{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:49:44Z","timestamp":1773294584104,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.biopsych.2007.02.020","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T13:42:59Z","timestamp":1175262179000},"page":"925-927","source":"Crossref","is-referenced-by-count":25,"title":["The Use of Prazosin for the Treatment of Trauma Nightmares and Sleep Disturbance in Combat Veterans with Post-Traumatic Stress Disorder"],"prefix":"10.1016","volume":"61","author":[{"given":"Andrew D.","family":"Krystal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.T.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2007.02.020_bib1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/archpsyc.61.5.508","article-title":"Sleep in lifetime post-traumatic stress disorder: A community-based polysomnographic study","volume":"61","author":"Breslau","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.02.020_bib2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1345\/aph.1E043","article-title":"Clonazepam for treatment of sleep disturbances associated with combat-related post-traumatic stress disorder","volume":"38","author":"Cates","year":"2004","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.biopsych.2007.02.020_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00004850-200403000-00005","article-title":"Remission in post-traumatic stress disorder (PTSD): Effects of sertraline as assessed by the Davidson Trauma Scale, clinical global impressions and the Clinician-Administered PTSD Scale","volume":"19","author":"Davidson","year":"2004","journal-title":"Int Clin Psychopharmacology"},{"key":"10.1016\/j.biopsych.2007.02.020_bib4","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/archpsyc.63.10.1158","article-title":"Treatment of post-traumatic stress disorder with venlafaxine extended release","volume":"63","author":"Davidson","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.02.020_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jts.20015","article-title":"Treatment of residual insomnia after CBT for PTSD: Case studies","volume":"18","author":"DeViva","year":"2005","journal-title":"J Trauma Stress"},{"key":"10.1016\/j.biopsych.2007.02.020_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004850-200301000-00001","article-title":"Adjunctive risperidone treatment in post-traumatic stress disorder: A preliminary controlled trial of effects on comorbid psychotic symptoms","volume":"18","author":"Hamner","year":"2003","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2007.02.020_bib7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00004714-200102000-00017","article-title":"A preliminary study of bupropion sustained-release for smoking cessation in patients with chronic post-traumatic stress disorder","volume":"21","author":"Hertzberg","year":"2001","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2007.02.020_bib8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1748-1716.1984.tb07396.x","article-title":"Effects of methoxamine, and alpha-1 adrenoceptor agonist, and prazosin, an alpha-1 antagonist, on the stages of the sleep-waking cycle in the cat","volume":"120","author":"Hilakivi","year":"1984","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.biopsych.2007.02.020_bib9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0014-2999(80)90346-5","article-title":"Prazosin increases paradoxical sleep","volume":"65","author":"Hilakivi","year":"1980","journal-title":"Eur J Pharmacol"},{"issue":"suppl 5","key":"10.1016\/j.biopsych.2007.02.020_bib10","first-page":"4","article-title":"Post-traumatic stress disorder: The burden to the individual and society","volume":"61","author":"Kessler","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2007.02.020_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000118560","article-title":"Effects of the selective alpha 1-adrenoceptor blocker prazosin on EEG sleep and waking stages in the rat","volume":"21","author":"Kleinlogel","year":"1989","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.biopsych.2007.02.020_bib12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0091-3057(86)90566-6","article-title":"Effect of alpha-adrenoceptor blockade on sleep and wakefulness in the rat","volume":"24","author":"Makela","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.biopsych.2007.02.020_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbr.2004.08.004","article-title":"Role of alpha and beta adrenoceptors in locus coeruleus stimulation-induced reduction in rapid eye movement sleep in freely moving rats","volume":"158","author":"Mallick","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.biopsych.2007.02.020_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/sleep\/20.1.46","article-title":"A polysomnographic comparison of veterans with combat-related PTSD, depressed men, and non-ill controls","volume":"20","author":"Mellman","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.biopsych.2007.02.020_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00004714-200304000-00012","article-title":"Low-dose risperidone as adjunctive therapy for irritable aggression in post-traumatic stress disorder","volume":"23","author":"Monnelly","year":"2003","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2007.02.020_bib16","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1176\/appi.ajp.163.12.2186","article-title":"No improvement of post-traumatic stress disorder symptoms with guanfacine treatment","volume":"13","author":"Neylan","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2007.02.020_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/sleep\/7.4.365","article-title":"Effects of methoxamine and alpha-adrenoceptor antagonists, prazosin and yohimbine, on the sleep-wake cycle of the rat","volume":"7","author":"Pellejero","year":"1984","journal-title":"Sleep"},{"key":"10.1016\/j.biopsych.2007.02.020_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2006.06.032","article-title":"A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder","author":"Raskind","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.02.020_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1176\/appi.ajp.160.2.371","article-title":"Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study","volume":"160","author":"Raskind","year":"2003","journal-title":"Am J Psychiatry"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322307001679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322307001679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T13:55:59Z","timestamp":1546955759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322307001679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0006322307001679"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2007.02.020","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}