{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:59:54Z","timestamp":1790085594574,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004507","name":"CSIR - Central Drug Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["GAP0457"],"award-info":[{"award-number":["GAP0457"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","award":["IHP0075"],"award-info":[{"award-number":["IHP0075"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","award":["IHP0074"],"award-info":[{"award-number":["IHP0074"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.biopha.2026.119810","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:25:37Z","timestamp":1786620337000},"page":"119810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Phlorizin attenuates chronic kidney disease induced bone loss by mitigating sclerostin mediated inhibition of Wnt\/\u03b2-catenin signaling and ameliorating metabolic alterations"],"prefix":"10.1016","volume":"203","author":[{"given":"Rajat","family":"Rathur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Ubaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manendra Singh","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinshuk Raj","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41413-022-00223-y","article-title":"Biomechanics and mechanobiology of the bone matrix","volume":"10","author":"Ma","year":"2022","journal-title":"Bone Res."},{"issue":"4","key":"10.1016\/j.biopha.2026.119810_bib2","article-title":"Bone aging, cellular senescence, and osteoporosis","volume":"5","author":"Pignolo","year":"2021","journal-title":"J. Bone Mineral. Res."},{"key":"10.1016\/j.biopha.2026.119810_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1217579","article-title":"The role of XBP1 in bone metabolism","volume":"14","author":"Lv","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2026.119810_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1287223","article-title":"Exploring the Nexus of lower extremity proprioception and postural stability in older adults with osteoporosis: a cross-sectional investigation","volume":"11","author":"Ahmad","year":"2023","journal-title":"Front. Public. Health"},{"issue":"54","key":"10.1016\/j.biopha.2026.119810_bib5","first-page":"150","article-title":"Trace elements and bone metabolism","author":"Cashman","year":"1998","journal-title":"Bibl. Nutr. Et. Dieta"},{"issue":"4","key":"10.1016\/j.biopha.2026.119810_bib6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1053\/j.ajkd.2020.12.024","article-title":"Osteoporosis and chronic kidney disease\u2013mineral and bone disorder (CKD-MBD): back to basics","volume":"78","author":"Pazianas","year":"2021","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2026.119810_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1549562","article-title":"Development of animal models with chronic kidney disease-mineral and bone disorder based on clinical characteristics and pathogenesis","volume":"16","author":"Tan","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.biopha.2026.119810_bib8","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1039\/D1FO03867B","article-title":"Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function","volume":"13","author":"Sharma","year":"2022","journal-title":"Food & Funct."},{"issue":"19","key":"10.1016\/j.biopha.2026.119810_bib9","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.3390\/nu15194127","article-title":"Sclerostin, osteocytes, and Wnt signaling in pediatric renal osteodystrophy","volume":"15","author":"Laster","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2026.119810_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1120308","article-title":"Updates in the chronic kidney disease-mineral bone disorder show the role of osteocytic proteins, a potential mechanism of the bone\u2014vascular paradox, a therapeutic target, and a biomarker","volume":"14","author":"Williams","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2026.119810_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X231197094","article-title":"Anti-sclerostin antibodies: a new frontier in fragility fractures treatment","volume":"15","author":"Iolascon","year":"2023","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"issue":"3","key":"10.1016\/j.biopha.2026.119810_bib12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3390\/molecules29030741","article-title":"Phlorizin, an important glucoside: research progress on its biological activity and mechanism","volume":"29","author":"Ni","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2026.119810_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111769","article-title":"Anti-aging effect of phlorizin on D-galactose\u2013induced aging in mice through antioxidant and anti-inflammatory activity, prevention of apoptosis, and regulation of the gut microbiota","volume":"163","author":"Chen","year":"2022","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119810_bib14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s12010-024-05056-5","article-title":"Cardioprotective effects of phlorizin on hyperlipidemia-induced myocardial injury: involvement of suppression in pyroptosis via regulating HK1\/NLRP3\/caspase-1 signaling pathway","volume":"197","author":"Zhang","year":"2025","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.biopha.2026.119810_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2024.09.008","article-title":"Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice","volume":"123","author":"Zhang","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.biopha.2026.119810_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/jms.4964","article-title":"A pharmacokinetic study to correlate the hypoglycemic effect of phlorizin in rats: identification of metabolites as inhibitors of sodium\/glucose cotransporters","volume":"58","author":"Borkar","year":"2023","journal-title":"J. Mass. Spectrom."},{"key":"10.1016\/j.biopha.2026.119810_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jnutbio.2017.07.014","article-title":"Dietary phlorizin enhances osteoblastogenic bone formation through enhancing \u03b2-catenin activity via GSK-3\u03b2 inhibition in a model of senile osteoporosis","volume":"49","author":"Antika","year":"2017","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11892-021-01442-z","article-title":"Renal protection with SGLT2 inhibitors: effects in acute and chronic kidney disease","volume":"22","author":"Bailey","year":"2022","journal-title":"Curr. Diabetes Rep."},{"issue":"6","key":"10.1016\/j.biopha.2026.119810_bib19","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.kint.2024.03.019","article-title":"Kidney protective mechanisms of SGLT2 inhibitors: evidence for a hemodynamic effect","volume":"105","author":"Yau","year":"2024","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2026.119810_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1115413","article-title":"Possible renoprotective mechanisms of SGLT2 inhibitors","volume":"10","author":"Nishiyama","year":"2023","journal-title":"Front. Med."},{"issue":"32","key":"10.1016\/j.biopha.2026.119810_bib21","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001273","article-title":"Evidence for chronic kidney disease-mineral and bone disorder associated with metabolic pathway changes","volume":"94","author":"Wu","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.biopha.2026.119810_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cca.2013.03.033","article-title":"Metabolomics in chronic kidney disease","volume":"422","author":"Zhao","year":"2013","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.biopha.2026.119810_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3390\/pathophysiology30040033","article-title":"CKD urine metabolomics: modern concepts and approaches","volume":"30","author":"Danilova","year":"2023","journal-title":"Pathophysiology"},{"issue":"7","key":"10.1016\/j.biopha.2026.119810_bib24","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3390\/metabo11070434","article-title":"Metabolomics in bone research","volume":"11","author":"Fan","year":"2021","journal-title":"Metabolites"},{"issue":"8","key":"10.1016\/j.biopha.2026.119810_bib25","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1039\/D4FO04943H","article-title":"Comparative assessment of flavonoid content in banana pulp and peel and their role in mitigating bone loss conditions and promoting osteoblast differentiation","volume":"16","author":"Sinha","year":"2025","journal-title":"Food & Funct."},{"issue":"11","key":"10.1016\/j.biopha.2026.119810_bib26","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/jbmr.465","article-title":"Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo","volume":"26","author":"Woo","year":"2011","journal-title":"J. Bone Mineral. Res."},{"key":"10.1016\/j.biopha.2026.119810_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2022.09.013","article-title":"The effects of prostaglandin E2 on gene expression of IDG-SW3-derived osteocytes in 2D and 3D culture","volume":"630","author":"Wilmoth","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2026.119810_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116751","article-title":"Pym-18a, a novel pyrimidine derivative ameliorates glucocorticoid induced osteoblast apoptosis and promotes osteogenesis via autophagy and PINK 1\/Parkin mediated mitophagy induction","volume":"233","author":"Khanka","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119810_bib29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1039\/D3MD00500C","article-title":"Design, synthesis and biological evaluation of novel pyrimidine derivatives as bone anabolic agents promoting osteogenesis via the BMP2\/SMAD1 signaling pathway","volume":"15","author":"Rastogi","year":"2024","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.biopha.2026.119810_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.freeradbiomed.2022.11.026","article-title":"Chebulinic acid alleviates LPS-induced inflammatory bone loss by targeting the crosstalk between reactive oxygen species\/NF\u03baB signaling in osteoblast cells","volume":"194","author":"Sharma","year":"2023","journal-title":"Free. Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41398-018-0096-8","article-title":"Methylphenidate enhances neuronal differentiation and reduces proliferation concomitant to activation of Wnt signal transduction pathways","volume":"8","author":"Gr\u00fcnblatt","year":"2018","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.biopha.2026.119810_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5051\/jpis.2303840192","article-title":"Osteogenic potential of Frondoside A in human periodontal ligament cells: an RNA-Seq analysis","volume":"54","author":"Kim","year":"2024","journal-title":"J. Periodontal & Implant. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cpbi.3","article-title":"Comparative protein structure modeling using MODELLER","volume":"54","author":"Webb","year":"2016","journal-title":"Curr. Protoc. Bioinforma."},{"issue":"2","key":"10.1016\/j.biopha.2026.119810_bib34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"issue":"16","key":"10.1016\/j.biopha.2026.119810_bib36","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nmeth.4067","article-title":"CHARMM36m: an improved force field for folded and intrinsically disordered proteins","volume":"14","author":"Huang","year":"2017","journal-title":"Nat. Methods"},{"issue":"7","key":"10.1016\/j.biopha.2026.119810_bib38","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein\u2212 protein docking approach based on biochemical or biophysical information","volume":"125","author":"Dominguez","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biopha.2026.119810_bib39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.biomaterials.2015.07.021","article-title":"Structural and functional insights into sclerostin-glycosaminoglycan interactions in bone","volume":"67","author":"Salbach-Hirsch","year":"2015","journal-title":"Biomaterials"},{"issue":"22","key":"10.1016\/j.biopha.2026.119810_bib40","doi-asserted-by":"crossref","first-page":"14004","DOI":"10.1074\/jbc.M114.628818","article-title":"WNT1-induced secreted protein-1 (WISP1), a novel regulator of bone turnover and Wnt signaling","volume":"290","author":"Maeda","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119810_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2025.106336","article-title":"TGF-\u03b21 regulates pannexin1 channels and evokes apoptotic response in osteoblasts","author":"Liu","year":"2025","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.biopha.2026.119810_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118501","article-title":"Human sclerostin-inspired short peptides reverse osteoporosis and suppress joint degeneration in osteoarthritis via opposing Wnt pathways","volume":"191","author":"Sharma","year":"2025","journal-title":"Biomed. & Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00705-025-06460-w","article-title":"Permissive infection of murine osteoblastic MC3T3-E1 cells by goatpox virus: establishing a novel cell model for mechanistic studies of host-pathogen interactions","volume":"171","author":"Wang","year":"2026","journal-title":"Arch. Virol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119810_bib44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.11005\/jbm.25.841","article-title":"Comparison of differences in cell migration during the osteogenic and adipogenic differentiation of the bone marrow-derived stem cells","volume":"32","author":"Sardar","year":"2025","journal-title":"J. Bone Metab."},{"issue":"10","key":"10.1016\/j.biopha.2026.119810_bib45","article-title":"IL-33 prevents age-related bone loss and memory impairment by suppression of Th17 response: evidence in a D-galactose\u2013induced aging mouse model","volume":"8","author":"Kaushal","year":"2024","journal-title":"JBMR"},{"key":"10.1016\/j.biopha.2026.119810_bib46","first-page":"1","article-title":"Isovitexin, a natural adiponectin agonist, prevents glucocorticoid-induced osteosarcopenia","author":"Kulkarni","year":"2025","journal-title":"Endocrine"},{"key":"10.1016\/j.biopha.2026.119810_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1540237","article-title":"Fortified Withaferin A accelerates the transition from fibrovascular to bone remodeling phase during endochondral bone formation to promote ossification","volume":"16","author":"Chutani","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.biopha.2026.119810_bib48","article-title":"Increased osteoblast G\u03b1S promotes ossification by suppressing cartilage and enhancing callus mineralization during fracture repair in mice","volume":"7","author":"Lee","year":"2023","journal-title":"J. Bone Mineral. Res."},{"key":"10.1016\/j.biopha.2026.119810_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.biopha.2016.11.140","article-title":"Ethanolic extract of Dalbergia sissoo promotes rapid regeneration of cortical bone in drill-hole defect model of rat","volume":"86","author":"Khedgikar","year":"2017","journal-title":"Biomed. & Pharmacother."},{"issue":"8","key":"10.1016\/j.biopha.2026.119810_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.70017","article-title":"Anti-osteoporosis and bone protective effects of resveratrol in rats with chronic kidney disease-induced osteoporosis","volume":"69","author":"Zhao","year":"2025","journal-title":"Mol. Nutr. & Food Res."},{"issue":"3","key":"10.1016\/j.biopha.2026.119810_bib51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.etp.2005.09.005","article-title":"Suitability of 5\/6 nephrectomy (5\/6NX) for the induction of interstitial renal fibrosis in rats\u2013influence of sex, strain, and surgical procedure","volume":"57","author":"Fleck","year":"2006","journal-title":"Exp. Toxicol. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119810_bib52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12020-025-04180-4","article-title":"Multifaceted skeletal effects of sevelamer carbonate in a secondary hyperparathyroidism model","volume":"88","author":"Sharma","year":"2025","journal-title":"Endocrine"},{"key":"10.1016\/j.biopha.2026.119810_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177297","article-title":"A new phytopharmaceutical obtained from Polyalthia longifolia with anti-dyslipidemic potential: Mechanistic pathway insights exploiting co-inverse miRNA-mRNA expression analysis","volume":"991","author":"Khandelwal","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2026.119810_bib54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00223-023-01170-4","article-title":"The role of osteogenic effect and vascular function in bone health in hypertensive rats: a study of anti-hypertensive and hemorheologic drugs","volume":"114","author":"Pal","year":"2024","journal-title":"Calcif. Tissue Int."},{"issue":"8","key":"10.1016\/j.biopha.2026.119810_bib55","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s12272-024-01509-x","article-title":"Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy","volume":"47","author":"Rajput","year":"2024","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.biopha.2026.119810_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138791","article-title":"Metabolic dysregulation and temporal dynamics of NF-\u03baB-p65\/NLRP3, TXNIP, endoplasmic reticulum and mitochondrial stress in silica-induced pulmonary fibrosis in rats","author":"Washimkar","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.biopha.2026.119810_bib57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11255-019-02290-3","article-title":"Sclerostin: a new biomarker of CKD\u2013MBD","volume":"52","author":"Figurek","year":"2020","journal-title":"Int. Urol. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2026.119810_bib58","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000447954","article-title":"Metabolomics in diabetic kidney disease: unraveling the biochemistry of a silent killer","volume":"44","author":"Darshi","year":"2016","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.biopha.2026.119810_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.kint.2025.01.022","article-title":"Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder","author":"Hsu","year":"2025","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.biopha.2026.119810_bib60","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/2211-5463.12258","article-title":"Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption","volume":"7","author":"Watanabe","year":"2017","journal-title":"FEBS Open. Bio"},{"issue":"2","key":"10.1016\/j.biopha.2026.119810_bib61","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cmet.2025.01.005","article-title":"The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer","volume":"37","author":"Shafer","year":"2025","journal-title":"Cell. Metab."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226008462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226008462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:04:11Z","timestamp":1790082251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226008462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":61,"alternative-id":["S0753332226008462"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119810","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phlorizin attenuates chronic kidney disease induced bone loss by mitigating sclerostin mediated inhibition of Wnt\/\u03b2-catenin signaling and ameliorating metabolic alterations","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119810"}}