{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:59:29Z","timestamp":1790665169848,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.biopsych.2008.03.026","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T08:12:40Z","timestamp":1210666360000},"page":"336-343","source":"Crossref","is-referenced-by-count":50,"title":["Calcium-Sensitive Adenylyl Cyclases in Depression and Anxiety: Behavioral and Biochemical Consequences of Isoform Targeting"],"prefix":"10.1016","volume":"64","author":[{"given":"Vaishnav","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Mazei-Robison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane C.","family":"Lagace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Shim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Birnbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia J.","family":"Eisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyung-Lim","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venetia","family":"Zachariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Nestler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2008.03.026_bib1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0143-4004(03)00060-2","article-title":"Differential expression of membrane and soluble adenylyl cyclase isoforms in cytotrophoblast cells and syncytiotrophoblasts of human placenta","volume":"24","author":"Bernatchez","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.biopsych.2008.03.026_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0303-7207(97)04013-6","article-title":"Adenylyl cyclases: Structure, regulation and function in an enzyme superfamily","volume":"128","author":"Hanoune","year":"1997","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.biopsych.2008.03.026_bib3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/mol.63.3.463","article-title":"Calmodulin-regulated adenylyl cyclases: Cross-talk and plasticity in the central nervous system","volume":"63","author":"Wang","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biopsych.2008.03.026_bib4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuroscience.2007.01.045","article-title":"Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain","volume":"146","author":"Conti","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopsych.2008.03.026_bib5","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1124\/mol.106.025783","article-title":"Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses","volume":"70","author":"Li","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biopsych.2008.03.026_bib6","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1523\/JNEUROSCI.4273-04.2005","article-title":"Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity","volume":"25","author":"Maas","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1744-8069-2-7","article-title":"Genetic reduction of chronic muscle pain in mice lacking calcium\/calmodulin-stimulated adenylyl cyclases","volume":"2","author":"Vadakkan","year":"2006","journal-title":"Mol Pain"},{"key":"10.1016\/j.biopsych.2008.03.026_bib8","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0896-6273(02)01019-X","article-title":"Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases","volume":"36","author":"Wei","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2008.03.026_bib9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1523\/JNEUROSCI.3292-05.2006","article-title":"Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice","volume":"26","author":"Wei","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0896-6273(01)80036-2","article-title":"Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP","volume":"23","author":"Wong","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2008.03.026_bib11","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1152\/physrev.00049.2006","article-title":"Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains","volume":"87","author":"Willoughby","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.biopsych.2008.03.026_bib12","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.0508812103","article-title":"Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action","volume":"103","author":"Kim","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2008.03.026_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2007.05.038","article-title":"Type 5 adenylyl cyclase disruption increases longevity and protects against stress","volume":"130","author":"Yan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2008.03.026_bib14","doi-asserted-by":"crossref","first-page":"pe64","DOI":"10.1126\/stke.4132007pe64","article-title":"Adenylyl cyclase 5: A new clue in the search for the \u201cfountain of youth\u201d?","volume":"2007","author":"Chester","year":"2007","journal-title":"Sci STKE"},{"key":"10.1016\/j.biopsych.2008.03.026_bib15","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1523\/JNEUROSCI.22-18-07931.2002","article-title":"Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase","volume":"22","author":"Lee","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib16","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.biopsych.2007.11.021","article-title":"Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: Behavioral, electrophysiological, and molecular studies","volume":"63","author":"Zachariou","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.03.026_bib17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2008.03.026_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biopsych.2006.03.021","article-title":"Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors","volume":"61","author":"Monteggia","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.03.026_bib19","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2005.07.025","article-title":"Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice","volume":"59","author":"Gemelli","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.03.026_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/hipo.20265","article-title":"Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice","volume":"17","author":"Lagace","year":"2007","journal-title":"Hippocampus"},{"key":"10.1016\/j.biopsych.2008.03.026_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s002130100694","article-title":"Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice","volume":"155","author":"Lucki","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.biopsych.2008.03.026_bib22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.biopsych.2008.03.026_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00008877-200605000-00008","article-title":"Selective effects of citalopram in a mouse model of stress-induced anhedonia with a control for chronic stress","volume":"17","author":"Strekalova","year":"2006","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.biopsych.2008.03.026_bib24","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nn1969","article-title":"Adult hippocampal neurogenesis in depression","volume":"10","author":"Sahay","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib25","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nn1971","article-title":"New insights into BDNF function in depression and anxiety","volume":"10","author":"Martinowich","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbrainres.2004.12.020","article-title":"Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs","volume":"136","author":"Karege","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.biopsych.2008.03.026_bib27","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nn1944","article-title":"Targeting abnormal neural circuits in mood and anxiety disorders: From the laboratory to the clinic","volume":"10","author":"Ressler","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.pharmtox.41.1.145","article-title":"Regulation and role of adenylyl cyclase isoforms","volume":"41","author":"Hanoune","year":"2001","journal-title":"Ann Rev Pharmacol Toxicol"},{"key":"10.1016\/j.biopsych.2008.03.026_bib29","doi-asserted-by":"crossref","first-page":"9377","DOI":"10.1073\/pnas.0503584102","article-title":"Regulation of dopaminergic transmission and cocaine reward by the Clock gene","volume":"102","author":"McClung","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2008.03.026_bib30","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1073\/pnas.0609625104","article-title":"Mania-like behavior induced by disruption of CLOCK","volume":"104","author":"Roybal","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2008.03.026_bib31","first-page":"1","article-title":"Lithium preferentially inhibits adenylyl cyclase V and VII isoforms [published online ahead of print January 21]","author":"Mann","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.biopsych.2008.03.026_bib32","doi-asserted-by":"crossref","first-page":"12609","DOI":"10.1523\/JNEUROSCI.1040-06.2006","article-title":"A sex-specific role of type VII adenylyl cyclase in depression","volume":"26","author":"Hines","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib33","doi-asserted-by":"crossref","first-page":"13208","DOI":"10.1073\/pnas.0605180103","article-title":"Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects","volume":"103","author":"Govindarajan","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2008.03.026_bib34","doi-asserted-by":"crossref","first-page":"9022","DOI":"10.1523\/JNEUROSCI.5216-05.2006","article-title":"Transgenic mice overexpressing glycogen synthase kinase 3beta: A putative model of hyperactivity and mania","volume":"26","author":"Prickaerts","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.03.026_bib35","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.biopsych.2005.05.040","article-title":"Platelet adenylyl cyclase activity: A biological marker for major depression and recent drug use","volume":"58","author":"Hines","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.03.026_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/0953710021000062905","article-title":"Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets","volume":"14","author":"Katsel","year":"2003","journal-title":"Platelets"},{"key":"10.1016\/j.biopsych.2008.03.026_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.biopsych.2007.07.016","article-title":"Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression","volume":"63","author":"Gourley","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.03.026_bib38","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.biopsych.2006.05.047","article-title":"A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment","volume":"61","author":"Duman","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"suppl 2","key":"10.1016\/j.biopsych.2008.03.026_bib39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1601-183X.2006.00228.x","article-title":"A hitchhiker's guide to behavioral analysis in laboratory rodents","volume":"5","author":"Sousa","year":"2006","journal-title":"Genes Brain Behav"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322308003922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322308003922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T09:11:35Z","timestamp":1557565895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322308003922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0006322308003922"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2008.03.026","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}