{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:59:39Z","timestamp":1790085579034,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Anusandhan National Research Foundation","doi-asserted-by":"publisher","award":["EEQ\/2018\/001446"],"award-info":[{"award-number":["EEQ\/2018\/001446"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018979","name":"Research Foundation of Bharathidasan University","doi-asserted-by":"publisher","award":["147425\/ DIR-RES\/URF\/2022"],"award-info":[{"award-number":["147425\/ DIR-RES\/URF\/2022"]}],"id":[{"id":"10.13039\/501100018979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific & Industrial Research","doi-asserted-by":"publisher","award":["09\/0475(23358)\/2025-EMR-I"],"award-info":[{"award-number":["09\/0475(23358)\/2025-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.biopha.2026.119910","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:09:10Z","timestamp":1789189750000},"page":"119910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["In vivo acute oral tolerability and antitumor activity of the novel small molecule YB-1 modulator AIGM-2024\u20134 in a DMBA- induced rat mammary tumor model"],"prefix":"10.1016","volume":"203","author":[{"given":"Maharaja","family":"Somasundaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7722-3284","authenticated-orcid":false,"given":"Jeeva","family":"Gothandam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxman","family":"Kota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilangovan","family":"Andivelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathan","family":"Ganeshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2026.119910_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-019-6311-z","article-title":"The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2026.119910_bib2","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","article-title":"Global patterns and trends in breast cancer incidence and mortality across 185 countries","volume":"31","author":"Kim","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2026.119910_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-021-00572-w","article-title":"Small molecules in targeted cancer therapy: advances, challenges, and future perspectives","volume":"6","author":"Zhong","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.biopha.2026.119910_bib4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature04873","article-title":"Validating cancer drug targets","volume":"441","author":"Benson","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2026.119910_bib5","first-page":"1402","article-title":"Y-box-binding protein 1 (YB-1) and its functions","volume":"76","author":"Eliseeva","year":"2011","journal-title":"Biochem"},{"key":"10.1016\/j.biopha.2026.119910_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/wrna.1200","article-title":"YB-1 protein: functions and regulation","volume":"5","author":"Lyabin","year":"2014","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.biopha.2026.119910_bib7","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/sj.bjc.6602452","article-title":"Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells","volume":"92","author":"Henderson","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biopha.2026.119910_bib8","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ijc.1610","article-title":"Y-box factor YB-1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI-1","volume":"97","author":"Janz","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2026.119910_bib9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3390\/ijms25020717","article-title":"Y-box binding Protein 1: unraveling the multifaceted role in cancer development and therapeutic potential","volume":"25","author":"Dinh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119910_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/bcr2202","article-title":"Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells","volume":"10","author":"Stratford","year":"2008","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.biopha.2026.119910_bib11","doi-asserted-by":"crossref","first-page":"12145","DOI":"10.1074\/jbc.M115.705368","article-title":"Extracellular Signal-regulated Kinase (ERK)-dependent phosphorylation of Y-Box-binding protein 1 (YB-1) enhances gene expression in granulosa cells in response to follicle-stimulating hormone (FSH)","volume":"291","author":"Donaubauer","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119910_bib12","first-page":"1217","article-title":"YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy","volume":"11","author":"Yin","year":"2022","journal-title":"Cells 2022"},{"key":"10.1016\/j.biopha.2026.119910_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80387","article-title":"Targeting RNA:Protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors","volume":"12","author":"El Hage","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.biopha.2026.119910_bib14","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.18632\/oncotarget.1790","article-title":"YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin","volume":"5","author":"Khan","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2026.119910_bib15","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.chembiol.2021.02.014","article-title":"Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer","volume":"28","author":"Tailor","year":"2021","journal-title":"Cell. Chem. Biol."},{"key":"10.1016\/j.biopha.2026.119910_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1478-811X-11-63","article-title":"Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities","volume":"11","author":"Van Roeyen","year":"2013","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.biopha.2026.119910_bib17","first-page":"1","article-title":"Discovery of a novel small-molecule modulator for full-length YB-1 protein via integrated computational and in vitro biophysical approaches","author":"Somasundaram","year":"2026","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.biopha.2026.119910_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1517\/14740338.7.2.107","article-title":"The role of early in vivo toxicity testing in drug discovery toxicology","volume":"7","author":"Fielden","year":"2008","journal-title":"Expert. Opin. Drug. Saf."},{"key":"10.1016\/j.biopha.2026.119910_bib19","article-title":"Test No. 425: acute oral toxicity: up-and\u2011down procedure","volume":"4","author":"OECD","year":"2022","journal-title":"OECD Guidel. Test. Chem. Sect."},{"key":"10.1016\/j.biopha.2026.119910_bib20","first-page":"1199","article-title":"Induction of mammary tumors in virgin female BALB\/c mice by single low doses of 7,12-dimethylbenz[a]anthracene","volume":"69","author":"Ethier","year":"1982","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.biopha.2026.119910_bib21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/BF00300234","article-title":"Determination of subcutaneous tumor size in athymic (nude) mice","volume":"24","author":"Tomayko","year":"1989","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119910_bib22","article-title":"Boundaries in mammary carcinogenesis","volume":"57","author":"Russo","year":"1991","journal-title":"Basic. Life Sci."},{"key":"10.1016\/j.biopha.2026.119910_bib23","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119910_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] Catalase in Vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biopha.2026.119910_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2026.119910_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2026.119910_bib27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.biopha.2026.119910_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/096032719501400401","article-title":"Reducing animal numbers in the fixed-dose procedure","volume":"14","author":"Stallard","year":"1995","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biopha.2026.119910_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2133\/dmpk.DMPK-10-RV-062","article-title":"Mechanisms of drug toxicity and relevance to pharmaceutical development","volume":"26","author":"Guengerich","year":"2010","journal-title":"Drug. Metab. Pharmacokinet."},{"key":"10.1016\/j.biopha.2026.119910_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0300-483X(76)90050-0","article-title":"The value of relative organ weights","volume":"5","author":"Stevens","year":"1976","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2026.119910_bib31","first-page":"3461","article-title":"Management of hepatotoxicity of chemotherapy and targeted agents","volume":"11","author":"Mudd","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.biopha.2026.119910_bib32","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/ndt\/gfw338","article-title":"Nephrotoxicity of anticancer treatment","volume":"32","author":"Ma\u0142yszko","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2026.119910_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/JEP.S349047","article-title":"Oral Intragastric DMBA administration induces acute lymphocytic leukemia and other tumors in male wistar rats","volume":"14","author":"El-Masry","year":"2022","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119910_bib34","article-title":"New fluorobenzamidine exerts antitumor activity against breast cancer in mice via pro-apoptotic activity","volume":"13","author":"Saleh","year":"2022","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.biopha.2026.119910_bib35","article-title":"Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy","volume":"5","author":"Dheeraj","year":"2024","journal-title":"Cell. Rep. Med."},{"key":"10.1016\/j.biopha.2026.119910_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3835(01)00593-6","article-title":"Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21Cip1","volume":"170","author":"Jang","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2026.119910_bib37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.biomaterials.2010.09.037","article-title":"The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen","volume":"32","author":"Jain","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2026.119910_bib38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/fcp.12397","article-title":"Therapeutic effect of simvastatin on DMBA-induced breast cancer in mice","volume":"33","author":"Karimi","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119910_bib39","doi-asserted-by":"crossref","first-page":"891","DOI":"10.7863\/jum.2010.29.6.891","article-title":"Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements","volume":"29","author":"Ayers","year":"2010","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.biopha.2026.119910_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1178568","article-title":"Pan-cancer evaluation of clinical value of mitotic network activity index (MNAI) and its predictive value for immunotherapy","volume":"13","author":"Mao","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biopha.2026.119910_bib41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/15287390590925438","article-title":"Toxicity induced by the chemical carcinogen 7,12-dimethylbenz[a]anthracene and the protective effects of selenium in Wistar rats","volume":"68","author":"Kocdor","year":"2005","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.biopha.2026.119910_bib42","first-page":"1632","article-title":"DMBA promotes ErbB2-mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability","volume":"40","author":"Ma","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2026.119910_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001231","article-title":"Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK\/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells","volume":"6","author":"J\u00fcrchott","year":"2010","journal-title":"PLOS Genet."},{"key":"10.1016\/j.biopha.2026.119910_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25020717","article-title":"Y-box binding Protein 1: unraveling the multifaceted role in cancer development and therapeutic potential","volume":"25","author":"Dinh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119910_bib45","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1158\/0008-5472.CAN-07-2362","article-title":"Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers","volume":"68","author":"Fujii","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2026.119910_bib46","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.7150\/jca.17689","article-title":"Role of Y box protein-1 in cancer: As potential biomarker and novel therapeutic target","volume":"8","author":"Maurya","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.biopha.2026.119910_bib47","first-page":"49","article-title":"YB-1 is a transcription\/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression","volume":"2","author":"Wu","year":"2007","journal-title":"Transl. Oncogenom."},{"key":"10.1016\/j.biopha.2026.119910_bib48","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1158\/0008-5472.CAN-08-1082","article-title":"Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR\/STAT3 pathway and suppresses tumor growth in mice","volume":"68","author":"Lee","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2026.119910_bib49","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/labinvest.3700077","article-title":"Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma","volume":"84","author":"Di Fiore","year":"2004","journal-title":"Lab. Investig."},{"key":"10.1016\/j.biopha.2026.119910_bib50","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1038\/sj.onc.1208504","article-title":"Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells","volume":"24","author":"Berquin","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2026.119910_bib51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10549-011-1731-8","article-title":"Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer","volume":"133","author":"Ito","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.biopha.2026.119910_bib52","doi-asserted-by":"crossref","DOI":"10.1186\/bcr2156","article-title":"Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes","volume":"10","author":"Habibi","year":"2008","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.biopha.2026.119910_bib53","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1158\/0008-5472.CAN-05-3561","article-title":"Disruption of the Y-box binding Protein-1 results in suppression of the epidermal growth factor receptor and HER-2","volume":"66","author":"Wu","year":"2006","journal-title":"Cancer Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226009467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226009467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:02:02Z","timestamp":1790082122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226009467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":53,"alternative-id":["S0753332226009467"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119910","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo acute oral tolerability and antitumor activity of the novel small molecule YB-1 modulator AIGM-2024\u20134 in a DMBA- induced rat mammary tumor model","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119910"}}