{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:18:13Z","timestamp":1768623493108,"version":"3.49.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.biopsych.2008.09.020","type":"journal-article","created":{"date-parts":[[2008,11,15]],"date-time":"2008-11-15T09:10:05Z","timestamp":1226740205000},"page":"527-534","source":"Crossref","is-referenced-by-count":28,"title":["Genetic Overlap Among Intelligence and Other Candidate Endophenotypes for Schizophrenia"],"prefix":"10.1016","volume":"65","author":[{"given":"Maartje F.","family":"Aukes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrooz Z.","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margriet M.","family":"Sitskoorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Kemner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roel A.","family":"Ophoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 S.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopsych.2008.09.020_bib1","series-title":"Schizophrenia and Genetics: A Twin Study Vantage Point","author":"Gottesman","year":"1972"},{"key":"10.1016\/j.biopsych.2008.09.020_bib2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/sj.mp.4002068","article-title":"Endophenotypes in psychiatric genetics","volume":"12","author":"Walters","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0168-9525(00)89163-5","article-title":"Polygenic disease: Methods for mapping complex disease traits","volume":"11","author":"Weeks","year":"1995","journal-title":"Trends Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: Etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1037\/0894-4105.12.3.426","article-title":"Neurocognitive deficit in schizophrenia: A quantitative review of the evidence","volume":"12","author":"Heinrichs","year":"1998","journal-title":"Neuropsychology"},{"key":"10.1016\/j.biopsych.2008.09.020_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.schres.2004.03.007","article-title":"Cognitive deficits in relatives of patients with schizophrenia: A meta-analysis","volume":"71","author":"Sitskoorn","year":"2004","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.mp.4001563","article-title":"Phenotype of schizophrenia: A review and formulation","volume":"10","author":"Tamminga","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/schbul\/sbl055","article-title":"The Consortium on the Genetics of Schizophrenia: Neurocognitive endophenotypes","volume":"33","author":"Gur","year":"2007","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2008.09.020_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/schbul\/sbl060","article-title":"Neurophysiological endophenotypes of schizophrenia: The viability of selected candidate measures","volume":"33","author":"Turetsky","year":"2007","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.biopsych.2008.09.020_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/1096-8628(20010108)105:1<20::AID-AJMG1047>3.0.CO;2-C","article-title":"Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7)","volume":"105","author":"Freedman","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib11","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1093\/hmg\/ddh184","article-title":"Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q","volume":"13","author":"Paunio","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2008.09.020_bib12","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1186\/1471-2156-6-S1-S19","article-title":"Linkage mapping of a complex trait in the New York population of the GAW14 simulated dataset: A multivariate phenotype approach","volume":"6","author":"Ghosh","year":"2005","journal-title":"BMC Genet"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2008.09.020_bib13","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1186\/1471-2156-6-S1-S117","article-title":"A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes","volume":"6","author":"Warren","year":"2005","journal-title":"BMC Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib14","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1086\/302571","article-title":"Joint multipoint linkage analysis of multivariate qualitative and quantitative traits","volume":"65","author":"Williams","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib15","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/archpsyc.64.11.1242","article-title":"Initial heritability analyses of endophenotypic measures for schizophrenia: The consortium on the genetics of schizophrenia","volume":"64","author":"Greenwood","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib16","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/ajmg.b.30318","article-title":"Genetic overlap between P300, P50, and duration mismatch negativity","volume":"141","author":"Hall","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10519-005-6188-2","article-title":"Genetic covariation between event-related potential (ERP) and behavioral non-ERP measures of working-memory, processing speed, and IQ","volume":"35","author":"Hansell","year":"2005","journal-title":"Behav Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1023\/A:1013397428612","article-title":"Genetic covariance among measures of information processing speed, working memory, and IQ","volume":"31","author":"Luciano","year":"2001","journal-title":"Behav Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nn0202-83","article-title":"The association between brain volume and intelligence is of genetic origin","volume":"5","author":"Posthuma","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.biopsych.2008.09.020_bib20","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1001\/archpsyc.62.12.1297","article-title":"Elaboration on premorbid intellectual performance in schizophrenia: Premorbid intellectual decline and risk for schizophrenia","volume":"62","author":"Reichenberg","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib21","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1001\/archpsyc.64.12.1348","article-title":"Substantial genetic overlap between neurocognition and schizophrenia: Genetic modeling in twin samples","volume":"64","author":"Toulopoulou","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib22","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1176\/appi.ajp.2008.07081242","article-title":"Premorbid IQ in schizophrenia: A meta-analytic review","volume":"165","author":"Woodberry","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/neu.10160","article-title":"Genetic and environmental influences on human psychological differences","volume":"54","author":"Bouchard","year":"2003","journal-title":"J Neurobiol"},{"key":"10.1016\/j.biopsych.2008.09.020_bib24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/hmg\/8.5.915","article-title":"DNA pooling identifies QTLs on chromosome 4 for general cognitive ability in children","volume":"8","author":"Fisher","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib25","series-title":"The G Factor: The Science of Mental Ability","author":"Jensen","year":"1998"},{"key":"10.1016\/j.biopsych.2008.09.020_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.intell.2003.12.002","article-title":"Working memory is (almost) perfectly predicted by g","volume":"32","author":"Colom","year":"2004","journal-title":"Intelligence"},{"key":"10.1016\/j.biopsych.2008.09.020_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1037\/0096-3445.128.3.309","article-title":"Working memory, short-term memory, and general fluid intelligence: A latent-variable approach","volume":"128","author":"Engle","year":"1999","journal-title":"J Exp Psychol Gen"},{"key":"10.1016\/j.biopsych.2008.09.020_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1023\/A:1021667213066","article-title":"Multivariate path analysis of specific cognitive abilities data at 12 years of age in the Colorado Adoption Project","volume":"28","author":"Alarcon","year":"1998","journal-title":"Behav Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0160-2896(94)90024-8","article-title":"Is there G beyond G - is there genetic influence on specific cognitive-abilities independent of genetic influence on general cognitive-ability","volume":"18","author":"Pedersen","year":"1994","journal-title":"Intelligence"},{"key":"10.1016\/j.biopsych.2008.09.020_bib30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/1467-8721.ep11512833","article-title":"Molarity versus modularity of cognitive functioning?","volume":"6","author":"Petrill","year":"1997","journal-title":"Curr Dir Psychol Sci"},{"key":"10.1016\/j.biopsych.2008.09.020_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1364-6613(00)01853-2","article-title":"Genetics and general cognitive ability (g)","volume":"6","author":"Plomin","year":"2002","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.biopsych.2008.09.020_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11920-999-0006-0","article-title":"The genetics of schizophrenia","volume":"1","author":"Tsuang","year":"1999","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.biopsych.2008.09.020_bib33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2007.12.013","article-title":"Finding suitable phenotypes for genetic studies of schizophrenia: Heritability and segregation analysis","volume":"64","author":"Aukes","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib34","series-title":"Molecular Genetics Initiative: Family Interview for Genetic Studies","year":"1991"},{"key":"10.1016\/j.biopsych.2008.09.020_bib35","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archpsyc.1992.01820080023004","article-title":"The Comprehensive Assessment of Symptoms and History (CASH)","volume":"49","author":"Andreasen","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib36","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib37","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s002130100810","article-title":"Human studies of prepulse inhibition of startle: Normal subjects, patient groups, and pharmacological studies","volume":"156","author":"Braff","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.biopsych.2008.09.020_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0165-1781(97)03096-5","article-title":"Relationship between the five-factor model of personality and unipolar, bipolar and schizophrenic patients","volume":"70","author":"Bagby","year":"1997","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.psychres.2004.09.002","article-title":"Personality traits in schizophrenia and related personality disorders","volume":"133","author":"Camisa","year":"2005","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib40","series-title":"Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual","author":"Costa","year":"1992"},{"key":"10.1016\/j.biopsych.2008.09.020_bib41","series-title":"NEO PI-R; NEO FFI; Big Five Persoonlijkheidsvragenlijsten; Handleiding","author":"Hoekstra","year":"1996"},{"key":"10.1016\/j.biopsych.2008.09.020_bib42","series-title":"The Groninger Intelligence Test (in Dutch)","author":"Luteijn","year":"1983"},{"key":"10.1016\/j.biopsych.2008.09.020_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0920-9964(02)00282-7","article-title":"Letter and category fluency in schizophrenic patients: A meta-analysis","volume":"64","author":"Bokat","year":"2003","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13546800344000309","article-title":"A meta-analytic review of verbal fluency deficits in schizophrenia relative to other neurocognitive deficits","volume":"10","author":"Henry","year":"2005","journal-title":"Cognit Neuropsychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib45","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1017\/S003329170200716X","article-title":"Forward and backward visual masking in schizophrenia: Influence of age","volume":"33","author":"Green","year":"2003","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2008.09.020_bib46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/mpr.126","article-title":"Development of a computerized assessment for visual masking","volume":"11","author":"Green","year":"2002","journal-title":"Int J Methods Psychiatr Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib47","series-title":"Wechsler Memory Scale, 3rd ed","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.biopsych.2008.09.020_bib48","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1037\/0021-843X.114.4.599","article-title":"Working memory impairments in schizophrenia: A meta-analysis","volume":"114","author":"Lee","year":"2005","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.biopsych.2008.09.020_bib49","series-title":"WAIS-III Nederlandstalige Bewerking","author":"Wechsler","year":"2000"},{"key":"10.1016\/j.biopsych.2008.09.020_bib50","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0920-9964(00)00017-7","article-title":"Short form of the WAIS-III for use with patients with schizophrenia","volume":"46","author":"Blyler","year":"2000","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib51","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO;2-K","article-title":"Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages","volume":"14","author":"Almasy","year":"1997","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.biopsych.2008.09.020_bib52","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib53","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ajmg.1320140315","article-title":"Extensions to pedigree analysis","volume":"14","author":"Lange","year":"1983","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib54","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1086\/302487","article-title":"Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure","volume":"65","author":"Allison","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib55","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.schres.2006.03.041","article-title":"Are deficits in executive sub-processes simply reflecting more general cognitive decline in schizophrenia?","volume":"85","author":"Donohoe","year":"2006","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0160-2896(05)80012-1","article-title":"Reasoning ability is (little more than) working-memory capacity","volume":"14","author":"Kyllonen","year":"1990","journal-title":"Intelligence"},{"key":"10.1016\/j.biopsych.2008.09.020_bib57","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1651-2227.2000.tb00086.x","article-title":"Prepulse inhibition of startle, intelligence and familial primary nocturnal enuresis","volume":"89","author":"Ornitz","year":"2000","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.biopsych.2008.09.020_bib58","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.biopsych.2006.08.015","article-title":"Prepulse inhibition and P50 suppression are both deficient but not correlated in schizophrenia patients","volume":"61","author":"Braff","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib59","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0006-3223(98)00128-0","article-title":"P50 suppression and prepulse inhibition of the startle reflex in humans: A correlational study","volume":"45","author":"Oranje","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib60","series-title":"Handbook of Personality Psychology","first-page":"825","article-title":"Conceptions and correlates of openness to experience","author":"McCrae","year":"1997"},{"key":"10.1016\/j.biopsych.2008.09.020_bib61","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2466\/pr0.2003.92.3c.1151","article-title":"Relationship between WAIS-R intelligence and the five-factor model of personality in a normal elderly sample","volume":"92","author":"Saggino","year":"2003","journal-title":"Psychol Rep"},{"key":"10.1016\/j.biopsych.2008.09.020_bib62","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.schres.2007.02.007","article-title":"Schizotypy versus openness and intelligence as predictors of creativity","volume":"93","author":"Miller","year":"2007","journal-title":"Schizophr Res"},{"key":"10.1016\/j.biopsych.2008.09.020_bib63","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/per.2410080404","article-title":"Openness to experience--expanding the boundaries of Factor-V","volume":"8","author":"McCrae","year":"1994","journal-title":"Eur J Pers"},{"key":"10.1016\/j.biopsych.2008.09.020_bib64","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1086\/432647","article-title":"A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p","volume":"77","author":"Posthuma","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib65","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10519-005-9009-8","article-title":"Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample","volume":"36","author":"Dick","year":"2006","journal-title":"Behav Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib66","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10519-005-9003-1","article-title":"Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q","volume":"36","author":"Luciano","year":"2006","journal-title":"Behav Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib67","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ng1195-235","article-title":"Schizophrenia susceptibility and chromosome 6p24-22","volume":"11","author":"Antonarakis","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib68","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000026690","article-title":"Genome scan for susceptibility loci for schizophrenia","volume":"42","author":"Bailer","year":"2000","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.biopsych.2008.09.020_bib69","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/9.7.1049","article-title":"Genome-wide scan for schizophrenia in the Finnish population: Evidence for a locus on chromosome 7q22","volume":"9","author":"Ekelund","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib70","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/hmg\/ddl462","article-title":"Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1","volume":"16","author":"Hennah","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib71","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/sj.mp.4000443","article-title":"Linkage analysis of putative schizophrenia gene candidate regions on chromosomes 3p, 5q, 6p, 8p, 20p and 22q in a population-based sampled Finnish family set","volume":"3","author":"Hovatta","year":"1998","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib72","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00439-005-1320-1","article-title":"Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia","volume":"117","author":"Klei","year":"2005","journal-title":"Hum Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib73","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/sj.mp.4001322","article-title":"Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24","volume":"8","author":"Lerer","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib74","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1086\/376549","article-title":"Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia","volume":"73","author":"Lewis","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib75","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/(SICI)1096-8628(19990820)88:4<369::AID-AJMG14>3.0.CO;2-9","article-title":"Linkage analysis of a large Swedish kindred provides further support for a susceptibility locus for schizophrenia on chromosome 6p23","volume":"88","author":"Lindholm","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib76","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/sj.mp.4000915","article-title":"A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: A linkage study in 13 target chromosomes","volume":"6","author":"Maziade","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib77","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1093\/hmg\/10.26.3037","article-title":"Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q","volume":"10","author":"Paunio","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib78","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/sj.mp.4000791","article-title":"A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: Support for loci on chromosome 10p and 6","volume":"5","author":"Schwab","year":"2000","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib79","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/sj.mp.4001051","article-title":"Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes","volume":"7","author":"Straub","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib80","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/sj.mp.4002047","article-title":"Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families","volume":"13","author":"Wedenoja","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib81","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/sj.mp.4001356","article-title":"Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: Evidence for linkage to chromosome 2q","volume":"8","author":"Wijsman","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib82","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10519-005-9002-2","article-title":"Linkage analyses of event-related potential slow wave phenotypes recorded in a working memory task","volume":"36","author":"Hansell","year":"2006","journal-title":"Behav Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib83","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/sj.mp.4001731","article-title":"A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia","volume":"10","author":"Hennah","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib84","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/sj.mp.4001878","article-title":"Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls","volume":"11","author":"Nicodemus","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib85","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/sj.mp.4001988","article-title":"Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression","volume":"12","author":"Straub","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib86","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1172\/JCI30413","article-title":"Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition","volume":"117","author":"Meyer-Lindenberg","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biopsych.2008.09.020_bib87","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/hmg\/ddi481","article-title":"Genetic variation in DTNBP1 influences general cognitive ability","volume":"15","author":"Burdick","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib88","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.neuropsychologia.2006.06.016","article-title":"Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: A preliminary study","volume":"45","author":"Donohoe","year":"2007","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.biopsych.2008.09.020_bib89","first-page":"109","article-title":"Uniqueness and redundancy in GABA production","volume":"5","author":"Pinal","year":"1998","journal-title":"Perspect Dev Neurobiol"},{"key":"10.1016\/j.biopsych.2008.09.020_bib90","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/sj.mp.4001613","article-title":"Reelin glycoprotein: Structure, biology and roles in health and disease","volume":"10","author":"Fatemi","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopsych.2008.09.020_bib91","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0896-6273(00)81176-9","article-title":"Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses","volume":"26","author":"Huang","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.biopsych.2008.09.020_bib92","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/343369a0","article-title":"Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices","volume":"343","author":"Halpain","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.biopsych.2008.09.020_bib93","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1172\/JCI200420425","article-title":"Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia","volume":"113","author":"Talbot","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biopsych.2008.09.020_bib94","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/hmg\/ddh280","article-title":"Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia","volume":"13","author":"Numakawa","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.biopsych.2008.09.020_bib95","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tics.2006.03.001","article-title":"Generalist genes: Implications for the cognitive sciences","volume":"10","author":"Kovas","year":"2006","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.biopsych.2008.09.020_bib96","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322308011554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322308011554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T09:58:19Z","timestamp":1545645499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322308011554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":96,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0006322308011554"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2008.09.020","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}