{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:20:48Z","timestamp":1759530048596},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.biopsych.2007.11.023","type":"journal-article","created":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T14:29:03Z","timestamp":1202480943000},"page":"121-127","source":"Crossref","is-referenced-by-count":46,"title":["Novel Linkage to Chromosome 20p Using Latent Classes of Psychotic Illness in 270 Irish High-Density Families"],"prefix":"10.1016","volume":"64","author":[{"given":"Ayman H.","family":"Fanous","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Neale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley T.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Straub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis A.","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dermot","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brien P.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth S.","family":"Kendler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"suppl 1","key":"10.1016\/j.biopsych.2007.11.023_bib1","first-page":"4","article-title":"The economic impact of schizophrenia","volume":"60","author":"Rice","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib2","series-title":"Dementia Praecox, or The Group of Schizophrenias","author":"Bleuler","year":"1950"},{"key":"10.1016\/j.biopsych.2007.11.023_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/sj.mp.4001558","article-title":"Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence","volume":"10","author":"Harrison","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1086\/425279","article-title":"Association of the DTNBP1 locus with schizophrenia in a U.S. population","volume":"75","author":"Funke","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.biopsych.2004.01.025","article-title":"Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria","volume":"55","author":"Kirov","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1086\/341750","article-title":"Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia","volume":"71","author":"Straub","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib7","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/sj.mp.4001430","article-title":"Family-based association study of DTNBP1 in 6p22.3 and schizophrenia","volume":"8","author":"Tang","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib8","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1086\/379928","article-title":"The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease","volume":"73","author":"Van Den Bogaert","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/archpsyc.61.4.336","article-title":"Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1)","volume":"61","author":"Williams","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/sj.mp.4001718","article-title":"Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations","volume":"10","author":"Li","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1176\/appi.ajp.157.3.402","article-title":"Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families","volume":"157","author":"Kendler","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib12","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/sj.mp.4001045","article-title":"Genetic heterogeneity in schizophrenia II: Conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q","volume":"7","author":"Chiu","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib13","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1176\/appi.ajp.162.10.1824","article-title":"Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia","volume":"162","author":"Fanous","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1176\/appi.ajp.163.3.532","article-title":"Dysbindin genotype and negative symptoms in schizophrenia","volume":"163","author":"DeRosse","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib15","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/sj.mp.4001051","article-title":"Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes","volume":"7","author":"Straub","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1096-8628(19960409)67:2<179::AID-AJMG8>3.0.CO;2-N","article-title":"Irish study on high-density schizophrenia families: Field methods and power to detect linkage","volume":"67","author":"Kendler","year":"1996","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib17","series-title":"Structured Clinical Interview for DSM-III-R Patient Version","author":"Spitzer","year":"1987"},{"key":"10.1016\/j.biopsych.2007.11.023_bib18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/archpsyc.1991.01810320088015","article-title":"A polydiagnostic application of operational criteria in studies of psychotic illness","volume":"48","author":"McGuffin","year":"1991","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib19","series-title":"SAS\/STAT Software, version 8","year":"1999"},{"key":"10.1016\/j.biopsych.2007.11.023_bib20","series-title":"LEM: A General Program for the Analysis of Categorical Data","author":"Vermunt","year":"1997"},{"key":"10.1016\/j.biopsych.2007.11.023_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/geno.1993.1008","article-title":"A microsatellite genetic linkage map of human chromosome 18","volume":"15","author":"Straub","year":"1993","journal-title":"Genomics"},{"key":"10.1016\/j.biopsych.2007.11.023_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/sj.mp.4000518","article-title":"Susceptibility genes for nicotine dependence: A genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study","volume":"4","author":"Straub","year":"1999","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib23","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1086\/301592","article-title":"Allele-sharing models: LOD scores and accurate linkage tests","volume":"61","author":"Kong","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees","volume":"30","author":"Abecasis","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib25","first-page":"1149","article-title":"Consanguinity and the sib-pair method: An approach using identity by descent between and within individuals","volume":"59","author":"Genin","year":"1996","journal-title":"Am J Hum Genet"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2007.11.023_bib26","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2156-6-S1-S6","article-title":"The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees","volume":"6","author":"Levinson","year":"2005","journal-title":"BMC Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF02294359","article-title":"Factor analysis and AIC","volume":"52","author":"Akaike","year":"1987","journal-title":"Psychometrika"},{"key":"10.1016\/j.biopsych.2007.11.023_bib28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1086\/346173","article-title":"A note on calculation of empirical p values from Monte Carlo procedure","volume":"72","author":"North","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/(SICI)1096-8628(19980710)81:4<296::AID-AJMG4>3.0.CO;2-S","article-title":"A schizophrenia locus may be located in region 10p15-p11","volume":"81","author":"Straub","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/ng1195-287","article-title":"A potential vulnerability locus for schizophrenia on chromosome 6p24-22: Evidence for genetic heterogeneity","volume":"11","author":"Straub","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.mp.4000258","article-title":"Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families","volume":"2","author":"Straub","year":"1997","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib32","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/1096-8628(20001204)96:6<864::AID-AJMG35>3.0.CO;2-D","article-title":"Second stage of a genome scan of schizophrenia: Study of five positive regions in an expanded sample","volume":"96","author":"Mowry","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib33","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4001273","article-title":"Linkage analysis of candidate regions using a composite neurocognitive phenotype correlated with schizophrenia","volume":"8","author":"Hallmayer","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q","article-title":"Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q","volume":"74","author":"Detera-Wadleigh","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1086\/376549","article-title":"Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia","volume":"73","author":"Lewis","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng1195-321","article-title":"An international two-stage genome-wide search for schizophrenia susceptibility genes","volume":"11","author":"Moises","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib37","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1086\/498122","article-title":"Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p","volume":"77","author":"Arinami","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib38","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1086\/302528","article-title":"Replication of linkage studies of complex traits: an examination of variation in location estimates","volume":"65","author":"Roberts","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib39","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1086\/425586","article-title":"Disrupted in schizophrenia 1 (DISC1): Association with schizophrenia, schizoaffective disorder, and bipolar disorder","volume":"75","author":"Hodgkinson","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib40","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/archpsyc.62.6.642","article-title":"Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder","volume":"62","author":"Green","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.mp.4001453","article-title":"Findings in an independent sample support an association between bipolar affective disorder and the G72\/G30 locus on chromosome 13q33","volume":"9","author":"Chen","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib42","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1086\/374822","article-title":"Polymorphisms at the G72\/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series","volume":"72","author":"Hattori","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.mp.4001421","article-title":"Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder","volume":"9","author":"Schumacher","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/archpsyc.58.2.165","article-title":"A separate disease within the syndrome of schizophrenia","volume":"58","author":"Kirkpatrick","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib45","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1176\/ajp.151.3.343","article-title":"Clinical subtypes of schizophrenia: differences in brain and CSF volume","volume":"151","author":"Gur","year":"1994","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib46","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archpsyc.1995.03950240079013","article-title":"Frontal and temporal lobe brain volumes in schizophrenia","volume":"52","author":"Turetsky","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1001\/archpsyc.1990.01810130037006","article-title":"Magnetic resonance imaging of the brain in schizophrenia","volume":"47","author":"Andreasen","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib48","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1176\/appi.ajp.160.9.1606","article-title":"Reduced cortical folding in schizophrenia: An MRI morphometric study","volume":"160","author":"Sallet","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib49","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1086\/432816","article-title":"Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit","volume":"77","author":"Hallmayer","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib50","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0920-9964(01)00393-0","article-title":"Longitudinal study of symptoms and cognitive function in chronic schizophrenia","volume":"59","author":"Hughes","year":"2003","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2007.11.023_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(03)00097-5","article-title":"Correlates of cognitive deficits in first episode schizophrenia","volume":"68","author":"Heydebrand","year":"2004","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2007.11.023_bib52","first-page":"1279","article-title":"Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q","volume":"58","author":"Detera-Wadleigh","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/geno.1996.4486","article-title":"Two-locus admixture linkage analysis of bipolar and unipolar affective disorder supports the presence of susceptibility loci on chromosomes 11p15 and 21q22","volume":"39","author":"Smyth","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/j.biopsych.2007.11.023_bib54","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1086\/302185","article-title":"A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus","volume":"64","author":"Aita","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib55","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng1194-291","article-title":"A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3","volume":"8","author":"Straub","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2007.11.023_bib56","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.mp.4001759","article-title":"Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3","volume":"11","author":"McQuillin","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/sj.mp.4001571","article-title":"Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: Searching for a framework","volume":"10","author":"Fanous","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib58","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/sj.mp.4001857","article-title":"Subtyping schizophrenia: Implications for genetic research","volume":"11","author":"Jablensky","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2007.11.023_bib59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0920-9964(00)00071-2","article-title":"How many and which are the psychopathological dimensions in schizophrenia?","volume":"49","author":"Peralta","year":"2001","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2007.11.023_bib60","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1037\/1082-989X.10.1.21","article-title":"Investigating population heterogeneity with factor mixture models","volume":"10","author":"Lubke","year":"2005","journal-title":"Psychol Methods"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322307011997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322307011997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:22:56Z","timestamp":1546294976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322307011997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0006322307011997"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2007.11.023","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}