{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:59:17Z","timestamp":1790085557807,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.biopha.2026.119925","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:17:42Z","timestamp":1789121862000},"page":"119925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparative analysis of platinum nanoparticles interactions with Mitomycin C and its activated metabolite"],"prefix":"10.1016","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-7996","authenticated-orcid":false,"given":"Marcin","family":"Zakrzewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Kalisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-5197","authenticated-orcid":false,"given":"Patrycja","family":"Be\u0142dzi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3666-7934","authenticated-orcid":false,"given":"Katarzyna","family":"Grzyb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Bury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Jamr\u00f3giewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Wyrzykowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-0497","authenticated-orcid":false,"given":"Grzegorz","family":"Go\u0142u\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Piosik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2026.119925_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12032-024-02598-w","article-title":"Platinum nanoparticles in cancer therapy: chemotherapeutic enhancement and ROS generation","volume":"42","author":"Faderin","year":"2025","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2026.119925_bib2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10876-022-02225-6","article-title":"Platinum nanoparticles as potent anticancer and antimicrobial agent: green synthesis, physical characterization, and in-vitro biological activity","volume":"34","author":"Gholami-Shabani","year":"2022","journal-title":"J. Clust. Sci."},{"key":"10.1016\/j.biopha.2026.119925_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110375","article-title":"Improved delivery of doxorubicin using rationally designed PEGylated platinum nanoparticles for the treatment of melanoma","volume":"108","author":"Mukherjee","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.biopha.2026.119925_bib4","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1021\/acs.molpharmaceut.5b00531","article-title":"A novel platinum\u2013maurocalcine conjugate induces apoptosis of human glioblastoma cells by acting through the ROS-ERK\/AKT-p53 pathway","volume":"12","author":"Aroui","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biopha.2026.119925_bib5","doi-asserted-by":"crossref","first-page":"48502","DOI":"10.1021\/acsami.2c15143","article-title":"Novel platinum nanoclusters activate PI3K\/AKT\/mTOR signaling pathway-mediated autophagy for cisplatin-resistant ovarian cancer therapy","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biopha.2026.119925_bib6","doi-asserted-by":"crossref","first-page":"14367","DOI":"10.1007\/s00210-025-04080-4","article-title":"Enhanced therapeutic efficacy of platinum-doxorubicin nanoparticles on colon and breast cancer cell lines","volume":"398","author":"Kal\u0131ndemirta\u015f","year":"2025","journal-title":"Naunyn. Schmiede Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2026.119925_bib7","series-title":"Mitomycin","author":"Sinawe","year":"2023"},{"key":"10.1016\/j.biopha.2026.119925_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1053\/ctrv.2000.0202","article-title":"Mitomycin C: a clinical update","volume":"27","author":"Bradner","year":"2001","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.biopha.2026.119925_bib9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/1074-5521(95)90120-5","article-title":"Mitomycin C: small, fast and deadly (but very selective)","volume":"2","author":"Tomasz","year":"1995","journal-title":"Chem. Biol."},{"key":"10.1016\/j.biopha.2026.119925_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0167-8140(87)80020-8","article-title":"Mitomycin C-induced hemolytic uremic syndrome. Six casereports and review of the literature on renal, pulmonary and cardiac side effects of the drug","volume":"8","author":"Verweij","year":"1987","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.biopha.2026.119925_bib11","unstructured":"Mitomycin C. (#51854) Datasheet Without Images | Cell Signaling Technology, (n.d.). https:\/\/www.cellsignal.com\/products\/51854\/datasheet?utm_source=chatgpt.com (accessed May 19, 2026)."},{"key":"10.1016\/j.biopha.2026.119925_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0378-5173(85)90022-5","article-title":"Degradation of Mitomycin C in acidic solution","volume":"24","author":"Beijnen","year":"1985","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2026.119925_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/ejhpharm-2023-003743","article-title":"Physicochemical stability of ready-to-administer Mitomycin C solutions for intravesical instillation","volume":"31","author":"Almasi","year":"2024","journal-title":"Eur. J. Hosp. Pharm."},{"key":"10.1016\/j.biopha.2026.119925_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0304-3835(95)03694-R","article-title":"Noncovalent binding of a Mitomycin C metabolite, 2,7-diaminomitosene, to duplex DNA","volume":"90","author":"Peterson","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2026.119925_bib15","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1021\/ja9607401","article-title":"2,7-diaminomitosene, a monofunctional Mitomycin C derivative, alkylates DNA in the major groove. Structure and base-sequence specificity of the DNA adduct and mechanism of the alkylation","volume":"118","author":"Kumar","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biopha.2026.119925_bib16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0021-9258(17)43551-4","article-title":"Reductive activation of Mitomycin C and Mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase","volume":"259","author":"Pan","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2026.119925_bib17","first-page":"29","article-title":"The Ames Salmonella\/microsome mutagenicity assay","volume":"455","author":"Mortelmans","year":"2000","journal-title":"Mutat. Res. \/Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.biopha.2026.119925_bib18","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1021\/jm0209883","article-title":"Mitomycin antitumor compounds. 2.\u2020 Interaction of transition metal ions with Mitomycin C. Solution structure and biological activity of a Pd2+\u2212MMC complex","volume":"46","author":"Fiallo","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2026.119925_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/740821","article-title":"Heterocyclic aromatic amines heterocomplexation with biologically active aromatic compounds and its possible role in chemoprevention","volume":"2013","author":"Woziwodzka","year":"2013","journal-title":"ISRN Biophys."},{"key":"10.1016\/j.biopha.2026.119925_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/pharmaceutics15010209","article-title":"Central composite design for optimization of Mitomycin C-loaded quantum dots\/chitosan nanoparticles as drug nanocarrier vectors","volume":"15","author":"Manan","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biopha.2026.119925_bib21","article-title":"On the nature of hydrogen bonds to platinum(ii) \u2013 which interaction can predict their strength?","author":"Serhan","year":"2015","journal-title":"Phys. Chem. Chem. Phys. 2019-Novemb."},{"key":"10.1016\/j.biopha.2026.119925_bib22","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s42247-021-00335-x","article-title":"Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems","volume":"5","author":"Chandrakala","year":"2022","journal-title":"Emergent Mater."},{"key":"10.1016\/j.biopha.2026.119925_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107094","article-title":"Size dependent impact of platinum nanoparticles on doxorubicin activity","volume":"209","author":"Be\u0142dzi\u0144ska","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2026.119925_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2025.114866","article-title":"Platinum nanoparticles interact with epirubicin in size dependent manner and affect its biological activity","volume":"216","author":"Be\u0142dzi\u0144ska","year":"2025","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biopha.2026.119925_bib25","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1039\/D0SM00723D","article-title":"Role of particle aggregation in the structure of dried colloidal silica layers","volume":"17","author":"Lesaine","year":"2021","journal-title":"Soft Matter"},{"key":"10.1016\/j.biopha.2026.119925_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.trac.2016.01.012","article-title":"Recent advances on the characterization of nanoparticles using infrared spectroscopy","volume":"84","author":"L\u00f3pez-Lorente","year":"2016","journal-title":"TrAC. Trends Anal. Chem."},{"issue":"16","key":"10.1016\/j.biopha.2026.119925_bib27","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.3390\/ijms16012034","article-title":"Efficient Synthesis of a Maghemite\/Gold Hybrid Nanoparticle System as a Magnetic Carrier for the Transport of Platinum-Based Metallotherapeutics","volume":"16","author":"\u0160tarha","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2026.119925_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/pharmaceutics13111776","article-title":"Development of Mitomycin C-loaded nanoparticles prepared using the micellar assembly driven by the combined effect of hydrogen bonding and \u03c0\u2013\u03c0 stacking and its therapeutic application in bladder cancer","volume":"13","author":"Qi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biopha.2026.119925_bib29","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s11671-009-9312-z","article-title":"New method to prepare Mitomycin C loaded PLA-nanoparticles with high drug entrapment efficiency","volume":"4","author":"Hou","year":"2009","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.biopha.2026.119925_bib30","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1021\/acs.molpharmaceut.6b00865","article-title":"Characterization of pegylated liposomal Mitomycin C lipid-based prodrug (Promitil) by high sensitivity differential scanning calorimetry and cryogenic transmission electron microscopy","volume":"14","author":"Wei","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biopha.2026.119925_bib31","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1163\/156856200743562","article-title":"Sustained release of Mitomycin-C from poly(DL-lactide) \/poly(DL-lactide-co-glycolide) films","volume":"11","author":"G\u00fcm\u00fc\u015fderelio\u01e7lu","year":"2000","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.biopha.2026.119925_bib32","doi-asserted-by":"crossref","first-page":"35407","DOI":"10.1039\/D5RA02827B","article-title":"The effect of platinum nanoparticles on the physicochemical properties of daunorubicin","volume":"15","author":"Zakrzewski","year":"2025","journal-title":"RSC Adv."},{"issue":"1","key":"10.1016\/j.biopha.2026.119925_bib33","first-page":"4987","article-title":"Interactions of newly synthesized platinum nanoparticles with ICR-191 and their potential application","volume":"9","author":"Borowik","year":"2019","journal-title":"Sci. Rep. 2019"},{"key":"10.1016\/j.biopha.2026.119925_bib34","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3390\/nano12060937","article-title":"Cellular uptake of gold nanorods in breast cancer cell lines","volume":"12","author":"White","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.biopha.2026.119925_bib35","article-title":"Influence of silver nanoparticles\u2019 size on their direct interactions with doxorubicin and its biological effects","volume":"14","author":"Go\u0142u\u0144ski","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2026.119925_bib36","first-page":"13","article-title":"Molecular, cellular, and technical aspects of breast cancer cell lines as a foundational tool in cancer research","volume":"13","author":"Witt","year":"2023","journal-title":"Life 2023"},{"key":"10.1016\/j.biopha.2026.119925_bib37","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3390\/genes14030702","article-title":"Doxorubicin and cisplatin modulate miR-21, miR-106, miR-126, miR-155 and miR-199 levels in MCF7, MDA-MB-231 and SK-BR-3 cells that makes them potential elements of the DNA-damaging drug treatment response monitoring in breast cancer cells\u2014a preliminary S\u2026","volume":"14","author":"Mizielska","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.biopha.2026.119925_bib38","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.15419\/bmrat.v12i2.955","article-title":"Exploring the therapeutic potential of naringin and melatonin in breast cancer: a focus on SKBR3 and MCF-7 cell lines","volume":"12","author":"Azizpour","year":"2025","journal-title":"Biomed. Res. Ther."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226009613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332226009613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:59:45Z","timestamp":1790081985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332226009613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S0753332226009613"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119925","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative analysis of platinum nanoparticles interactions with Mitomycin C and its activated metabolite","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2026.119925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"119925"}}