{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:05:14Z","timestamp":1769144714521,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.biopsych.2006.04.030","type":"journal-article","created":{"date-parts":[[2006,7,30]],"date-time":"2006-07-30T05:24:37Z","timestamp":1154237077000},"page":"111-118","source":"Crossref","is-referenced-by-count":72,"title":["Catechol-O-Methyltransferase (COMT) Gene Variants Predict Response to Bupropion Therapy for Tobacco Dependence"],"prefix":"10.1016","volume":"61","author":[{"given":"Wade H.","family":"Berrettini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Paul","family":"Wileyto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Restine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Hawk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Shields","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray","family":"Niaura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caryn","family":"Lerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2006.04.030_bib1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/hmg\/6.4.577","article-title":"A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia","volume":"6","author":"Arinami","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2006.04.030_bib2","unstructured":"Ascher J, Cole J, Colin J Bupropion (1995): A review of its mechanism of antidepressant activity. J Clin Psychiatry 56:395\u2013401."},{"key":"10.1016\/j.biopsych.2006.04.030_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0166-4328(00)00202-3","article-title":"The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence","volume":"113","author":"Balfour","year":"1995","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2006.04.030_bib5","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1476-5381.1995.tb13248.x","article-title":"Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine","volume":"114","author":"Benwell","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.biopsych.2006.04.030_bib6","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1176\/appi.ajp.162.8.1441","article-title":"Pharmacotherapy and pharmacogenetics of nicotine dependence","volume":"162","author":"Berrettini","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2006.04.030_bib7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1086\/376578","article-title":"A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain","volume":"73","author":"Bray","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2006.04.030_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1037\/0893-164X.12.2.101","article-title":"Reliability and validity of a smoking timeline follow-back interview","volume":"12","author":"Brown","year":"1998","journal-title":"Psychol Addict Behav"},{"key":"10.1016\/j.biopsych.2006.04.030_bib9","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1086\/425589","article-title":"Functional analysis of genetic variation in catechol-o-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain","volume":"75","author":"Chen","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2006.04.030_bib10","series-title":"Geneassoc: STATA modules for gene association analyses","author":"Clayton","year":"2002"},{"key":"10.1016\/j.biopsych.2006.04.030_bib11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/01213011-200506000-00004","article-title":"Association of Catechol-O-Methyltransferase with smoking cessation in two independent studies of women","volume":"15","author":"Colilla","year":"2005","journal-title":"Pharmacogenetics Genomics"},{"key":"10.1016\/j.biopsych.2006.04.030_bib12","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1378\/chest.119.5.1357","article-title":"Bupropion for smoking cessation: predictors of successful outcome","volume":"119","author":"Dale","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.biopsych.2006.04.030_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0920-9964(01)00217-1","article-title":"Initiation of daily smoking and nicotine dependence in schizophrenia and mood disorders","volume":"56","author":"de Leone","year":"2002","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2006.04.030_bib15","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1073\/pnas.111134598","article-title":"Effect of COMT Val108\/158 Met genotype on frontal lobe function and risk for schizophrenia","volume":"98","author":"Egan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2006.04.030_bib17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.2042-7158.1990.tb06592.x","article-title":"A rapid gas-liquid chromatographic method for the determination of cotinine and nicotine in biological fluids","volume":"42","author":"Feyerabend","year":"1990","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.biopsych.2006.04.030_bib18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archpsyc.60.9.889","article-title":"Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia","volume":"60","author":"Goldberg","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2006.04.030_bib19","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1360-0443.1991.tb01879.x","article-title":"The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire","volume":"86","author":"Heatherton","year":"1991","journal-title":"Br J Addict"},{"key":"10.1016\/j.biopsych.2006.04.030_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/1462220031000070552","article-title":"Measure of abstinence in clinical trials: issues and recommendations","volume":"5","author":"Hughes","year":"2003","journal-title":"Nicotine Tobacco Res"},{"key":"10.1016\/j.biopsych.2006.04.030_bib21","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJM199710233371703","article-title":"A comparison of sustained-release bupropion and placebo for smoking cessation","volume":"337","author":"Hurt","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopsych.2006.04.030_bib22","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/archpsyc.59.7.662","article-title":"COMT Val-108\/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test","volume":"59","author":"Joober","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2006.04.030_bib23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM199903043400903","article-title":"A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation","volume":"340","author":"Jorenby","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopsych.2006.04.030_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/14622200110072156","article-title":"Attention-deficit hyperactivity disorder (ADHD) symptoms and smoking patterns among participants in a smoking cessation program","volume":"3","author":"Lerman","year":"2001","journal-title":"Nicotine Tobacco Res"},{"key":"10.1016\/j.biopsych.2006.04.030_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.npp.1300861","article-title":"The role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials","volume":"31","author":"Lerman","year":"2006","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2006.04.030_bib26","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1200\/JCO.2005.04.058","article-title":"Treating tobacco dependence: state of the science and new directions","volume":"23","author":"Lerman","year":"2005","journal-title":"J Clin Oncology"},{"key":"10.1016\/j.biopsych.2006.04.030_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1037\/0278-6133.22.5.541","article-title":"Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial","volume":"22","author":"Lerman","year":"2003","journal-title":"Health Psychol"},{"key":"10.1016\/j.biopsych.2006.04.030_bib28","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1176\/appi.ajp.159.4.652","article-title":"A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition","volume":"159","author":"Malhotra","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2006.04.030_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/1536867X0100100104","article-title":"Haplotype analysis in population-based association studies","volume":"1","author":"Mander","year":"2001","journal-title":"Stata Journal"},{"key":"10.1016\/j.biopsych.2006.04.030_bib30","series-title":"HAPIPF: Stata module to perform haplotype analysis","author":"Mander","year":"2002"},{"key":"10.1016\/j.biopsych.2006.04.030_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1600-0773.1994.tb00373.x","article-title":"Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release","volume":"75","author":"Nisell","year":"1994","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.biopsych.2006.04.030_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/382255a0","article-title":"Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs","volume":"382","author":"Pontieri","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2006.04.030_bib33","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","article-title":"Inference of population structure using multilocus genotype data","volume":"155","author":"Pritchard","year":"2000","journal-title":"Genetics"},{"key":"10.1016\/j.biopsych.2006.04.030_bib34","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1158\/1055-9965.EPI-04-0649","article-title":"The Catechol-O-Methyl-Transferase (COMT) functional polymorphism and nicotine dependence: An evaluation of non-replicated results","volume":"14","author":"Redden","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.biopsych.2006.04.030_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nn1244","article-title":"Nicotine amplifies reward-related dopamine signals in striatum","volume":"7","author":"Rice","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2006.04.030_bib37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1023\/A:1006986824213","article-title":"Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding","volume":"19","author":"Sanchez","year":"1999","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.biopsych.2006.04.030_bib38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.mp.4001386","article-title":"Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes","volume":"9","author":"Shield","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2006.04.030_bib39","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1086\/344514","article-title":"A highly significant association between a COMT haplotype and schizophrenia","volume":"71","author":"Shifman","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2006.04.030_bib40","first-page":"149","article-title":"Biochemical verification of tobacco use and cessation","year":"2001","journal-title":"Soc Res Nicotine Tobacco"},{"key":"10.1016\/j.biopsych.2006.04.030_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/sj.tpj.6500281","article-title":"Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR","volume":"5","author":"Swan","year":"2005","journal-title":"Pharmacogenom J"},{"key":"10.1016\/j.biopsych.2006.04.030_bib42","first-page":"2107","article-title":"Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk","volume":"58","author":"Thompson","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.biopsych.2006.04.030_bib43","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nn1243","article-title":"Frequency-dependent modulation of dopamine release by nicotine","volume":"7","author":"Zhang","year":"2004","journal-title":"Nature Neurosci"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322306005646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322306005646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T20:33:05Z","timestamp":1627677185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322306005646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0006322306005646"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2006.04.030","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}