasma microRNA-15a\/16-1-based machine learning for early detection of hepatitis B virus-related hepatocellular carcinoma","volume":"8","author":"Wei","year":"2024","journal-title":"Liver Res."},{"key":"10.1016\/j.biopha.2026.119607_bib351","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132220","article-title":"Unveiling miRNA-124 as a biomarker in hypertrophic cardiomyopathy: An innovative approach using machine learning and intelligent data analysis","volume":"410","author":"Pisklova","year":"2024","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2026.119607_bib352","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2021.05.007","article-title":"Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice","volume":"25","author":"Momen-Heravi","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biopha.2026.119607_bib353","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201696","article-title":"MicroRNA-132 attenuated cardiac fibrosis in myocardial infarction-induced heart failure rats","volume":"40","author":"Wang","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.biopha.2026.119607_bib354","doi-asserted-by":"crossref","unstructured":"Z. Liao, Z. Ni, J. Cao, J. Liao, H. Zhu, X. Zhong, G. Cao, L. Huang, X. Li, G. Jiang, F. Pei, LncRNA MALAT1-Targeting Antisense Oligonucleotide Ameliorates the AngII-Induced Vascular Smooth Muscle Cell Proliferation and Migration Through Nrf2\/GPX4 Antioxidant Pathway, 2024. \u3008https:\/\/doi.org\/10.1097\/FJC.0000000000001521\u3009.","DOI":"10.1097\/FJC.0000000000001521"},{"key":"10.1016\/j.biopha.2026.119607_bib355","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107044","article-title":"CRISPR\/Cas9 based knockout of lncRNA MALAT1 attenuates TGF-\u03b21 induced Smad 2\/3 mediated fibrosis during AKI-to-CKD transition","volume":"207","author":"Puri","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib356","doi-asserted-by":"crossref","DOI":"10.1016\/j.jgeb.2025.100556","article-title":"Exploring the therapeutic potential of microRNAs: targeted gene regulation strategies for enhanced cancer therapy","volume":"23","author":"Pandey","year":"2025","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.biopha.2026.119607_bib357","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2014-308430","article-title":"MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway","volume":"65","author":"Wu","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2026.119607_bib358","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2017.04.121","article-title":"miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway","volume":"487","author":"Kim","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2026.119607_bib359","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10993","article-title":"MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression","volume":"7","author":"Hyun","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2026.119607_bib360","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00290.2015","article-title":"Microrna-141 regulates the expression level of ICAM-1 on endothelium to decrease myocardial ischemia-reperfusion injury","volume":"309","author":"Liu","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2026.119607_bib361","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-020-01404-9","article-title":"MiR-708-3p alleviates inflammation and myocardial injury after myocardial infarction by suppressing ADAM17 expression","volume":"44","author":"Qu","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.biopha.2026.119607_bib362","doi-asserted-by":"crossref","DOI":"10.1007\/s12265-025-10686-z","article-title":"Long non-coding RNA based therapy for cardiovascular disease","volume":"18","author":"Bellon Quinones","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.biopha.2026.119607_bib363","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073630","article-title":"Non-coding RNA-targeted therapy: a state-of-the-art review","volume":"25","author":"Nappi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib364","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai9118","article-title":"The long noncoding RNA Wisper controls cardiac fibrosis and remodeling","volume":"9","author":"Micheletti","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib365","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108956","article-title":"RNA renaissance: harnessing non-coding RNA therapeutics for hepatocellular carcinoma","volume":"277","author":"Das","year":"2026","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2026.119607_bib366","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26209861","article-title":"RNA interference and its key targets for spinal cord injury therapy: what is known so far?","volume":"26","author":"Chudakova","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119607_bib367","doi-asserted-by":"crossref","DOI":"10.1038\/s41565-019-0591-y","article-title":"The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs","volume":"14","author":"Akinc","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biopha.2026.119607_bib368","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.2673","article-title":"Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling","volume":"14","author":"Konkalmatt","year":"2012","journal-title":"J. Gene Med."},{"key":"10.1016\/j.biopha.2026.119607_bib369","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113097","article-title":"The challenges and opportunities in the development of microrna therapeutics: a multidisciplinary viewpoint","volume":"10","author":"Momin","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2026.119607_bib370","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2023.110738","article-title":"Liver transcriptomic and proteomic analyses provide new insight into the pathogenesis of liver fibrosis in mice","volume":"115","author":"Zhang","year":"2023","journal-title":"Genomics"},{"key":"10.1016\/j.biopha.2026.119607_bib371","article-title":"Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies","volume":"6","author":"Yang","year":"2025","journal-title":"Cell. Rep. Med."},{"key":"10.1016\/j.biopha.2026.119607_bib372","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-024-10575-w","article-title":"Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF","volume":"25","author":"Abudurexiti","year":"2024","journal-title":"BMC Genom."},{"key":"10.1016\/j.biopha.2026.119607_bib373","article-title":"MicroRNAs in heart failure pathogenesis and progression: mechanistic control","volume":"16","author":"Zivalj","year":"2026","journal-title":"Biomark. Potential. Transl. Perspect."},{"key":"10.1016\/j.biopha.2026.119607_bib374","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-025-01484-w","article-title":"The multifaceted roles of non-coding RNAs in cell-cell communication in cardiovascular health and disease","volume":"15","author":"Jimenez-Gallegos","year":"2025","journal-title":"Cell. Biosci."},{"key":"10.1016\/j.biopha.2026.119607_bib375","doi-asserted-by":"crossref","DOI":"10.1172\/JCI84424","article-title":"Targeting noncoding RNAs in disease","volume":"127","author":"Adams","year":"2017","journal-title":"J. Clin. Investig."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226006438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226006438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:45:32Z","timestamp":1784529932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226006438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":375,"alternative-id":["S0753332226006438"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119607","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unifying and unique roles of non-coding RNA biomarkers in liver and heart fibrosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119607"}}