{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:28:46Z","timestamp":1790400526594,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003335","name":"Ministry of Education, Youth and Science","doi-asserted-by":"publisher","award":["MSM111100001"],"award-info":[{"award-number":["MSM111100001"]}],"id":[{"id":"10.13039\/501100003335","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.biopsych.2004.01.014","type":"journal-article","created":{"date-parts":[[2004,3,28]],"date-time":"2004-03-28T19:36:12Z","timestamp":1080502572000},"page":"981-988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia"],"prefix":"10.1016","volume":"55","author":[{"given":"Pavla","family":"Stopkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demitri F","family":"Papolos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vevera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Paclt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilja","family":"Zukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonina B","family":"Bersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rael D","family":"Strous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert M","family":"Lachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2004.01.014_BIB1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/sj.mp.4001114","article-title":"A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 was well as chromosomes 9, 13, and 19","volume":"7","author":"Badenhop","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/sj.mp.4001268","article-title":"Evidence for a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder","volume":"8","author":"Barrett","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0006-3223(00)00883-0","article-title":"Are schizophrenia and bipolar disorders related? A review of family and molecular studies","volume":"48","author":"Berrettini","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB4","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.91.13.5918","article-title":"Chromosome 18 DNA markers and manic-depressive illness","volume":"91","author":"Berrettini","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/341197a0","article-title":"Inositol phosphates and cell signaling","volume":"341","author":"Berridge","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.288.5466.678","article-title":"Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22","volume":"288","author":"Brzustowicz","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0006-3223(91)91285-Y","article-title":"Effects of chronic lithium treatment on protein kinase C and cyclic AMP-dependent protein phosphorylation","volume":"29","author":"Casebolt","year":"1991","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0898-6568(98)00056-4","article-title":"Differential association of phosphatidylinositol-5-phosphate 4-kinase with the EGF\/ErbB family of receptors","volume":"11","author":"Castellino","year":"1999","journal-title":"Cell Signal"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB9","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1242\/jcs.114.6.1041","article-title":"Phosphoinositides in membrane traffic at the synapse","volume":"114","author":"Cremona","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB10","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nn903","article-title":"Phosphatidylinositol 3 kinase regulates synaptic specificity of hippocampal long-term depression","volume":"5","author":"Daw","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB11","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1073\/pnas.96.10.5604","article-title":"A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2","volume":"96","author":"Detera-Wadleigh","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q","article-title":"Initial genome scan of the NIMH genetics initiative bipolar pedigrees","volume":"74","author":"Detera-Wadleigh","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB13","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1073\/pnas.94.9.4757","article-title":"The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates","volume":"94","author":"Dixon","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bj2680015","article-title":"Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP","volume":"268","author":"Eberhard","year":"1990","journal-title":"Biochem J"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB15","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/hmg\/10.15.1611","article-title":"Chromosome 1 loci in Finnish schizophrenia families","volume":"10","author":"Ekelund","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1101\/gad.4.1.43","article-title":"A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression","volume":"4","author":"Elsholtz","year":"1990","journal-title":"Genes Dev"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB73","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","article-title":"A diagnostic interview: The schedule for affective disorders and schizophrenia","volume":"35","author":"Endicott","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ajmg.1205","article-title":"Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder","volume":"105","author":"Escamilla","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ajmg.10148","article-title":"Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands","volume":"114","author":"Ewald","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00041444-199700710-00001","article-title":"Susceptibility loci for bipolar affective disorder on chromosome 18? A review and a study of Danish families","volume":"7","author":"Ewald","year":"1997","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/(SICI)1096-8628(19980710)81:4<290::AID-AJMG3>3.0.CO;2-Y","article-title":"Genome scan of European-American schizophrenia pedigrees","volume":"81","author":"Faraone","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<607::AID-AJMG6>3.0.CO;2-Q","article-title":"Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortion","volume":"88","author":"Faraone","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/(SICI)1096-8628(20000207)96:1<18::AID-AJMG6>3.0.CO;2-G","article-title":"Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees","volume":"96","author":"Foroud","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB23","doi-asserted-by":"crossref","first-page":"15531","DOI":"10.1073\/pnas.95.26.15531","article-title":"A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish","volume":"95","author":"Ginns","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB24","first-page":"8100","article-title":"The effects of lithium and other agents on the activity of myo-inositol-1-phosphatase from bovine brain","volume":"261","author":"Hallcher","year":"1980","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB74","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1101\/gad.9.14.1679","article-title":"The POU domain: Versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain","volume":"9","author":"Her","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB25","doi-asserted-by":"crossref","first-page":"16341","DOI":"10.1074\/jbc.M011122200","article-title":"Phosphorylation of a synaptic vesicle-associated protein by an inositol hexakisphosphate-regulated protein kinase","volume":"276","author":"Hilton","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB26","doi-asserted-by":"crossref","first-page":"17878","DOI":"10.1074\/jbc.M000925200","article-title":"A pleckstrin homology domain specific for phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) and fused to green fluorescent protein identifies plasma membrane PtdIns-4,5-P2) as being important in exocytosis","volume":"275","author":"Holz","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB27","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1523\/JNEUROSCI.14-07-04318.1994","article-title":"Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics","volume":"14","author":"Hope","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB28","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1176\/appi.ajp.159.7.1174","article-title":"Expression of Oct-6, a POU III domain transcription factor, in schizophrenia","volume":"159","author":"Ilia","year":"2002","journal-title":"Am J Psychiatry"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2004.01.014_BIB29","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1038\/sj.mp.4001017","article-title":"Mood stabilizers, glycogen synthase kinase-3 beta and cell survival","volume":"7","author":"Jope","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB30","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/(SICI)1096-8628(19970418)74:2<121::AID-AJMG2>3.0.CO;2-X","article-title":"Linkage studies support a possible locus for bipolar disorder near the velo-cardio-facial syndrome region on chromosome 22","volume":"74","author":"Lachman","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1097-4652(199905)179:2<126::AID-JCP2>3.0.CO;2-M","article-title":"POU family transcription factors in the nervous system","volume":"179","author":"Latchman","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/sj.mp.4001306","article-title":"Molecular basis of lithium action","volume":"8","author":"Lenox","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB34","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1086\/303041","article-title":"Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q","volume":"67","author":"Levinson","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1176\/ajp.155.6.741","article-title":"Genome scan of schizophrenia","volume":"155","author":"Levinson","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB36","doi-asserted-by":"crossref","first-page":"35702","DOI":"10.1074\/jbc.M302004200","article-title":"Cyclin-dependent kinase-5 involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediated neuronal survival","volume":"278","author":"Li","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB37","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0896-6273(01)00433-0","article-title":"A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala","volume":"31","author":"Lin","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0169-328X(96)00238-0","article-title":"The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U","volume":"45","author":"Malik","year":"1997","journal-title":"Brain Res Mol Brain Res"},{"issue":"suppl","key":"10.1016\/j.biopsych.2004.01.014_BIB39","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1192\/bjp.178.41.s107","article-title":"Bipolar disorder","volume":"41","author":"Manji","year":"2001","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB40","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/sj.mp.4000915","article-title":"A search for specific and common susceptibility loci for schizophrenia and bipolar disorder","volume":"6","author":"Maziade","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB41","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/379353a0","article-title":"A presynaptic inositol-5-phosphatase","volume":"379","author":"McPherson","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB42","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1242\/jcs.00703","article-title":"Leading the way","volume":"116","author":"Merlot","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB43","first-page":"937","article-title":"Roles of synaptotagmin C2 domains in neurotransmitter secretion and inositol high polyphosphate binding at mammalian cholinergic synapses","volume":"77","author":"Mochida","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB44","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/1096-8628(20001204)96:6<864::AID-AJMG35>3.0.CO;2-D","article-title":"Second stage of a genome scan of schizophrenia","volume":"96","author":"Mowry","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB45","doi-asserted-by":"crossref","first-page":"18953","DOI":"10.1074\/jbc.M102376200","article-title":"Agonist dependent recruitment of phosphoinositide 3-kinase to the membrane by beta adrenergic receptor kinase. A role in receptor sequestration","volume":"276","author":"Naga Prasad","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB46","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.200202113","article-title":"Phosphoinositide 3-kinase regulates beta 2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor\/beta arrestin complex","volume":"158","author":"Naga Prasad","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB47","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.1411571","article-title":"Intracellular signaling by hydrolysis of phospholipid and activation of protein kinase C","volume":"258","author":"Nishizuka","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1096-8628(19990618)88:3<233::AID-AJMG5>3.0.CO;2-B","article-title":"Chromosome 6 workshop report","volume":"88","author":"Nurnberger","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB49","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1073\/pnas.86.8.2766","article-title":"Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms","volume":"86","author":"Orita","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB50","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1074\/jbc.275.2.1307","article-title":"An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells","volume":"275","author":"Perez-Juste","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB51","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1006\/jmbi.2000.4107","article-title":"The virtuosity of versatility","volume":"302","author":"Phillips","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB52","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1096-8628(19970531)74:3<247::AID-AJMG3>3.0.CO;2-N","volume":"74","author":"Rice","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB54","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.mp.4000871","article-title":"Mutation analysis of SYNJ1","volume":"6","author":"Saito","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB55","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/(SICI)1096-8628(19980710)81:4<302::AID-AJMG5>3.0.CO;2-V","article-title":"Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis","volume":"81","author":"Schwab","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB56","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/319154a0","article-title":"A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes","volume":"319","author":"Schwab","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB57","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/(SICI)1096-8628(19980907)81:5<364::AID-AJMG4>3.0.CO;2-T","article-title":"A genome-wide search for schizophrenia susceptibility genes","volume":"81","author":"Shaw","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB58","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/319154a0","article-title":"A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes","volume":"319","author":"Singh","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB59","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archpsyc.1978.01770300115013","article-title":"Research diagnostic criteria","volume":"35","author":"Spitzer","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1086\/345442","article-title":"Association of neuregulin 1 with schizophrenia confirmed in Scottish population","volume":"72","author":"Stefansson","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB61","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1086\/342734","article-title":"Neuregulin 1 and susceptibility to schizophrenia","volume":"71","author":"Stefansson","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB62","doi-asserted-by":"crossref","unstructured":"Stopkova P, Saito T, Fann CSJ, Papolos DF, Vevera J, Paclt I, et al (2003): Polymorphism screening of PIP5K2A: A candidate gene for chromosome 10p-linked psychiatric disorders. Am J Med Genet(online) 14 Mar 2003, DOI 10 1002\/ajmg:b.:20012","DOI":"10.1002\/ajmg.b.20012"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng1194-291","article-title":"A possible vulnerability locus for BP affective disorder on chromosome 21","volume":"8","author":"Straub","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB64","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/(SICI)1096-8628(19980710)81:4<296::AID-AJMG4>3.0.CO;2-S","article-title":"A schizophrenia locus may be located in region 10p15.1","volume":"81","author":"Straub","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB65","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1471-4159.1992.tb09309.x","article-title":"Lithium effects on inositol phospholipids and inositol phosphates","volume":"58","author":"Sun","year":"1992","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/42648","article-title":"Signalling through the lipid products of phosphoinositide-3-OH kinase","volume":"387","author":"Toker","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB67","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/ajmg.1550","article-title":"Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs cooperative study sample","volume":"105","author":"Tsuang","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB68","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0896-6273(01)00456-1","article-title":"PIP kinase Igamma is the majot PI(,5)P(2) synthesizing enzyme at the synapse","volume":"32","author":"Wenk","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB69","first-page":"127","article-title":"Structure and function of phosphoinositide 3-kinases","volume":"1436","author":"Wymann","year":"1998","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB70","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1013017821166","article-title":"PI-3 kinase and IP3 are both necessary and sufficient to mediate NT-3-induced synaptic potentiation","volume":"4","author":"Yang","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB71","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/sj.mp.4000835","article-title":"Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples","volume":"6","author":"Yoshikawa","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2004.01.014_BIB72","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0167-4781(02)00402-5","article-title":"Involvement of Oct-1 in transcriptional regulation beta-casein gene expression in mouse mammary gland","volume":"1577","author":"Zhao","year":"2002","journal-title":"Biochim Biophys Acta"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322304001003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322304001003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T14:48:49Z","timestamp":1757774929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322304001003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":73,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0006322304001003"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2004.01.014","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2004.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}