{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:10:45Z","timestamp":1792062645458,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.biopsych.2007.04.039","type":"journal-article","created":{"date-parts":[[2007,7,21]],"date-time":"2007-07-21T11:23:30Z","timestamp":1185017010000},"page":"1038-1047","source":"Crossref","is-referenced-by-count":103,"title":["Clinical, Morphological, and Biochemical Correlates of Head Circumference in Autism"],"prefix":"10.1016","volume":"62","author":[{"given":"Roberto","family":"Sacco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Militerni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Frolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Bravaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Gritti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Curatolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Manzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Trillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Lenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Saccani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raun","family":"Melmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Ludvig","family":"Reichelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Pascucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Puglisi-Allegra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio M.","family":"Persico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2007.04.039_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1994"},{"key":"10.1016\/j.biopsych.2007.04.039_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tins.2006.05.010","article-title":"Searching for ways out of the autism maze: Genetic, epigenetic and environmental clues","volume":"29","author":"Persico","year":"2006","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.biopsych.2007.04.039_bib3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1212\/WNL.59.2.175","article-title":"Effects of age on brain volume and head circumference in autism","volume":"59","author":"Aylward","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2007.04.039_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.pediatrneurol.2004.08.005","article-title":"Accelerated head growth in early development of individuals with autism","volume":"32","author":"Dementieva","year":"2005","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.biopsych.2007.04.039_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1017\/S0954579406060202","article-title":"Growth in stature and head circumference in high-functioning autism and Asperger disorder during the first 3 years of life","volume":"18","author":"Dissanayake","year":"2006","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.biopsych.2007.04.039_bib6","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1017\/S0012162200001365","article-title":"Macrocephaly in autism and other pervasive developmental disorders","volume":"42","author":"Fidler","year":"2000","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.biopsych.2007.04.039_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1023036509476","article-title":"Microcephaly and macrocephaly in autism","volume":"29","author":"Fombonne","year":"1999","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.biopsych.2007.04.039_bib8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00004583-199702000-00019","article-title":"Macrocephaly in children and adults with autism","volume":"36","author":"Lainhart","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib9","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/ajmg.a.31465","article-title":"Head circumference and height in autism: A study by the collaborative program of excellence in autism","volume":"140","author":"Lainhart","year":"2006","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2007.04.039_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/1096-8628(20001211)95:4<339::AID-AJMG9>3.0.CO;2-B","article-title":"Head circumference is an independent clinical finding associated with autism","volume":"95","author":"Miles","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2007.04.039_bib11","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/S0140-6736(05)62956-X","article-title":"Autism and macrocephaly","volume":"349","author":"Stevenson","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2007.04.039_bib12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1469-7610.1996.tb01458.x","article-title":"Head circumference in autism and other pervasive developmental disorders","volume":"37","author":"Woodhouse","year":"1996","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1212\/WNL.57.2.245","article-title":"Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study","volume":"57","author":"Courchesne","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2007.04.039_bib14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1212\/WNL.59.2.184","article-title":"Brain structural abnormalities in young children with autism spectrum disorder","volume":"59","author":"Sparks","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2007.04.039_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopsych.2005.03.026","article-title":"When is the brain enlarged in autism?","volume":"58","author":"Redcay","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib16","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1001\/archpsyc.62.12.1366","article-title":"Magnetic resonance imaging and head circumference study of brain size in autism: Birth through age 2 years","volume":"62","author":"Hazlett","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib17","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1006\/nimg.2002.1099","article-title":"Cerebral lobes in autism: Early hyperplasia and abnormal age effects","volume":"16","author":"Carper","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2007.04.039_bib18","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/brain\/awg110","article-title":"Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys","volume":"126","author":"Herbert","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.biopsych.2007.04.039_bib19","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1176\/ajp.2006.163.7.1290","article-title":"An MRI study of increased cortical thickness in autism","volume":"163","author":"Hardan","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.conb.2005.03.001","article-title":"Why the frontal cortex in autism might be talking only to itself: Local over-connectivity but long-distance disconnection","volume":"15","author":"Courchesne","year":"2005","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.biopsych.2007.04.039_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pneurobio.2005.10.005","article-title":"Macrocephaly and the control of brain growth in autistic disorders","volume":"77","author":"McCaffery","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.biopsych.2007.04.039_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1022903913547","article-title":"Brief report: Cognitive correlates of enlarged head circumference in children with autism","volume":"33","author":"Deutsch","year":"2003","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.biopsych.2007.04.039_bib23","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/sj.mp.4001714","article-title":"Paraoxonase gene variants are associated with autism in North America, but not in Italy: Possible regional specificity in gene-environment interactions","volume":"10","author":"D\u2019Amelio","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1086\/321292","article-title":"The Autism Genetic Resource Exchange: A resource for the study of autism and related neuropsychiatric conditions","volume":"69","author":"Geschwind","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.04.039_bib25","series-title":"ADOS, Autism Diagnostic Observation Schedule","author":"Lord","year":"2002"},{"key":"10.1016\/j.biopsych.2007.04.039_bib26","series-title":"ADI-R, Autism Diagnostic Interview-Revised","author":"Rutter","year":"2003"},{"key":"10.1016\/j.biopsych.2007.04.039_bib27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.biopsych.2003.10.005","article-title":"Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism","volume":"55","author":"Conciatori","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ajmg.b.30469","article-title":"HOXA1 gene variants influence head growth rates in humans","volume":"144","author":"Muscarella","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2007.04.039_bib29","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1136\/adc.67.10.1286","article-title":"Centiles for adult head circumference","volume":"67","author":"Bushby","year":"1992","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.biopsych.2007.04.039_bib30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/ajcn\/32.3.607","article-title":"Physical growth: National Center for Health Statistics percentiles","volume":"32","author":"Hamill","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.biopsych.2007.04.039_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1469-1809.1995.tb01608.x","article-title":"Monte Carlo tests for associations between disease and alleles at highly polymorphic loci","volume":"59","author":"Sham","year":"1995","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.biopsych.2007.04.039_bib32","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.biopsych.2004.09.014","article-title":"Autism and head circumference in the first year of life","volume":"56","author":"Torrey","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.04.039_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijdevneu.2004.09.006","article-title":"Neuroanatomic observations of the brain in autism: A review and future directions","volume":"23","author":"Bauman","year":"2005","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.biopsych.2007.04.039_bib34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1017\/S0001566000003706","article-title":"Chronological changes in genetic variance and heritability of anthropomometric characteristics among Chinese twin infants","volume":"39","author":"Chen","year":"1990","journal-title":"Acta Genet Med Gemellol (Roma)"},{"key":"10.1016\/j.biopsych.2007.04.039_bib35","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/jmg.2004.024646","article-title":"Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations","volume":"42","author":"Butler","year":"2005","journal-title":"J Med Genet"},{"key":"10.1016\/j.biopsych.2007.04.039_bib36","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1212\/01.wnl.0000229923.08213.1e","article-title":"Gray matter abnormalities in autism spectrum disorder revealed by T2 relaxation","volume":"67","author":"Petropoulos","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.biopsych.2007.04.039_bib37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.biopsych.2007.04.039_bib38","series-title":"Clinical Neuroimmunology","first-page":"1","article-title":"Introduction to immunology","author":"Birnbaum","year":"2005"},{"key":"10.1016\/j.biopsych.2007.04.039_bib39","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1046\/j.1365-2222.2001.01277.x","article-title":"Head circumference at birth and the development of allergic disease\u2013more questions than answers","volume":"31","author":"Beasley","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.biopsych.2007.04.039_bib40","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-2222.2003.01670.x","article-title":"Neonatal head circumference, neonatal weight, and risk of hayfever, asthma and eczema in a large cohort of adolescents from Sheffield, England","volume":"33","author":"Katz","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.biopsych.2007.04.039_bib41","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1365-2222.2005.2155.x","article-title":"Perinatal characteristics and obstetric complications as risk factors for asthma, allergy and eczema at the age of 6 years","volume":"35","author":"Bernsen","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.biopsych.2007.04.039_bib42","first-page":"2109","article-title":"Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle","volume":"63","author":"Menon","year":"2003","journal-title":"Cancer Res"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322307004301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322307004301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T11:22:43Z","timestamp":1556709763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322307004301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0006322307004301"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2007.04.039","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}