{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:52:14Z","timestamp":1785891134823,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H02879"],"award-info":[{"award-number":["JP23H02879"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K27570"],"award-info":[{"award-number":["JP23K27570"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.biopha.2026.119710","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:38:15Z","timestamp":1782308295000},"page":"119710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A potent and selective PHOX2B promoter-driven oncolytic adenovirus for targeted neuroblastoma therapy"],"prefix":"10.1016","volume":"201","author":[{"given":"Ryo","family":"Ikushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-627X","authenticated-orcid":false,"given":"Hideki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-1634","authenticated-orcid":false,"given":"Satoru","family":"Oya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6735-9681","authenticated-orcid":false,"given":"Akimasa","family":"Tomida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Miyachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4256-9783","authenticated-orcid":false,"given":"Shigeki","family":"Yagyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-7323","authenticated-orcid":false,"given":"Yoshiki","family":"Katsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Iehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.biopha.2026.119710_bib1","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1056\/NEJMra0804577","article-title":"Recent advances in neuroblastoma","volume":"362","author":"Maris","year":"2010","journal-title":"New. Engl. J. Med."},{"issue":"9579","key":"10.1016\/j.biopha.2026.119710_bib2","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(07)60983-0","article-title":"Neuroblastoma","volume":"369","author":"Maris","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.biopha.2026.119710_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/jjco\/hyx176","article-title":"Neuroblastoma","volume":"48","author":"Nakagawara","year":"2018","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.biopha.2026.119710_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.1055729","article-title":"Progress of oncolytic virotherapy for neuroblastoma","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Pediatr."},{"issue":"9","key":"10.1016\/j.biopha.2026.119710_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/children5090114","article-title":"High-risk neuroblastoma treatment review","volume":"5","author":"Smith","year":"2018","journal-title":"Children"},{"issue":"5","key":"10.1016\/j.biopha.2026.119710_bib6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/jjco\/hyac007","article-title":"Outcome of children with relapsed high-risk neuroblastoma in Japan and analysis of the role of allogeneic hematopoietic stem cell transplantation","volume":"52","author":"Hara","year":"2022","journal-title":"Jpn J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.biopha.2026.119710_bib7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-019-0029-0","article-title":"Optimizing oncolytic virotherapy in cancer treatment","volume":"18","author":"Harrington","year":"2019","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"10","key":"10.1016\/j.biopha.2026.119710_bib8","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/cas.13027","article-title":"Oncolytic virus therapy: a new era of cancer treatment at dawn","volume":"107","author":"Fukuhara","year":"2016","journal-title":"Cancer Sci."},{"issue":"6","key":"10.1016\/j.biopha.2026.119710_bib9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s40259-025-00743-z","article-title":"Oncolytic virotherapy in solid tumors: a current review","volume":"39","author":"Chen","year":"2025","journal-title":"BioDrugs"},{"key":"10.1016\/j.biopha.2026.119710_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvr.2025.200333","article-title":"Oncolytic virus and immunogenic cell death in cancer therapy","volume":"20","author":"Cao","year":"2025","journal-title":"Tumour Virus Res."},{"issue":"2","key":"10.1016\/j.biopha.2026.119710_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/mt.2013.220","article-title":"Oncolytic virotherapy and immunogenic cancer cell death: sharpening the sword for improved cancer treatment strategies","volume":"22","author":"Workenhe","year":"2014","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2026.119710_bib12","article-title":"Oncolytic virotherapy reverses the immunosuppressive tumor microenvironment and its potential in combination with immunotherapy","volume":"21","author":"Zhang","year":"2021","journal-title":"Cancer Cell. Int."},{"issue":"2","key":"10.1016\/j.biopha.2026.119710_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gendis.2017.04.001","article-title":"Adenovirus-mediated gene delivery: potential applications for gene and cell-based therapies in the new era of personalized medicine","volume":"4","author":"Lee","year":"2017","journal-title":"Genes. Dis."},{"key":"10.1016\/j.biopha.2026.119710_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105834","article-title":"Viral and non-viral vectors in gene therapy: current state and clinical perspectives","volume":"118","author":"Geng","year":"2025","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.biopha.2026.119710_bib15","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.ymthe.2025.03.062","article-title":"Four decades of adenovirus gene transfer vectors: history and current use","volume":"33","author":"Hackett","year":"2025","journal-title":"Mol. Ther."},{"issue":"6","key":"10.1016\/j.biopha.2026.119710_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10060201","article-title":"Designer oncolytic adenovirus: coming of age","volume":"10","author":"Baker","year":"2018","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.biopha.2026.119710_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mt.2009.266","article-title":"Current issues and future directions of oncolytic adenoviruses","volume":"18","author":"Yamamoto","year":"2010","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2026.119710_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100997","article-title":"Mutant myogenin promoter-controlled oncolytic adenovirus selectively kills PAX3-FOXO1-positive rhabdomyosarcoma cells","volume":"14","author":"Yoshida","year":"2021","journal-title":"Transl. Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119710_bib19","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.3390\/cimb46040200","article-title":"Revisiting Neuroblastoma: Nrf2, NF-kappaB and Phox2B as a Promising Network in Neuroblastoma","volume":"46","author":"Peggion","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119710_bib20","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/jnen\/nlab112","article-title":"PHOX2B as a reliable marker for neuroblastoma in tissue and cytology specimens","volume":"80","author":"Ma","year":"2021","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6734","key":"10.1016\/j.biopha.2026.119710_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/20700","article-title":"The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives","volume":"399","author":"Pattyn","year":"1999","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.biopha.2026.119710_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13215528","article-title":"A focus on regulatory networks linking MicroRNAs, transcription factors and target genes in neuroblastoma","volume":"13","author":"Perri","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1-2","key":"10.1016\/j.biopha.2026.119710_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbrainres.2004.02.023","article-title":"Molecular cloning and characterization of the promoter region of the human Phox2b gene","volume":"125","author":"Jong Hong","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"45","key":"10.1016\/j.biopha.2026.119710_bib24","doi-asserted-by":"crossref","first-page":"37439","DOI":"10.1074\/jbc.M508368200","article-title":"PHOX2B Regulates Its Own Expression by a Transcriptional Auto-regulatory Mechanism","volume":"280","author":"Cargnin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119710_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.nbd.2012.10.019","article-title":"Transcriptional dysregulation and impairment of PHOX2B auto-regulatory mechanism induced by polyalanine expansion mutations associated with congenital central hypoventilation syndrome","volume":"50","author":"Di Lascio","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.biopha.2026.119710_bib26","first-page":"375","article-title":"The G401 cell line, utilized for studies of chromosomal changes in Wilms' tumor, is derived from a rhabdoid tumor of the kidney","volume":"142","author":"Garvin","year":"1993","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119710_bib27","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1158\/1078-0432.CCR-07-1661","article-title":"Trastuzumab activates allogeneic or autologous antibody-dependent cellular cytotoxicity against malignant rhabdoid tumor cells and interleukin-2 augments the cytotoxicity","volume":"14","author":"Katsumi","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.biopha.2026.119710_bib28","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1158\/1535-7163.MCT-24-0710","article-title":"A novel conditionally replicative oncolytic adenovirus under the control of the SALL4 promoter inhibits the growth of rhabdoid tumors","volume":"24","author":"Oya","year":"2025","journal-title":"Mol. Cancer Ther."},{"issue":"42","key":"10.1016\/j.biopha.2026.119710_bib29","doi-asserted-by":"crossref","first-page":"72133","DOI":"10.18632\/oncotarget.19922","article-title":"Targeting ofPHOX2Bexpression allows the identification of drugs effective in counteracting neuroblastoma cell growth","volume":"8","author":"Zanni","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biopha.2026.119710_bib30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tcb.2015.01.001","article-title":"RIPK1 and RIPK3: critical regulators of inflammation and cell death","volume":"25","author":"Newton","year":"2015","journal-title":"Trends Cell. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119710_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.biopha.2026.119710_bib32","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.4049\/jimmunol.165.8.4522","article-title":"Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL)1","volume":"165","author":"Routes","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2026.119710_bib33","first-page":"225","article-title":"Oncolytic adenovirus-mediated E1A gene therapy induces tumor-cell apoptosis and reduces tumor angiogenesis leading to inhibition of hepatocellular carcinoma growth in animal model","volume":"21","author":"Ye","year":"2006","journal-title":"Cancer Biother. Radiopharm."},{"issue":"9","key":"10.1016\/j.biopha.2026.119710_bib34","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1128\/jvi.70.9.6207-6215.1996","article-title":"Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis","volume":"70","author":"Marcellus","year":"1996","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119710_bib35","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1186\/bcr1739","article-title":"Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells","volume":"9","author":"Sugimoto","year":"2007","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.biopha.2026.119710_bib36","doi-asserted-by":"crossref","first-page":"16076","DOI":"10.1038\/cddiscovery.2016.76","article-title":"E1A enhances cellular sensitivity to DNA-damage-induced apoptosis through PIDD-dependent caspase-2 activation","volume":"2","author":"Radke","year":"2016","journal-title":"Cell. Death Discov."},{"issue":"12","key":"10.1016\/j.biopha.2026.119710_bib37","first-page":"3123","article-title":"Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression","volume":"60","author":"Shao","year":"2000","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.biopha.2026.119710_bib38","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.immuni.2024.03.002","article-title":"DAMPs and DAMP-sensing receptors in inflammation and diseases","volume":"57","author":"Ma","year":"2024","journal-title":"Immunity"},{"issue":"20","key":"10.1016\/j.biopha.2026.119710_bib39","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1016\/j.molcel.2025.09.007","article-title":"DAMPs in the immunogenicity of cell death","volume":"85","author":"Chen","year":"2025","journal-title":"Mol. Cell."},{"issue":"46","key":"10.1016\/j.biopha.2026.119710_bib40","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1038\/onc.2016.104","article-title":"Damage-associated molecular patterns in cancer: a double-edged sword","volume":"35","author":"Hernandez","year":"2016","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.biopha.2026.119710_bib41","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat. Rev. Drug. Discov."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226007468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226007468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:26:29Z","timestamp":1785889589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226007468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":41,"alternative-id":["S0753332226007468"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119710","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A potent and selective PHOX2B promoter-driven oncolytic adenovirus for targeted neuroblastoma therapy","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119710"}}