{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:21:04Z","timestamp":1791274864929,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.biopsych.2009.01.031","type":"journal-article","created":{"date-parts":[[2009,3,7]],"date-time":"2009-03-07T09:13:54Z","timestamp":1236417234000},"page":"17-24","source":"Crossref","is-referenced-by-count":38,"title":["Serotonin and Sensitivity to Trauma-Related Exposure in Selective Serotonin Reuptake Inhibitors-Recovered Posttraumatic Stress Disorder"],"prefix":"10.1016","volume":"66","author":[{"given":"Felipe","family":"Corchs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Nutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Hood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Bernik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 5","key":"10.1016\/j.biopsych.2009.01.031_bib1","first-page":"4","article-title":"Posttraumatic stress disorder: the burden to the individual and to society","volume":"61","author":"Kessler","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1037\/0021-843X.99.1.49","article-title":"Psychophysiologic responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders","volume":"99","author":"Pitman","year":"1990","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib3","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/archpsyc.1987.01800230050009","article-title":"Psychophysiologic assessment of posttraumatic stress disorder imagery in Vietnam combat veterans","volume":"44","author":"Pitman","year":"1987","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3928\/00485713-20051101-04","article-title":"A new treatment algorithm to posttraumatic stress disorder","volume":"35","author":"Davidson","year":"2005","journal-title":"Psychiatr Ann"},{"key":"10.1016\/j.biopsych.2009.01.031_bib5","author":"Davidson"},{"key":"10.1016\/j.biopsych.2009.01.031_bib6","first-page":"1088","article-title":"Pharmacotherapy for post-traumatic stress disorder\u2014a systematic review and meta-analysis","volume":"96","author":"Ipser","year":"2006","journal-title":"S Afr Med J"},{"key":"10.1016\/j.biopsych.2009.01.031_bib7","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/archpsyc.1995.03950240066012","article-title":"Posttraumatic stress disorder in the National Comorbidity Survey","volume":"52","author":"Kessler","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00004850-200501000-00009","article-title":"Trauma, resilience and saliostasis: Effects of treatment in post-traumatic stress disorder","volume":"20","author":"Davidson","year":"2005","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1176\/appi.ajp.161.2.195","article-title":"Psychobiological mechanisms of resilience and vulnerability: Implications for successful adaptation to extreme stress","volume":"161","author":"Charney","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/026988119100500414","article-title":"5-HT and mechanisms of defence","volume":"5","author":"Deakin","year":"1991","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib11","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1080\/j.1440-1614.2005.01627.x","article-title":"Acute tryptophan depletion","volume":"39","author":"Hood","year":"2005","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1001\/archpsyc.1990.01810170011002","article-title":"Serotonin function and the mechanism of antidepressant action","volume":"47","author":"Delgado","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib13","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0140-6736(96)07044-4","article-title":"Relapse of depression after rapid depletion of tryptophan","volume":"349","author":"Smith","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.biopsych.2009.01.031_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00213-003-1401-6","article-title":"Tryptophan depletion decreases the recognition of fear in female volunteers","volume":"167","author":"Harmer","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.biopsych.2009.01.031_bib15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0006-3223(95)00393-2","article-title":"Tryptophan depletion in obsessive-compulsive patients","volume":"40","author":"Smeraldi","year":"1996","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000115778","article-title":"Effects of tryptophan depletion on cognitive functioning, obsessive-compulsive symptoms and mood in obsessive-compulsive disorder: Preliminary results","volume":"56","author":"Kulz","year":"2008","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.biopsych.2009.01.031_bib17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0006-3223(94)90091-4","article-title":"Effects of tryptophan depletion in panic disorder","volume":"36","author":"Goddard","year":"1994","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/026988110201600116","article-title":"Does 5-HT restrain panic?","volume":"16","author":"Bell","year":"2002","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.biopsych.2004.07.006","article-title":"Tryptophan depletion reverses the therapeutic effect of selective serotonin reuptake inhibitors in social anxiety disorder","volume":"56","author":"Argyropoulos","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/01.jcp.0000227704.79740.c0","article-title":"Depleting serotonin enhances both cardiovascular and psychological stress reactivity in recovered patients with anxiety disorders","volume":"26","author":"Davies","year":"2006","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0165-1781(98)00004-3","article-title":"Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge","volume":"77","author":"Klaassen","year":"1998","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.biopsych.2009.01.031_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.biopsych.2004.10.010","article-title":"Effect of acute tryptophan depletion on the response to controllable and uncontrollable noise stress","volume":"57","author":"Richell","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1590\/S0100-879X2000000500013","article-title":"Effects of tryptophan depletion on anxiety induced by simulated public speaking","volume":"33","author":"Monteiro-dos-Santos","year":"2000","journal-title":"Braz J Med Biol Res"},{"issue":"suppl 20","key":"10.1016\/j.biopsych.2009.01.031_bib24","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib25","series-title":"Early Clinical Drug Evaluation Unit Assessment Manual for Psychopharmacology","author":"Guy","year":"1976"},{"key":"10.1016\/j.biopsych.2009.01.031_bib26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1017\/S0033291796004229","article-title":"Assessment of a new self-rating scale for post-traumatic stress disorder","volume":"27","author":"Davidson","year":"1997","journal-title":"Psychol Med"},{"key":"10.1016\/j.biopsych.2009.01.031_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"Rating Scale for Depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib29","series-title":"Manual for the Profile of Mood States","author":"McNair","year":"1988"},{"key":"10.1016\/j.biopsych.2009.01.031_bib30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br J Med Psychol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib31","series-title":"Manual for the State-Trait Anxiety Inventory","author":"Spielberger","year":"1970"},{"key":"10.1016\/j.biopsych.2009.01.031_bib32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00431803","article-title":"Tryptophan depletion causes a rapid lowering of mood in normal males","volume":"87","author":"Young","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.biopsych.2009.01.031_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-3223(01)01279-3","article-title":"Pilot study of secondary prevention of posttraumatic stress disorder with propranolol","volume":"51","author":"Pitman","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2044-8341.1974.tb02285.x","article-title":"The use of analogue scales in rating subjective feelings","volume":"47","author":"Bond","year":"1974","journal-title":"Br J Med Psychol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib35","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1001\/archpsyc.1997.01830200083012","article-title":"Noradrenergic and serotonergic function in posttraumatic stress disorder","volume":"54","author":"Southwick","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/01.psy.0000188566.35902.e7","article-title":"Heart rate responsivity to script-driven imagery in posttraumatic stress disorder: specificity of response and effects of psychotherapy","volume":"68","author":"Lindauer","year":"2006","journal-title":"Psychosom Med"},{"key":"10.1016\/j.biopsych.2009.01.031_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/syn.890150310","article-title":"Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei","volume":"15","author":"Bel","year":"1993","journal-title":"Synapse"},{"key":"10.1016\/j.biopsych.2009.01.031_bib38","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1440-1681.2006.04521.x","article-title":"5-HT(1A) receptors in stress-induced cardiac changes: A possible link between mental and cardiac disorders","volume":"33","author":"Nalivaiko","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib39","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopsych.2004.06.035","article-title":"Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults","volume":"56","author":"Tyrka","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1600001","article-title":"The role of corticotropin-releasing factor in depression and anxiety disorders","volume":"160","author":"Arborelius","year":"1999","journal-title":"J Endocrinol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1176\/ajp.150.4.656","article-title":"Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression","volume":"150","author":"De Bellis","year":"1993","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.biopsych.2009.01.031_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-0327(00)00352-9","article-title":"Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy","volume":"62","author":"Holsboer","year":"2001","journal-title":"J Affect Disord"},{"issue":"suppl 1","key":"10.1016\/j.biopsych.2009.01.031_bib43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/S1516-44462003000500012","article-title":"[Posttraumatic stress disorder and major depression]","volume":"25","author":"Berlim","year":"2003","journal-title":"Rev Bras Psiquiatr"},{"key":"10.1016\/j.biopsych.2009.01.031_bib44","first-page":"A22","article-title":"A meta-analysis of acute tryptophan depletion studies in anxiety disorders using individual patients' data","volume":"18","author":"Hood","year":"2004","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib45","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/0269881107082359","article-title":"Panic and hypertension: brothers in arms through 5-HT?","volume":"21","author":"Davies","year":"2007","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3200\/BMED.34.4.125-132","article-title":"Hypertension in relation to posttraumatic stress disorder and depression in the US National Comorbidity Survey","volume":"34","author":"Kibler","year":"2009","journal-title":"Behav Med"},{"key":"10.1016\/j.biopsych.2009.01.031_bib47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1037\/0021-843X.113.2.189","article-title":"All symptoms are not created equal: The prominent role of hyperarousal in the natural course of posttraumatic psychological distress","volume":"113","author":"Schell","year":"2004","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.biopsych.2009.01.031_bib48","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0005-7967(94)00067-T","article-title":"Short-term follow-up of post-traumatic stress symptoms in motor vehicle accident victims","volume":"33","author":"Blanchard","year":"1995","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.biopsych.2009.01.031_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neubiorev.2003.12.004","article-title":"Serotonin, the periaqueductal gray and panic","volume":"28","author":"Graeff","year":"2004","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Biological Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309001292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006322309001292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T12:59:19Z","timestamp":1589633959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006322309001292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0006322309001292"],"URL":"https:\/\/doi.org\/10.1016\/j.biopsych.2009.01.031","relation":{},"ISSN":["0006-3223"],"issn-type":[{"value":"0006-3223","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}