{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:13:52Z","timestamp":1791357232208,"version":"4.3.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.biopsych.2008.07.009","type":"journal-article","created":{"date-parts":[[2008,8,17]],"date-time":"2008-08-17T04:41:52Z","timestamp":1218948112000},"page":"856-862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Impact of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Levels of Hippocampal N-Acetyl-Aspartate Assessed by Magnetic Resonance Spectroscopic Imaging at 3 Tesla"],"prefix":"10.1016","volume":"64","author":[{"given":"Alexa J.","family":"Stern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina A.","family":"Savostyanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem C.","family":"van der Veen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H.","family":"Callicott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata S.","family":"Mattay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Marenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2008.07.009_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ajmg.b.30150","article-title":"Association between BDNF val66 met genotype and episodic memory","volume":"134","author":"Dempster","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2008.07.009_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.biopsych.2008.07.009_bib3","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003","article-title":"Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance","volume":"23","author":"Hariri","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.schres.2005.03.012","article-title":"Effect of the BDNF Val66Met genotype on episodic memory in schizophrenia","volume":"77","author":"Tan","year":"2005","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2008.07.009_bib5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/archpsyc.63.7.731","article-title":"Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers","volume":"63","author":"Ho","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molbrainres.2005.07.008","article-title":"Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males","volume":"140","author":"Cheng","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.biopsych.2008.07.009_bib7","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/hmg\/ddh137","article-title":"Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations","volume":"13","author":"Ribases","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2008.07.009_bib8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/sj.mp.4000749","article-title":"Brain derived neurotrophic factor (BDNF) gene variants association with age at onset and therapeutic response in schizophrenia","volume":"5","author":"Krebs","year":"2000","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.mp.4001058","article-title":"Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus","volume":"7","author":"Sklar","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/sj.mp.4001685","article-title":"Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: Confirmation in a Hungarian sample","volume":"10","author":"Strauss","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biopsych.2005.04.006","article-title":"Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression","volume":"58","author":"Schumacher","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000074636","article-title":"Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior","volume":"48","author":"Hong","year":"2003","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.biopsych.2008.07.009_bib13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<724::AID-AJMG25>3.0.CO;2-7","article-title":"Heritability of BDNF alleles and their effect on brain morphology in schizophrenia","volume":"88","author":"Wassink","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2008.07.009_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ajmg.b.30097","article-title":"Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan","volume":"132B","author":"Itoh","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2008.07.009_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ajmg.b.30332","article-title":"Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence","volume":"141B","author":"Zhang","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2008.07.009_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/35049004","article-title":"Neurotrophins as synaptic modulators","volume":"2","author":"Poo","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib17","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1460-9568.1994.tb01001.x","article-title":"In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of [125I]BDNF, [125I]NT-4\/5 and [125I]NT-3","volume":"6","author":"Altar","year":"1994","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib18","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1523\/JNEUROSCI.0348-04.2004","article-title":"Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons","volume":"24","author":"Chen","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib19","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1601-183X.2007.00363.x","article-title":"Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly","volume":"7","author":"Miyajima","year":"2008","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.biopsych.2008.07.009_bib20","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2005.09.022","article-title":"BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects","volume":"59","author":"Bueller","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/archpsyc.64.4.410","article-title":"Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression","volume":"64","author":"Frodl","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib22","doi-asserted-by":"crossref","first-page":"10099","DOI":"10.1523\/JNEUROSCI.2680-04.2004","article-title":"The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology","volume":"24","author":"Pezawas","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.mp.4001656","article-title":"Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation","volume":"10","author":"Szeszko","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib24","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1098\/rspb.1999.0790","article-title":"Biochemical markers of intelligence: A proton MR spectroscopy study of normal human brain","volume":"266","author":"Jung","year":"1999","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib25","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1097\/00001756-199911080-00014","article-title":"Biochemical markers of cognition: A proton MR spectroscopy study of normal human brain","volume":"10","author":"Jung","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopsych.2008.07.009_bib26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1006\/nimg.2000.0629","article-title":"Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: Subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes","volume":"12","author":"Valenzuela","year":"2000","journal-title":"Neuroimage"},{"key":"10.1016\/j.biopsych.2008.07.009_bib27","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.pnpbp.2006.03.032","article-title":"Hippocampal 1H MRS in first-episode bipolar I patients","volume":"30","author":"Atmaca","year":"2006","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0006-3223(99)00183-3","article-title":"Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder","volume":"47","author":"Winsberg","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib29","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1460-9568.2006.05253.x","article-title":"Decreased N-acetyl-aspartate levels in anterior cingulate and hippocampus in subjects with post-traumatic stress disorder: A proton magnetic resonance spectroscopy study","volume":"25","author":"Ham","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jpsychires.2006.09.013","article-title":"Adolescent anorexia nervosa: Cross-sectional and follow-up frontal gray matter disturbances detected with proton magnetic resonance spectroscopy","volume":"41","author":"Castro-Fornieles","year":"2007","journal-title":"J Psychiatr Res"},{"issue":"suppl","key":"10.1016\/j.biopsych.2008.07.009_bib31","first-page":"19","article-title":"Magnetic resonance spectroscopy in social phobia: Preliminary findings","volume":"54","author":"Davidson","year":"1993","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0006-3223(98)00264-9","article-title":"Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: A possible intermediate neurobiological phenotype","volume":"44","author":"Callicott","year":"1998","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/0-387-30172-0_16","article-title":"In vivo NMR measures of NAA and the neurobiology of schizophrenia","volume":"576","author":"Marenco","year":"2006","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.biopsych.2008.07.009_bib34","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1176\/ajp.153.12.1554","article-title":"Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging","volume":"153","author":"Bertolino","year":"1996","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib35","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1176\/appi.ajp.157.8.1309","article-title":"Relative risk of attention deficits in siblings of patients with schizophrenia","volume":"157","author":"Egan","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib36","first-page":"1871","article-title":"Reproducibility of proton MR spectroscopic imaging findings","volume":"17","author":"Tedeschi","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.biopsych.2008.07.009_bib37","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1148\/radiology.217.1.r00oc36296","article-title":"Proton MR spectroscopic imaging without water suppression","volume":"217","author":"van Der Veen","year":"2000","journal-title":"Radiology"},{"key":"10.1016\/j.biopsych.2008.07.009_bib38","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/nbm.1055","article-title":"Single-voxel 1H PRESS at 4.0 T: Precision and variability of measurements in anterior cingulate and hippocampus","volume":"19","author":"Venkatraman","year":"2006","journal-title":"NMR Biomed"},{"key":"10.1016\/j.biopsych.2008.07.009_bib39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med Image Anal"},{"key":"10.1016\/j.biopsych.2008.07.009_bib40","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2008.07.009_bib41","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.biopsych.2007.06.006","article-title":"Heritability of brain morphology related to schizophrenia: A large-scale automated magnetic resonance imaging segmentation study","volume":"63","author":"Goldman","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00213-006-0647-1","article-title":"Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking","volume":"190","author":"Lang","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2008.07.009_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ajmg.b.30231","article-title":"Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers","volume":"139B","author":"Beuten","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2008.07.009_bib44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/JCP.0b013e31802dffde","article-title":"Abnormal hippocampal neurochemistry in smokers: Evidence from proton magnetic resonance spectroscopy at 3 T","volume":"27","author":"Gallinat","year":"2007","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2008.07.009_bib45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ajmg.b.30338","article-title":"BDNF gene variants and brain morphology in schizophrenia","volume":"141B","author":"Agartz","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2008.07.009_bib46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neulet.2008.02.004","article-title":"Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons","volume":"435","author":"Takahashi","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2008.07.009_bib47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2005.11.067","article-title":"The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology","volume":"397","author":"Nemoto","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.biopsych.2008.07.009_bib48","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1097\/00001756-199605310-00014","article-title":"Inhibition of N-acetylaspartate production: Implications for 1H MRS studies in vivo","volume":"7","author":"Bates","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopsych.2008.07.009_bib49","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/ana.10360","article-title":"Neuronal and glial metabolite content of the epileptogenic human hippocampus","volume":"52","author":"Petroff","year":"2002","journal-title":"Ann Neurol"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2008.07.009_bib50","first-page":"5310","article-title":"Role of the brain-derived neurotrophic factor at glutamatergic synapses","volume":"153","author":"Carvalho","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.biopsych.2008.07.009_bib51","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1096\/fj.02-0143fje","article-title":"Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus","volume":"16","author":"Katoh-Semba","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.biopsych.2008.07.009_bib52","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1523\/JNEUROSCI.21-17-06706.2001","article-title":"Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus","volume":"21","author":"Pencea","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib53","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/FBP.0b013e3282ee2aa8","article-title":"The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior","volume":"18","author":"Schmidt","year":"2007","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.biopsych.2008.07.009_bib54","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib55","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0006-3223(99)00247-4","article-title":"Stress and hippocampal neurogenesis","volume":"46","author":"Gould","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib56","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1523\/JNEUROSCI.17-07-02492.1997","article-title":"Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation","volume":"17","author":"Gould","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib57","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","article-title":"A molecular and cellular theory of depression","volume":"54","author":"Duman","year":"1997","journal-title":"Arch Gen Psychiatry"},{"issue":"suppl 3","key":"10.1016\/j.biopsych.2008.07.009_bib58","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0924-9338(02)00650-8","article-title":"Structural plasticity and tianeptine: Cellular and molecular targets","volume":"17","author":"McEwen","year":"2002","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib59","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopsych.2008.07.009_bib60","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1073\/pnas.211427898","article-title":"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine","volume":"98","author":"Czeh","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopsych.2008.07.009_bib61","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s00213-005-2184-8","article-title":"Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression","volume":"180","author":"Czeh","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2008.07.009_bib62","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/sj.mp.4001130","article-title":"Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume","volume":"7","author":"van der Hart","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib63","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0006-3223(02)01600-1","article-title":"Choline rise in the rat hippocampus induced by electroconvulsive shock treatment","volume":"53","author":"Sartorius","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-3223(00)00252-3","article-title":"Lithium increases N-acetyl-aspartate in the human brain: In vivo evidence in support of bcl-2's neurotrophic effects?","volume":"48","author":"Moore","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib65","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.biopsych.2007.09.012","article-title":"Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder","volume":"63","author":"Mathew","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib66","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4088\/JCP.v64n0706","article-title":"Long-term follow-up of magnetic resonance-detectable choline signal changes in the hippocampus of patients treated with electroconvulsive therapy","volume":"64","author":"Obergriesser","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib67","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/archpsyc.57.10.937","article-title":"The hippocampus in patients treated with electroconvulsive therapy: A proton magnetic resonance spectroscopic imaging study","volume":"57","author":"Ende","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2008.07.009_bib68","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1126\/science.1147851","article-title":"Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain","volume":"318","author":"Manganas","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.biopsych.2008.07.009_bib69","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322308008287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322308008287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:58:13Z","timestamp":1762099093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322308008287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0006322308008287"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2008.07.009","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Levels of Hippocampal N-Acetyl-Aspartate Assessed by Magnetic Resonance Spectroscopic Imaging at 3 Tesla","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopsych.2008.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}